Preferential utilization of newly synthesized cholesterol for brain growth in neonatal lambs

American Journal of Physiology - Endocrinology and Metabolism

Volumn 274, Issue 6 37-6, 1998, Pages

  Turley, Stephen D ^a   Burns, Dennis K ^a   Dietschy, John M ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Central nervous system; Cholesteryl ester; Hepatic; Low density lipoprotein; Ovine

Indexed keywords

CHOLESTEROL; LOW DENSITY LIPOPROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN GROWTH; CHOLESTEROL METABOLISM; CHOLESTEROL SYNTHESIS; CONCENTRATION RESPONSE; DRUG CLEARANCE; FEMALE; LAMB; MALE; NONHUMAN; PRIORITY JOURNAL; TISSUE DISTRIBUTION;

EID: 0031832632     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1998.274.6.e1099     Document Type: Article

References (38)

1. Acton, S., A. Rigotti, K. T. Landschulz, S. Xu, H. H. Hobbs, and M. Krieger. Identification of scavenger receptor SR-BI as a high density lipoprotein receptor. Science 271: 518-520, 1996.
2. Alling, C., and L. Svennerholm. Concentration and fatty acid composition of cholesteryl esters of normal human brain. J. Neurochem. 16: 751-759, 1969.
3. Blanchette-Mackie, E. J., N. K. Dwyer, L. M. Amende, H. S. Kruth, J. D. Butler, J. Sokol, M. E. Comly, M. T. Vanier, J. T. August, R. O. Brady, and P. G. Pentchev. Type-C Niemann-Pick disease: low density lipoprotein uptake is associated with premature cholesterol accumulation in the Golgi complex and excessive cholesterol storage in lysosomes. Proc. Natl. Acad. Sci. USA 85: 8022-8026, 1988.
4. Burris, M. J., and C. A. Baugus. Milk consumption and growth of suckling lambs. J. Anim. Sci. 14: 186-191, 1955.
5. Cavender, C. P., S. D. Turley, and J. M. Dietschy. Sterol metabolism in fetal, newborn, and suckled lambs and their response to cholesterol after weaning. Am. J. Physiol. 269 (Endocrinol. Metab. 32): E331-E340, 1995.
6. Clarenburg, R., I. L. Chaikoff, and M. D. Morris. Incorporation of injected cholesterol into the myelinating brain of the 17-day-old rabbit. J. Neurochem. 10: 135-143, 1963.
7. Cook, R. P. Cholesterol. Chemistry, Biochemistry, and Pathology. New York: Academic, 1958, p. 1-542.
8. Cooper, A. D. Hepatic uptake of chylomicron remnants. J. Lipid Res. 38: 2173-2192, 1997.
9. Cruz, M. L., F. Mimouni, W. Wong, D. L. Hachey, P. Klein, and R. C. Tsang. Effects of infant nutrition on cholesterol synthesis rates in infancy (Abstract). Clin. Res. 39: 689A, 1991.
10. Dehouck, B., L. Fenart, M.-P. Dehouck, A. Pierce, G. Torpier, and R. Cecchelli. A new function for the LDL receptor: transcytosis of LDL across the blood-brain barrier. J. Cell Biol. 138: 877-889, 1997.
11. De Silva, H. V., J. Más-Oliva, J. M. Taylor, and R. W. Mahley. Identification of apolipoprotein B-100 low density lipoproteins, apolipoprotein B-48 remnants, and apolipoprotein E-rich high density lipoproteins in the mouse. J. Lipid Res. 35: 1297-1310, 1994.
12. Dietschy, J. M., T. Kita, K. E. Suckling, J. L. Goldstein, and M. S. Brown. Cholesterol synthesis in vivo and in vitro in the WHHL rabbit, an animal with defective low density lipoprotein receptors. J. Lipid Res. 24: 469-480, 1983.
13. Dietschy, J. M., and D. K. Spady. Measurement of rates of cholesterol synthesis using tritiated water. J. Lipid Res. 25: 1469-1476, 1984.
14. Dietschy, J. M., S. D. Turley, and D. K. Spady. Role of liver in the maintenance of cholesterol and low density lipoprotein homeostasis in different animal species, including humans. J. Lipid Res. 34: 1637-1659, 1993.
15. Edmond, J., R. A. Korsak, J. W. Morrow, G. Torok-Both, and D. H. Catlin. Dietary cholesterol and the origin of cholesterol in the brain of developing rats. J. Nutr. 121: 1323-1330, 1991.
16. Hamilton, J. G., and K. Comai. Rapid separation of neutral lipids, free fatty acids and polar lipids using prepacked silica Sep-Pak columns. Lipids 23: 1146-1149, 1988.
17. Holstein, T. J., W. A. Fish, and W. M. Stokes. Pathway of cholesterol biosynthesis in the brain of the neonatal rat. J. Lipid Res. 7: 634-638, 1966.
18. Jurevics, H., and P. Morell. Cholesterol for synthesis of myelin is made locally, not imported into brain. J. Neurochem. 64: 895-901, 1995.
19. Kim, D.-H., H. Iijima, K. Goto, J. Sakai, H. Ishii, H.-J. Kim, H. Suzuki, H. Kondo, S. Saeki, and T. Yamamoto. Human apolipoprotein E receptor 2. J. Biol. Chem. 271: 8373-8380, 1996.
20. Kinney, H. C., J. Karthigasan, N. I. Borenshteyn, J. D. Flax, and D. A. Kirschner. Myelination in the developing human brain: biochemical correlates. Neurochem. Res. 19: 983-996, 1994.
21. Lentner, C. Geigy Scientific Tables. West Caldwell, NJ: Ciba-Geigy, 1981, p. 223.
22. Lütjohann, D., O. Bruer, G. Ahlborg, I. Nennesmo, Å. Sidén, U. Diczfalusy, and I. Björkhem. Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation. Proc. Natl. Acad. Sci. USA 93: 9799-9804, 1996.
23. Miyawaki, S., S. Mitsuoka, T. Sakiyama, and T. Kitagawa. Sphingomyelinosis, a new mutation in the mouse. J. Hered. 73: 257-263, 1982.
24. Ness, G. C. Developmental regulation of the expression of genes encoding proteins involved in cholesterol homeostasis. Am. J. Med. Genet. 50: 355-357, 1994.
25. Osono, Y., L. A. Woollett, J. Herz, and J. M. Dietschy. Role of the low density lipoprotein receptor in the flux of cholesterol through the plasma and across the tissues of the mouse. J. Clin. Invest. 95: 1124-1132, 1995.
26. Pitas, R. E. Cerebrospinal fluid lipoproteins, lipoprotein receptors, and neurite outgrowth. Nutr. Metab. Cardiovasc. Dis. 7: 202-209, 1997.
27. Ramsey, R. B., and A. N. Davison. Steryl esters and their relationship to normal and diseased human central nervous system. J. Lipid Res. 15: 249-255, 1974.
28. Salen, G., S. Shefer, A. K. Batta, G. S. Tint, G. Xu, A. Honda, M. Irons, and E. R. Elias. Abnormal cholesterol biosynthesis in the Smith-Lemli-Opitz syndrome. J. Lipid Res. 37: 1169-1180, 1996.
29. Snipes, G. J., and U. Suter. Cholesterol and myelin. In: Subcellular Biochemistry edited by R. Bittman. New York, NY: Plenum, 1997, vol. 28, chapt. 7, p. 173-204.
30. Spady, D. K., and J. M. Dietschy. Sterol synthesis in vivo in 18 tissues of the squirrel monkey, guinea pig, rabbit, hamster and rat. J. Lipid Res. 24: 303-315, 1983.
31. Swanson, L. W., D. M. Simmons, S. L. Hofmann, J. L. Goldstein, and M. S. Brown. Localization of mRNA for low density lipoprotein receptor and a cholesterol synthetic enzyme in rabbit nervous system by in situ hybridization. Proc. Natl. Acad. Sci. USA 85: 9821-9825, 1988.
32. Turley, S. D., J. M. Andersen, and J. M. Dietschy. Rates of sterol synthesis and uptake in the major organs of the rat in vivo. J. Lipid Res. 22: 551-569, 1981.
33. Turley, S. D., D. K. Burns, C. R. Rosenfeld, and J. M. Dietschy. Brain does not utilize low density lipoprotein-cholesterol during fetal and neonatal development in the sheep. J. Lipid Res. 37: 1953-1961, 1996.
34. Turley, S. D., and J. M. Dietschy. Mechanisms of LDL-cholesterol lowering action of psyllium hydrophillic mucilloid in the hamster. Biochim. Biophys. Acta 1255: 177-184, 1995.
35. Turley, S. D., M. W. Herndon, and J. M. Dietschy. Reevaluation and application of the dual-isotope plasma ratio method for the measurement of intestinal cholesterol absorption in the hamster. J. Lipid Res. 35: 328-339, 1994.
36. Turley, S. D., D. K Spady, and J. M. Dietschy. Identification of a metabolic difference accounting for the hyper- and hyporesponder phenotypes of cynomolgus monkey. J. Lipid Res. 38: 1598-1611, 1997.
37. Willnow, T. E., J. Hilpert, S. A. Armstrong, A. Rohlmann, R. E. Hammer, D. K. Burks, and J. Herz. Defective forebrain development in mice lacking gp330/megalin. Proc. Natl. Acad. Sci. USA 93: 8460-8464, 1996.
38. Wilson, J. D. The measurement of the exchangeable pools of cholesterol in the baboon. J. Clin. Invest. 49: 655-665, 1970.