Human subjects are protected from mast cell tryptase deficiency despite frequent inheritance of loss-of-function mutations

Journal of Allergy and Clinical Immunology

Volumn 124, Issue 5, 2009, Pages

  Trivedi, Neil N ^a,b,d   Tamraz, Bani ^a   Chu, Catherine ^a,b   Kwok, Pui Yan ^a,b   Caughey, George H ^a,b,c,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Veterans Health Research Institute   (United States)

^d SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

human genetics; mast cells; Tryptase

Indexed keywords

TRYPTASE;

ARTICLE; CHILD PARENT RELATION; CONTROLLED STUDY; ENZYME DEFICIENCY; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE SEQUENCE; GENETIC LINKAGE; GENOME; HAPLOTYPE; HUMAN; HUMAN CELL; INHERITANCE; LOSS OF FUNCTION MUTATION; NUCLEOTIDE SEQUENCE; PREDICTION; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

ALLELES; AMINO ACID SEQUENCE; CELL LINE; GENE DOSAGE; GENE FREQUENCY; GENOTYPE; HAPLOTYPES; HUMANS; HYPERSENSITIVITY; LINKAGE DISEQUILIBRIUM; MAST CELLS; MOLECULAR SEQUENCE DATA; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN CONFORMATION; SEQUENCE ALIGNMENT; TRYPTASES;

EID: 71749098499     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2009.07.026     Document Type: Article

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