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Volumn 39, Issue 1, 2008, Pages 30-36

CpG island methylation is frequently present in tubulovillous and villous adenomas and correlates with size, site, and villous component

Author keywords

Adenoma; BRAF; KRAS; Methylation; Villous

Indexed keywords

ARTICLE; BRAF GENE; COLORECTAL ADENOMA; CORRELATION ANALYSIS; CPG ISLAND; DNA METHYLATION; GENE; GENE MUTATION; HUMAN; KRAS GENE; MAJOR CLINICAL STUDY; PHENOTYPE; TUBULOVILLOUS ADENOMA; TUMOR VOLUME; VILLOUS ADENOMA;

EID: 36749036049     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humpath.2007.06.002     Document Type: Article
Times cited : (45)

References (33)
  • 1
    • 0034681117 scopus 로고    scopus 로고
    • Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype
    • Toyota M., Ohe-Toyota M., Ahuja N., and Issa J.P. Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype. Proc Natl Acad Sci U S A 97 (2000) 710-715
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 710-715
    • Toyota, M.1    Ohe-Toyota, M.2    Ahuja, N.3    Issa, J.P.4
  • 2
    • 0036242782 scopus 로고    scopus 로고
    • CpG island methylation in sporadic colorectal cancers and its relationship to microsatellite instability
    • Hawkins N., Norrie M., Cheong K., et al. CpG island methylation in sporadic colorectal cancers and its relationship to microsatellite instability. Gastroenterology 122 (2002) 1376-1387
    • (2002) Gastroenterology , vol.122 , pp. 1376-1387
    • Hawkins, N.1    Norrie, M.2    Cheong, K.3
  • 3
    • 24144449572 scopus 로고    scopus 로고
    • Evaluation of a large, population-based sample supports a CpG island methylator phenotype in colon cancer
    • Samowitz W.S., Albertsen H., Herrick J., et al. Evaluation of a large, population-based sample supports a CpG island methylator phenotype in colon cancer. Gastroenterology 129 (2005) 837-845
    • (2005) Gastroenterology , vol.129 , pp. 837-845
    • Samowitz, W.S.1    Albertsen, H.2    Herrick, J.3
  • 4
    • 0037372340 scopus 로고    scopus 로고
    • Frequent CpG island methylation in serrated adenomas of the colorectum
    • Park S.J., Rashid A., Lee J.H., Kim S.G., Hamilton S.R., and Wu T.T. Frequent CpG island methylation in serrated adenomas of the colorectum. Am J Pathol 162 (2003) 815-822
    • (2003) Am J Pathol , vol.162 , pp. 815-822
    • Park, S.J.1    Rashid, A.2    Lee, J.H.3    Kim, S.G.4    Hamilton, S.R.5    Wu, T.T.6
  • 5
    • 0042941629 scopus 로고    scopus 로고
    • BRAF and KRAS mutations in colorectal hyperplastic polyps and serrated adenomas
    • Cancer Genome Project
    • Chan T.L., Zhao W., Leung S.Y., Yuen S.T., and Cancer Genome Project. BRAF and KRAS mutations in colorectal hyperplastic polyps and serrated adenomas. Cancer Res 63 (2003) 4878-4881
    • (2003) Cancer Res , vol.63 , pp. 4878-4881
    • Chan, T.L.1    Zhao, W.2    Leung, S.Y.3    Yuen, S.T.4
  • 6
    • 3242686837 scopus 로고    scopus 로고
    • BRAF mutation is associated with DNA methylation in serrated polyps and cancers of the colorectum
    • Kambara T., Simms L.A., Whitehall V.L., et al. BRAF mutation is associated with DNA methylation in serrated polyps and cancers of the colorectum. Gut 53 (2004) 1137-1144
    • (2004) Gut , vol.53 , pp. 1137-1144
    • Kambara, T.1    Simms, L.A.2    Whitehall, V.L.3
  • 7
    • 7044253667 scopus 로고    scopus 로고
    • BRAF and KRAS mutations in hyperplastic polyps and serrated adenomas of the colorectum: relationship to histology and CpG island methylation status
    • Yang S., Farraye F.A., Mack C., Posnik O., and O'Brien M.J. BRAF and KRAS mutations in hyperplastic polyps and serrated adenomas of the colorectum: relationship to histology and CpG island methylation status. Am J Surg Pathol 28 (2004) 1452-1459
    • (2004) Am J Surg Pathol , vol.28 , pp. 1452-1459
    • Yang, S.1    Farraye, F.A.2    Mack, C.3    Posnik, O.4    O'Brien, M.J.5
  • 8
    • 13244264729 scopus 로고    scopus 로고
    • Progressive methylation during the serrated neoplasia pathway of the colorectum
    • Dong S.M., Lee E.J., Jeon E.S., Park C.K., and Kim K.M. Progressive methylation during the serrated neoplasia pathway of the colorectum. Mod Pathol 18 (2005) 170-178
    • (2005) Mod Pathol , vol.18 , pp. 170-178
    • Dong, S.M.1    Lee, E.J.2    Jeon, E.S.3    Park, C.K.4    Kim, K.M.5
  • 9
    • 33751320353 scopus 로고    scopus 로고
    • Comparison of microsatellite instability, CpG island methylation phenotype, BRAF and KRAS status in serrated polyps and traditional adenomas indicates separate pathways to distinct colorectal carcinoma end points
    • O'Brien M.J., Yang S., Mack C., et al. Comparison of microsatellite instability, CpG island methylation phenotype, BRAF and KRAS status in serrated polyps and traditional adenomas indicates separate pathways to distinct colorectal carcinoma end points. Am J Surg Pathol 30 (2006) 1491-1501
    • (2006) Am J Surg Pathol , vol.30 , pp. 1491-1501
    • O'Brien, M.J.1    Yang, S.2    Mack, C.3
  • 11
    • 19944432471 scopus 로고    scopus 로고
    • Aberrantly methylated CDKN2A, MGMT, and MLH1 in colon polyps and in fecal DNA from patients with colorectal polyps
    • Petko Z., Ghiassi M., Shuber A., et al. Aberrantly methylated CDKN2A, MGMT, and MLH1 in colon polyps and in fecal DNA from patients with colorectal polyps. Clin Cancer Res 11 (2005) 1203-1209
    • (2005) Clin Cancer Res , vol.11 , pp. 1203-1209
    • Petko, Z.1    Ghiassi, M.2    Shuber, A.3
  • 12
    • 33644875316 scopus 로고    scopus 로고
    • CpG island methylation as an early event during adenoma progression in carcinogenesis of sporadic colorectal cancer
    • Kim H.C., Roh S.A., Ga I.H., Kim J.S., Yu C.S., and Kim J.C. CpG island methylation as an early event during adenoma progression in carcinogenesis of sporadic colorectal cancer. J Gastroenterol Hepatol 20 (2005) 1920-1926
    • (2005) J Gastroenterol Hepatol , vol.20 , pp. 1920-1926
    • Kim, H.C.1    Roh, S.A.2    Ga, I.H.3    Kim, J.S.4    Yu, C.S.5    Kim, J.C.6
  • 13
    • 33745714364 scopus 로고    scopus 로고
    • CpG island methylation of genes accumulates during the adenoma progression step of the multistep pathogenesis of colorectal cancer
    • Kim Y.H., Petko Z., Dzieciatkowski S., et al. CpG island methylation of genes accumulates during the adenoma progression step of the multistep pathogenesis of colorectal cancer. Genes Chromosomes Cancer 45 (2006) 781-789
    • (2006) Genes Chromosomes Cancer , vol.45 , pp. 781-789
    • Kim, Y.H.1    Petko, Z.2    Dzieciatkowski, S.3
  • 15
    • 0026546907 scopus 로고
    • Long-term risk of colorectal cancer after excision of rectosigmoid adenomas
    • Atkin W.S., Morson B.C., and Cuzick J. Long-term risk of colorectal cancer after excision of rectosigmoid adenomas. N Engl J Med 326 (1992) 658-662
    • (1992) N Engl J Med , vol.326 , pp. 658-662
    • Atkin, W.S.1    Morson, B.C.2    Cuzick, J.3
  • 17
    • 13244273529 scopus 로고    scopus 로고
    • Colorectal cancer risk after colonoscopic polypectomy: a population-based study and literature search
    • Loeve F., van Ballegooijen M., Snel P., and Habbema J.D. Colorectal cancer risk after colonoscopic polypectomy: a population-based study and literature search. Eur J Cancer 41 (2005) 416-422
    • (2005) Eur J Cancer , vol.41 , pp. 416-422
    • Loeve, F.1    van Ballegooijen, M.2    Snel, P.3    Habbema, J.D.4
  • 18
    • 33646361037 scopus 로고    scopus 로고
    • Guidelines for colonoscopy surveillance after polypectomy: a consensus update by the US Multi-Society Task Force on Colorectal Cancer and the American Cancer Society
    • Winawer S.J., Zauber A.G., Fletcher R.H., et al. Guidelines for colonoscopy surveillance after polypectomy: a consensus update by the US Multi-Society Task Force on Colorectal Cancer and the American Cancer Society. Gastroenterology 130 (2006) 1872-1885
    • (2006) Gastroenterology , vol.130 , pp. 1872-1885
    • Winawer, S.J.1    Zauber, A.G.2    Fletcher, R.H.3
  • 19
    • 33644822519 scopus 로고    scopus 로고
    • Expression of mucin core proteins, trefoil factors, APC and p21 in subsets of colorectal polyps and cancers suggests a distinct pathway of pathogenesis of mucinous carcinoma of the colorectum
    • Kim D.H., Kim J.W., Cho J.H., et al. Expression of mucin core proteins, trefoil factors, APC and p21 in subsets of colorectal polyps and cancers suggests a distinct pathway of pathogenesis of mucinous carcinoma of the colorectum. Int J Oncol 27 (2005) 957-964
    • (2005) Int J Oncol , vol.27 , pp. 957-964
    • Kim, D.H.1    Kim, J.W.2    Cho, J.H.3
  • 20
    • 33646372471 scopus 로고    scopus 로고
    • BRAF mutation, CpG island methylator phenotype and microsatellite instability occur more frequently and concordantly in mucinous than non-mucinous colorectal cancer
    • Tanaka H., Deng G., Matsuzaki K., et al. BRAF mutation, CpG island methylator phenotype and microsatellite instability occur more frequently and concordantly in mucinous than non-mucinous colorectal cancer. Int J Cancer 118 (2006) 2765-2771
    • (2006) Int J Cancer , vol.118 , pp. 2765-2771
    • Tanaka, H.1    Deng, G.2    Matsuzaki, K.3
  • 21
    • 0034032746 scopus 로고    scopus 로고
    • Adenoma size and number are predictive of adenoma recurrence: implications for surveillance colonoscopy
    • Noshirwani K.C., van Stolk R.U., Rybicki L.A., and Beck G.J. Adenoma size and number are predictive of adenoma recurrence: implications for surveillance colonoscopy. Gastrointest Endosc 51 (2000) 433-437
    • (2000) Gastrointest Endosc , vol.51 , pp. 433-437
    • Noshirwani, K.C.1    van Stolk, R.U.2    Rybicki, L.A.3    Beck, G.J.4
  • 22
    • 0028794564 scopus 로고
    • Structure, function, and inhibition of O6-alkylguanine-DNA alkyltransferase
    • Pegg A.E., Dolan M.E., and Moschel R.C. Structure, function, and inhibition of O6-alkylguanine-DNA alkyltransferase. Prog Nucleic Acid Res Mol Biol 51 (1995) 167-223
    • (1995) Prog Nucleic Acid Res Mol Biol , vol.51 , pp. 167-223
    • Pegg, A.E.1    Dolan, M.E.2    Moschel, R.C.3
  • 23
    • 19244370208 scopus 로고    scopus 로고
    • Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis
    • Esteller M., Toyota M., Sanchez-Cespedes M., et al. Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis. Cancer Res 60 (2000) 2368-2371
    • (2000) Cancer Res , vol.60 , pp. 2368-2371
    • Esteller, M.1    Toyota, M.2    Sanchez-Cespedes, M.3
  • 24
    • 0035874892 scopus 로고    scopus 로고
    • Promoter hypermethylation of the DNA repair gene O(6)-methylguanine-DNA methyltransferase is associated with the presence of G:C to A:T transition mutations in p53 in human colorectal tumorigenesis
    • Esteller M., Risques R.A., Toyota M., et al. Promoter hypermethylation of the DNA repair gene O(6)-methylguanine-DNA methyltransferase is associated with the presence of G:C to A:T transition mutations in p53 in human colorectal tumorigenesis. Cancer Res 61 (2001) 4689-4692
    • (2001) Cancer Res , vol.61 , pp. 4689-4692
    • Esteller, M.1    Risques, R.A.2    Toyota, M.3
  • 25
    • 0035117307 scopus 로고    scopus 로고
    • Methylation of O-6-methylguanine DNA methyltransferase characterizes a subset of colorectal cancer with low-level DNA microsatellite instability
    • Whitehall V.L., Walsh M.D., Young J., Leggett B.A., and Jass J.R. Methylation of O-6-methylguanine DNA methyltransferase characterizes a subset of colorectal cancer with low-level DNA microsatellite instability. Cancer Res 61 (2001) 827-830
    • (2001) Cancer Res , vol.61 , pp. 827-830
    • Whitehall, V.L.1    Walsh, M.D.2    Young, J.3    Leggett, B.A.4    Jass, J.R.5
  • 26
    • 0037443773 scopus 로고    scopus 로고
    • Frequency of loss of hMLH1 expression in colorectal carcinoma increases with advancing age
    • Kakar S., Burgart L.J., Thibodeau S.N., et al. Frequency of loss of hMLH1 expression in colorectal carcinoma increases with advancing age. Cancer 97 (2003) 1421-1427
    • (2003) Cancer , vol.97 , pp. 1421-1427
    • Kakar, S.1    Burgart, L.J.2    Thibodeau, S.N.3
  • 27
    • 32944478445 scopus 로고    scopus 로고
    • Mutually exclusive promoter hypermethylation patterns of hMLH1 and O6-methylguanine DNA methyltransferase in colorectal cancer
    • Fox E.J., Leahy D.T., Geraghty R., et al. Mutually exclusive promoter hypermethylation patterns of hMLH1 and O6-methylguanine DNA methyltransferase in colorectal cancer. J Mol Diagn 8 (2006) 68-75
    • (2006) J Mol Diagn , vol.8 , pp. 68-75
    • Fox, E.J.1    Leahy, D.T.2    Geraghty, R.3
  • 28
    • 33845451110 scopus 로고    scopus 로고
    • Correlation between hypermethylation of the RASSF2A promoter and K-ras/BRAF mutations in microsatellite-stable colorectal cancers
    • Park H.W., Kang H.C., Kim I.J., et al. Correlation between hypermethylation of the RASSF2A promoter and K-ras/BRAF mutations in microsatellite-stable colorectal cancers. Int J Cancer 120 (2007) 7-12
    • (2007) Int J Cancer , vol.120 , pp. 7-12
    • Park, H.W.1    Kang, H.C.2    Kim, I.J.3
  • 29
    • 0037133034 scopus 로고    scopus 로고
    • Identification of a novel Ras-regulated proapoptotic pathway
    • Khokhlatchev A., Rabizadeh S., Xavier R., et al. Identification of a novel Ras-regulated proapoptotic pathway. Curr Biol 12 (2002) 253-265
    • (2002) Curr Biol , vol.12 , pp. 253-265
    • Khokhlatchev, A.1    Rabizadeh, S.2    Xavier, R.3
  • 30
    • 22344435817 scopus 로고    scopus 로고
    • The Ras effector RASSF2 is a novel tumor-suppressor gene in human colorectal cancer
    • Akino K., Toyota M., Suzuki H., et al. The Ras effector RASSF2 is a novel tumor-suppressor gene in human colorectal cancer. Gastroenterology 129 (2005) 156-169
    • (2005) Gastroenterology , vol.129 , pp. 156-169
    • Akino, K.1    Toyota, M.2    Suzuki, H.3
  • 31
    • 20544445183 scopus 로고    scopus 로고
    • CpG island promoter hypermethylation of a novel Ras-effector gene RASSF2A is an early event in colon carcinogenesis and correlates inversely with K-ras mutations
    • Hesson L.B., Wilson R., Morton D., et al. CpG island promoter hypermethylation of a novel Ras-effector gene RASSF2A is an early event in colon carcinogenesis and correlates inversely with K-ras mutations. Oncogene 24 (2005) 3987-3994
    • (2005) Oncogene , vol.24 , pp. 3987-3994
    • Hesson, L.B.1    Wilson, R.2    Morton, D.3
  • 32
    • 0034910649 scopus 로고    scopus 로고
    • Ki-ras proto-oncogene mutations in sporadic colorectal adenomas: relationship to histologic and clinical characteristics
    • Maltzman T., Knoll K., Martinez M.E., et al. Ki-ras proto-oncogene mutations in sporadic colorectal adenomas: relationship to histologic and clinical characteristics. Gastroenterology 121 (2001) 302-309
    • (2001) Gastroenterology , vol.121 , pp. 302-309
    • Maltzman, T.1    Knoll, K.2    Martinez, M.E.3
  • 33
    • 33644530040 scopus 로고    scopus 로고
    • K-ras mutations in incident sporadic colorectal adenomas
    • Barry E.L., Baron J.A., Grau M.V., Wallace K., and Haile R.W. K-ras mutations in incident sporadic colorectal adenomas. Cancer 106 (2006) 1036-1040
    • (2006) Cancer , vol.106 , pp. 1036-1040
    • Barry, E.L.1    Baron, J.A.2    Grau, M.V.3    Wallace, K.4    Haile, R.W.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.