Early stellate cell activation and veno-occlusive-disease (VOD)-like hepatotoxicity in dogs treated with AR-H047108, an imidazopyridine proton pump inhibitor

Toxicologic Pathology

Volumn 36, Issue 5, 2008, Pages 727-737

  Berg, Anna Lena ^a   Böttcher, Gerhard ^b   Andersson, Kjell ^b   Carlsson, Enar ^b   Lindström, Anna Karin ^a   Huby, Russell ^c   Håkansson, Helen ^d   Skånberg Wilhelmsson, Inger ^a   Hellmold, Heike ^a  

^a ASTRAZENECA R AND D   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

^c ASTRAZENECA   (United Kingdom)

^d KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Fibrosis; Hepatotoxicity; Imidazopyridine; Stellate cells; Veno occlusive disease; VOD

Indexed keywords

8 [(2 ETHYL 6 METHYLBENZYL)AMINO] 2,3 DIMETHYLIMIDAZO[1,2 A]PYRIDINE 6 CARBOXAMIDE; AR H047108; IMIDAZOPYRIDINE DERIVATIVE; PROCOLLAGEN; PROCOLLAGEN 1ALPHA2; PROTON PUMP INHIBITOR; RETINOID; RETINOL ESTER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; AREA UNDER THE CURVE; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; DOG; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG DOSE REDUCTION; DRUG MEGADOSE; ENDOTHELIUM INJURY; FEMALE; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INFLAMMATION; KUPFFER CELL; LIVER FIBROSIS; LIVER INJURY; LIVER TOXICITY; MALE; MYOFIBROBLAST; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SMOOTH MUSCLE FIBER; STELLATE CELL; VEIN OCCLUSION;

CANIS FAMILIARIS;

EID: 49749147164     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1177/0192623308320802     Document Type: Article

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