Silicon switch approach in TRPV1 antagonist MK-056 and its analogues

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 1, 2010, Pages 111-116

  Chang, Minsun ^a   Park, Seol Rin ^a   Kim, Juhyun ^a   Jang, Mijung ^a   Park, Jeong Hyun ^a   Park, Ji Eun ^a   Park, Hyeung Geun ^b   Suh, Young Ger ^b   Jeong, Yeon Su ^c   Park, Young Ho ^c   Kim, Hee Doo ^a  

^a Sookmyung Women's University   (South Korea)

^b Seoul National University   (South Korea)

^c AmorePacific R and D Center 314 1   (South Korea)

Author keywords

1,3 Dibenzylthiourea; Antagonist; Silicon switch; TRPV1

Indexed keywords

ANALGESIC AGENT; ATC 120; METHYL GROUP; MK 056; N [2 FLUORO 4 [3 (4 TRIMETHYLSILANYLBENZYL)THIOUREIDOMETHYL]PHENYL]METHANESULFONAMIDE; N [4 [1 [3 (4 TRIETHYLSILANYLBENZYL)THIOUREIDO]ETHYL]PHENYL)METHANESULFONAMIDE; N [4 [1 [3 (4 TRIMETHYLSILANYLBENZYL)THIOUREIDO]ETHYL]PHENYL]METHANESULFONAMIDE; N [4 [1 [3 [4 (ETHYLDIMETHYLSILANYL)BENZYL]THIOUREIDO]ETHYL]PHENYL]METHANESULFONAMIDE; N [4 [3 (4 ETHYLDIMETHYLSILANYLBENZYL)THIOUREIDOMETHYL]PHENYL]METHANESULFONAMIDE; N [4 [3 (4 TRIETHYLSILANYLBENZYL)THIOUREIDOMETHYL]PHENYL]METHANESULFONAMIDE; N [4 [3 (4 TRIMETHYLSILANYLBENZYL)THIOUREIDOMETHYL]PHENYL]METHANESULFONAMIDE; SC 0030; SILICON; TRIMETHYLSILANYL; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; NEWBORN; NONHUMAN; RAT; SUBSTITUTION REACTION;

ANIMALS; CALCIUM; CELLS, CULTURED; MOLECULAR STRUCTURE; NEURONS; PHENYLTHIOUREA; RATS; RATS, SPRAGUE-DAWLEY; SILICON; TRPV CATION CHANNELS;

EID: 72049098174     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.11.014     Document Type: Article

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