Nitroimidazole conjugates of bis(thiosemicarbazonato)64Cu(II) - Potential combination agents for the PET imaging of hypoxia

Journal of Inorganic Biochemistry

Volumn 104, Issue 2, 2010, Pages 126-135

  Bonnitcha, Paul D ^a   Bayly, Simon R ^a   Theobald, Mark B M ^a   Betts, Helen M ^a   Lewis, Jason S ^b   Dilworth, Jonathan R ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Bis(thiosemicarbazone); Copper 64; Hypoxia; Molecular imaging; Radiochemistry

Indexed keywords

BIS(THIOSEMICARBAZONATO)COPPER NITROIMIDAZOLE CONJUGATE; COPPER 64; OXYGEN; TRACER; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG UPTAKE; EX VIVO STUDY; FEMALE; HYPOXEMIA; HYPOXIA; IMAGE ANALYSIS; IN VITRO STUDY; ISOTOPE LABELING; MOLECULAR IMAGING; MOUSE; NONHUMAN; OXIDATION REDUCTION REACTION; OXYGEN CONCENTRATION; POSITRON EMISSION TOMOGRAPHY; RADIOACTIVITY; RADIOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANOXIA; BIOLOGICAL TRANSPORT; CELL HYPOXIA; CELL LINE, TUMOR; COPPER RADIOISOTOPES; FEMALE; MAMMARY NEOPLASMS, ANIMAL; MICE; MICE, INBRED BALB C; MODELS, CHEMICAL; MOLECULAR STRUCTURE; NITROIMIDAZOLES; ORGANOMETALLIC COMPOUNDS; OXYGEN; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; THIOSEMICARBAZONES; TISSUE DISTRIBUTION;

MUS;

EID: 71849109939     PISSN: 01620134     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jinorgbio.2009.10.009     Document Type: Article

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