Manganese tissue dosimetry in rats and monkeys: Accounting for dietary and inhaled Mn with physiologically based pharmacokinetic modeling

Toxicological Sciences

Volumn 108, Issue 1, 2009, Pages 22-34

  Nong, Andy ^a   Taylor, Michael D ^b   Clewell, Harvey J ^a   Dorman, David C ^a,c   Andersen, Melvin E ^a  

^a HAMNER INSTITUTES FOR HEALTH SCIENCES   (United States)

^b AFTON CHEMICAL CORPORATION   (United States)

^c NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

Asymmetrical diffusional flux; Biliary induction; Dose dependent regulation; Inhalation exposures; Manganese; Nonhuman primates; PBPK; Saturable tissue binding

Indexed keywords

MANGANESE;

ADULT ANIMAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILIARY EXCRETION; BIOACCUMULATION; BIOLOGICAL MODEL; BRAIN REGION; CALIBRATION; CONTROLLED STUDY; DIETARY INTAKE; INHALATION; NEUROTOXICITY; NONHUMAN; RAT; RHESUS MONKEY; RISK ASSESSMENT; STEADY STATE; TISSUE LEVEL;

ADMINISTRATION, INHALATION; ADMINISTRATION, ORAL; ANIMALS; BRAIN CHEMISTRY; CALIBRATION; COMPUTER SIMULATION; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; INHALATION EXPOSURE; LIVER; MACACA MULATTA; MANGANESE; MODELS, BIOLOGICAL; RATS; SENSITIVITY AND SPECIFICITY;

MACACA MULATTA; PRIMATES; RATTUS;

EID: 61349184596     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfn264     Document Type: Article

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