Differential regulation of microglial motility by ATP/ADP and adenosine

Parkinsonism and Related Disorders

Volumn 15, Issue SUPPL. 3, 2009, Pages

  Gyoneva, Stefka ^a   Orr, Anna G ^b   Traynelis, Stephen F ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

A2A receptor; ATP, adenosine; Chemotaxis; Microglia; Neurodegeneration

Indexed keywords

ADENOSINE; ADENOSINE A2A RECEPTOR; ADENOSINE DIPHOSPHATE; ADENOSINE RECEPTOR; ADENOSINE TRIPHOSPHATE; LIPOPOLYSACCHARIDE; PURINERGIC P2Y12 RECEPTOR;

ARTICLE; BRAIN INJURY; BRAIN ISCHEMIA; CELL MIGRATION; CELL MOTILITY; CHEMOTAXIS; DOWN REGULATION; ENCEPHALITIS; HUMAN; MICROGLIA; NERVE DEGENERATION; NONHUMAN; PARENCHYMA; PARKINSON DISEASE; PATHOPHYSIOLOGY; PHAGOCYTOSIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; UPREGULATION;

ADENOSINE; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ANIMALS; BRAIN INJURIES; CELL MOVEMENT; HUMANS; MICROGLIA; RECEPTOR, ADENOSINE A2A; UP-REGULATION;

EID: 71849101064     PISSN: 13538020     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1353-8020(09)70813-2     Document Type: Article

References (48)

1. Ulvestad E., Williams K., Bjerkvig R., Tiekotter K., Antel J., and Matre R. Human microglial cells have phenotypic and functional characteristics in common with both macrophages and dendritic antigen-presenting cells. J Leukocyte Biol 56 (1994) 732-740
2. Streit W.J. Microglia as neuroprotective, immunocompetent cells of the CNS. Glia 40 (2002) 133-139
3. Stence N., Waite M., and Dailey M.E. Dynamics of microglial activation: a confocal time-lapse analysis in hippocampal slices. Glia 33 (2001) 256-266
4. Kreutzberg G.W. Microglia: a sensor for pathological events in the CNS. Trends Neurosci 19 8 (1996) 312-318
5. Nimmerjahn A., Kirchhoff F., and Helmchen F. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 308 (2005) 1314-1318
6. Davalos D., Grutzendler J., Yang G., Kim J.V., Zuo Y., Jung S., et al. ATP mediates rapid microglial response to local brain injury in vivo. Nat Neurosci 8 6 (2005) 752-758
7. 12 receptor regulates microglial activation by extracellular nucleotides. Nat Neurosci 9 12 (2006) 1512-1519
8. Hanisch U.-K., and Kettenman H. Microglia: active sensors and versatile effector cells in the normal and pathologic brain. Nat Neurosci 10 11 (2007) 1387-1394
9. Brockhaus J., Moller T., and Kettenman H. Phagocytozing ameboid microglial cells studied in a mouse corpus callosum slice preparation. Glia 16 (1996) 81-90
10. Petersen M.A., and Dailey M.E. Diverse microglial motility behaviors during clearance of dead cells in hippocampal slices. Glia 46 (2004) 195-206
11. i/o-coupled P2Y receptors. J Neurosci 21 6 (2001) 1975-1982
12. Kurpius D., Nolley E.P., and Dailey M.E. Purines induce directed migration and rapid homing of microglia to injured pyramidal neurons in developing hippocampus. Glia 55 (2007) 873-884
13. 2A receptor mediates microglial process retraction. Nat Neurosci 12 7 (2009) 872-878
14. Yao J., Harvath L., Gilbert D.L., and Colton C.A. Chemotaxis by a CNS macrophage, the microglia. J Neurosci Res 27 (1990) 36-42
15. Hayashi M., Luo Y., Laning J., Strieter R.M., and Dorf M.E. Production and function of monocyte chemoattractant protein-1 and other b-chemokines in murine glial cells. J Neuroimmunol 60 (1995) 143-150
16. Cross A.K., and Woodroofe M.N. Chemokines induce migration and changes in actin polymerization in adult rat brain microglia and a human fetal microglial cell line in vitro. J Neurosci Res 55 (1999) 17-23
17. Nolte C., Kirchhoff F., and Kettenman H. Epidermal growth factor is a motility factor for microglial cells in vitro: evidence for EGF receptor expression. Eur J Neurosci 9 (1997) 1690-1698
18. Gilad G.M., and Gilad V.H. Chemotaxis and accumulation of nerve growth factor by microglia and macrophages. J Neurosci Res 41 (1995) 594-602
19. 42 activates a G-protein-coupled chemoattractant receptor, FPR-Like-1. J Neurosci 21 RC123 (2001) 1-5
20. Yan S.D., Zhu H., Fu J., Yan S.F., Roher A., Tourtellotte W.W., et al. Amyloid-β peptide-receptor for advanced glycation endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: A proinflammatory pathway in Alzheimer disease. Proc Natl Acad Sci USA 94 (1997) 5296-5301
21. Tiffany H.L., Lavigne M.C., Cui Y.-H., Wang J.-M., Leto T.L., Gao J.-L., et al. Amyloid-β induces chemotaxis and oxidant stress by acting at formylpeptide receptor 2, a G protein-coupled receptor expressed in phagocytes and brain. J Biol Chem 276 (2001) 23645-23652
22. Rogers J., Strohmeyer R., Kovelowski C.L., and Li R. Microglia and inflammatory mechanisms in the clearance of amyloid β peptide. Glia 40 (2002) 260-269
23. Nolte C., Moller T., Walter T., and Kettenman H. Complement 5a controls motility of murine microglial cells in vitro via activation of an inhibitory G-protein and the rearrangement of the actin cytoskeleton. Neuroscience 73 4 (1996) 1091-1107
24. 2A adenosine receptor induction. Biochem J 391 575-580 (2005) 575
25. 2A receptor-mediated inhibition of TLR responses in microglia. J Immunol 182 (2009) 7603-7612
26. 3 receptor-induced CCL2 synthesis in cultured mouse astrocytes. Glia 46 (2004) 410-418
27. Makranz C., Cohen G., Rechert F., Kodama T., and Rotshenker S. cAMP cascade (PKA, epac, adenylyl cyclase, Gi, and phosphodiesterases) regulates myelin phagocytosis mediated by complement-receptor-3 and scavenger receptor-AI/II in microglia and macrophages. Glia 53 4 (2006) 441-448
28. Bryn T., Mahic M., Enserink J.M., Schwede F., Aandahl E.M., and Tasken K. The cyclic AMP-Epac-Rap1 pathway is dissociated from regulation of effector functions in monocytes but acquires immunoregulatory function in mature macrophages. J Immunol 176 12 (2006) 7361-7370
29. Lee Y.B., Nagai A., and Kim S.U. Cytokines, chemokines, and cytokine receptors in human microglia. J Neurosci Res 69 (2002) 94-103
30. 2A receptors attenuates acute traumatic brain injury in the mouse cortical impact model. Exp Neurol 215 (2009) 69-76
31. 2A receptors in Parkinson's disease. Trends Neurosci 29 11 (2006) 647-654
32. 2A receptor in ischemia. Ann NY Acad Sci 939 (2001) 74-84
33. Blum D., Hourez R., Galas M.-C., Popoli P., and Schiffmann S. Adenosine receptors and Huntington's disease: implications for pathogenesis and therapeutics. Lancet Neurol 2 (2003) 366-374
34. Ascherio A., Zhang S.M., Hernán M.A., Kawachi I., Colditz G.A., Speizer F.E., et al. Prospective study of caffeine consumption and risk of Parkinson's disease in men and women. Ann Neurol 50 (2001) 56-63
35. Ross G.W., Abbott R.D., Petrovitch H., Morens D.M., Grandinetti A., Tung K.-H., et al. Association of coffee and caffeine intake with the risk of Parkinson disease. JAMA 283 20 (2000) 2674-2679
36. 2A adenosine receptor inactivation in a model of Parkinson's disease. J Neurosci 21 RC143 (2001) 1-6
37. 2A antagonist: a novel antiparkinsonian agent that does not provoke dyskinesia in parkinsonian monkeys. Ann Neurol 43 (1998) 507-513
38. 2A receptors modify motor function in MPTP-treated common marmosets. Neuroreport 9 (1998) 2857-2860
39. 2A antagonist KW-6002 with L-Dopa or with selective D1 or D2 dopamine agonists increases antiparkinsonian activity but not dyskinesia in MPTP-treated monkeys. Exp Neurol 162 (2000) 321-327
40. 2A receptor blockade in experimental models of Parkinson's disease. J Neurochem 80 (2002) 262-270
41. Xu K., Xu Y.-H., Chen J.-F., and Schwarzschild M.A. Caffeine's neuroprotection against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity shows no tolerance to chronic caffeine administration in mice. Neurosci Lett 322 (2002) 13-16
42. 2A adenosine receptor antagonists on cerebral ischemic injury in the gerbil. Brain Res 705 (1995) 79-84
43. Monopoli A., Lozza G., Forlani A., Mattavelli A., and Ongini E. Blockade of adenosine A(2A) receptors by SCH 58261 results in neuroprotective effects in cerebral ischaemia in rats. Neuroreport 9 17 (1998) 3955-3959
44. 2A adenosine receptor blockade. Neuropharmacology 47 (2004) 884-891
45. Braun N., Lenz C., Gillardon F., Zimmermann M., and Zimmermann H. Focal cerebral ischemia enhances glial expression of ecto-5′-nucleotidase. Brain Res 766 (1997) 213-226
46. 2A-receptors. Glia 18 (1996) 152-160
47. 2A receptor stimulation potentiates nitric oxide release by activated microglia. J Neurochem 95 (2005) 919-929
48. 2A receptor antagonist. Brain Res 800 (1998) 328-335