A polymorphism in the zinc transporter gene SLC30A8 confers resistance against posttransplantation diabetes mellitus in renal allograft recipients

Diabetes

Volumn 57, Issue 4, 2008, Pages 1043-1047

  Kang, Eun Seok ^a   Kim, Myoung Soo ^a   Kim, Yu Seun ^a   Kim, Chul Hoon ^a   Han, Seung Jin ^a   Chun, Sung Wan ^a   Hur, Kyu Yeon ^a   Nam, Chung Mo ^a   Ahn, Chul Woo ^a   Cha, Bong Soo ^a   Kim, Soon Il ^a   Lee, Hyun Chul ^a  

^a Yonsei University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDIABETIC AGENT; CALCINEURIN INHIBITOR; GLUCOCORTICOID; INSULIN; TACROLIMUS; ZINC TRANSPORTER; CATION TRANSPORT PROTEIN; DNA; SLC30A8 PROTEIN, HUMAN; UNCLASSIFIED DRUG;

ADULT; ALLELE; ARTICLE; BODY WEIGHT; DIABETES MELLITUS; DIABETIC PATIENT; DISEASE RESISTANCE; FEMALE; GENE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; GRAFT RECIPIENT; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY ALLOGRAFT; KIDNEY GRAFT REJECTION; KIDNEY TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; PREVALENCE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RISK REDUCTION; SLC30A8 GENE; WEIGHT GAIN; ALLOTRANSPLANTATION; BLOOD; GENETICS; ISOLATION AND PURIFICATION; PATIENT SELECTION; PHYSIOLOGY; POSTOPERATIVE COMPLICATION; RETROSPECTIVE STUDY;

CATION TRANSPORT PROTEINS; DIABETES MELLITUS; DNA; GENE FREQUENCY; GENOTYPE; HUMANS; HYPOGLYCEMIC AGENTS; KIDNEY TRANSPLANTATION; PATIENT SELECTION; POLYMORPHISM, GENETIC; POSTOPERATIVE COMPLICATIONS; RETROSPECTIVE STUDIES; RISK REDUCTION BEHAVIOR; TRANSPLANTATION, HOMOLOGOUS; VARIATION (GENETICS);

EID: 41949136789     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db07-0761     Document Type: Article

References (32)

1. Ducloux D, Kazory A, Chalopin JM: Posttransplant diabetes mellitus and atherosclerotic events in renal transplant recipients: a prospective study. Transplantation 79:438-443, 2005
2. Rodrigo E, Fernandez-Fresnedo G, Valero R, Ruiz JC, Pinera C, Palomar R, Gonzalez-Cotorruelo J, Gomez-Alamillo C, Arias M: New-onset diabetes after kidney transplantation: risk factors. J Am, Soc Nephrol 17:S291-S295, 2006
3. Fernandez-Fresnedo G, Escallada R, de Francisco AL, Rodrigo E, Zubi-mendi JA, Ruiz JC, Pinera C, Herraez I, Arias M: Posttransplant diabetes is a cardiovascular risk factor in renal transplant patients. Transplant Proc 35: 700, 2003
4. Hjelmesaeth J, Hartmann A, Leivestad T, Holdaas H, Sagedal S, Olstad M, Jenssen T: The impact of early-diagnosed new-onset post-transplantation diabetes mellitus on survival and major cardiac events. Kidney Int 69:588-595, 2006
5. Montori VM, Basu A, Erwin PJ, Velosa JA, Gabriel SE, Kudva YC: Posttransplantation diabetes: a systematic review of the literature. Diabetes Care 25:583-592, 2002
6. Hathaway DK, Tolley EA, Blakely ML, Winsett RP, Gaber AO: Development of an index to predict posttransplant diabetes mellitus. Clin Transplant 7:330-338, 1993
7. Ojo AO, Hanson JA, Wolfe RA, Leichtman AB, Agodoa LY, Port FK: Long-term survival in renal transplant recipients with graft function. Kidney Int 57:307-313, 2000
8. Kasiske BL, Snyder JJ, Gilbertson D, Matas AJ: Diabetes mellitus after kidney transplantation in the United States. Am, J Transplant 3:178-185, 2003
9. Heisel O, Heisel R, Balshaw R, Keown P: New onset diabetes mellitus in patients receiving calcineurin inhibitors: a systematic review and meta-analysis. Am J Transplant 4:583-595, 2004
10. Nam JH, Mun JI, Kim SI, Kang SW, Choi KH, Park K, Ahn CW, Cha BS, Song YD, Lim SK, Kim KR, Lee HC, Huh KB: Beta-cell dysfunction rather than insulin resistance is the main contributing factor for the development of postrenal transplantation diabetes mellitus. Transplantation 71:1417-1423, 2001
11. Vesco L, Busson M, Bedrossian J, Bitker MO, Hiesse C, Lang P: Diabetes mellitus after renal transplantation: characteristics, outcome, and risk factors. Transplantation 61:1475-1478, 1996
12. Sumrani N, Delaney V, Ding Z, Davis R, Daskalakis P, Friedman EA, Butt KM, Hong JH: Posttransplant diabetes mellitus in cyclosporine-treated renal transplant recipients. Transplant Proc 23:1249-1250, 1991
13. Numakura K, Satoh S, Tsuchiya N, Horikawa Y, Inoue T, Kakinuma H, Matsuura S, Saito M, Tada H, Suzuki T, Habuchi T: Clinical and genetic risk factors for posttransplant diabetes mellitus in adult renal transplant recipients treated with tacrolimus. Transplantation 80:1419-1424, 2005
14. Bamoulid J, Courivaud C, Deschamps M, Mercier P, Ferrand C, Penfornis A, Tiberghien P, Chalopin JM, Saas P, Ducloux D: IL-6 promoter polymorphism-174 is associated with new-onset diabetes after transplantation. J Am Soc Nephrol 17:2333-2340, 2006
15. Hur KY, Kim MS, Kim YS, Kang ES, Nam JH, Kim SH, Nam CM, Ahn CW, Cha BS, Kim SI, Lee HC: Risk factors associated with the onset and progression of posttransplantation diabetes in renal allograft recipients. Diabetes Care 30:609-615, 2007
16. Chausmer AB: Zinc, insulin and diabetes. J Am Coll Nutr 17:109-115, 1998
17. Emdin SO, Dodson GG, Cutfield JM, Cutfield SM: Role of zinc in insulin biosynthesis: some possible zinc-insulin interactions in the pancreatic B-cell. Diabetologia 19:174-182, 1980
18. Dodson G, Steiner D: The role of assembly in insulin's biosynthesis. Curr Opin Struct Biol 8:189-194, 1998
19. Chimienti F, Devergnas S, Favier A, Seve M: Identification and cloning of a β-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules. Diabetes 53:2330-2337, 2004
20. Chimienti F, Devergnas S, Pattou F, Schuit F, Garcia-Cuenca R, Vande-walle B, Kerr-Conte J, Van Lommel L, Grunwald D, Favier A, Seve M: In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion. J Cell Sci 119:4199-4206, 2006
21. Chimienti F, Favier A, Seve M: ZnT-8, a pancreatic beta-cell-specific zinc transporter. Biometals 18:313-317, 2005
22. Sladek R, Rocheleau G, Rung J, Dina C, Shen L, Serre D, Boutin P, Vincent D, Belisle A, Hadjadj S, Balkau B, Heude B, Charpentier G, Hudson TJ, Montpetit A, Pshezhetsky AV, Prentki M, Posner BI, Balding DJ, Meyre D, Polychronakos C, Froguel P: A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 445:881-885, 2007
23. Scott LJ, Mohlke KL, Bonnycastle LL, Willer CJ, Li Y, Duren WL, Erdos MR, Stringham HM, Chines PS, Jackson AU, Prokunina-Olsson L, Ding CJ, Swift AJ, Narisu N, Hu T, Pruim R, Xiao R, Li XY, Conneely KN, Riebow NL, Sprau AG, Tong M, White PP, Hetrick KN, Barnhart MW, Bark CW, Goldstein JL, Watkins L, Xiang F, Saramies J, Buchanan TA, Watanabe RM, Valle TT, Kinnunen L, Abecasis GR, Pugh EW, Doheny KF, Bergman RN, Tuomilehto J, Collins FS, Boehnke M: A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 316:1341-1345, 2007
24. Steinthorsdottir V, Thorleifsson G, Reynisdottir I, Benediktsson R, Jonsdottir T, Walters GB, Styrkarsdottir U, Gretarsdottir S, Emilsson V, Ghosh S, Baker A, Snorradottir S, Bjarnason H, Ng MC, Hansen T, Bagger Y, Wilensky RL, Reilly MP, Adeyemo A, Chen Y, Zhou J, Gudnason V, Chen G, Huang H, Lashley K, Doumatey A, So WY, Ma RC, Andersen G, Borch-Johnsen K, Jorgensen T, van Vliet-Ostaptchouk JV, Hofker MH, Wijmenga C, Christiansen C, Rader DJ, Rotimi C, Gurney M, Chan JC, Pedersen O, Sigurdsson G, Gulcher JR, Thorsteinsdottir U, Kong A, Stefansson K: A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet 39:770-775, 2007
25. Zeggini E, Weedon MN, Lindgren CM, Frayling TM, Elliott KS, Lango H, Timpson NJ, Perry JR, Rayner NW, Freathy RM, Barrett JC, Shields B, Morris AP, Ellard S, Groves CJ, Harries LW, Marchini JL, Owen KR, Knight B, Cardon LR, Walker M, Hitman GA, Morris AD, Doney AS, McCarthy MI, Hattersley AT: Replication of genome-wide association signals in UK-samples reveals risk loci for type 2 diabetes. Science 316:1336-1341, 2007
26. Diagnosis and classification of diabetes mellitus. Diabetes Care 30 (Suppl. 1):S42-S47, 2007
27. Albareda M, Rodriguez-Espinosa J, Murugo M, de Leiva A, Corcoy R: Assessment of insulin sensitivity and beta-cell function from measurements in the fasting state and during an oral glucose tolerance test. Diabetologia 43:1507-1511, 2000
28. Eide DJ: The SLC39 family of metal ion transporters. Pflugers Arch 447:796-800, 2004
29. Seve M, Chimienti F, Devergnas S, Favier A: In silico identification and expression of SLC30 family genes: an expressed sequence tag data mining strategy for the characterization of zinc transporters' tissue expression. BMC Genomics 5: 32, 2004
30. Hitman GA, Mannan N, McDermott MF, Aganna E, Ogunkolade BW, Hales CN, Boucher BJ: Vitamin D receptor gene polymorphisms influence insulin secretion in Bangladeshi Asians. Diabetes 47:688-690, 1998
31. Bourlon PM, Faure-Dussert A, Billaudel B, Sutter BC, Tramu G, Thomasset M: Relationship between calbindin-D28K levels in the A and B cells of the rat endocrine pancreas and the secretion of insulin and glucagon: influence of vitamin D3 deficiency and 1,25-dihydroxyvitamin D3. J Endocrinol 148:223-232, 1996
32. Ogunkolade BW, Boucher BJ, Prahl JM, Bustin SA, Burrin JM, Noonan K, North BV, Mannan N, McDermott MF, DeLuca HF, Hitman GA: Vitamin D receptor (VDR) mRNA and VDR protein levels in relation to vitamin D status, insulin secretory capacity, and VDR genotype in Bangladeshi Asians. Diabetes 51:2294-2300, 2002