Topological requirements and signaling properties of T cell-activating, anti-CD28 antibody superagonists

Journal of Experimental Medicine

Volumn 197, Issue 8, 2003, Pages 955-966

  Lühder, Fred ^a   Huang, Yun ^a,b   Dennehy, Kevin M ^a   Guntermann, Christine ^b   Müller, Ingrid ^a   Winkler, Erna ^b   Kerkau, Thomas ^a   Ikemizu, Shinji ^c   Davis, Simon J ^d   Hanke, Thomas ^a,b   Hünig, Thomas ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b TeGenero ImmunoTherapeutics AG   (Germany)

^c KUMAMOTO UNIVERSITY   (Japan)

^d UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

CD28; Costimulation; Lymphocyte activation; Receptor structure; T cells

Indexed keywords

CD28 ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY SUPERAGONIST; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

AGONIST; ANIMAL MODEL; ANTIBODY AFFINITY; ANTIBODY COMBINING SITE; ARTICLE; BINDING AFFINITY; BINDING KINETICS; CONTROLLED STUDY; CROSS LINKING; FLUORESCENCE ACTIVATED CELL SORTING; HYBRIDOMA; IN VIVO STUDY; LIGAND BINDING; LYMPHOCYTE PROLIFERATION; MITOGENICITY; MOLECULAR CLONING; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD28; EPITOPES; HUMANS; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MODELS, MOLECULAR; NF-KAPPA B; PROTEIN CONFORMATION; PROTEIN-TYROSINE KINASES; RATS; RATS, INBRED LEW; RECEPTORS, ANTIGEN, T-CELL; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; ZAP-70 PROTEIN-TYROSINE KINASE;

EID: 0042505740     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20021024     Document Type: Article

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