Efficiency of T-cell costimulation by CD80 and CD86 cross-linking correlates with calcium entry

Immunology

Volumn 129, Issue 1, 2010, Pages 28-40

  Thiel, Markus ^a   Wolfs, Melodie Jo ^b   Bauer, Stefan ^a   Wenning, Anna S ^b   Burckhart, Tanja ^a   Schwarz, Eva C ^b   Scott, Andrew M ^c   Renner, Christoph ^a   Hoth, Markus ^b  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b SAARLAND UNIVERSITY   (Germany)

^c AUSTIN HOSPITAL   (Australia)

Author keywords

Calcium channel; Calcium release activated Ca2+ channel; Lymphocyte; ORAI channel

Indexed keywords

B7 ANTIGEN; BISPECIFIC ANTIBODY; CALCIUM ION; CD28 ANTIGEN; CD86 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; MEMBRANE PROTEIN; STROMAL INTERACTION MOLECULE 2;

ANIMAL CELL; ANTIGEN EXPRESSION; ANTIGEN FUNCTION; ARTICLE; CALCIUM DEPLETION; CALCIUM SIGNALING; CALCIUM TRANSPORT; CD8+ T LYMPHOCYTE; CELL ASSAY; CELL KILLING; CONTROLLED STUDY; CROSS LINKING; EFFECTOR CELL; EMBRYO; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; LYMPHOCYTE PROLIFERATION; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

EID: 71649112051     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2009.03155.x     Document Type: Article

References (59)

1. Friedl P, den Boer AT, Gunzer M. Tuning immune responses: diversity and adaptation of the immunological synapse. Nat Rev Immunol 2005 5: 532.
2. Jacobelli J, Andres PG, Boisvert J, Krummel MF. New views of the immunological synapse: variations in assembly and function. Curr Opin Immunol 2004 16: 345.
3. Samelson LE. Signal transduction mediated by the T cell antigen receptor: the role of adapter proteins. Annu Rev Immunol 2002 20: 371.
4. Lanzavecchia A, Sallusto F. Antigen decoding by T lymphocytes: from synapses to fate determination. Nat Immunol 2001 2: 487.
5. Crabtree GR, Olson EN. NFAT signaling: choreographing the social lives of cells. Cell 2002 109 (Suppl S67.
6. Parekh AB, Putney JW Jr. Store-operated calcium channels. Physiol Rev 2005 85: 757.
7. Feske S. Calcium signalling in lymphocyte activation and disease. Nat Rev Immunol 2007 7: 690.
8. Lewis RS. The molecular choreography of a store-operated calcium channel. Nature 2007 446: 284.
9. Quintana A, Griesemer D, Schwarz EC, Hoth M. Calcium-dependent activation of T-lymphocytes. Pflugers Arch 2005 450: 1.
10. Hoth M, Penner R. Depletion of intracellular calcium stores activates a calcium current in mast cells. Nature 1992 355: 353.
11. 2+ stores. Proc Natl Acad Sci U S A 1993 90: 6295.
12. Feske S, Gwack Y, Prakriya M et al. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature 2006 441: 179.
13. Peinelt C, Vig M, Koomoa DL et al. Amplification of CRAC current by STIM1 and CRACM1 (Orai1). Nat Cell Biol 2006 8: 771.
14. Prakriya M, Feske S, Gwack Y, Srikanth S, Rao A, Hogan PG. Orai1 is an essential pore subunit of the CRAC channel. Nature 2006 443: 230.
15. Yeromin AV, Zhang SL, Jiang W, Yu Y, Safrina O, Cahalan MD. Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai. Nature 2006 443: 226.
16. 2+ store to the plasma membrane. Nature 2005 437: 902.
17. 2+ channel function. J Cell Biol 2005 169: 435.
18. 2+ influx. Curr Biol 2005 15: 1235.
19. 2+ entry. Curr Biol 2006 16: 1465.
20. Soboloff J, Spassova MA, Tang XD, Hewavitharana T, Xu W, Gill DL. Orai1 and STIM reconstitute store-operated calcium channel function. J Biol Chem 2006 281: 20661.
21. Parvez S, Beck A, Peinelt C et al. STIM2 protein mediates distinct store-dependent and store-independent modes of CRAC channel activation. FASEB J 2007 22: 752.
22. Oh-Hora M, Yamashita M, Hogan PG et al. Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance. Nat Immunol 2008 9: 432.
23. Schwarz EC, Kummerow C, Wenning AS et al. Calcium dependence of T cell proliferation following focal stimulation. Eur J Immunol 2007 37: 2723.
24. 2+ entry and NFAT activation in lymphocytes. Cell Calcium 2007 42: 145.
25. Hogan PG, Chen L, Nardone J, Rao A. Transcriptional regulation by calcium, calcineurin, and NFAT. Genes Dev 2003 17: 2205.
26. Feske S, Giltnane J, Dolmetsch R, Staudt LM, Rao A. Gene regulation mediated by calcium signals in T lymphocytes. Nat Immunol 2001 2: 316.
27. + channel gating in T cells from immunodeficient patients. J Exp Med 2005 202: 651.
28. 2+ channels and T-lymphocyte activation by the pyrazole derivative BTP2. J Biol Chem 2004 279: 12427.
29. Partiseti M, Le Deist F, Hivroz C, Fischer A, Korn H, Choquet D. The calcium current activated by T cell receptor and store depletion in human lymphocytes is absent in a primary immunodeficiency. J Biol Chem 1994 269: 32327.
30. Alegre ML, Frauwirth KA, Thompson CB. T-cell regulation by CD28 and CTLA-4. Nat Rev Immunol 2001 1: 220.
31. Chen L. Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity. Nat Rev Immunol 2004 4: 336.
32. Linsley PS, Greene JL, Brady W, Bajorath J, Ledbetter JA, Peach R. Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors. Immunity 1994 1: 793.
33. Collins AV, Brodie DW, Gilbert RJ et al. The interaction properties of costimulatory molecules revisited. Immunity 2002 17: 201.
34. van der Merwe PA, Bodian DL, Daenke S, Linsley P, Davis SJ. CD80 (B7-1) binds both CD28 and CTLA-4 with a low affinity and very fast kinetics. J Exp Med 1997 185: 393.
35. + regulatory T cells. Eur J Immunol 2002 32: 2888.
36. Zheng Y, Manzotti CN, Liu M, Burke F, Mead KI, Sansom DM. CD86 and CD80 differentially modulate the suppressive function of human regulatory T cells. J Immunol 2004 172: 2778.
37. Pentcheva-Hoang T, Egen JG, Wojnoonski K, Allison JP. B7-1 and B7-2 selectively recruit CTLA-4 and CD28 to the immunological synapse. Immunity 2004 21: 401.
38. Egen JG, Allison JP. Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength. Immunity 2002 16: 23.
39. Teh HS, Teh SJ. Direct evidence for a two-signal mechanism of cytotoxic T-lymphocyte activation. Nature 1980 285: 163.
40. Fanger CM, Hoth M, Crabtree GR, Lewis RS. Characterization of T cell mutants with defects in capacitative calcium entry: genetic evidence for the physiological roles of CRAC channels. J Cell Biol 1995 131: 655.
41. Bauer S, Adrian N, Williamson B et al. Targeted bioactivity of membrane-anchored TNF by an antibody-derived TNF fusion protein. J Immunol 2004 172: 3930.
42. Thirion S, Motmans K, Heyligen H, Janssens J, Raus J, Vandevyver C. Mono-and bispecific single-chain antibody fragments for cancer therapy. Eur J Cancer Prev 1996 5: 507.
43. Nicholson IC, Lenton KA, Little DJ, Decorso T, Lee FT, Scott AM, Zola H, Hohmann AW. Construction and characterisation of a functional CD19 specific single chain Fv fragment for immunotherapy of B lineage leukaemia and lymphoma. Mol Immunol 1997 34: 1157.
44. Renner C, Jung W, Sahin U, van Lier R, Pfreundschuh M. The role of lymphocyte subsets and adhesion molecules in T cell-dependent cytotoxicity mediated by CD3 and CD28 bispecific monoclonal antibodies. Eur J Immunol 1995 25: 2027.
45. Co MS, Avdalovic NM, Caron PC, Avdalovic MV, Scheinberg DA, Queen C. Chimeric and humanized antibodies with specificity for the CD33 antigen. J Immunol, 1992 148: 1149.
46. Meissner P, Pick H, Kulangara A, Chatellard P, Friedrich K, Wurm FM. Transient gene expression: recombinant protein production with suspension-adapted HEK293-EBNA cells. Biotechnol Bioeng 2001 75: 197.
47. Kipriyanov SM, Moldenhauer G, Little M. High level production of soluble single chain antibodies in small-scale Escherichia coli cultures. J Immunol Methods 1997 200: 69.
48. Bauer S, Adrian N, Fischer E et al. Structure-activity profiles of Ab-derived TNF fusion proteins. J Immunol 2006 177: 2423.
49. Renner C, Pfitzenmeier JP, Gerlach K, Held G, Ohnesorge S, Sahin U, Bauer S, Pfreundschuh M. RP1, a new member of the adenomatous polyposis coli-binding EB1-like gene family, is differentially expressed in activated T cells. J Immunol 1997 159: 1276.
50. Quintana A, Schwarz EC, Schwindling C, Lipp P, Kaestner L, Hoth M. Sustained activity of calcium release-activated calcium channels requires translocation of mitochondria to the plasma membrane. J Biol Chem 2006 281: 40302.
51. Quintana A, Schwindling C, Wenning AS, Becherer U, Rettig J, Schwarz EC, Hoth M. T cell activation requires mitochondrial translocation to the immunological synapse. Proc Natl Acad Sci U S A 2007 104: 14418.
52. Challita-Eid PM, Penichet ML, Shin SU et al. A B7.1-antibody fusion protein retains antibody specificity and ability to activate via the T cell costimulatory pathway. J Immunol 1998 160: 3419.
53. Peinelt C, Lis A, Beck A, Fleig A, Penner R. 2-Aminoethoxydiphenyl borate directly facilitates and indirectly inhibits STIM1-dependent gating of CRAC channels. J Physiol 2008 586: 3061.
54. 2+ channels by 2-aminoethyldiphenyl borate (2-APB) occurs independently of IP(3) receptors. J Physiol 2001 536: 3.
55. Zang X, Allison JP. The B7 family and cancer therapy: costimulation and coinhibition. Clin Cancer Res 2007 13: 5271.
56. Carlring J, Barr TA, Buckle AM, Heath AW. Anti-CD28 has a potent adjuvant effect on the antibody response to soluble antigens mediated through CTLA-4 by-pass. Eur J Immunol 2003 33: 135.
57. Luhder F, Huang Y, Dennehy KM et al. Topological requirements and signaling properties of T cell-activating, anti-CD28 antibody superagonists. J Exp Med 2003 197: 955.
58. Suntharalingam G, Perry MR, Ward S, Brett SJ, Castello-Cortes A, Brunner MD, Panoskaltsis N. Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412. N Engl J Med 2006 355: 1018.
59. Bluestone JA, St Clair EW, Turka LA. CTLA4Ig: bridging the basic immunology with clinical application. Immunity 2006 24: 233.