Transport-metabolism interplay: LXRα-mediated induction of human ABC transporter ABCC2 (cMOAT/MRP2) in HepG2 cells

Molecular Pharmaceutics

Volumn 6, Issue 6, 2009, Pages 1678-1688

  Adachi, Tatsuhiko ^a   Nakagawa, Hiroshi ^a   Hagiya, Yuichiro ^a   Yasuoka, Tatsuya ^a   Ishikawa, Toshihisa ^a  

^a TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

ABC transporter; cMOAT; Induction; Liver X receptor; MRP2; Nuclear receptor

Indexed keywords

22 HYDROXYCHOLESTEROL; ABC TRANSPORTER; ABC TRANSPORTER C2; ABC TRANSPORTER G1; ANTIBIOTIC AGENT; ANTINEOPLASTIC AGENT; BILE SALT; CELL NUCLEUS RECEPTOR; CHOLESTEROL DERIVATIVE; HETERODIMER; LIGAND; LIVER X RECEPTOR ALPHA; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 2; N (2,2,2 TRIFLUOROETHYL) N [4 [2,2,2 TRIFLUORO 1 HYDROXY 1 (TRIFLUOROMETHOXY)ETHYL]PHENYL]BENZENESULFONAMIDE; PAXILLINE; PLANT MEDICINAL PRODUCT; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; CARCINOMA CELL; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG BINDING; DRUG METABOLISM; DRUG TRANSPORT; GENE EXPRESSION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; TRANSIENT TRANSFECTION;

ANTI-INFECTIVE AGENTS; ATP-BINDING CASSETTE TRANSPORTERS; CELL LINE; CELL LINE, TUMOR; CYCLOSPORINE; DOXORUBICIN; GENE EXPRESSION REGULATION; HUMANS; HYDROCARBONS, FLUORINATED; HYDROXYCHOLESTEROLS; IMMUNOBLOTTING; INDOLES; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; ORPHAN NUCLEAR RECEPTORS; RETINOID X RECEPTOR ALPHA; RNA, SMALL INTERFERING; SIROLIMUS; SULFONAMIDES;

EID: 71949097075     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp9001156     Document Type: Article

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