Medical applications of nanoparticles and nanomaterials

Studies in Health Technology and Informatics

Volumn 149, Issue , 2009, Pages 257-283

  Burgess, Rob ^a  

^a Medical Nanotechnologies

Author keywords

[No Author keywords available]

Indexed keywords

DISEASES; MEDICAL APPLICATIONS; NANOSTRUCTURED MATERIALS; NANOTECHNOLOGY;

CLINICAL DIAGNOSTICS; MEDICAL METHODS; NANO-SCALE MATERIALS; PHYSIOLOGICAL DISORDERS; SIDE EFFECT; SPECIFIC SITES; TARGET CELLS; VIRAL INFECTIONS;

DIAGNOSIS;

EID: 71749097871     PISSN: 09269630     EISSN: 18798365     Source Type: Book Series    
DOI: 10.3233/978-1-60750-050-6-257     Document Type: Conference Paper

References (131)

1. M. Ferrari, "Cancer nanotechnology: opportunities and challenges," Nat Rev Cancer. 2005; 5(3): 161-71.
2. RA Freitas, "Nanomedicine, Volume I: Basic Capabilities," 1999; Landis Bioscience Publishers.
3. Peter Searson Interview, Nanomaterials and Nanotechnology, March 19, 2007.
4. Editorial. (2006). "Nanomedicine: A matter of rhetoric?". Nat Materials. 5(4): 243.
5. National Institutes of Health, US Department of Health and Human Services. http://nihroadmap.nih.gov/nanomedicine/.
6. RRH Coombs and DW Robinson, "Nanotechnology in Medicine and the Biosciences," 1996; Taylor & Francis, Inc. Publishers.
7. Therapeutic Index as defined by Wikipedia, http://en.wikipedia.org/wiki/ Therapeutic-index.
8. V.P. Torchilin (editor), "Nanoparticulates as Pharmaceutical Carriers," 2006; London, UK: Imperial College Press.
9. A.M. Dyer, M. HInchcliffe, P. Watts, J. Castile, I. Jabbal-Gill, R. Nankervis, A. Smith, L. Illum, "Nasal delivery of insulin using novel chitosan based formulations: a comparative study in two animal models between simple chitosan formulations and chitosan nanoparticles," Pharm Res. 2002; 19: 998-1008.
10. M.G. Cascone, L. Lazzeri, C. Carmignani, Z. Zhu, "Gelatin nanoparticles produced by a simple W/O emulsion as delivery system for methotrexate," J Mater Sci Mater Med. 2002; 13: 523-526.
11. A.K. Gupta, M. Gupta, "Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications," Biomaterials. 2005; 26: 3995-4021.
12. Y. Patil and J. Panyam, "Polymeric nanoparticles for siRNA delivery and gene silencing." Int J Pharm 2009 Feb 9; 367(1-2): 195-203.
13. S.A. Wissing, R.H. Muller, "a novel sunscreen system based on tocopherol acetate incorporated into solid lipid nanoparticles," Int J Cosmet Sci. 2001; 23: 233-243.
14. A. Senyel, K. Widder, C. Czerlinski, "Magnetic guidance of drug carrying microspheres," J Appl Phys. 1978; 49: 3578-3583.
15. K.J. Widder, A.E. Senyel, G.D. Scarpelli, "Magnetic microspheres: a model system of site-specific drug delivery in vivo," Proc Soc Exp Biol Med. 1978; 158: 141-146.
16. N. Nitin, L.E.W. LaConte, O. Zurkiya et al, "Functionalization and peptide-based delivery of magnetic nanoparticles as an intracellular MRA contrast agent," J Biol Inorg Chem. 2004; 9: 706-712.
17. D.Y. Godovsky, A.V. Varfolomeev, G.D. Efremova et al, "Magnetic properties of polyvinyl alcohol-based composites containing iron oxide nanoparticles," Adv Mat Opt Elec. 2005; 9: 87-93.
18. C. Mah, I. Zolotukhin, T.J. Fraites et al, "Macrosphere-mediated delivery of recombinant AAV vectors in vitro and in vivo," Molec Therapy. 2000; 1: S239.
19. M.W. Wilson, R.K Kerlan, N.A. Fidelman, "Hepatocellular carcinoma: Regional therapy with a magnetic targeted carrier bound to doxorubicin in a dual MR imaging/conventional angiography suite-initial experience with 4 patients," Radiology. 2004; 230: 287-293.
20. C. Liu, C.C. Mi, B.Q. Li, "Energy absorption of gold nanoshells in hyperthermia therapy," IEEE Trans Nanobioscience. 2008 Sep; 7(3): 206-14.
21. K. Na, K.H. Lee, D.H. Lee et al, "Biodegradable thermo-sensitive nanoparticles from poly(L-lactic acid/poly(ethylene glycol) alternating multi-block copolymer for potential anti-cancer drug carrier," Eur J Pharm Sci. 2006; 27: 115-122.
22. M. Edetsberger, E. Gaubitzer, E. Valic et al, "Detection of nanometer-sized particles in living cells using modern fluorescence fluctuation methods," Biochem Biophys Res Commun. 2005; 332: 109-116.
23. J. Panyam, W.Z. Zhou, S. Prabha et al, "Rapid endo-lysosomal escape of poly(DL-lactide-co-glycolide) nanoparticles: implications for drug and gene delivery," FASEB J. 2002, 16: 1217-26.
24. Y.N. Konan, J. Chevaltier, R. Gurny et al, "Encapsulation of p-THPP into nanoparticles: cellular uptake, subcellular localization and effect of serum on photodynamic activity," Photochem Photobiol. 2003; 77: 638-644.
25. A. Weissenbock, M. Wirth, F. Gabor, "WGA-grafted PLGA-nanospheres: preparation and association with Caco-2 single cells," J Contr Rel. 2004; 99: 383-392.
26. P. Chakravarty, R. Marches, N.S. Zimmerman, A.D.E. Swafford, P. Bajaj, I.H. Musselman, P. Pantano, R.K. Draper, E.S. Vitetta, "Thermal ablation of tumor cells with antibody-functionalized single-walled carbon nanotubes," Proc Natl Acad Sci USA. 2008; 105: 8697-8702.
27. J.L Bourges, S.F. Gautier, F. Delie et al, "Ocular drug delivery targeting the retina and retinal pigment epithelium using polylactide nanoparticles," Invest Ophthalmol Vis Sci. 2003; 44: 3562-9.
28. H. Tada, H. Higuchi, T.M. Wanatabe, N. Ohuchi, "In vivo real-time tracking of single quantum dots conjugated with monoclonal anti-HER2 antibody tumors in mice," Cancer Res. 2007; 67: 1138-1144.
29. D.D. Lasic, F.J. Martin, "Stealth Liposomes," Boca Raton, FL, CRC Press, 1995.
30. G.S. Kwon, K. Kataoka, "Block copolymer micelles as long-circulating drug vehicles," Adv Drug Deliv Rev. 1995, 16: 295-309.
31. H. Maeda, J. Wu, T. Sawa et al, "Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review," J Control Release. 2000, 65: 271-284.
32. L. Raffaghello, G. Pagnan, F. Pastorino et al, "Immunoliposomal fenretinide: a novel anti-tumoral drug for human neuroblastoma," Cancer Lett. 2003; 197: 151-155.
33. A. Rubio-Demirovic, C. Marty, S. Console, S.M. Zeisberger, C. Ruch, R. Jaussi, R.A. Schwendener, K. Ballmer-Hofer, "Targeting human cancer cells with VEGF receptor-2-directed liposomes," Oncol Rep. 2005; 13: 319-324.
34. K. Kato, C. Itoh, T. Yasukouchi, T. Nagammune, "Rapid protein anchoring into the membranes of mammalian cells using oleyl chain and poly(ethylene glycol) derivatives," Biotechnol Prog. 2004; 20: 897-904.
35. S. Ni, S.M. Stephenson, R.J. Lee, "Folate receptor targeted delivery of liposomal daunorubicin into tumor cells. Anticancer Res. 2002; 22: 2131-2135.
36. X.Q. Pan, H. Wang, R.J. Lee, "Antitumor activity of folate receptor-targeted liposomal doxorubicin in a KB oral carcinoma murine xenograft model," Pharm Res. 2003; 20: 417-422.
37. S. Bhattacharya, A. Franz, X. Li, B. Jasti, "Synthesis of folate-conjugated amphiphiles for tumor-targeted drug delivery," J Drug Target. 2008; 4: 1 Epub ahead of print.
38. R.K. Gilchrist, R. Medal, W.D. Shorey, R.C. Hanselman, J.C. Parrot, C.B. Taylor, "Selective inductive heating of lymph nodes," Ann Surgery. 1957; 146: 596-606.
39. I. Hilger, R. Kiergeist, R. Hergt, K. Winnefeld, H. Schubert, W.A. Kaiser, "Thermal ablation of tumors using magnetic nanoparticles: an in vivo feasibility study," Invest Radiol. 2002; 37: 580-586.
40. M. Johannsen, U. Gneveckow, B. Thiesen, K. Taymoorian, C.H. Cho, N. Waldofner, R. Scholz, A. Jordan, S.A. Loening, P. Wust, "Thermotherapy of prostate cancer using magnetic nanoparticles: feasibility, imaging, and three-dimensional temperature distribution," Eur Urol. 2007; 52: 1661-1662.
41. Aduro BioTech Website: www.aduro-biotech.com.
42. R.B. Campbell, "Battling tumors with magnetic nanotherapeutics and hyperthermia: turning up the heat," Nanomed. 2007; 2: 649-652.
43. A. Ito, M. Fujioka, T. Yoshida, K. Wakamatsu, S. Ito, T. Yamashita, K. Jimbow, H. Honda, "4-S-Cysteaminylpheno-loaded magnetite cationic liposomes for combination therapy of hyperthermia with chemotherapy against malignant melanoma," Cancer Sci. 2007; 98: 424-430.
44. A. Ito, Y. Kuga, H. Honda, H. Kikkawa, A. Horiuchi, Y. Watanabe, T. Kobayashi, "Magnetite nanoparticle-loaded anti-HER2 immunoliposomes for combination of antibody therapy with hyperthermia," Cancer Lett. 2004; 212: 167-75.
45. T. Kikumori, T. Kobayashi, M. Sawaki, T. Imai, "Anti-cancer effect of hyperthermia on breast cancer by magnetite nanoparticle-loaded anti-HER2 immunoliposomes," Breast Cancer Res Treat. 2008; Mar 2, Epub ahead of print.
46. Nanotech Now Website: www.nanotech-now.com.
47. L.R. Hirsch, R.J. Stafford, J.A. Bankson, S.R. Sershen, B. Rivera, R.E. Price, J.D. Hazle, N.J. Halas, J.L. West, "Nanoshell-mediated near infrared thermal therapy of tumors under magnetic resonance guidance," Proc Natl Acad, Sci USA. 2003; 100: 13549-13554.
48. A.R. Lowery, A.M. Gobin, E.S. Day et al, "Immunonanoshells for targeted photo-thermal ablation of tumor cells," Int J Nanomedicine. 2006; 1: 149-154.
49. R.J. Bernardi, A.R. Lowery, P.A. Thompson, S.M. Blaney, J.L. West, "Immunonanoshells for targeted photo-thermal ablation in medulloblastoma and glioma: an in vitro evaluation using human cell lines," J Neurooncol. 2008; 86: 165-172.
50. J.M. Stern, J. Stanfield, Y. Lotan et al, "Efficacy of laser-activated gold nanoshells in ablating prostate cancer cells in vitro," J Endourol. 2007; 21: 939-943.
51. Nanotech Now Website: www.nanotech-now.com.
52. N.W. Kam, M. O'Connell, J.A. Wisdom, H. Dai, "Carbon nanotubes as multifunctional biological transporters and near-infrared agents for selective cancer cell destruction," Proc Natl Acad Sci USA. 2005. 102: 11600-11605.
53. R. Saito, G. Dresselhaus, M.S. Dresselhaus, "Physical Properties of Carbon Nanotubes," Imperial College Press (London), 2000; 258 pages.
54. Zyvex Performance Materials unpublished results per collaboration with Therm Med, LLC.
55. M. Panhuis, S. Gowrisanker, D.J. Vanesko, C.A. Mire, H. Jia, H. Xie, R.H. Baughman, I.H. Musselman, B.E. Gnade, G.R. Dieckmann, R.K. Draper, "Nanotube network transistors from peptide-wrapped single-walled carbon nanotubes," Small. 2005; 1: 820-823.
56. A. Nish, J.Y. Hwang, J. Doig, R.J. Nicholas, "Highly selective dispersion of single-walled carbon nanotubes using aromatic polymers," Nat Nanotechnol. 2007; 2: 640-646.
57. C.J. Gannon, P. Cherukuri, B.I. Yakobson, L. Cognet, J.S. Kanzius, C. Kittrell, R.B. Weisman, M. Pasquali, H.K. Schmidt, R.E. Smalley, S.A. Curley, "Carbon Nanotube-enhanced thermal destruction of cancer cells in a noninvasive radiofrequency field," Cancer. 2007; 110: 2654-2665.
58. C.J. Gannon, P. Mukherjee, S.A. Curley, "In vitro gold nanoparticle targeting enhances non-invasive radiofrequency depletion of gastrointestinal malignancies," 2007 Gastrointestinal Cancers Symposium Abstract.
59. P. Chakravarty, R. Marches, N.S. Zimmerman, A.D.E. Swafford, P. Bajaj, I.H. Musselman, P. Pantano, R.K. Draper, E.S. Vitetta, "Thermal ablation of tumor cells with antibody-functionalized single-walled carbon nanotubes," Proc Natl Acad Sci USA. 2008; 105: 8697-8702.
60. C. Tilcock, E. Unger, P. Cullis, P. MacDougall, "Liposomal Gd-DTPA: preparation and characterization of relaxivity," Radiology. 1989; 171: 77-80.
61. G.W. Kabalka, M.A. Davis, E. Holmberg et al, "Gadolinium-labeled liposomes containing amphiphilic Gd-DTPA derivatives of varying chain length: targeted MRA contrast enhancement agents for the liver," Magn Reson Imaging. 1991; 9: 373-377.
62. V.S. Trubetskoy, M.D. Frank-Kamenetsky, K.R. Whiteman, G.L. Wolf, V.P. Torchilin, "Stable polymeric micelles: lymphangiographic contrast media for gamma scintigraphy and magnetic resonance imaging," Acad Radiol. 1996; 3: 232-238.
63. J. Alper, "Shining a light on cancer research," NCI Alliance for Nanotechnology in Cancer USA, 2005.
64. L. Qu, X. Peng, "Control of photoluminescence properties of CdSe nanocrystals in growth. J Am Chem Soc. 2002; 124: 2049-2055.
65. X. Michalet, F.F. Pinaud, L.A. Bentolila, J.M. Tsay, S. Doose, J.J. Li, G. Sundaresan, A.M. Wu, S.S. Gambhir, S. Weiss, "Quantum dots for live cells, in vivo imaging, and diagnostics," Science. 2005; 307: 538-544.
66. C.P. Parungo, Y.L. Colson, S.W. Kim et al, "Sentinel lymph node mapping of the pleural space," Chest. 2005; 127: 1799-1804.
67. Y. Wang, X. Xie, X. Wang et al, "Photo-acoustic tomography of a nanoshell contrast agent in the in vivo rat brain," Nano Lett. 2004; 4: 1689-1692.
68. G.M. Lanza, K.D. Wallace, M.J. Scott, W.P. Cacheris, D.R. Abendschein, D.H. Christy, A.M. Sharkey, J.G. Miller, P.J. Gaffney, S.A. Wickline, "A novel site-targeted ultrasonic contrast agent with broad biomedical application," Circulation. 1996; 94: 3334-3340.
69. Kereos Incorporated Website: www.kereos.com.
70. R. Weissleder, G. Elizondo, J. Wittenberg, C.A. Rabito, H.H. Bengele, L. Josephson, "Ultrasmall superparamagnetic iron oxide: characterization of a new class of contrast agents for MR imaging," Radiology. 1990; 175: 489-493.
71. S.C. Michel, T.M. Keller, J.M. Frohlich et al, "Preoperative breast cancer staging: MR imaging of the axilla with ultrasmall superparamagnetic iron oxide enhancement," Radiology. 2002; 225: 527-536.
72. B.C. Nguyen, W. Stanford, B.H. Thompson et al, "Multicenter clinical trial of ultrasmall superparamagnetic iron oxide in the evaluation of mediastinal lymph nodes in patients with primary lung carcinoma," J Magn Reson Imaging. 1999; 10: 468-473.
73. M.G. Harisinghani, J. Barentsz, P.F. Han et al, "Noninvasive detection of clinical occult lymph-node metastases in prostate cancer," N Engl J Med. 2003; 348: 2491-2499.
74. A.G. Rockall, S.A. Sohaib, M.G. Harisinghani et al, "Diagnostic performance of nanoparticle-enhanced magnetic resonance imaging in the diagnosis of lymph node metastases in patients with endometrial and cervical cancer," J Clin Oncol. 2005; 23: 2813-2821.
75. X. Gao, Y. Cui, R.M. Levenson, L.W. Chung, S. Nie, "In vivo cancer targeting and imaging with semiconductor quantum dots," Nat Biotechnol. 2004; 22: 969-976.
76. R.A. Tripp, R. Alvarez, B. Anderson, L. Jones, C. Weeks, W. Chen, "Bioconjugated nanoparticle detection of respiratory syncytial virus infection," Int J Nanomedicine. 2007; 2: 117-124.
77. C. Loo, A. Lowery, N. Halas, J. West, R. Drezek, "Immunotargeted nanoshells for integrated cancer imaging and therapy," Nano Lett. 2005; 5: 709-711.
78. C. Leuschner, C. Kumar, M.O. Urbina et al, "The use of ligand conjugated supraparamagnetic iron oxide nanoparticles for early detection of metastasis," NSTI Nanotechnol. 2005; 1: 5-6.
79. J. Grimm, J.M. Perez, L. Josephson, R. Weissleder, "Novel nanosensors for rapid analysis of telomerase activity," Cancer Res. 2004; 64: 639-643.
80. E.E. Connor, J. Mwamuka, A. Gole et al, "Gold nanoparticles are taken up by human cells but do not cause acute cytotoxicity," Small. 2005; 1: 325-327.
81. D. Shenoy, W. Fu, J. Li et al, "Surface functionalization of gold nanoparticles using hetero-bifunctional poly(ethylene glycol) spacer for intracellular tracking and delivery," Int J Nanomedicine. 2006; 1: 51-57.
82. T. Niidome, M. Yamagat, Y. Okamoto et al, "PEG-modified gold nanorods with a stealth character for in vivo applications," J Control Release. 2006; 114: 343-347.
83. A.R. Lowery, A.M. Gobin, E.S. Day, N.J. Halas, J.L. West, "Immunonanoshells for targeted photo-thermal ablation of tumor cells," Int J Nanomedicine. 2006; 1: 149-154.
84. R.J. Bernardi, A.R. Lowery, P.A. Thompson, S.M. Blaney, J.L. West, "Immunonanoshells for targeted photo-thermal ablation in medulloblastoma and glioma: an in vitro evaluation using human cell lines," J Neurooncol. 2008; 86: 165-172.
85. J.M. Stern, J. Stanfield, Y. Lotan, S. Park, J.T. Hsieh, J.A. Cadeddu, "Efficacy of laser-activated gold nanoshells in ablating prostate cancer cells in vitro," J Enourol. 2007, 21: 939-943.
86. T. W. Ebbesen, P.M. Ajayan, "Large-scale synthesis of carbon nanotubes," Nature. 1992: 358: 220-222.
87. T. Guo, Ting (1995). "Catalytic growth of single-walled nanotubes by laser vaporization". Chem. Phys. Lett 1995; 243: 49-54.
88. M. José-Yacamán, "Catalytic growth of carbon microtubules with fullerene structure". Appl. Phys. Lett. 1993; 62: 657.
89. Y. Issa, P. Brunton, C.M. Waters, D.C. Watts, "Cytotoxicity of metal ions to human oligodendroglial cells and human gingival fibroblasts assessed by mitochondrial dehydrogense activity," Dent Mater. 2008; 24: 281-287.
90. A.A. Shvedova, V. Castranove, E.R. Kisin et al, "Exposure to carbon nanotube material: assessment of nanotube Cytotoxicity using human keratinocyte cells," J Toxicol Environm Health Part A. 2003; 66: 1909-1926.
91. C.M. Sayes, f. Liang, J.L. Hudson et al, "Functionalization density dependence of single-walled carbon nanotubes Cytotoxicity in vitro," Toxicol Lett. 2006; 161: 135-142.
92. D.B. Warheit, B.R. Laurence, K.L. Reed et al, "Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats," Toxicol Sci. 2004; 77: 117-125.
93. J. Muller, F. Huaux, N. Moreau t al, "Respiratory toxicity of multi-wall carbon nanotubes," Toxicol Appl Pharmacol. 2005; 207: 221-231.
94. F. Yang, R. Murugan, S. Ramakrishna, X. Wang, Y.X. Ma, S. Wang, "Fabrication of nano-structured porous PLLA scaffold intended for nerve tissue engineering," Biomaterials. 2004; 25: 1891-1900.
95. Y. Yamakoshi, N. Umezawa, A. Ryu et al, "Active oxygen species generated from photo-excited fullerene (C60) as potential medicines," J Am Chem Soc. 2003; 125: 12803-12809.
96. S.B. Lovern, R. Klaper, "Daphnia magna mortality when exposed to titanium dioxide and fullerene (C60) nanoparticles," Environ Toxicol Chem. 2006; 25: 1132-1137.
97. S. Zhu, E. Oberdorster, M.L. Haasch, "Toxicity of an engineered nanoparticle(fullerene, C60) in to aquatic species. Daphnia flathead minnow," Mar Environ Res. 2006; 62 (Suppl): S5-S9.
98. E. Oberdorster, "Manufactured nanomaterials (fullerenes, C60) induce oxidative stress in the brain of juvenile largemouth bass," Environ Health Perspect. 2004; 112: 1058-1062.
99. M.A. Reed, "Quantum Dots," Scientific American, 1993; January: 118-125.
100. J. Lovrie, S.J. Cho, F.M. Winnik et al, "Unmodified cadmium telluride quantum dots induce reactive oxygen species formation leading to multiple organelle damage and cell death," Chem Biol. 2005; 12: 1159-1161.
101. L Wang, D.K. Nagesha, S. Selvarasah, M.R. Dokmeci, R.L. Carrier, "Toxicity of CdSe nanoparticles on Caco-2 cell cultures," J Nanobiotechnology. 2008; 6: 11.
102. R. Hardman, "A toxicological review of quantum dots: toxicity depends on physicochemical and environmental factors," Environ Health Perspect. 2006; 114: 165-182.
103. N.R. Luman, M.W. Grinstaff, "Synthesis and aqueous aggregation properties of amphiphilic surface-block dendrimers," Org Lett. 2005; 7: 4863-4866.
104. S. Svenson, D.A. Tomalia, "Dendrimers in biomedical applications - reflections on the field," Adv Drug Del Rev. 2005; 57: 2106-2129.
105. N.A. Stasko, C.B. Johnson, M.H. Schoenfisch, T.A. Johnson, E.L. Holmuhamedov, "Cytotoxicity of polypropylenimine dendrimers conjugates on culture endothelial cells," Biomacromolecules. 2007; 8: 3853-3859.
106. R.B. Kolhatkar, K.M. Kitchens, P.W. Swaan, H. Ghandehari, "Surface acetylation of polyamidoamine (PAMAM) dendrimers decreases Cytotoxicity while maintaining membrane permeability," Bioconjug Chem. 2007; 18: 2054-2060.
107. J.L. Gilmore, X. Yi, L. Quan, A.V. Kabanov, "Novel nanomaterials for clinical neuroscience," J Neuroimmune Pharmacol. 2008; 3: 83-94.
108. V. Lovat, D. Pantarotto, L. Lagostena, B. Cacciari, et al, "Carbon nanotube substrates boost neuronal electrical signaling," Nano Lett., 2005; 5: 1107-1110.
109. S.T. Yang, X. Wang, G. Jia, Y. Gu, T. Wang, H. Nie, C. Ge, H. Wang, Y. Liu, "Long-term accumulation and low toxicity of single-walled carbon nanotubes in intravenously exposed mice," Toxicol Lett. 2008; 181: 182-189.
110. A. G. de Boer, P.J. Gaillard, "Drug targeting to the brain," Annu Rev Pharmacol Toxicol. 2007; 47: 323-355.
111. N. Shi, Y. Zhang, C. Zhu, R.J. Boado, W.M. Pardridge, "Brain-specific expression of an exogenous gene after i.v. administration," Proc Natl Acad Sci USA. 2001; 98: 12754-12759.
112. J. Kreuter, P. Ramge, V. Petrov, S. Hamm, S.E., Gelperina, B. Engelhardt, R. Alyautdin, H. von Briesen, D.J. Begley, "Direct evidence that polysorbate-80-coated poly(butylcyanoacrylate) nanoparticles deliver drugs to the CNS via specific mechanisms requiring prior binding of drug to the nanoparticles," Pharm Res. 2003; 20: 409-416.
113. R. Vasita, I.K. Shanmugam, D.S. Katt, "Improved biomaterials for tissue engineering applications: surface modification of polymers," Curr Top Med Chem. 2008; 8: 34353.
114. J.A. Matthews, G.E. Wnek, D.G. Simpson et al, "Electrospinning of collagen nanofibers," Biomacromolecules. 2002, 3: 232-238.
115. X. Geng, O.H. Kwon, J. Jang, "Electrospinning of chitosan dissolved in concentrated acetic acid solution," Biomaterials. 2005; 26: 5427-5432.
116. I.C. Um, D. Fang, B.s. Hsiao et al, "Electrospinning and electro-blowing of hyaluronic acid," Biomacromolecules. 2004; 5: 1428-1436.
117. Y. Zhang, H. Ouyang, C.T. Lim et al, "Electrospinning of gelatin fibers and gelatin/PCL composite fibrous scaffolds," J Biomed Mater Res Part B: Appl Biomater. 2005; 72B: 156-165.
118. H. Yoshimoto, Y.M. Shin, H. Terai et al, "A biodegradable nanofiber scaffold by electrospinning and its potential for bone tissue engineering," Biomaterials. 2003; 24: 2077-2082.
119. M. Shin H. Yoshimoto, J.P. Vacanti, "In vivo bone tissue engineering using mesenchymal stem cells on a novel electrospun nanofibrous scaffold," Tissue Eng. 2004; 10: 33-41.
120. W.J. Li, K.G. Danielson, P.G. Alexander et al, "Biological response of chondrocytes cultured in three-dimensional nanofibrous poly(E-caprolactone) scaffolds," J. Biomedi Mater Res A. 2003; 67A: 1105-1114.
121. B.M. Min, G. Lee, S.H. Kim et al, "Electrospinning of silk fibrotin nanofibers and its effect on the adhesion and spreading of normal human keratinocytes and fibroblasts in vitro," Biomaterials. 2004; 25: 1289-1297.
122. X.M. Mo, C.Y. Xu, M. Kotaki et al, "Electrospun P(LLA-CL) nanofiber: a biomimetic extracellular matrix for smooth muscle cell and endothelial cell proliferation," Biomaterials. 2004; 25: 1883-1890.
123. T.C. McDevitt, S.P. Palecek, "Innovation in the culture and derivation of pluripotent human stem cells," Curr Opin Biotechnol. 2008; 19: 527-33.
124. D. Ilic, G. Giritharan, T. Zdravkovic, E. Caceres, O. Genbacev, S. Fisher, A. Krtolica, "Derivation of human embryonic stem cell lines from biopsied blastomeres on human feeders with minimal exposure to xenomaterials," Stem Cells Dev. 2009; Epub ahead of print.
125. D.S. Kommireddy, S.M. Sriram, Y.M. Lvov, D.K. Mills, "Stem cell attachment to layer-by-layer assembled TiO2 nanoparticle thin films," Biomaterials. 2006; 27: 4296-303.
126. K. Shimizu, A. Ito, T. Yoshida, Y. Yamada, M. Ueda, H. Honda, "Bone tissue engineering with human mesenchymal stem cell sheets constructed using magnetite nanoparticles and magnetic force," J Biomed Mater Res B Appl Biomater. 2007; 82: 471-80.
127. L.S. Sefcik, R.A. Neal, S.N. Kaszuba, A.M. Parker, A.J. Katz, R.C. Ogle, E.A. Botchwey, "Collagen nanofibres are a biomimetic substrate for the serum-free osteogenic differentiation of human adipose stem cells," J Tissue Eng Regen Med. 2008; 2: 210-20.
128. U. Salli, T.E. Fox, N. Carkaci-Sali, A. Sharma, G.P. Robertson, M. Kester, K. Vrana, "Propagation of undifferentiated human embryonic stem cells with nano-liposomal ceramide," Stem Cells Dev. 2008; Epub ahead of print.
129. R.A. Freitas, Jr., "The future of nanofabrication and molecular scale devices in medicine," Chapter from Future Health Technology, Ed. R. Bushko, IOS Press, 2002.
130. R.A. Freitas, Jr., "Exploratory design in medical nanotechnology: A mechanical artificial red cell," Artificial Cells, Blood Substitutes, and Immobil. Biotech. 1998; 26: 411-430.
131. C. Mao, W. Sun, Z. Shen, N.C. Seeman, "A nanomechanical device based on the B-Z transition of DNA," Nature. 1999; 397: 144-146.