메뉴 건너뛰기




Volumn 56, Issue 94-95, 2009, Pages 1395-1402

The efficacy of low dose azathioprine/6-mercaptopurine in patients with inflammatory bowel disease

Author keywords

6 mercaptopurine; Azathioprine; Inflammatory bowel disease

Indexed keywords

AMYLASE; AZATHIOPRINE; MERCAPTOPURINE; TRIACYLGLYCEROL LIPASE;

EID: 71949104060     PISSN: 01726390     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (17)

References (47)
  • 1
    • 0036278519 scopus 로고    scopus 로고
    • The efficacy of azathioprine for the treatment of inflammatory bowel disease: A 30 year review
    • Fraser AG, Orchard TR, Jewell DP: The efficacy of azathioprine for the treatment of inflammatory bowel disease: a 30 year review. Gut 2002; 50:485-489.
    • (2002) Gut , vol.50 , pp. 485-489
    • Fraser, A.G.1    Orchard, T.R.2    Jewell, D.P.3
  • 2
    • 0033776995 scopus 로고    scopus 로고
    • Retrospective case series analysis of patients with inflammatory bowel disease on azathioprine. A district general hospital experience
    • Khan ZH, Mayberry JF, Spiers N, Wicks AC: Retrospective case series analysis of patients with inflammatory bowel disease on azathioprine. A district general hospital experience. Digestion 2000; 62:249-254.
    • (2000) Digestion , vol.62 , pp. 249-254
    • Khan, Z.H.1    Mayberry, J.F.2    Spiers, N.3    Wicks, A.C.4
  • 3
    • 0028790186 scopus 로고
    • A controlled double blind study of azathioprine in the management of Crohn's disease
    • Candy S, Wright J, Gerber M, Adams G, Gerig M, Goodman R: A controlled double blind study of azathioprine in the management of Crohn's disease. Gut 1995; 37:674-678.
    • (1995) Gut , vol.37 , pp. 674-678
    • Candy, S.1    Wright, J.2    Gerber, M.3    Adams, G.4    Gerig, M.5    Goodman, R.6
  • 6
    • 39149120115 scopus 로고    scopus 로고
    • Azathioprine and 6-mercaptopurine for maintenance of remission in ulcerative colitis
    • CD000478
    • Timmer A, McDonald JW, Macdonald JK: Azathioprine and 6-mercaptopurine for maintenance of remission in ulcerative colitis. Cochrane Database Syst Rev 2007:CD000478.
    • (2007) Cochrane Database Syst Rev
    • Timmer, A.1    McDonald, J.W.2    Macdonald, J.K.3
  • 8
    • 0018888679 scopus 로고
    • Treatment of Crohn's disease with 6-mercaptopurine. a long-term, randomized, double-blind study
    • Present DH, Korelitz BI, Wisch N, Glass JL, Sachar DB, Pasternack BS: Treatment of Crohn's disease with 6-mercaptopurine. A long-term, randomized, double-blind study. N Engl J Med 1980; 302:981-987. (Pubitemid 10125406)
    • (1980) New England Journal of Medicine , vol.302 , Issue.18 , pp. 981-987
    • Present, D.H.1    Korelitz, B.I.2    Wisch, N.3
  • 9
    • 0028267896 scopus 로고
    • Frequency of glucocorticoid resistance and dependency in Crohn's diseasee
    • Munkholm P, Langholz E, Davidsen M, Binder V: Frequency of glucocorticoid resistance and dependency in Crohn's disease. Gut 1994; 35:360-362. (Pubitemid 24092906)
    • (1994) Gut , vol.35 , Issue.3 , pp. 360-362
    • Munkholm, P.1    Langholz, E.2    Davidsen, M.3    Binder, V.4
  • 10
    • 0037717938 scopus 로고    scopus 로고
    • Azathioprine: State of the art in inflammatory bowel disease
    • Sandborn WJ: Azathioprine: state of the art in inflammatory bowel disease. Scand J Gastroenterol Suppl 1998; 225:92-99.
    • (1998) Scand J Gastroenterol Suppl , vol.225 , pp. 92-99
    • Sandborn, W.J.1
  • 11
    • 0141521863 scopus 로고    scopus 로고
    • Low-dose azathioprine is effective and safe for maintenance of remission in patients with ulcerative colitis
    • DOI 10.1007/s00535-003-1139-2
    • Hibi T, Naganuma M, Kitahora T, Kinjyo F, Shimoyama T: Low-dose azathioprine is effective and safe for maintenance of remission in patients with ulcerative colitis. J Gastroenterol 2003; 38:740-746. (Pubitemid 37161337)
    • (2003) Journal of Gastroenterology , vol.38 , Issue.8 , pp. 740-746
    • Hibi, T.1    Naganuma, M.2    Kitahora, T.3    Kinjyo, F.4    Shimoyama, T.5
  • 12
    • 0019319257 scopus 로고
    • A simple index of Crohn's-disease activity
    • Harvey RF, Bradshaw JM: A simple index of Crohn's-disease activity. Lancet 1980; 1:514.
    • (1980) Lancet , vol.1 , pp. 514
    • Harvey, R.F.1    Bradshaw, J.M.2
  • 13
    • 0019782219 scopus 로고
    • Imuran in the treatment of ulcerative colitis
    • Theodor E, Niv Y, Bat L: Imuran in the treatment of ulcerative colitis. Am J Gastroenterol 1981; 76:262-266.
    • (1981) Am J Gastroenterol , vol.76 , pp. 262-266
    • Theodor, E.1    Niv, Y.2    Bat, L.3
  • 15
    • 0030041584 scopus 로고    scopus 로고
    • Long-term follow-up of patients with Crohn's disease treated with azathioprine or 6-mercaptopurine
    • DOI 10.1016/S0140-6736(96)90402-X
    • Bouhnik Y, Lemann M, Mary JY, Scemama G, Tai R, Matuchansky C, Modigliani R, Rambaud JC: Long-term follow-up of patients with Crohn's disease treated with azathioprine or 6-mercaptopurine. Lancet 1996; 347:215-219. (Pubitemid 26035245)
    • (1996) Lancet , vol.347 , Issue.8996 , pp. 215-219
    • Bouhnik, Y.1    Lemann, M.2    Mary, J.-Y.3    Scemama, G.4    Tai, R.5    Matuchansky, C.6    Modigliani, R.7    Rambaud, J.-C.8
  • 17
    • 33644527608 scopus 로고    scopus 로고
    • Inflammatory bowel disease: Current therapeutic options
    • DOI 10.1159/000089781, Bacterial Flora in Digestive Disease
    • Domenech E: Inflammatory bowel disease: current therapeutic options. Digestion 2006; 73 Suppl 1:67-76. (Pubitemid 43296219)
    • (2006) Digestion , vol.73 , Issue.SUPPL. 1 , pp. 67-76
    • Domenech, E.1
  • 19
    • 0034772988 scopus 로고    scopus 로고
    • Review article: The treatment of inflammatory bowel disease with 6-mercaptopurine or azathioprine
    • DOI 10.1046/j.1365-2036.2001.01102.x
    • Nielsen OH, Vainer B, Rask-Madsen J: Review article: the treatment of inflammatory bowel disease with 6-mercaptopurine or azathioprine. Aliment Pharmacol Ther 2001; 15:1699-1708. (Pubitemid 33001133)
    • (2001) Alimentary Pharmacology and Therapeutics , vol.15 , Issue.11 , pp. 1699-1708
    • Nielsen, O.H.1    Vainer, B.2    Rask-Madsen, J.3
  • 20
    • 0024457688 scopus 로고
    • 6-mercaptopurine in the management of inflammatory bowel disease: Short- And long-term toxicity
    • Present DH, Meltzer SJ, Krumholz MP, Wolke A, Korelitz BI: 6-Mercaptopurine in the management of inflammatory bowel disease: short- and long-term toxicity. Ann Intern Med 1989; 111:641-649. (Pubitemid 19259182)
    • (1989) Annals of Internal Medicine , vol.111 , Issue.8 , pp. 641-649
    • Present, D.H.1    Meltzer, S.J.2    Krumholz, M.P.3    Wolke, A.4    Korelitz, B.I.5
  • 21
    • 0036076821 scopus 로고    scopus 로고
    • TPMT in the treatment of Crohn's disease with azathioprine
    • DOI 10.1136/gut.51.2.143
    • Lennard L: TPMT in the treatment of Crohn's disease with azathioprine. Gut 2002; 51:143-146. (Pubitemid 34791433)
    • (2002) Gut , vol.51 , Issue.2 , pp. 143-146
    • Lennard, L.1
  • 22
    • 0033828949 scopus 로고    scopus 로고
    • Genetic polymorphism of thiopurine S-methyltransferase: Molecular mechanisms and clinical importance
    • Krynetski EY, Evans WE: Genetic polymorphism of thiopurine S-methyltransferase: molecular mechanisms and clinical importance. Pharmacology 2000; 61:136-146.
    • (2000) Pharmacology , vol.61 , pp. 136-146
    • Krynetski, E.Y.1    Evans, W.E.2
  • 23
    • 0034745462 scopus 로고    scopus 로고
    • High-thoughput genotyping of thiopurine s-methyltransferase by denaturing hplc
    • Schaeffeler E, Lang T, Zanger UM, Eichelbaum M, Schwab M: High-throughput genotyping of thiopurine S-methyltransferase by denaturing HPLC. Clin Chem 2001; 47:548-555. (Pubitemid 32222472)
    • (2001) Clinical Chemistry , vol.47 , Issue.3 , pp. 548-555
    • Schaeffeler, E.1    Lang, T.2    Zanger, U.M.3    Eichelbaum, M.4    Schwab, M.5
  • 24
    • 0035056404 scopus 로고    scopus 로고
    • Thiopurine pharmacogenetics: Clinical and molecular studies of thiopurine methyltransferase
    • Weinshilboum R: Thiopurine pharmacogenetics: clinical and molecular studies of thiopurine methyltransferase. Drug Metab Dispos 2001; 29:601-605. (Pubitemid 32275544)
    • (2001) Drug Metabolism and Disposition , vol.29 , Issue.4 II , pp. 601-605
    • Weinshilboum, R.1
  • 27
    • 0035755993 scopus 로고    scopus 로고
    • Recent advances in the pharmacogenomics of thiopurine methyltransferase
    • Coulthard SA, Hall AG: Recent advances in the pharmacogenomics of thiopurine methyltransferase. Pharmacogenomics J 2001; 1:254-261.
    • (2001) Pharmacogenomics J , vol.1 , pp. 254-261
    • Coulthard, S.A.1    Hall, A.G.2
  • 29
    • 4344579337 scopus 로고    scopus 로고
    • Pharmacogenetics of thiopurine S-methyltransferase and thiopurine therapy
    • Evans WE: Pharmacogenetics of thiopurine S-methyltransferase and thiopurine therapy. Ther Drug Monit 2004; 26:186-191.
    • (2004) Ther Drug Monit , vol.26 , pp. 186-191
    • Evans, W.E.1
  • 30
    • 4744353095 scopus 로고    scopus 로고
    • Frequency distribution of thiopurine S-methyltransferase alleles in a polish population
    • DOI 10.1097/00007691-200410000-00013
    • Kurzawski M, Gawronska-Szklarz B, Drozdzik M: Frequency distribution of thiopurine S-methyltransferase alleles in a polish population. Ther Drug Monit 2004; 26:541-545. (Pubitemid 39314323)
    • (2004) Therapeutic Drug Monitoring , vol.26 , Issue.5 , pp. 541-545
    • Kurzawski, M.1    Gawronska-Szklarz, B.2    Drozdzik, M.3
  • 31
    • 0034850189 scopus 로고    scopus 로고
    • Frequencies of thiopurine S-methyltransferase mutant alleles (TPMT*2, *3A, *3B and *3C) in 151 healthy Japanese subjects and the inheritance of TPMT*3C in the family of a propositus
    • DOI 10.1046/j.1365-2125.2001.01371.x
    • Kubota T, Chiba K: Frequencies of thiopurine S-methyltransferase mutant alleles (TPMT*2, *3A, *3B and *3C) in 151 healthy Japanese subjects and the inheritance of TPMT*3C in the family of a propositus. Br J Clin Pharmacol 2001; 51:475-477. (Pubitemid 32852986)
    • (2001) British Journal of Clinical Pharmacology , vol.51 , Issue.5 , pp. 475-477
    • Kubota, T.1    Chiba, K.2
  • 34
    • 3242762099 scopus 로고    scopus 로고
    • Comprehensive analysis of thiopurine S-methyltransferase phenotype-genotype correlation in a large population of German-caucasians and identification of novel TPMT variants
    • DOI 10.1097/01.fpc.0000114745.08559.db
    • Schaeffeler E, Fischer C, Brockmeier D, Wernet D, Moerike K, Eichelbaum M, Zanger UM, Schwab M: Comprehensive analysis of thiopurine S-methyltransferase phenotype-genotype correlation in a large population of German-Caucasians and identification of novel TPMT variants. Pharmacogenetics 2004; 14:407-417. (Pubitemid 38971231)
    • (2004) Pharmacogenetics , vol.14 , Issue.7 , pp. 407-417
    • Schaeffeler, E.1    Fischer, C.2    Brockmeier, D.3    Wernet, D.4    Moerike, K.5    Eichelbaum, M.6    Zanger, U.M.7    Schwab, M.8
  • 35
    • 3242704015 scopus 로고    scopus 로고
    • Thiopurine methyltransferase: Should it be measured before commencing thiopurine drug therapy?
    • Sanderson J, Ansari A, Marinaki T, Duley J: Thiopurine methyltransferase: should it be measured before commencing thiopurine drug therapy? Ann Clin Biochem 2004; 41:294-302.
    • (2004) Ann Clin Biochem , vol.41 , pp. 294-302
    • Sanderson, J.1    Ansari, A.2    Marinaki, T.3    Duley, J.4
  • 36
    • 0034036355 scopus 로고    scopus 로고
    • Normal thiopurine methyltransferase levels do not eliminate 6-mercaptopurine or azathioprine toxicity in children with inflammatory bowel disease
    • Kader HA, Wenner WJ, Jr., Telega GW, Maller ES, Baldassano RN: Normal thiopurine methyltransferase levels do not eliminate 6-mercaptopurine or azathioprine toxicity in children with inflammatory bowel disease. J Clin Gastroenterol 2000; 30:409-413.
    • (2000) J Clin Gastroenterol , vol.30 , pp. 409-413
    • Kader, H.A.1    Wenner Jr., W.J.2    Telega, G.W.3    Maller, E.S.4    Baldassano, R.N.5
  • 37
    • 33845415085 scopus 로고    scopus 로고
    • Thiopurine methyltransferase (TPMT) activity and adverse effects of azathioprine in inflammatory bowel disease: Long-term follow-up study of 394 patients
    • DOI 10.1111/j.1572-0241.2006.00843.x
    • Gisbert JP, Nino P, Rodrigo L, Cara C, Guijarro LG: Thiopurine methyltransferase (TPMT) activity and adverse effects of azathioprine in inflammatory bowel disease: long-term follow-up study of 394 patients. Am J Gastroenterol 2006; 101:2769-2776. (Pubitemid 44902649)
    • (2006) American Journal of Gastroenterology , vol.101 , Issue.12 , pp. 2769-2776
    • Gisbert, J.P.1    Nino, P.2    Rodrigo, L.3    Cara, C.4    Guijarro, L.G.5
  • 38
    • 33745460088 scopus 로고    scopus 로고
    • Choice of azathioprine or 6-mercaptopurine dose based on thiopurine methyltransferase (TPMT) activity to avoid myelosuppression. a prospective study
    • Gisbert JP, Luna M, Mate J, Gonzalez-Guijarro L, Cara C, Pajares JM: Choice of azathioprine or 6-mercaptopurine dose based on thiopurine methyltransferase (TPMT) activity to avoid myelosuppression. A prospective study. Hepatogastroenterology 2006; 53:399-404. (Pubitemid 43954416)
    • (2006) Hepato-Gastroenterology , vol.53 , Issue.69 , pp. 399-404
    • Gisbert, J.P.1    Luna, M.2    Mate, J.3    Gonzalez-Guijarro, L.4    Cara, C.5    Pajares, J.M.6
  • 39
    • 0033830262 scopus 로고    scopus 로고
    • Allelic variants of the thiopurine S-methyltranferase deficiency in patients with ulcerative colitis and in healthy controls
    • DOI 10.1016/S0002-9270(00)01048-0, PII S0002927000010480
    • Corominas H, Domenech M, Gonzalez D, Diaz C, Roca M, Garcia-Gonzalez MA, Pena S, Baiget M: Allelic variants of the thiopurine S-methyltransferase deficiency in patients with ulcerative colitis and in healthy controls. Am J Gastroenterol 2000; 95:2313-2317. (Pubitemid 30707394)
    • (2000) American Journal of Gastroenterology , vol.95 , Issue.9 , pp. 2313-2317
    • Corominas, H.1    Domenech, M.2    Gonzalez, D.3    Diaz, C.4    Roca, M.5    Garcia-Gonzalez, M.A.6    Pena, S.7    Baiget, M.8
  • 41
    • 0026907122 scopus 로고
    • Human liver thiopurine methyltransferase pharmacogenetics: Biochemical properties, liver-erythrocyte correlation and presence of isozymes
    • Szumlanski CL, Honchel R, Scott MC, Weinshilboum RM: Human liver thiopurine methyltransferase pharmacogenetics: biochemical properties, liver-erythrocyte correlation and presence of isozymes. Pharmacogenetics 1992; 2:148-159.
    • (1992) Pharmacogenetics , vol.2 , pp. 148-159
    • Szumlanski, C.L.1    Honchel, R.2    Scott, M.C.3    Weinshilboum, R.M.4
  • 42
    • 29944443581 scopus 로고    scopus 로고
    • Thiopurine S-methyltransferase polymorphisms and the relationship between the mutant alleles and the adverse effects in systemic lupus erythematosus patients taking azathioprine
    • Jun JB, Cho DY, Kang C, Bae SC: Thiopurine S-methyltransferase polymorphisms and the relationship between the mutant alleles and the adverse effects in systemic lupus erythematosus patients taking azathioprine. Clin Exp Rheumatol 2005; 23:873-876. (Pubitemid 43040517)
    • (2005) Clinical and Experimental Rheumatology , vol.23 , Issue.6 , pp. 873-876
    • Jun, J.-B.1    Cho, D.-Y.2    Kang, C.3    Bae, S.-C.4
  • 43
    • 0027164795 scopus 로고
    • Bone marrow toxicity caused by azathioprine in inflammatory bowel disease: 27 years of experience
    • Connell WR, Kamm MA, Ritchie JK, Lennard-Jones JE: Bone marrow toxicity caused by azathioprine in inflammatory bowel disease: 27 years of experience. Gut 1993; 34:1081-1085.
    • (1993) Gut , vol.34 , pp. 1081-1085
    • Connell, W.R.1    Kamm, M.A.2    Ritchie, J.K.3    Lennard-Jones, J.E.4
  • 44
    • 0028293868 scopus 로고
    • The role of leukopenia in the 6-mercaptopurine-induced remission of refractory Crohn's disease
    • Colonna T, Korelitz BI: The role of leukopenia in the 6-mercaptopurine-induced remission of refractory Crohn's disease. Am J Gastroenterol 1994; 89:362-366. (Pubitemid 24074394)
    • (1994) American Journal of Gastroenterology , vol.89 , Issue.3 , pp. 362-366
    • Colonna, T.1    Korelitz, B.I.2
  • 45
    • 0034802320 scopus 로고    scopus 로고
    • Neutropenia is not required for clinical remission during azathioprine therapy in inflammatory bowel disease
    • DOI 10.1097/00042737-200109000-00009
    • Persley KM, Present DH: Neutropenia is not required for clinical remission during azathioprine therapy in inflammatory bowel disease. Eur J Gastroenterol Hepatol 2001; 13:1053-1055. (Pubitemid 32905197)
    • (2001) European Journal of Gastroenterology and Hepatology , vol.13 , Issue.9 , pp. 1053-1055
    • Persley, K.M.1    Present, D.H.2
  • 46
    • 0034812896 scopus 로고    scopus 로고
    • Is neutropenia required for effective maintenance of remission during azathioprine therapy in inflammatory bowel disease?
    • DOI 10.1097/00042737-200109000-00013
    • Campbell S, Ghosh S: Is neutropenia required for effective maintenance of remission during azathioprine therapy in inflammatory bowel disease? Eur J Gastroenterol Hepatol 2001; 13:1073-1076. (Pubitemid 32905201)
    • (2001) European Journal of Gastroenterology and Hepatology , vol.13 , Issue.9 , pp. 1073-1076
    • Campbell, S.1    Ghosh, S.2
  • 47
    • 0024344693 scopus 로고
    • Ulcerative colitis: Prolonged remission following azathioprine-induced pancytopenia
    • Burke DA, Dixon MF, Axon AT: Ulcerative colitis: prolonged remission following azathioprine-induced pancytopenia. J Clin Gastroenterol 1989; 11:327-330.
    • (1989) J Clin Gastroenterol , vol.11 , pp. 327-330
    • Burke, D.A.1    Dixon, M.F.2    Axon, A.T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.