Zolpidem and traffic safety - The importance of treatment compliance

Current Drug Safety

Volumn 2, Issue 3, 2007, Pages 220-226

  Verster, Joris C ^a   Volkerts, Edmund R ^a   Olivier, Berend ^a   Johnson, William ^b   Liddicoat, Laura ^b  

^a UTRECHT UNIVERSITY   (Netherlands)

^b WISCONSIN STATE LABORATORY OF HYGIENE   (United States)

Author keywords

Accidents; Compliance; Driving; Zolpidem

Indexed keywords

ALCOHOL; ANTIDEPRESSANT AGENT; ANTIHISTAMINIC AGENT; ANXIOLYTIC AGENT; BENZODIAZEPINE DERIVATIVE; FLUOXETINE; HYDROCODONE; HYPNOTIC AGENT; PLACEBO; PSYCHOTROPIC AGENT; ZALEPLON; ZOLPIDEM; ZOPICLONE;

BALANCE DISORDER; BEDTIME DOSAGE; CLINICAL FEATURE; CONFUSION; DIZZINESS; DRIVING ABILITY; DROWSINESS; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG INDICATION; DRUG MISUSE; DRUG SAFETY; DRUG USE; EVIDENCE BASED MEDICINE; EXPERIMENTAL STUDY; HALLUCINATION; HUMAN; INSOMNIA; MEMORY DISORDER; MOOD DISORDER; PATIENT COMPLIANCE; PRESCRIPTION; PRIORITY JOURNAL; RECOMMENDED DRUG DOSE; REVIEW; SINGLE DRUG DOSE; SOMNOLENCE; SPEECH DISORDER; TRAFFIC ACCIDENT; TRAFFIC SAFETY;

AUTOMOBILE DRIVING; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; HUMANS; HYPNOTICS AND SEDATIVES; PATIENT COMPLIANCE; PSYCHOMOTOR PERFORMANCE; PYRIDINES; SLEEP INITIATION AND MAINTENANCE DISORDERS; TIME FACTORS;

EID: 35348836565     PISSN: 15748863     EISSN: None     Source Type: Journal    
DOI: 10.2174/157488607781668882     Document Type: Review

References (35)

1. Connor J, Whitlock G, Norton R, Jackson R. The role of driver sleepiness in car crashes: a systematic review of epidemiological studies. Accid Anal Prev 2001; 33: 31-41.
2. Connor J, Norton R, Ameratunga S, et al. Driver sleepiness and risk of serious injury to car occupants: population based case control study. BMJ 2002; 324: 1-5.
3. Flatley D, Reyner LA, Home JA. Steep related crashes on sections of different road types in the UK (1995-2001). Department of Transport, London, UK, 2004. Road Safety Research Report No.52.
4. The Gallup Organization. National survey of distracted and drowsy driving attitudes and behaviors: 2002. Volume I-Findings report. National Highway Traffic Safety Administration, Washington DC, USA, 2003.
5. Drover D, Lemmens H, Naidu S, Cevallos W, Darwish M, Stanski D. Pharmacokinetics, pharmacodynamics, and relative pharmacokinetic/ pharmacodynamic profiles of zaleplon and zolpidem. Clin Ther 2000; 22: 1443-1461.
6. Holm KJ, Goa KL. Zolpidem. An update of its pharmacology, therapeutic efficacy and tolerability in the treatment of insomnial. Drugs 2000; 59: 865-889.
7. Verster JC, Veldhuijzen DS, Volkerts ER. Residual effects of sleep medication on driving ability. Sleep Med Rev 2004; 8: 309-325.
8. Verster JC, Veldhuijzen DS, Patat A, Olivier B, Volkerts ER. Hypnotics and driving safety: meta-analyses of randomized controlled trials applying the on-the-road driving test. Curr Drug Saf 2006; 1(1):63-72.
9. Barbone F, McMahon AD, Davey PG, et al. Association of road-traffic accidents with benzodiazepine use. Lancet 1998; 352: 1331-1336.
10. Saul S. Some sleeping pill users range far beyond bed. New York Times. March 8, 2006.
11. Ramaekers JG. Antidepressants and driver impairment: empirical evidence from a standard on-the-road test. J Clin Psychiatry 2003; 64: 20-29
12. Verster JC, Volkerts ER. Antihistamines and driving ability: Evidence from on-the-road driving studies during normal traffic. Ann Allergy Asthma Immunol 2004; 92: 294-303, quiz 303-5, 355; Review Erratum in: Ann Allergie Asthma Immunol 2004; 92: 675. Ann Allergy Asthma Immunol 2005; 94(3): 409-10.
13. Verster JC, Veldhuijzen DS, Volkerts ER. Is it safe to drive a car when treated with anxiolytics? Evidence from on-the-road driving studies during normal traffic. Curr Psychiatry Rev 2005; 1(2): 215-225.
14. Vermeeren A, O'Hanlon JF, DeClerck AC, Kho L. Acute effects of zolpidem and flunitrazepam an sleep, memory and driving performance, compared to those of partial sleep deprivation and placebo. Acta, Ther 1995; 21: 47-64.
15. Berthelon C, Becca ML, Denise P, Pottier A. Do zopiclone, zolpidem and flunitrazepam have residual effects on simulated task of collision anticipation? J Psychopharmacol 2003; 17: 324-331.
16. Staner L, Ertle S, Boeijinga P, et al. Next-day residual effects of hypnotics in DSM-IV primary insomnia: a driving simulator study with simultaneous electroencephalogram monitoring. Psychopharmacology 2005; 181: 790-798.
17. Bocca ML, Le Doze F, Etard O, Portier M, L'Hoste J, Dense P. Residual effect of zolpidem 10 mg and zopiclone 7.5 mg versus flunitrazepam 1 mg and placebo on driving performance and ocular saccades. Psychopharmacology 1999; 143: 373-379.
18. Bensimon G, Foret J, Warot D, Lacomblez L, Tniercelin JF, Simon P. Daytime wakefulness following a bedtime oral dose of zolpidem 20 mg, flunitrazepam 2 mg and placebo. Br J Clin Pharmacol 1990; 30: 463-469.
19. Quera-Salva MA, McCann C, Boudet J, et al. Effects ot zolpidem on sleep architecture, night time ventilation daytime vigilance and performance in heavy snorers. Br J Clin Pharmacol 1994; 37: 539-543.
20. Partinen M, Hirvonen K, Hublin C, Halavaara M, Hiltunen H. Effects of after-midnight intake of zolpidem and temazepam on driving ability in women with non-organic insomnia. Sleep Med 2004; 4: 553-561.
21. Verster JC, Volkerts ER, Schreuder AHCML, et al. Residual effects of middle-of-the-night administration of zaleplon and zolpidem on driving ability, memory functions and psychomotor performance. J Clin Psychopharmacol 2002; 22: 576-583.
22. Louwerens JW, Gloerich ABM, De Vries G, et al. The relationship between drivers' blood ethanol concentration (BAC) and actual driving performance during high speed travel. In: Noordzij, P.C. and Roszbach R. (Eds), Alcohol, Drugs and Traffic Safety. Proceedings of the 10th International Conference on Alcohol, Drugs and Traffic Safety, Amsterdam: Excerpta Medica, 1987; p. 183-192
23. Danjou P, Paty I, Fruncillo R, et al. A comparison of the residual effects of zaleplon and zolpidem following administration 5 to 2 h before awakening. Br J Clin Pharmacol 1999; 48: 367-74.
24. Mattila MJ, Vanakoski J, Kalska H, Seppälä T. Effects of alcohol, zolpidem, and some other sedatives and hypnotics on human performance and memory. Pharmacol Biochem Behav 1998; 59: 917-923.
25. Mintzer MZ, Griffiths RR. Selective effects of zolpidem on human memory functions. J Psychopharmacol 1999; 13: 18-31.
26. Mintzer MZ, Griffiths. Triazolam and zolpidem: effects on human memory and attentional processes. Psychopharmacology 1999; 144: 8-19.
27. Richens A, Mercer AJ, Jones DM, Griffiths A, Marshall RW. Effects of zolpidem on saccadic eye movements and psychomotor performance: a double-blind, placebo-controlled study in healthy volunteers. Br J Clin Pharmacol 1993; 36: 61-65.
28. Roehrs T, Merlotti L, Zorick F, Roth T. Sedative, memory, and performance effects of hypnotics. Psychopharmacology 1994, 116: 130-134.
29. Rush CR, Armstrong DL, Ali JA, Pazzaglia PJ. Benzodiazepine-receptor ligands in humans: acute performance-impairing, subject-rated and observer-rated effects. J Clin Psychopharmacol 1998; 18: 154-166.
30. Wesensten NJ, Balkin TJ, Belenky GL. Effects of daytime administration of zolpidem versus triazolam on memory. Eur J Clin Pharmacol 1995; 48: 115-122.
31. Wesensten NJ, Balkin TJ, Belenky GL. Effects of daytime administration of zolpidem and triazolam on performance. Aviat Space Environ Med 1996; 67: 115-120.
32. Forrester MB. Comparison of zolpidem and zaleplon exposures in Texas, 1998-2004. J Toxicol Environ Health (Part A) 2006; 69: 1883-1892.
33. Logan BK, Couper FJ. Zolpidem and driving impairment. J Forensic Sci 2001; 46: 105-110.
34. Coleman DE, Ota K. Hallucinations with zolpidem and fluoxetine in an impaired driver. J Forensic Sci 2004; 49: 392-393.
35. Johnson W, Harding P, Cochems A, Liddicoat L. Zolpidem Impaired Drivers in Wisconsin-A Six Year Retrospective. Presentation at Society of Forensic Toxicologists, Inc. 2005 annual meeting.