Design, synthesis, and biological evaluation of novel diarylalkyl amides as TRPV1 antagonists

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 10, 2009, Pages 3557-3567

  Li, Fu Nan ^a   Kim, Nam Jung ^a   Paek, Seung Mann ^a   Kwon, Do Yeon ^a   Min, Kyung Hoon ^b   Jeong, Yeon Su ^c   Kim, Sun Young ^c   Park, Young Ho ^c   Kim, Hee Doo ^d   Park, Hyeung Geun ^a   Suh, Young Ger ^a  

^a Seoul National University   (South Korea)

^b Chung Ang University   (South Korea)

^c AmorePacific Corporation   (South Korea)

^d Sookmyung Women's University   (South Korea)

Author keywords

Diarylalkyl amides; TRPV1 antagonists

Indexed keywords

ALKYL GROUP; AROMATIC AMIDE; N [3 CYANO 5 FLUORO 4 (METHYLSULFONAMIDO)BENZYL] 3 (5,5,8,8 TETRAMETHYL 5,6,7,8 TETRAHYDRONAPHTHALEN 2 YL)PROPANAMIDE; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1;

ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; EVALUATION; IC 50; INHIBITION KINETICS; NERVE CELL; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

AMIDES; ANIMALS; CALCIUM; CELLS, CULTURED; DRUG DESIGN; INHIBITORY CONCENTRATION 50; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; TETRAHYDRONAPHTHALENES; TRPV CATION CHANNELS;

RATTUS;

EID: 65349151388     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.04.010     Document Type: Article

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