Maintenance of adrenergic vascular tone by MMP transactivation of the EGFR requires PI3K and mitochondrial ATP synthesis

Cardiovascular Research

Volumn 84, Issue 3, 2009, Pages 368-377

  Nagareddy, Prabhakara Reddy ^a,b   Chow, Fung Lan ^a   Hao, Li ^a   Wang, Xiang ^a   Nishimura, Tamiko ^a   MacLeod, Kathleen M ^b   McNeill, John H ^b   Fernandez Patron, Carlos ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Adrenergic tone; ATP; Epidermal growth factor receptor; Matrix metalloproteinase; Phosphoinositide 3 kinase

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; ADENOSINE TRIPHOSPHATE; ANGIOTENSIN II; CADHERIN; CALCIUM; EPIDERMAL GROWTH FACTOR RECEPTOR; G PROTEIN COUPLED RECEPTOR; GELATINASE A; GLUCOSE TRANSPORTER 4; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; ILOMASTAT; MATRILYSIN; MATRIX METALLOPROTEINASE; PHENYLEPHRINE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PURINERGIC P2X RECEPTOR; SMALL INTERFERING RNA; WORTMANNIN;

ADRENERGIC SYSTEM; ANIMAL CELL; ARTICLE; BLOOD VESSEL TONE; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HYPERTENSION; MALE; MESENTERIC ARTERY; MITOCHONDRION; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; SIGNAL TRANSDUCTION; SYNTHESIS; TRANSACTIVATION; VASCULAR SMOOTH MUSCLE; VASODILATATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADENOSINE TRIPHOSPHATE; ANIMALS; CELLS, CULTURED; MALE; MATRIX METALLOPROTEINASE 7; MESENTERIC ARTERIES; METALLOPROTEASES; MITOCHONDRIA; MODELS, ANIMAL; MUSCLE, SMOOTH, VASCULAR; NITRIC OXIDE; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, ADRENERGIC; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; VASOCONSTRICTION;

EID: 70849132893     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvp230     Document Type: Article

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