Pilot Study: Association of Traditional and Genetic Risk Factors and New-Onset Diabetes Mellitus Following Kidney Transplantation

Transplantation Proceedings

Volumn 41, Issue 10, 2009, Pages 4172-4177

  Chakkera, H A ^a   Hanson, R L ^a,c   Raza, S M ^a   DiStefano, J K ^b   Millis, M P ^b   Heilman, R L ^c   Mulligan, D C ^a   Reddy, K S ^a   Mazur, M J ^a   Hamawi, K ^a   Moss, A A ^a   Mekeel, K L ^a   Cerhan, J R ^d  

^a MAYO CLINIC   (United States)

^b TRANSLATIONAL GENOMICS RESEARCH INSTITUTE   (United States)

^c NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^d MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ALLELE; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; FAMILY HISTORY; FEMALE; FOLLOW UP; GENETIC SUSCEPTIBILITY; GENOTYPE; HEREDITY; HUMAN; HYPERTRIGLYCERIDEMIA; KIDNEY TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PILOT STUDY; PRIORITY JOURNAL; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; UNIVARIATE ANALYSIS;

AGE FACTORS; BODY MASS INDEX; COHORT STUDIES; DIABETES MELLITUS; FAMILY; FEMALE; GENOTYPE; HUMANS; KIDNEY TRANSPLANTATION; MALE; MEDICAL HISTORY TAKING; PILOT PROJECTS; POLYMORPHISM, SINGLE NUCLEOTIDE; POSTOPERATIVE COMPLICATIONS; REGRESSION ANALYSIS; RISK FACTORS; WEIGHT GAIN;

EID: 71249148630     PISSN: 00411345     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.transproceed.2009.08.063     Document Type: Article

References (43)

1. Montori V.M., Basu A., Erwin P.J., et al. Posttransplantation diabetes: a systematic review of the literature. Diabetes Care 25 (2002) 583
2. Cosio F.G., Pesavento T.E., Kim S., et al. Patient survival after renal transplantation: IV. Impact of post-transplant diabetes. Kidney Int 62 (2002) 1440
3. Kasiske B.L., Snyder J.J., Gilbertson D., et al. Diabetes mellitus after kidney transplantation in the United States. Am J Transplant 3 (2003) 178
4. Revanur V.K., Jardine A.G., Kingsmore D.B., et al. Influence of diabetes mellitus on patient and graft survival in recipients of kidney transplantation. Clin Transplant 15 (2001) 89
5. Reisaeter A.V., and Hartmann A. Risk factors and incidence of posttransplant diabetes mellitus. Transplant Proc 33 5A suppl (2001) 8S
6. Sumrani N.B., Delaney V., Ding Z.K., et al. Diabetes mellitus after renal transplantation in the cyclosporine era-an analysis of risk factors. Transplantation 51 (1991) 343
7. Miles A.M., Sumrani N., Horowitz R., et al. Diabetes mellitus after renal transplantation: as deleterious as non-transplant-associated diabetes?. Transplantation 65 (1998) 380
8. Boudreaux J.P., McHugh L., Canafax D.M., et al. The impact of cyclosporine and combination immunosuppression on the incidence of posttransplant diabetes in renal allograft recipients. Transplantation 44 (1987) 376
9. Bloom R.D., Rao V., Weng F., et al. Association of hepatitis C with posttransplant diabetes in renal transplant patients on tacrolimus. J Am Soc Nephrol 13 (2002) 1374
10. Arner P., Gunnarsson R., Blomdahl S., et al. Some characteristics of steroid diabetes: a study in renal-transplant recipients receiving high-dose corticosteroid therapy. Diabetes Care 6 (1983) 23
11. David D.S., Cheigh J.S., Braun Jr. D.W., et al. HLA-A28 and steroid-induced diabetes in renal transplant patients. JAMA 243 (1980) 532
12. Drachenberg C.B., Klassen D.K., Weir M.R., et al. Islet cell damage associated with tacrolimus and cyclosporine: morphological features in pancreas allograft biopsies and clinical correlation. Transplantation 68 (1999) 396
13. Vincenti F., Jensik S.C., Filo R.S., et al. A long-term comparison of tacrolimus (FK506) and cyclosporine in kidney transplantation: evidence for improved allograft survival at five years. Transplantation 73 (2002) 775
14. Knoll G.A., and Bell R.C. Tacrolimus versus cyclosporin for immunosuppression in renal transplantation: meta-analysis of randomised trials. BMJ 318 (1999) 1104
15. Johnston O., Rose C.L., Webster A.C., et al. Sirolimus is associated with new-onset diabetes in kidney transplant recipients. J Am Soc Nephrol 19 (2008) 1411
16. Andrews R.C., and Walker B.R. Glucocorticoids and insulin resistance: old hormones, new targets. Clin Sci (Lond) 96 (1999) 513
17. Henriksen J.E., Alford F., Ward G.M., et al. Risk and mechanism of dexamethasone-induced deterioration of glucose tolerance in non-diabetic first-degree relatives of NIDDM patients. Diabetologia 40 (1997) 1439
18. Chin E.R., Olson E.N., Richardson J.A., et al. A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type. Genes Dev 12 (1998) 2499
19. Dmitrewski J., Krentz A.J., Mayer A.D., et al. Metabolic and hormonal effects of tacrolimus (FK506) or cyclosporin immunosuppression following renal transplantation. Diabetes Obes Metab 3 (2001) 287
20. Ikeuchi M., Kida K., Goto Y., et al. In vivo and in vitro effects of cyclosporin A on glucose transport by soleus muscles of mice. Biochem Pharmacol 43 (1992) 1459
21. Kutkuhn B., Hollenbeck M., Heering P., et al. Development of insulin resistance and elevated blood pressure during therapy with cyclosporine A. Blood Press 6 (1997) 13
22. Menegazzo L.A., Ursich M.J., Fukui R.T., et al. Mechanism of the diabetogenic action of cyclosporin A. Horm Metab Res 30 (1998) 663
23. Ryder J.W., Bassel-Duby R., Olson E.N., et al. Skeletal muscle reprogramming by activation of calcineurin improves insulin action on metabolic pathways. J Biol Chem 278 (2003) 44298
24. Tamura K., Fujimura T., Tsutsumi T., et al. Transcriptional inhibition of insulin by FK506 and possible involvement of FK506 binding protein-12 in pancreatic beta-cell. Transplantation 59 (1995) 1606
25. Wahlstrom H.E., Akimoto R., Endres D., et al. Recovery and hypersecretion of insulin and reversal of insulin resistance after withdrawal of short-term cyclosporine treatment. Transplantation 53 (1992) 1190
26. Bonora E., Targher G., Alberiche M., et al. Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity. Diabetes Care 23 (2000) 57
27. Altshuler D., Hirschhorn J.N., Klannemark M., et al. The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat Genet 26 (2000) 76
28. Barroso I. Genetics of type 2 diabetes. Diabet Med 22 (2005) 517
29. Florez J.C., Hirschhorn J., and Altshuler D. The inherited basis of diabetes mellitus: implications for the genetic analysis of complex traits. Annu Rev Genomics Hum Genet 4 (2003) 257
30. Florez J.C., Jablonski K.A., Bayley N., et al. TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program. N Engl J Med 355 (2006) 241
31. Grant S.F., Thorleifsson G., Reynisdottir I., et al. Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet 38 (2006) 320
32. Steinthorsdottir V., Thorleifsson G., Reynisdottir I., et al. A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet 39 (2007) 770
33. van Dam R.M., Hoebee B., Seidell J.C., et al. Common variants in the ATP-sensitive K+ channel genes KCNJ11 (Kir6.2) and ABCC8 (SUR1) in relation to glucose intolerance: population-based studies and meta-analyses. Diabet Med 22 (2005) 590
34. Zeggini E., Weedon M.N., Lindgren C.M., et al. Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 316 (2007) 1336
35. Zhang C., Qi L., Hunter D.J., et al. Variant of transcription factor 7-like 2 (TCF7L2) gene and the risk of type 2 diabetes in large cohorts of U.S. women and men. Diabetes 55 (2006) 2645
36. Grarup N., Rose C.S., Andersson E.A., et al. Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies. Diabetes 56 (2007) 3105
37. Pascoe L., Tura A., Patel S.K., et al. Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function. Diabetes 56 (2007) 3101
38. Rong R., Hanson R.L., Ortiz D., et al. Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians. Diabetes 58 (2009) 478
39. Kang E.S., Kim M.S., Kim Y.S., et al. A polymorphism in the zinc transporter gene SLC30A8 confers resistance against posttransplantation diabetes mellitus in renal allograft recipients. Diabetes 57 (2008) 1043
40. Knowler W.C., Barrett-Connor E., Fowler S.E., et al. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 346 (2002) 393
41. Pan X.R., Li G.W., Hu Y.H., et al. Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study. Diabetes Care 20 (1997) 537
42. Tuomilehto J., Lindstrom J., Eriksson J.G., et al. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 344 (2001) 1343
43. Saxena R., Voight B.F., Lyssenko V., et al. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 316 (2007) 1331