Synthesis and in vitro evaluation of aspartate transcarbamoylase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 22, 2009, Pages 7680-7689

  Coudray, Laëtitia ^a   Pennebaker, Anne F ^a   Montchamp, Jean Luc ^a  

^a TEXAS CHRISTIAN UNIVERSITY   (United States)

Author keywords

Aspartate transcarbamoylase; Enzyme inhibitor; Phosphinate; Phosphonate

Indexed keywords

ASPARTATE CARBAMOYLTRANSFERASE; ASPARTATE CARBAMOYLTRANSFERASE INHIBITOR; CARBOXYLIC ACID DERIVATIVE; ENZYME INHIBITOR; PHOSPHINIC ACID DERIVATIVE; PHOSPHORUS; SPARFOSIC ACID; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL REACTION; DRUG DESIGN; DRUG MECHANISM; DRUG SYNTHESIS; ENZYME INHIBITION; IN VITRO STUDY; NONHUMAN; PROTON TRANSPORT;

ASPARTATE CARBAMOYLTRANSFERASE; ASPARTIC ACID; BINDING SITES; BIOCATALYSIS; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; ENZYME STABILITY; ESCHERICHIA COLI; MODELS, CHEMICAL; PHOSPHONOACETIC ACID; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 71849094203     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.09.045     Document Type: Article

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