Sequestration of free cholesterol in cell membranes by prions correlates with cytoplasmic phospholipase A2 activation

BMC Biology

Volumn 6, Issue , 2008, Pages

  Bate, Clive ^a   Tayebi, Mourad ^a   Williams, Alun ^a  

^a ROYAL VETERINARY COLLEGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL ESTER; MEVALONIC ACID; PHOSPHOLIPASE A2; PRION PROTEIN; PROSTAGLANDIN E2; CHOLESTEROL;

ANIMAL CELL; ARTICLE; BRAIN NERVE CELL; CELL MEMBRANE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; CORRELATION FUNCTION; CYTOPLASM; DEGENERATIVE DISEASE; EMBRYO; ENZYME ACTIVATION; IMMUNOPRECIPITATION; LIPID COMPOSITION; MOUSE; NERVE CELL CULTURE; NEUROPATHOLOGY; NONHUMAN; PRION DISEASE; PROSTAGLANDIN SYNTHESIS; PROTEIN PHOSPHORYLATION; ANALYSIS OF VARIANCE; ANIMAL; BIOSYNTHESIS; CELL LINE; EMBRYO (ANATOMY); ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYMOLOGY; METABOLISM; NERVE CELL;

ANALYSIS OF VARIANCE; ANIMALS; CELL LINE; CELL MEMBRANE; CHOLESTEROL; CYTOPLASM; EMBRYO, MAMMALIAN; ENZYME ACTIVATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; IMMUNOPRECIPITATION; MICE; NEURONS; PHOSPHOLIPASES A2; PRION DISEASES; PRPC PROTEINS; PRPSC PROTEINS;

EID: 41549105318     PISSN: None     EISSN: 17417007     Source Type: Journal    
DOI: 10.1186/1741-7007-6-8     Document Type: Article

References (37)

1. Simons M Keller P Dichgans J Schulz JB Cholesterol and Alzheimer's disease: Is there a link? Neurology 2001, 57(6):1089-1093. 11571339
2. Neuhaus O Stuve O Zamvil SS Hartung HP Evaluation of HMG-CoA reductase inhibitors for multiple sclerosis: Opportunities and obstacles CNS Drugs 2005, 19(10):833-41. 10.2165/00023210-200519100-00003 16185093
3. Fai Mok SW Thelen KM Riemer C Bamme T Gultner S Lutjohann D Baier M Simvastatin prolongs survival times in prion infections of the central nervous system Biochemical and Biophysical Research Communications 2006, 348(2):697-702. 10.1016/j.bbrc.2006.07.123 16890918
4. Prusiner SB Prions Proc Natl Acad Sci USA 1998, 95(23):13363-13383. 33918 9811807 10.1073/pnas.95.23.13363
5. Cunningham C Deacon R Wells H Boche D Waters S Diniz CP Scott H Rawlins JN Perry VH Synaptic changes characterize early behavioural signs in the ME7 model of murine prion disease Eur J Neurosci 2003, 17(10):2147-2155. 10.1046/j.1460-9568.2003.02662.x 12786981
6. Jeffrey M Halliday WG Bell J Johnston AR MacLeod NK Ingham C Sayers AR Brown DA Fraser JR Synapse loss associated with abnormal PrP precedes neuronal degeneration in the scrapie-infected murine hippocampus Neuropathol Appl Neurobiol 2000, 26(1):41-54. 10.1046/ j.1365-2990.2000.00216.x 10736066
7. Russelakis-Carneiro M Hetz C Maundrell K Soto C Prion replication alters the distribution of synaptophysin and caveolin 1 in neuronal lipid rafts Am J Pathol 2004, 165(5):1839-1848. 1618653 15509552
8. Pike LJ Lipid rafts: Heterogeneity on the high seas Biochem J 2004, 378(Pt 2):281-292. 1223991 14662007 10.1042/BJ20031672
9. Ikonen E Roles of lipid rafts in membrane transport Curr Opin Cell Biol 2001, 13:470-477. 10.1016/S0955-0674(00)00238-6 11454454
10. Varma R Mayor S GPI-anchored proteins are organized in submicron domains at the cell surface Nature 1998, 394(6695):798-801. 10.1038/29563 9723621
11. Vey M Pilkuhn S Wille H Nixon R DeArmond SJ Smart EJ Anderson RG Taraboulos A Prusiner SB Subcellular colocalization of the cellular and scrapie prion proteins in caveolae-like membranous domains Proc Natl Acad Sci USA 1996, 93(25):14945-14949. 26242 8962161 10.1073/ pnas.93.25.14945
12. Rothberg KG Ying YS Kamen BA Anderson RG Cholesterol controls the clustering of the glycophospholipid-anchored membrane receptor for 5-methyltetrahydrofolate J Cell Biol 1990, 111(6 Pt 2):2931-2938. 10.1083/jcb.111.6.2931 2148564
13. Bilderback TR Grigsby RJ Dobrowsky RT Association of p75(NTR) with caveolin and localization of neurotrophin-induced sphingomyelin hydrolysis to caveolae Journal of Biological Chemistry 1997, 272(16):10922-10927. 10.1074/jbc.272.16.10922 9099750
14. Baenziger JE Morris ML Darsaut TE Ryan SE Effect of membrane lipid composition on the conformational equilibria of the nicotinic acetylcholine receptor Journal of Biological Chemistry 2000, 275(2):777-784. 10.1074/jbc.275.2.777 10625607
15. Sooksawate T Simmonds MA Effects of membrane cholesterol on the sensitivity of the GABA(A) receptor to GABA in acutely dissociated rat hippocampal neurones Neuropharmacology 2001, 40(2):178-184. 10.1016/ S0028-3908(00)00159-3 11114396
16. Li S Couet J Lisanti MP Src Tyrosine Kinases, Galpha Subunits, and H-Ras Share a Common Membrane-anchored Scaffolding Protein, Caveolin. Caveolin binding negatively regulates the auto-activation of Src tyrosine kinases Journal of Biological Chemistry 1996, 271(46):29182-29190. 10.1074/ jbc.271.46.28995 8910575
17. Cooper DMF Crossthwaite AJ Higher-order organization and regulation of adenylyl cyclases Trends in Pharmacological Sciences 2006, 27(8):426-431. 10.1016/j.tips.2006.06.002 16820220
18. Oh P Schnitzer JE Segregation of heterotrimeric G proteins in cell surface microdomains. G(q) binds caveolin to concentrate in caveolae, whereas G(i) and G(s) target lipid rafts by default Mol Biol Cell 2001, 12(3):685-698. 30973 11251080
19. Graziani AV Bricko V Carmignani M Graier WF Groschner K Cholesterol- and caveolin-rich membrane domains are essential for phospholipase A(2)-dependent EDHF formation Cardiovasc Res 2004, 64(2):234-242. 10.1016/j.cardiores.2004.06.026 15485682
20. Simons K Toomre D Lipid rafts and signal transduction Nat Rev Mol Cell Biol 2000, 1(1):31-39. 10.1038/35036052 11413487
21. Bate C Salmona M Williams A The role of platelet activating factor in prion and amyloid-β neurotoxicity Neuroreport 2004, 15:509-513. 10.1097/00001756-200403010-00025 15094513
22. Nordstrom EK Luhr KM Ibanez C Kristensson K Inhibitors of the Mitogen-Activated Protein Kinase Kinase 1/2 Signaling Pathway Clear Prion-Infected Cells from PrPSc Journal of Neuroscience 2005, 25(37):8451-8456. 10.1523/JNEUROSCI.2349-05.2005 16162927
23. Alberts AW Chen J Kuron G Hunt V Huff J Hoffman C Rothrock J Lopez M Joshua H Harris E Patchett A Monaghan R Currie S Stapley E Albers-Schonberg G Hensens O Hirshfield J Hoogsteen K Liesch J Springer J Mevinolin: A highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent Proc Natl Acad Sci USA 1980, 77(7):3957-3961. 349746 6933445 10.1073/pnas.77.7.3957
24. Simons K Ikonen E Functional rafts in cell membranes Nature 1997, 387:569-572. 10.1038/42408 9177342
25. Bate C Reid S Williams A Phospholipase A2 inhibitors or platelet activating factor antagonists prevent prion replication Journal of Biological Chemistry 2004, 279:36405-36411. 10.1074/jbc.M404086200 15210691
26. Diomede L Forloni G Bugiani O Tagliavini F Salmona M The prion protein and cellular cholesterol homeostasis Neurobiology of lipids 2002 1(3)
27. Chang TY Chang AC Cheng D ACYL-COENZYME A:CHOLESTEROL ACYLTRANSFERASE Annual Review of Biochemistry 1997, 66(1):613-638. 10.1146/ annurev.biochem.66.1.613 9242919
28. Schroeder F Gallegos AM Atshaves BP Storey SM McIntosh AL Petrescu AD Huang H Starodub O Chao H Yang H Frolov A Kier AB Recent Advances in Membrane Microdomains: Rafts, Caveolae, and Intracellular Cholesterol Trafficking Experimental Biology and Medicine 2001, 226(10):873-890. 11682693
29. Massimino ML Griffoni C Spisni E Toni M Tomasi V Involvement of caveolae and caveolae-like domains in signalling, cell survival and angiogenesis Cell Signal 2002, 14(2):93-98. 10.1016/S0898-6568(01)00232-7 11781132
30. Schmitt-Ulms G Legname G Baldwin MA Ball HL Bradon N Bosque PJ Crossin KL Edelman GM DeArmond SJ Cohen FE Prusiner SB Binding of neural cell adhesion molecules (N-CAMs) to the cellular prion protein J Mol Biol 2001, 314(5):1209-1225. 10.1006/jmbi.2000.5183 11743735
31. Pfrieger FW Role of cholesterol in synapse formation and function Biochimica et Biophysica Acta (BBA) - Biomembranes 2003, 1610(2):271-280. 10.1016/S0005-2736(03)00024-5 12648780
32. Sandberg MK Low P Altered Interaction and Expression of Proteins Involved in Neurosecretion in Scrapie-infected GT1-1 Cells Journal of Biological Chemistry 2005, 280(2):1264-1271. 10.1074/jbc.M411439200 15528199
33. Gyllberg H Lofgren K Lindegren H Bedecs K Increased Src kinase level results in increased protein tyrosine phosphorylation in scrapie-infected neuronal cell lines FEBS Letters 2006, 580(11):2603-2608. 10.1016/j.febslet.2006.03.092 16647068
34. Bate C Salmona M Diomede L Williams A Squalestatin cures prion-infected neurones and protects against prion neurotoxicity Journal of Biological Chemistry 2004, 279:14983-14990. 10.1074/jbc.M313061200 14754889
35. Liu J Takano T Papillon J Khadir A Cybulsky AV Cytosolic phospholipase A2-alpha associates with plasma membrane, endoplasmic reticulum and nuclear membrane in glomerular epithelial cells Biochem J 2001, 353(Pt 1):79-90. 1221545 11115401
36. Williams AE Van Dam AM Man AHW Berkenbosch F Eikelenboom P Fraser H Cytokines, prostaglandins and lipocortin-1 are present in the brains of scrapie-infected mice Brain Res 1994, 654(2):200-206. 10.1016/ 0006-8993(94)90480-4 7987669
37. Minghetti L Cardone F Greco A Puopolo M Levi G Green AJ Knight R Pocchiari M Increased CSF levels of prostaglandin E(2) in variant Creutzfeldt-Jakob disease Neurology 2002, 58(1):127-129. 11781418