Design, synthesis, and bioactivity of novel inhibitors of E. coli aspartate transcarbamoylase

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 7, 2007, Pages 2086-2090

  Eldo, Joby ^a   Heng, Sabrina ^a   Kantrowitz, Evan R ^a  

^a BOSTON COLLEGE   (United States)

Author keywords

Allosteric enzyme; Aspartate carbamoyltransferase; Bi substrate analogue

Indexed keywords

AMIDE; ASPARTATE CARBAMOYLTRANSFERASE; ASPARTATE CARBAMOYLTRANSFERASE INHIBITOR; BACTERIAL ENZYME; CARBOXYLIC ACID; ENZYME INHIBITOR; SPARFOSIC ACID; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG DESIGN; DRUG SYNTHESIS; ENZYME INHIBITION; ESCHERICHIA COLI; NONHUMAN;

AMIDES; ASPARTATE CARBAMOYLTRANSFERASE; ASPARTIC ACID; CATALYTIC DOMAIN; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; ESCHERICHIA COLI; KINETICS; MODELS, CHEMICAL; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; PHOSPHONOACETIC ACID; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 33847679071     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.12.050     Document Type: Article

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