Design, synthesis and activity of bisubstrate, transition-state analogues and competitive inhibitors of aspartate transcarbamylase

European Journal of Medicinal Chemistry

Volumn 39, Issue 4, 2004, Pages 333-344

  Grison, Claude ^a   Coutrot, Philippe ^a   Comoy, Corinne ^a   Balas, Laurence ^a   Joliez, Stéphane ^a   Lavecchia, Guido ^a   Oliger, Patrick ^a   Penverne, Bernadette ^b   Serre, Valérie ^b   Hervé, Guy ^b  

^a UNIVERSITÉ DE LORRAINE   (France)

^b CNRS   (France)

Author keywords

ATCase inhibitors; Carbamylphosphate analogues; Fluorinated phosphonates; Phosphonopeptides

Indexed keywords

ANTINEOPLASTIC AGENT; ASPARTATE CARBAMOYLTRANSFERASE; BISUBSTRATE; ENZYME INHIBITOR; N PHOSPHONACETYLGLUTAMATE; N PHOSPHONODIFLUOROACETYLASPARTATE; NUCLEIC ACID; UNCLASSIFIED DRUG;

ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; DRUG TARGETING; ENZYME INHIBITION; ESCHERICHIA COLI; EXPERIMENTAL MODEL; NONHUMAN; PHASE TRANSITION; STRUCTURE ANALYSIS;

ANIMALS; ASPARTATE CARBAMOYLTRANSFERASE; ASPARTIC ACID; BINDING, COMPETITIVE; DRUG DESIGN; ENZYME INHIBITORS; ESCHERICHIA COLI; KINETICS; MODELS, CHEMICAL; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 11144355292     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejmech.2004.01.006     Document Type: Article

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