In vitro and in vivo evaluations of a hydrophilic 64Cu- Bis(thiosemicarbazonato)-glucose conjugate for hypoxia imaging

Journal of Nuclear Medicine

Volumn 49, Issue 11, 2008, Pages 1862-1868

  Bayly, Simon R ^a   King, Robert C ^b   Honess, Davina J ^b   Barnard, Peter J ^a   Betts, Helen M ^a   Holland, Jason P ^a   Hueting, Rebekka ^a,b   Bonnitcha, Paul D ^a   Dilworth, Jonathan R ^a   Aigbirhio, Franklin I ^c   Christlieb, Martin ^b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

64Cu ATSM; Biodistribution; Hypoxia; Molecular imaging; PET

Indexed keywords

DIACETYLBIS(N 4 METHYLTHIOSEMICARBAZONE) CU 64; DIACETYLBIS(N 4 METHYLTHIOSEMICARBAZONE) GLUCOSE CONJUGATE CU 64; DISSOLVED OXYGEN; FLUORODEOXYGLUCOSE F 18; TRACER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANOXIA; ARTICLE; BLADDER; BRAIN; CARCINOSARCOMA; CELL HYPOXIA; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG STABILITY; DRUG UPTAKE; EXPERIMENTAL MODEL; GLUCOSE METABOLISM; HEART; HELA CELL; HUMAN; HUMAN CELL; HYDROPHILICITY; MALE; MOLECULAR IMAGING; NONHUMAN; OXYGEN CONSUMPTION; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RAT; TISSUE DISTRIBUTION;

ANIMALS; ANOXIA; CARCINOSARCOMA; COPPER RADIOISOTOPES; FLUORODEOXYGLUCOSE F18; GLUCOSE; HELA CELLS; HUMANS; MALE; OXYGEN; POSITRON-EMISSION TOMOGRAPHY; RATS; THIOSEMICARBAZONES;

EID: 57349174677     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.108.054015     Document Type: Article

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