Effect of Quercitrin on acute and chronic experimental colitis in the rat

Journal of Pharmacology and Experimental Therapeutics

Volumn 278, Issue 2, 1996, Pages 771-779

  Fermin Sanchez De Medina, L H ^a   Gálvez, Julio ^a   Romero, José Antonio ^a   Zarzuelo, Antonio ^a  

^a UNIVERSITY OF GRANADA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; GLUTATHIONE; LEUKOTRIENE B4; MYELOPEROXIDASE; QUERCETIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CLINICAL FEATURE; COLITIS; COLON ABSORPTION; DIARRHEA; DRUG EFFECT; DRUG EFFICACY; ENZYME ACTIVITY; FEMALE; NONHUMAN; ORAL DRUG ADMINISTRATION; OXIDATION; PRIORITY JOURNAL; RAT;

ANIMALS; ANTIDIARRHEALS; COLITIS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GLUTATHIONE; QUERCETIN; RATS; RATS, WISTAR;

EID: 0009646130     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (55)

1. 2 before and after induction of colitis with trinitrobenzenesulfonic acid in rats decreases inflammation. Gastroenterology 96: 1290-1300, 1989.
2. ANDERSON, M. E.: Determination of glutathione and glutathione disulfide in biological samples. Methods Enzymol. 113: 548-555, 1985.
3. BELL, C. J., GALL, D. G. AND WALLACE, J. L.: Disruption of colonic electrolyte transport in experimental colitis. Am. J. Physiol. 268: G622-G630, 1995.
4. BESSEY, O. A., LOWRY, O. H. AND BROOK, M. J.: Rapid colorimetric method for the determination of alkaline phosphatase in five cubic mililiters of serum. J. Biol. Chem. 164: 321-329, 1946.
5. BOKKENHAUSER, V. D. AND WINTER, J.: Hidrolysis of flavonoids by human intestinal bacteria. In Plant Flavonoids in Biology and Medicine II: Biochemical, Cellular, and Medicinal Properties, ed. by V. Cody, E. Middleton Jr., J. B. Harborne and A. Beretz, pp. 143-145, Alan R. Liss, Inc., New York, 1988.
6. BORS, W., HELLER, W., MICHEL, C. AND SARAN, M.: Flavonoids as antioxidants: Determination of radical-scavenging efficiencies. Methods Enzymol. 186: 343-355, 1990.
7. BRADFORD, M. M.: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72: 248-254, 1976.
8. BUELL, M. G. AND BERIN, M. C.: Neutrophil-independence of the initiation of colonic injury. Comparison of results from three models of experimental colitis in the rat. Dig. Dis. Sci. 39: 2575-2588, 1994.
9. COOKE, E. M., FILIPE, M. T. AND DAWSON, I. M. P.: The production of colonic auto-antibodies in rabbits by immunization with Escherichia coli. J. Pathol. Bacteriol. 96: 125-129, 1968.
10. COOPER, H. S. AND STEPLEWSKI, Z.: Immunohistologic study of ulcerative colitis with monoclonal antibodies against tumor-associated and/or differentiation antigens. Gastroenterology 95: 686-693, 1989.
11. EBERHART, C. E. AND DUBOIS, R. N.: Eicosanoids and the gastrointestinal tract. Gastroenterology 109: 285-301, 1995.
12. FERRIOLA, P. C., CODY, V. AND MDDDLETON, E. JR.: Protein kinase C inhibition by plant flavonoids. Kinetic mechanisms and structure-activity relationships. Biochem. Pharmacol. 38: 1617-1624, 1989.
13. 4 receptor antagonist SC-41930 on colonic inflammation in rat, guinea pig and rabbit. J. Pharmacol. Exp. Ther. 258: 572-576, 1990.
14. GALSANOV, S. B., TUROVA, A. D. AND KLIMENKO, E. D.: Effect of quercitrin on structural changes in the large and small intestines during experimental enterocolitis. Byull. Eksp. Biol. Med. 81: 623-625, 1976.
15. GÁLVEZ, J., CRESPO, M. E., JIMÉNEZ, J., SUÁREZ, A. AND ZARZUELO, A.: Antidiarrhoeic activity of quercitrin in mice and rats. J. Pharm. Pharmacol. 45: 157-159, 1993.
16. GÁLVEZ, J., DE LA CRUZ, J. P., ZARZUELO, A., SÁNCHEZ DE MEDINA JR., F., JIMÉNEZ, J. AND SÁNCHEZ DE LA CUESTA, F.: Oral administration of quercitrin modifies intestinal oxidative status in rats. Gen. Pharmacol. 25: 1237-1243, 1994.
17. GÁLVEZ, J., SÁNCHEZ DE MEDINA, F., JIMÉNEZ, J., TORRES, M. I., FERNÁNDEZ, M. I., NÚÑEZ, M. C., RIOS, A., GIL, A. AND ZARZUELO, A.: Effect of quercitrin on lactose-induced chronic diarrhoea in rats. Planta Med. 61: 302-306, 1995.
18. GRISHAM, M. B.: The hapten, trinitrobenzenesulfonic acid (TNBS), is metabolized to produce cytotoxic oxygen radicals: possible mechanism for the induction of colitis (Abstract). Gastroenterology 98: A452, 1990.
19. HARBORNE, J. B.: Phenolic compounds. In Phytochemical Methods, ed. by J. B. Harborne, pp. 37-99, Chapman and Hall, New York, 1984.
20. HARRIS, M. L., SCHILLER, H. J., REILLY, P. M., DONOWITZ, M., GRISHAM, M. B. AND BULKLEY, G. B.: Free radicals and other reactive oxygen metabolites in inflammatory bowel disease: Cause, consequence or epiphenomenon? Pharmacol. Ther. 53: 375-408, 1992.
21. HATTORI, S.: Glycosides of flavones and flavonols. In The Chemistry of Flavonoid Compounds, ed. by T. A. Geissman, pp. 317-352, Pergamon Press Inc., New York, 1962.
22. HAVSTEEN, B.: Flavonoids, a class of natural products of high pharmacological potency. Biochem. Pharmacol. 32: 1141-1148, 1983.
23. HODNICK, W. F., KALYANARAMAN, B., PRITSOS, C. A. AND PARDINI, R. S.: The production of hydroxyl and semiquinone free radicals during the autoxidation of redox active flavonoids. In Oxygen Radicals in Biology and Medicine, ed. by M. G. Simic, K. A. Taylor, J. F. Ward and C. von Sonntag, pp. 149-152, Plenum Press, New York, 1989.
24. KRAWISZ, J. E., SHARON, P. AND STENSON, W. F.: Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity. Assessment of inflammation in rat and hamster models. Gastroenterology 87: 1344-1350, 1984.
25. KUHNAU, J.: The flavonoids. A class of semi-essential food components: their role in human nutrition. World Rev. Nutr. Diet. 24: 117-191, 1976.
26. LAUGHTON, M. J., EVANS, P. J., MORONEY, M. A., HOULT, J. R. S. AND HALLIWELL, B.: Inhibition of mammalian 5-lipoxygenase and cyclo-oxygenase by flavonoids and phenolic dietary additives. Relationship to antioxidant activity and to iron-reducing ability. Biochem. Pharmacol. 42: 1673-1681, 1991.
27. LAUTERBUKG, B. H., BILZER, M., ROWEDDER, E. AND INAUEN, W.: Decreased glutathione in inflamed colonic mucosa in man. Possible role of hypochlorous acid and prevention by 5-aminosalicylic acid. In Inflammatory Bowel Disease: Current Status and Future Approach, ed. by R. P. MacDermott, pp. 273-277, Elsevier Science Publishers, Amsterdam, 1988.
28. LEE, T.-P., MATTELIANO, M. L. AND MIDDLETON, E.: Effect of quercetin on human polymorphonuclear leukocyte lysosomal enzyme release and phospholipid metabolism. Life Sci. 31: 2765-2774, 1982.
29. LEVINE, D. S.: Clinical features and complications of Crohn's disease. In Inflammatory Bowel Disease: Prom Bench to Bedside, ed. by S. R. Targan and F. Shanahan, pp. 296-316, Williams & Wilkins, Baltimore, MD, 1994.
30. LUCK, M. S. AND BASS, P.: Effect of epidermal growth factor on experimental colitis in the rat. J. Pharmacol. Exp. Ther. 264: 984-990, 1993.
31. MCCAFFERTY, D. M., RIOUX, K. AND WALLACE, J. L.: Granulocyte infiltration in experimental colitis in the rat is interleukin-1 dependent and leukotriene independent. Eicosanoids 5: 121-125, 1992.
32. MCHUGH, K. J., COLLINS, S. M. AND WEINGARTEN, H. P.: Central interleukin receptors contribute to suppression of feeding after acute colitis in the rat. Am. J. Physiol. 266: R1659-R1663, 1994.
33. MCHUGH, K. J., WEINGARTEN, H. P., KEENAN, C., WALLACE, J. L. AND COLLINS, S. M.: On the suppression of food intake in experimental models of colitis in the rat. Am. J. Physiol. 264: R871-R876, 1993.
34. MIDDLETON, E. AND KANDASWAMI, C.: Plant flavonoid modulation of immune and inflammatory cell functions. In Human Nutrition - A Comprehensive Treatise, ed. by D. M. Klurfeld, vol. 8: Nutrition and Immunology, pp. 239-266, Plenum Press, New York, 1993.
35. MORONEY, M.-A., ALCARAZ, M. J., FORDER, R. A., CAREY, F. AND HOULT, J. R. S.: Selectivity of neutrophil 5-lipoxygenase and cyclo-oxygenase inhibition by an anti-inflammatory flavonoid glycoside and related aglycone flavonoids. J. Pharm. Pharmacol. 40: 787-792, 1988.
36. MORRIS, G. P., BECK, P. L., HERRIDGE, W., DEPEW, W., SZEWCZUK, M. R. AND WALLACE, J. L.: Hapten-induced model of chronic inflammation and ulceration in the rat colon. Gastroenterology 96: 795-803, 1989.
37. NAKAYAMA, T., YAMADA, M., OSAWA, T. AND KAWAKISHI, S.: Suppression of active oxygen-induced cytotoxicity by flavonoids. Biochem. Pharmacol. 45: 265-267, 1993.
38. NISHIOKA, H., IMOTO, M., SAWA, T., HAMADA, M., NAGANAWA, H., TAKEUCHI, T. AND UMEZAWA, K.: Screening of phosphatidylinositol kinase inhibitors from Streptomyces. J. Antibiot. 42: 823-825, 1989.
39. PEH, K. H., WAN, B. Y. C. AND PARKE, D. V.: Determination of glutathione content and myeloperoxidase activity in rat models of induced rectocolonic inflammation (Abstract). Br. J. Pharmacol. 97: 548P, 1989.
40. PINCEMAIL, J., DEBY, C., THIRION, A., DE BRUYN-DISTER, M. AND GOUTIER, M.: Human myeloperoxidase activity is inhibited in vitro by quercetin. Comparison with three related compounds. Experientia 44: 450-453, 1988.
41. RACHMILEWITZ, D., SIMON, P. L., SCHWARTZ, L. W., GRISWOLD, D. E., FONDACARO, J. D. AND WASSERMAN, M. A.: Inflammatory mediators of experimental colitis in rats. Gastroenterology 97: 326-337, 1989.
42. SHARON, P. AND STENSON, W. F.: Metabolism of arachidonic acid in acetic acid colitis in the rat: Similarity to human inflammatory bowel disease. Gastroenterology 88: 55-63, 1985.
43. 2. Free Rad. Biol. Med. 11: 1-8, 1991.
44. STENSON, W. F.: Animal models of inflammatory bowel disease. In Inflammatory Bowel Disease: From Bench To Bedside, ed. by S. R. Targan and F. Shanahan, pp. 180-192, Williams & Wilkins, Baltimore, MD, 1994.
45. UENO, I., KOHNO, M., HARAIKAWA, K. AND HIRONO, I.: Interaction between quercetin and superoxide radicals. Reduction of the quercetin mutagenicity. J. Pharm. Dyn. 7: 798-803, 1984.
46. VELJACA, M., LESCH, C. A., PLLANA, R., SANCHEZ, B., CHAN, K. AND GUGLIETTA, A.: BPC-15 reduces trinitrobenzene sulfonic acid-induced colonic damage in rats. J. Pharmacol. Exp. Ther. 272: 417-422, 1995.
47. VERSPAGET, H. W., MULDER, T. P. J., VAN DER SLUYS VEER, A., PEÑA, A. S. AND LAMERS, C. B. H. W.: Reactive oxygen metabolites and colitis; a disturbed balance between damage and protection. A selective review. Scand. J. Gastroenterol. 26: suppl. 188, 44-51, 1991.
48. 4 potentiates colonic ulceration in the rat. Dig. Dis. Sci. 35: 622-629, 1990.
49. WALLACE, J. L.: Eicosanoids. In Inflammatory Bowel Disease: From Bench To Bedside, ed. by S. R. Targan and F. Shanahan, pp. 123-132, Williams & Wilkins, Baltimore, MD, 1994.
50. WALLACE, J. L., MACNAUGHTON, W. K., MORRIS, G. P. AND BECK, P. L.: Inhibition of leukotriene synthesis markedly accelerates healing in a rat model of inflammatory bowel disease. Gastroenterology 96: 29-36, 1989.
51. WALLACE, J. L., WHITTLE, B. J. R. AND BOUGHTON-SMITH, N. K.: Prostaglandin protection of rat colonic mucosa from damage induced by ethanol. Dig. Dis. Sci. 30: 866-876, 1985.
52. WELTON, A. F., HURLEY, J. AND WILL, P.: Flavonoids and arachidonic acid metabolism. In Plant Flavonoids in Biology and Medicine II: Biochemical, Cellular, and Medicinal Properties, ed. by V. Cody, E. Middleton Jr., J. B. Harborne and A. Beretz, pp. 301-312, Alan R. Liss, Inc., New York, 1988.
53. YAMADA, T. AND GRISHAM, M. B.: Pathogenesis of tissue injury: Role of reactive metabolites of oxygen and nitrogen. In Inflammatory Bowel Disease: From Bench To Bedside, ed. by S. R. Targan and F. Shanahan, pp. 133-150, Williams & Wilkins, Baltimore, MD, 1994.
54. YAMADA, T., MARSHALL, S., SPECIAN, R. D. AND GRISHAM, M. B.: A comparative study of two models of experimental colitis in rats. Gastroenterology 102: 1524-1534, 1992.
55. YUE, G., SUN, F. F., DUNN, C., YIN, K. AND WONG, P. Y.-K.: The 21-aminosteroid tirilazad can ameliorate inflammatory bowel disease in rats. J. Pharmacol. Exp. Ther. 276: 265-270, 1996.