WK175, a novel antitumor agent, decreases the intracellular nicotinamide adenine dinucleotide concentration and induces the apoptotic cascade in human leukemia cells

Cancer Research

Volumn 62, Issue 4, 2002, Pages 1057-1062

  Wosikowski, Katja ^a   Mattern, Karin ^a   Schemainda, Isabel ^a   Hasmann, Max ^a   Rattel, Benno ^a   Löser, Roland ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLTYROSYLVALYLALANYLASPARTALDEHYDE; ANTINEOPLASTIC AGENT; BENZYLOXYCARBONYLASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLLEUCYLGLUTAMYLHISTIDYLASPARTYL FLUOROMETHYL KETONE; BONGKREKIC ACID; CASPASE 3; CASPASE INHIBITOR; CYTOCHROME C; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; UNCLASSIFIED DRUG; WK 175;

ACUTE MONOCYTIC LEUKEMIA; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL METABOLISM; CONTROLLED STUDY; DNA DEGRADATION; DRUG EFFICACY; ENZYME ACTIVITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IN VITRO STUDY; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BONGKREKIC ACID; CASPASE 3; CASPASE 9; CASPASES; CELL CYCLE; CYTOCHROME C GROUP; DNA, NEOPLASM; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; INTRACELLULAR MEMBRANES; LEUKEMIA, MONOCYTIC, ACUTE; MEMBRANE POTENTIALS; MITOCHONDRIA; NAD; ORGANIC CHEMICALS; POLY(ADP-RIBOSE) POLYMERASES; SUBCELLULAR FRACTIONS; TUMOR CELLS, CULTURED;

EID: 0036170579     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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