Moderating effects of DRD2 on depression

Stress and Health

Volumn 25, Issue 5, 2009, Pages 453-462

  Vaske, Jamie ^a   Beaver, Kevin M ^b   Wright, John Paul ^c   Boisvert, Danielle ^d   Makarios, Matthew ^e  

^a WESTERN CAROLINA UNIVERSITY   (United States)

^b FLORIDA STATE UNIVERSITY   (United States)

^c UNIVERSITY OF CINCINNATI   (United States)

^d PENNSYLVANIA STATE UNIVERSITY   (United States)

^e UNIVERSITY OF WISCONSIN PARKSIDE   (United States)

Author keywords

Ethnicity; Gene environment interaction; Stressful life circumstances

Indexed keywords

DOPAMINE 2 RECEPTOR; SEROTONIN TRANSPORTER; TAQ POLYMERASE;

ADULT; AFRICAN AMERICAN; ARTICLE; CAUCASIAN; CONTROLLED STUDY; DEPRESSION; EMOTIONAL ATTACHMENT; ETHNICITY; FEMALE; GENETIC POLYMORPHISM; GENETIC RISK; GENOTYPE; HUMAN; HUMAN CELL; LIFE EVENT; LIFE STRESS; MALE; PERSONAL EXPERIENCE; PREDICTION; PROMOTER REGION; PROTEIN FUNCTION; RACE DIFFERENCE; RISK ASSESSMENT; SELF REPORT; SEX DIFFERENCE;

EID: 72149121830     PISSN: 15323005     EISSN: 15322998     Source Type: Journal    
DOI: 10.1002/smi.1277     Document Type: Article

References (56)

1. Add Health Biomarkers Team. No date. Biomarkers in wave III of the Add Health study. Chapel Hill, NC: Carolina Population Center, University of North Carolina at Chapel Hill.
2. Aiken, L., & West, S.G. (1991). Multiple regression: Testing and interpreting interactions. Newbury Park, CA: Sage Publications.
3. Asberg, M. (1997). The evidence from cerebrospinal fluid studies. Annals of the New York Academy of Sciences, 836, 158-181.
4. Asberg, M., Thoren, P., Traskman, L., Bertilsson, L., & Ringberger, V. (1976). 'Serotonin depression' - a biochemical subgroup within the affective disorders? Science, 191(4226), 478-480.
5. Beaver, K.M., Wright, J.P., DeLisi, M., Daigle, L.E., Swatt, M.L., & Gibson, C.L. (2007). Evidence of a gene X environment interaction in the creation of victimization. International Journal of Offender Therapy and Comparative Criminology, 51, 620-645.
6. Berman, S.M., & Noble, E.P. (1997a). The D2 dopamine receptor (DRD2) gene and family stress; Interactive effects on cognitive functions in children. Behavior Genetics, 27, 33-43.
7. Berman, S.M., Ozkaragoz, T., Noble, E.P., Antolin, T., Sheen, C., Siddarth, P., Conner, T., & Ritchie, T. (1997b). Differential associations of sex and D2 dopamine receptor (DRD2) genotype with negative affect and other substance abuse risk markers in children of alcoholics. Alcohol, 30, 201-210.
8. Brown, G.W., & Moran, P. (1997). Single mothers, poverty and depression. Psychological Medicine, 27, 21-33.
9. Brown, G.W., Bifulco, A., & Harris, T.O. (1987). Life events, vulnerability and onset of depression: Some refinements. British Journal of Psychiatry, 150, 30-42. (Pubitemid 17081815)
10. Brummett, B.H., Boyle, S.H., Siegler, I.C., Kuhn, C.M., Ashley-Koch, A., Jonassaint, C.R., Züchner, S., Collins, A., & Williams, R.B. (2008). Effects of environmental stress and gender on associations among symptom of depression and the serotonin transporter gene linked polymorphic region. (5HTTLPR). Behavior Genetics, 38, 34-43. (Pubitemid 351164912)
11. Cabib, S., & Puglisi-Allegra, S. (1996). Stress, depression and the mesolimbic dopamine system. Psychopharmacology, 128, 331-342. (Pubitemid 26417674)
12. Caspi, A., Sugden, K., Moffitt, T.E., Taylor, A., Craig, I.W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., & Poulton, R. (2003). Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science, 301(5631), 386-389. (Pubitemid 36877077)
13. Castiglione, C.M., Deinard, A.S., Speed, W.C., Sirugo, G., Rosenbaum, H.C., Zhang, Y., Grandy, D.K., Grigorenko, E.L., Bonne-Tamir, B., Pakstis, A.J., Kidd, J.R., & Kidd, K.K. (1995). Evolution of haplotypes at the DRD2 locus. American Journal of Human Genetics, 57, 1445-1456.
14. Cervilla, J.A., Molina, E., Rivera, M., Torres-González, F., Bellón, J.A., Moreno, B., Luna, J.D., Lorente, J.A., Mayoral, F., King, M., Nazareth, I., the PREDICT Study Core Group, & Gutiérrez, B. (2007). The risk for depression conferred by stressful life events is modified by variation at the serotonin transporter 5HTTLPR genotype: Evidence from the Spanish PREDICT-gene cohort. Molecular Psychiatry, 12, 748-755.
15. Cutrona, C.E., Russell, D.W., Hessling, R.M., Brown, P.A., & Murry, V. (2000). Direct and moderating effects of community context on the psychological well-being of African American Women. Journal of Personality and Social Psychology, 79, 1088-1101.
16. Eley, T.C., Sugden, K., Corsico, A., Gregory, A.M., Sham, P., McGuffin, P., Plomin, R., & Craig, I.W. (2004). Gene-environment interaction analysis of serotonin system markers with adolescent depression. Molecular Psychiatry, 9, 908-915. (Pubitemid 39381955)
17. Elovainio, M., Jokela, M., Kivimäki, M., Pulkki-Råback, L., Lehtimäki, T., Airla, N., & Keltikangas-Järvinen, L. (2007). Genetic variants in the DRD2 gene moderate the relationship between stressful life events and depressive symptoms in adults: Cardiovascular risk in young Finns study. Psychosomatic Medicine, 69, 391-395. (Pubitemid 46987880)
18. Gelernter, J., Kranzler, H., Cubells, J.F., Ichinose, H., & Nagatsu, T. (1998). DRD2 allele frequencies and linkage disequilibria, including the - 141Ins/Del promoter polymorphism, in European-American, African-American, and Japanese subjects. Genomics, 51, 21-26. (Pubitemid 28373369)
19. Gibbs, J.T., & Fuery, D. (1994). Mental health and well-being of black women: Toward strategies of empowerment. American Journal of Community Psychology, 22, 559-582.
20. Gillespie, N.A., Whitfield, J.B., Williams, B., Heath, A.C., & Martin, N.G. (2005). The relationship between stressful life events, the serotonin transporter (5HTTLPR) genotype and major depression. Psychological Medicine, 35, 101-111. (Pubitemid 40201920)
21. Gorman-Smith, D., Henry, D.B., & Tolan, P.H. (2004). Exposure to community violence and violence perpetration: The protective effects of family functioning. Journal of Clinical Child and Adolescent Psychology, 33, 439-449. (Pubitemid 39209988)
22. Grabe, H.J., Lange, M., Wolff, B., Völzke, H., Lucht, M., Freyberger, H.J., John, U., & Cascorbi, I. (2005). Mental and physical distress is modulated by a polymorphism in the 5-HT transporter gene interacting with social stressors and chronic disease burden. Molecular Psychiatry, 10, 220-224. (Pubitemid 40188517)
23. Hammen, C., Ellicott, A., & Gitlin, M. (1989). Sociotrophy/autonomy and vulnerability to specific life events in patients with unipolar depression and bipolar disorders. Journal of Abnormal Psychology, 98,154-160. (Pubitemid 19134403)
24. Kapur, S., & Mann, J.J. (1992). Role of the dopaminergic system in depression. Biological Psychiatry, 32, 1-17.
25. Kaufman, J., Yang, B.Z., Douglas-Palumberi, H., Houshyar, S., Lipschitz, D., Krystal, J.H., Gelernter, J., & McEwen, B.S. (2004). Social supports and serotonin transporter gene moderate depression in maltreated children. Proceedings of the National Academy of Sciences, 101(49), 17316-17321. (Pubitemid 39627817)
26. Kendler, K.S., & Karkowski-Shuman, L. (1997). Stressful life events and genetic liability to major depression: Genetic control of exposure to the environment. Psychological medicine, 27, 539-547.
27. Kendler, K.S., Karkowski, L.M., & Prescott, C.A. (1999). Causal relationship between stressful life events and the onset of major depression. American Journal of Psychiatry, 156, 837-841. (Pubitemid 29260336)
28. Kendler, K.S., Thornton, L.M., & Prescott, C.A. (2001). Gender differences in the rates of exposure to stressful life events and sensitivity to their depressogenic effects. American Journal of Psychiatry, 158, 587-593.
29. Kendler, K.S., Hettema, J.M., Butera, F., Gardner, C.O., & Prescott, C.A. (2003). Life event dimensions of loss, humiliation, entrapment, and danger in the prediction of onsets of major depression and generalized anxiety. Archives of General Psychiatry, 60, 789-796. (Pubitemid 36960910)
30. Kendler, K.S., Kessler, R.C., Neale, M.C., Heath, A.C., & Eaves, J.C. (1993). The prediction of major depression in women: Toward an integrated etiologic model. American Journal of Psychiatry, 150, 1139-1148.
31. Kendler, K.S., Kuhn, J.W., Vittum, J., Prescott, C.A., & Riley, B. (2005). The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: A replication. Archives of General Psychiatry, 62(5), 529-535. (Pubitemid 40628882)
32. Kendler, K.S., Kessler, R.C., Walters, E.E., MacLean, C., Neale, M.C., Heath, A.C., & Eaves, L.J. (1995). Stressful life events, genetic liability, and onset of an episode of major depression in women. American Journal of Psychiatry, 152, 833-842.
33. Kim, J., Stewart, R., Kim, S., Yang, S., Shin, I., Kim, Y., & Yoon, J. (2007). Interactions between life stressors and susceptibility genes (5-HTTLPR and BDNF) on depression in Korean elders. Biological Psychiatry, 62, 423-428. (Pubitemid 47284032)
34. Lang, A.J., Stein, M.B., Kennedy, C.M., & Foy, D.W. (2004). Adult psychopathology and intimate partner violence among survivors of childhood maltreatment. Journal of interpersonal violence, 19, 1102-1118. (Pubitemid 39289291)
35. Lenze, E.J., Munin, M.C., Ferrell, R.E., Pollock, B.G., Skidmore, E., Lotrich, F., Rogers, J.C., Quear, T., Houck, P., & Reynolds, C.F. (2005). Association of the serotonin transporter gene-linked polymorphic region (5-HTTLPR) genotype with depression in elderly persons after hip fracture. Archives of General Psychiatry, 13(5), 428-432. (Pubitemid 40617488)
36. Lesch, K.P., Bengel, D., Heils, A., Sabol, S.Z., Greenberg, B.D., Petri, S., Benjamin, J., Müller, C.R., Hamer, D.H., & Murphy, D.L.M. (1996). Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science, 274(5292), 1527-1531. (Pubitemid 26403928)
37. Mandelli, L., Serretti, A., Marino, E., Pirovano, A., Calati, R., & Colombo, C. (2007). Interaction between serotonin transporter gene, catechol-O-methyltransferase gene and stressful life events in mood disorders. International Journal of Neuropsychopharmacology, 10(04), 437-447. (Pubitemid 46985252)
38. Monroe, S.M., & Reid, M.W. (2008). Gene-environment interactions in depression research: Genetic polymorphisms and life-stress polymorphisms. Psychological Science, 19, 947-956.
39. Monroe, S.M., & Simons, A.D. (1991). Diathesis-stress theories in the context of life stress research: Implications for the depressive disorders. Psychological Bulletin, 110, 406-425.
40. Nestler, E.J., & Carlezon, W.A. (2006). The mesolimbic dopamine reward circuit in depression. Biological psychiatry, 59, 1151-1159.
41. Noble, E.P. (2003). D2 dopamine receptor gene in psychiatric and neurologic disorders and its phenotypes. American Journal of Medical Genetics Part B, 116B, 103-125. (Pubitemid 37063624)
42. Porcerelli, J.H., Cogan, R., West, P.P., Rose, E.A., Lambrecht, D., Wilson, K.E., Severson, R.K., & Karana, D. (2003). Violent victimization of women and men: Physical and psychiatric symptoms. Journal of the American Board of Family Practice, 16, 32-39.
43. Radloff, L.S. (1977). The CES-D scale: A self-report depression scale for research in the general population. Applied Psychological Measurement, 1, 385-401.
44. Reis, J. (1989). The structure of depression in community based young adolescent, older adolescent, and adult mothers. Family Relations, 38, 164-168.
45. Rogers, W. (1993). Regression standard errors in clustered samples. STATA Technical Bulletin, 13, 19-23.
46. Sanders-Phillips, K., Moisan, P.A., Wadlington, S., Morgan, S., & English, K. (1995). Ethnic differences in psychological functioning among Black and Latino sexually abused girls. Child Abuse & Neglect, 19, 691-706.
47. Scheid, J.M., Holzman, C.B., Jones, N., Friderici, K.H., Nummy, K.A., Symonds, L.L., Sikorskii, A., Regier, M.K., & Fisher, R. (2007). Depressive symptoms in midpregnancy, lifetime stressors and the 5HTTLPR genotype. Genes, Brain, and Behavior, 6, 453-464. (Pubitemid 47024957)
48. Silberg, J., Rutter, M., Neale, M., & Eaves, L. (2001). Genetic moderation of environmental risk for depression and anxiety in adolescent girls. British Journal of Psychiatry, 179, 116-121. (Pubitemid 32756493)
49. Sjöberg, R.L., Nilsson, K.W., Nordquist, N., Öhrvik, J., Leppert, Lindström, & Oreland, L. (2006). Development of depression: Sex and the interaction between environment and a promoter polymorphism of the serotonin transporter gene. International Journal of Neuropsychopharmacology, 9, 443-449. (Pubitemid 43979704)
50. Taylor, S.E., Way, B.M., Welch, W.T., Hilmert, C.J., Lehman, B.J., & Eisenberger, N.I. (2006). Early family environment, current adversity, the serotonin transporter promoter polymorphism, and depressive symptomatology. Biological Psychiatry, 60(7), 671-676.
51. Tomasulo, G.C., & McNamara, J.R. (2007). The relationship of abuse to women's health status and health habits. Journal of Family Violence, 22, 231-235.
52. Uher, R., & McGuffin, P. (2007). The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: Review and methodological analysis. Molecular Psychiatry, 1, 1-16.
53. Vaske, J., Makarios, M., Boisvert, D., Beaver, K.M., & Wright, J.P. (2008). The interaction of DRD2 and violent victimization on depression: An analysis by gender and race. Journal of Affective Disorders, 112, 120-125.
54. Widom, C.S., & Ames, M.A. (1994). Criminal consequences of childhood sexual victimization. Child Abuse & Neglect, 18, 303-318.
55. Wilhelm, K., Mitchell, P.B., Niven, H., Finch, A., Wedgwood, L., Scimone, A., Blair, I.P., Parker, G., & Schøfield, P.R. (2006). Life events, first depression onset and the serotonin transporter gene. The British Journal of Psychiatry, 188(3), 210-215. (Pubitemid 43341646)
56. Zalsman, G., Huang, Y., Oquendo, M.A., Burke, A.K., Hu, X., Brent, D.A., Ellis, S.P., Goldman, D., & Mann, J.J. (2006). Association of a triallelic serotonin transporter gene promoter region (5-HTTLPR) polymorphism with stressful life events and severity of depression. American Journal of Psychiatry, 163(9), 1588-1593. (Pubitemid 44465760)