TCF7L2 rs12255372 and SLC30A8 rs13266634 confer susceptibility to type 2 diabetes in a Russian population

Diabetes and Metabolic Syndrome: Clinical Research and Reviews

Volumn 3, Issue 4, 2009, Pages 219-223

  Potapov, Viktor A ^a   Chistiakov, Dimitry A ^a   Shamkhalova, Minara S ^b   Shestakova, Marina V ^b   Nosikov, Valery V ^a  

^a STATE RESEARCH INSTITUTE OF GENETICS AND SELECTION OF INDUSTRIAL MICROORGANISMS   (Russian Federation)

^b N N BLOKHIN NATIONAL MEDICAL RESEARCH CENTER OF ONCOLOGY   (Russian Federation)

Author keywords

Insulin secretion; Russian population; SLC30A8; TCF7L2; Type 2 diabetes

Indexed keywords

CARRIER PROTEIN; INSULIN; SOLUTE CARRIER FAMILY 30 MEMBER 8; TRANSCRIPTION FACTOR 7 LIKE 2; UNCLASSIFIED DRUG;

ADULT; ALLELE; ARTICLE; CONTROLLED STUDY; DIABETIC PATIENT; DISEASE PREDISPOSITION; DNA SEQUENCE; FEMALE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HOMOZYGOTE; HUMAN; INSULIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MUTATIONAL ANALYSIS; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; PATHOGENESIS; PRIORITY JOURNAL; RISK FACTOR; RUSSIAN FEDERATION; SEQUENCE ANALYSIS;

EID: 70849135641     PISSN: 18714021     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dsx.2009.07.005     Document Type: Article

References (43)

1. Florez J.C. Newly identified loci highlight beta cell dysfunction as a key cause of type 2 diabetes: where are the insulin resistance genes?. Diabetologia 51 (2008) 1100-1110
2. Jin T., and Liu L. The Wnt signaling pathway effector TCF7L2 and type 2 diabetes mellitus. Mol Endocrinol 22 (2008) 2383-2392
3. Grant S.F., Thorleifsson G., Reynisdottir I., Benediktsson R., Jonsdottir T., Walters G.B., et al. Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet 38 (2006) 320-323
4. Cauchi S., Meyre D., Dina C., Choquet H., Samson C., Gallina S., et al. Transcription factor TCF7L2 genetic study in the French population: expression in human beta-cells and adipose tissue and strong association with type 2 diabetes. Diabetes 55 (2006) 2903-2908
5. Groves C.J., Zeggini E., Minton J., Frayling T.M., Weedon M.N., Rayner N.W., et al. Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk. Diabetes 55 (2006) 2640-2644
6. Saxena R., Gianniny L., Burtt N.P., Lyssenko V., Guidicci C., Sjögren M., et al. Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals. Diabetes 55 (2006) 2890-2895
7. Scott L.J., Bonnycastle L.L., Willer C.J., Sprau A.G., Jackson A.U., and Narisu N. Association of transcription factor 7-like 2 (TCF7L2) variants with type 2 diabetes in a Finnish sample. Diabetes 55 (2006) 2649-2653
8. Zhang C., Qi L., Hunter D.J., Manson J.E., van Dam R.M., and Hu F.B. Variant of transcription factor 7-like 2 (TCF7L2) gene and the risk of type 2 diabetes in large cohorts of U.S. women and men. Diabetes 55 (2006) 2645-2648
9. Chandak G.R., Janipalli C.S., Bhaskar S., Kulkarni S.R., Mohankrishna P., Hattersley A.T., et al. Common variants in the TCF7L2 gene are strongly associated with type 2 diabetes mellitus in the Indian population. Diabetologia 50 (2007) 63-67
10. Marzi C., Huth C., Kolz M., Grallert H., Meisinger C., Wichmann H.E., et al. Variants of the transcription factor 7-like 2 gene (TCF7L2) are strongly associated with type 2 diabetes but not with the metabolic syndrome in the MONICA/KORA surveys. Horm Metab Res 39 (2007) 46-52
11. Bodhini D., Radha V., Dhar M., Narayani N., and Mohan V. The rs12255372 (G/T) and rs7903146 (C/T) polymorphisms of the TCF7L2 gene are associated with type 2 diabetes mellitus in Asian Indians. Metabolism 56 (2007) 1174-1178
12. Horikoshi M., Hara K., Ito C., Nagai R., Froguel P., and Kadowaki T. A genetic variation of the transcription factor 7-like 2 gene is associated with risk of type 2 diabetes in the Japanese population. Diabetologia 50 (2007) 747-751
13. Ng M.C., Tam C.H., Lam V.K., So W.Y., Ma R.C., and Chan J.C. Replication and identification of novel variants at TCF7L2 associated with type 2 diabetes in Hong Kong Chinese. J Clin Endocrinol Metab 92 (2007) 3733-3737
14. Humphries S.E., Gable D., Cooper J.A., Ireland H., Stephens J.W., Hurel S.J., et al. Common variants in the TCF7L2 gene and predisposition to type 2 diabetes in UK European Whites, Indian Asians and Afro-Caribbean men and women. J Mol Med 84 (2006) 1-10
15. Lewis J.P., Palmer N.D., Hicks P.J., Sale M.M., Langefeld C.D., Freedman B.I., et al. Association analysis in African Americans of European-derived type 2 diabetes single nucleotide polymorphisms from whole-genome association studies. Diabetes 57 (2008) 2220-2225
16. Helgason A., Pálsson S., Thorleifsson G., Grant S.F., Emilsson V., Gunnarsdottir S., et al. Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution. Nat Genet 39 (2007) 218-225
17. Loos R.J., Franks P.W., Francis R.W., Barroso I., Gribble F.M., Savage D.B., et al. TCF7L2 polymorphisms modulate proinsulin levels and beta-cell function in a British Europid population. Diabetes 56 (2007) 1943-1947
18. Schäfer S.A., Tschritter O., Machicao F., Thamer C., Stefan N., and Gallwitz B. Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms. Diabetologia 50 (2007) 2443-2450
19. Kirchhoff K., Machicao F., Haupt A., Schäfer S.A., Tschritter O., Staiger H., et al. Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion. Diabetologia 51 (2008) 597-601
20. Sladek R., Rocheleau G., Rung J., Dina C., Shen L., Serre D., et al. A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 445 (2007) 881-885
21. Saxena R., Voight B.F., Lyssenko V., Burtt N.P., de Bakker P.I., Chen H., et al. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 316 (2007) 1331-1336
22. Scott L.J., Mohlke K.L., Bonnycastle L.L., Willer C.J., Li Y., Duren W.L., et al. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 316 (2007) 1341-1345
23. Zeggini E., Weedon M.N., Lingren C.M., Frayling T.M., Elliott K.S., Lango H., et al. Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 316 (2007) 1336-1341
24. Horikawa Y., Miyake K., Yasuda K., Enya M., Hirota Y., Yamagata K., et al. Replication of genome-wide association studies of type 2 diabetes susceptibility in Japan. J Clin Endocrinol Metab 93 (2008) 3136-3141
25. Ng M.C., Park K.S., Oh B., Tam C.H., Cho Y.M., Shin H.D., et al. Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians. Diabetes 57 (2008) 2226-2233
26. Chimienti F., Favier A., and Seve M. ZnT-8, a pancreatic beta-cell-specific zinc transporter. Biometals 18 (2008) 313-317
27. Boesgaard T.W., Zilinskaite J., Vänttinen M., Laakso M., Jansson P.A., Hammarstedt A., et al. The common SLC30A8 Arg325Trp variant is associated with reduced first-phase insulin release in 846 non-diabetic offspring of type 2 diabetes patients-the EUGENE2 study. Diabetologia 51 (2008) 816-820
28. Khemlani SL. Prevention of type 2 diabetes is crucial. New Europe The European Weekly 2008; 22 sept; issue 800. Available at http://www.neurope.eu/articles/89822.php.
29. Alberti K.G.M.M., and Zimmet P.Z. WHO Consultation. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus. Provisional report of a WHO Consultation. Diabet Med 15 (1998) 539-553
30. Balkau B., and Charles M.A. Comment on the provisional report from the WHO consultation. European Group for the Study of Insulin Resistance (EGIR). Diabet Med 16 (1999) 442-443
31. Friedewald W.T., Levy R.I., and Fredrickson D.S. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18 (1972) 499-502
32. Matthews D.R., Hosker J.P., Rudenski A.S., Naylor B.A., Treacher D.F., and Turner R.C. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28 (1985) 412-419
33. Watanabe R.M., Allayee H., Xiang A.H., Trigo E., Hartiala J., Lawrence J.M., et al. Transcription factor 7-like 2 (TCF7L2) is associated with gestational diabetes mellitus and interacts with adiposity to alter insulin secretion in Mexican Americans. Diabetes 56 (2007) 1481-1485
34. Munoz J., Lok K.H., Gower B.A., Fernandez J.R., Hunter G.R., Lara-Castro C., et al. Polymorphism in the transcription factor 7-like 2 (TCF7L2) gene is associated with reduced insulin secretion in nondiabetic women. Diabetes 55 (2006) 3630-3634
35. Palmer N.D., Lehtinen A.B., Langefeld C.D., Campbell J.K., Haffner S.M., Norris J.M., et al. Association of TCF7L2 gene polymorphisms with reduced acute insulin response in Hispanic Americans. J Clin Endocrinol Metab 93 (2008) 304-309
36. Florez J.C., Jablonski K.A., Bayley N., Pollin T.I., de Bakker P.I., Shuldiner A.R., et al. TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program. N Engl J Med 355 (2006) 241-250
37. Lyssenko V., Lupi R., Marchetti P., Del Guerra S., Orho-Melander M., Almgren P., et al. Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes. J Clin Invest 117 (2007) 2155-2163
38. Dahlgren A., Zethelius B., Jensevik K., Syvanen A.C., and Berne C. Variants of the TCF7L2 gene are associated with beta cell dysfunction and confer an increased risk of type 2 diabetes mellitus in the ULSAM cohort of Swedish elderly men. Diabetologia 50 (2007) 1852-1857
39. Cauchi S., Choquet H., Gutiérrez-Aguilar R., Capel F., Grau K., Proença C., et al. Effects of TCF7L2 polymorphisms on obesity in European populations. Obesity (Silver Spring) 16 (2008) 476-482
40. Shu L., Sauter N.S., Schulthess, Matveyenko A.V., Oberholzer J., and Maedler K. Transcription factor 7-like 2 regulates beta-cell survival and function in human pancreatic islets. Diabetes 57 (2008) 645-653
41. da Silva Xavier G., Loder M.K., McDonald A., Tarasov A.I., Carzaniga R., Kronenberger K., et al. TCF7L2 regulates late events in insulin secretion from pancreatic islet β-cells. Diabetes 58 (2009) 894-905
42. Kawasaki E., Uga M., and Nakamura K. Association between anti-ZnT8 autoantibody specificities and SLC30A8 Arg325Trp variant in Japanese patients with type 1 diabetes. Diabetologia 51 (2008) 2299-2302
43. Xiang J., Li X.Y., Xu M., Huang Y., Tan J.R., Lu X., et al. Zinc transporter-8 gene (SLC30A8) is associated with type 2 diabetes in Chinese. J Clin Endocrinol Metab 93 (2008) 4107-4112