Prion-induced activation of cholesterogenic gene expression by Srebp2 in neuronal cells

Journal of Biological Chemistry

Volumn 284, Issue 45, 2009, Pages 31260-31269

  Bach, Christian ^a,b   Gilch, Sabine ^a   Rost, Romina ^a   Greenwood, Alex D ^b,f   Horsch, Marion ^b   Hajj, Glaucia N M ^c   Brodesser, Susanne ^d,g   Facius, Axel ^b,h   Schädler, Sandra ^b   Sandhoff, Konrad ^d   Beckers, Johannes ^a,b   Leib Mösch, Christine ^b,e   Schätzl, Hermann M ^a   Vorberg, Ina ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c LUDWIG INSTITUTE FOR CANCER RESEARCH   (Brazil)

^d UNIVERSITY OF BONN   (Germany)

^e UNIVERSITY OF HEIDELBERG   (Germany)

^f LEIBNIZ INSTITUTE FOR ZOO AND WILDLIFE RESEARCH   (Germany)

^g UNIVERSITY OF COLOGNE   (Germany)

^h Nycomed GmbH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELLULAR CHOLESTEROL; CELLULAR RESPONSE; CHOLESTEROL SYNTHESIS; ELEVATED LEVEL; HIPPOCAMPAL NEURONS; HYDROXYMETHYLGLUTARYL; ISOFORMS; MICROARRAY ANALYSIS; MICROGLIAL CELLS; NEURODEGENERATIVE DISEASE; NEURONAL CELL; PRION DISEASE; PRION PROPAGATION; PRION PROTEIN; RATE LIMITING; REGULATED GENES; STEROL REGULATORY ELEMENT-BINDING PROTEINS; TRANSCRIPT LEVEL; UP-REGULATION;

BIOCHEMISTRY; BIOSYNTHESIS; FLUORINE CONTAINING POLYMERS; GENE EXPRESSION; LAWS AND LEGISLATION; NEURONS; PROTEINS;

CHOLESTEROL;

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A SYNTHASE; PRION PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 2;

ANIMAL CELL; ARTICLE; ASTROCYTE; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; GENE EXPRESSION; HIPPOCAMPUS; MICROARRAY ANALYSIS; MICROGLIA; MOUSE; NERVE CELL; NONHUMAN; PRION DISEASE; PRIORITY JOURNAL; PROTEIN ANALYSIS; UPREGULATION;

ANIMALS; CELL LINE, TUMOR; CELLS, CULTURED; CHOLESTEROL; GENE EXPRESSION; MICE; MICE, INBRED C57BL; NEURONS; PRION DISEASES; PRIONS; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; UP-REGULATION;

EID: 71449102371     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.004382     Document Type: Article

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