T-state inhibitors of E. coli aspartate transcarbamoylase that prevent the allosteric transition

Biochemistry

Volumn 45, Issue 33, 2006, Pages 10062-10071

  Heng, Sabrina ^a   Stieglitz, Kimberly A ^a   Eldo, Joby ^a   Xia, Jiarong ^a   Cardia, James P ^a   Kantrowitz, Evan R ^a  

^a BOSTON COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; CATALYST ACTIVITY; CONCENTRATION (PROCESS); ESCHERICHIA COLI; REACTION KINETICS; SATURATION (MATERIALS COMPOSITION);

ASPARTATE BINDING SITES; ASPARTATE TRANSCARBAMOYLASE (ATCASE); CARBAMOYL PHOSPHATE (CP); E. COLI ASPARTATE;

ENZYMES;

ACETAMIDE DERIVATIVE; ASPARTATE CARBAMOYLTRANSFERASE; ASPARTIC ACID; ASPARTIC ACID DERIVATIVE; CARBAMOYL PHOSPHATE; PHOSPHATE; PYRIMIDINE NUCLEOTIDE; SPARFOSIC ACID; SUCCINIC ACID DERIVATIVE;

ALLOSTERISM; ARTICLE; BINDING AFFINITY; BINDING SITE; CHEMICAL BINDING; CONCENTRATION (PARAMETERS); CONFORMATIONAL TRANSITION; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME MECHANISM; ENZYME STRUCTURE; ESCHERICHIA COLI; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN TARGETING; PYRIMIDINE SYNTHESIS; SYNTHESIS;

ALLOSTERIC REGULATION; ASPARTATE CARBAMOYLTRANSFERASE; ASPARTIC ACID; BINDING SITES; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; ESCHERICHIA COLI; KINETICS; MODELS, MOLECULAR; ORGANOPHOSPHORUS COMPOUNDS; PHOSPHATES; SPECTROMETRY, FLUORESCENCE;

ESCHERICHIA COLI;

EID: 33747517933     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0601095     Document Type: Article

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