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Volumn 85, Issue 1, 2007, Pages 97-104

Therapeutic potential of the epidermal growth factor receptor transactivation in hypertension: A convergent signaling pathway of vascular tone, oxidative stress, and hypertrophic growth downstream of vasoactive G-protein-coupled receptors?

Author keywords

EGFR; Hypertension; MMP

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; G PROTEIN COUPLED RECEPTOR; MATRIX METALLOPROTEINASE; ADAM PROTEIN; ALPHA 1 ADRENERGIC RECEPTOR; ANTIHYPERTENSIVE AGENT; METALLOPROTEINASE; REACTIVE OXYGEN METABOLITE; VASOCONSTRICTOR AGENT;

EID: 34250858414     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/Y06-097     Document Type: Review
Times cited : (30)

References (59)
  • 2
    • 0036152858 scopus 로고    scopus 로고
    • Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: Metalloproteinase inhibitors as a new therapy
    • doi:10. 1038/nm0102-35
    • Asakura, M., Kitakaze, M., Takashima, S., Liao, Y., Ishikura, F., Yoshinaka, T., et al. 2002. Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: metalloproteinase inhibitors as a new therapy. Nat. Med. 8: 35-40. doi:10. 1038/nm0102-35.
    • (2002) Nat. Med , vol.8 , pp. 35-40
    • Asakura, M.1    Kitakaze, M.2    Takashima, S.3    Liao, Y.4    Ishikura, F.5    Yoshinaka, T.6
  • 3
    • 0036118347 scopus 로고    scopus 로고
    • Doxycycline modulates smooth muscle cell growth, migration, and matrix remodeling after arterial injury
    • Bendeck, M.P., Conte, M., Zhang, M., Nili, N., Strauss, B.H., and Farwell, S.M. 2002. Doxycycline modulates smooth muscle cell growth, migration, and matrix remodeling after arterial injury. Am. J. Pathol. 160: 1089-1095.
    • (2002) Am. J. Pathol , vol.160 , pp. 1089-1095
    • Bendeck, M.P.1    Conte, M.2    Zhang, M.3    Nili, N.4    Strauss, B.H.5    Farwell, S.M.6
  • 4
    • 0034953381 scopus 로고    scopus 로고
    • Vascular smooth muscle growth: Autocrine growth mechanisms
    • Berk, B.C. 2001. Vascular smooth muscle growth: autocrine growth mechanisms. Physiol. Rev. 81: 999-1030.
    • (2001) Physiol. Rev , vol.81 , pp. 999-1030
    • Berk, B.C.1
  • 5
    • 0042379916 scopus 로고    scopus 로고
    • The vascular NAD(P)H oxidases as therapeutic targets in cardiovascular diseases
    • doi:10.1016/S0165-6147(03)00233-5
    • Cai, H., Griendling, K.K., and Harrison, D.G. 2003. The vascular NAD(P)H oxidases as therapeutic targets in cardiovascular diseases. Trends Pharmacol. Sci. 24: 471-478. doi:10.1016/S0165-6147(03)00233-5.
    • (2003) Trends Pharmacol. Sci , vol.24 , pp. 471-478
    • Cai, H.1    Griendling, K.K.2    Harrison, D.G.3
  • 6
    • 0034681203 scopus 로고    scopus 로고
    • EGF receptor transactivation mediated by the proteolytic production of EGF-like agonists
    • Carpenter, G. 2000. EGF receptor transactivation mediated by the proteolytic production of EGF-like agonists. Sci. STKE, 2000: PE1.
    • (2000) Sci. STKE , vol.2000
    • Carpenter, G.1
  • 7
    • 0035844273 scopus 로고    scopus 로고
    • c-Jun N-terminal kinase activation by hydrogen peroxide in endothelial cells involves SRC-dependent epidermal growth factor receptor transactivation
    • doi:10.1074/jbc.M011766200
    • Chen, K., Vita, J.A., Berk, B.C., and Keaney, J.F., Jr. 2001. c-Jun N-terminal kinase activation by hydrogen peroxide in endothelial cells involves SRC-dependent epidermal growth factor receptor transactivation. J. Biol. Chem. 276: 16045-16050. doi:10.1074/jbc.M011766200.
    • (2001) J. Biol. Chem , vol.276 , pp. 16045-16050
    • Chen, K.1    Vita, J.A.2    Berk, B.C.3    Keaney Jr., J.F.4
  • 9
    • 1842779857 scopus 로고    scopus 로고
    • Inward remodeling of the rabbit aorta is blocked by the matrix metalloproteinase inhibitor doxycycline
    • doi:10.1159/000077145
    • Courtman, D.W., Franco, C.D., Meng, Q., and Bendeck, M.P. 2004. Inward remodeling of the rabbit aorta is blocked by the matrix metalloproteinase inhibitor doxycycline. J. Vasc. Res. 41: 157-165. doi:10.1159/000077145.
    • (2004) J. Vasc. Res , vol.41 , pp. 157-165
    • Courtman, D.W.1    Franco, C.D.2    Meng, Q.3    Bendeck, M.P.4
  • 10
    • 0033989282 scopus 로고    scopus 로고
    • Elastase and matrix metalloproteinase inhibitors induce regression, and tenascin-C antisense prevents progression, of vascular disease
    • Cowan, K.N., Jones, P.L., and Rabinovitch, M. 2000. Elastase and matrix metalloproteinase inhibitors induce regression, and tenascin-C antisense prevents progression, of vascular disease. J. Clin. Invest. 105: 21-34.
    • (2000) J. Clin. Invest , vol.105 , pp. 21-34
    • Cowan, K.N.1    Jones, P.L.2    Rabinovitch, M.3
  • 11
    • 4644340883 scopus 로고    scopus 로고
    • Activation of proteinase-activated receptor 1 promotes human colon cancer cell proliferation through epidermal growth factor receptor transactivation
    • Darmoul, D., Gratio, V., Devaud, H., Peiretti, F., and Laburth, M. 2004. Activation of proteinase-activated receptor 1 promotes human colon cancer cell proliferation through epidermal growth factor receptor transactivation. Mol. Cancer Res. 2: 514-522.
    • (2004) Mol. Cancer Res , vol.2 , pp. 514-522
    • Darmoul, D.1    Gratio, V.2    Devaud, H.3    Peiretti, F.4    Laburth, M.5
  • 14
    • 0032828541 scopus 로고    scopus 로고
    • Rapid release of matrix metalloproteinase (MMP)-2 by thrombin in the rat aorta: Modulation by protein tyrosine kinase/phosphatase
    • Fernandez-Patron, C., Zhang, Y., Radomski, M.W., Hollenberg, M.D., and Davidge, S.T. 1999b. Rapid release of matrix metalloproteinase (MMP)-2 by thrombin in the rat aorta: modulation by protein tyrosine kinase/phosphatase. Thromb. Haemost. 82: 1353-1357.
    • (1999) Thromb. Haemost , vol.82 , pp. 1353-1357
    • Fernandez-Patron, C.1    Zhang, Y.2    Radomski, M.W.3    Hollenberg, M.D.4    Davidge, S.T.5
  • 15
    • 0034733807 scopus 로고    scopus 로고
    • Redox-dependent signal transduction
    • doi:10.1016/S0014-5793(00)01669-0
    • Finkel, T. 2000. Redox-dependent signal transduction. FEBS Lett. 476: 52-54. doi:10.1016/S0014-5793(00)01669-0.
    • (2000) FEBS Lett , vol.476 , pp. 52-54
    • Finkel, T.1
  • 16
    • 0036139524 scopus 로고    scopus 로고
    • Reactive oxygen species and signal transduction
    • Finkel, T. 2001. Reactive oxygen species and signal transduction. IUBMB Life, 52: 3-6.
    • (2001) IUBMB Life , vol.52 , pp. 3-6
    • Finkel, T.1
  • 17
    • 0032896273 scopus 로고    scopus 로고
    • Epidermal growth factor: A potent vasoconstrictor in experimental hypertension
    • Florian, J.A., and Watts, S.W. 1999. Epidermal growth factor: a potent vasoconstrictor in experimental hypertension. Am. J. Physiol. 276: H976-H983.
    • (1999) Am. J. Physiol , vol.276
    • Florian, J.A.1    Watts, S.W.2
  • 18
    • 22144494121 scopus 로고    scopus 로고
    • Oxidative stress and vascular remodelling
    • doi:10.1113/expphysiol.2005.030098
    • Fortuno, A., Jose, G.S., Moreno, M.U., Diez, J., and Zalba, G. 2005. Oxidative stress and vascular remodelling. Exp. Physiol. 90: 457-462. doi:10.1113/expphysiol.2005.030098.
    • (2005) Exp. Physiol , vol.90 , pp. 457-462
    • Fortuno, A.1    Jose, G.S.2    Moreno, M.U.3    Diez, J.4    Zalba, G.5
  • 19
    • 0032076161 scopus 로고    scopus 로고
    • Enhanced expression of heparin-binding EGF-like growth factor and its receptor in hypertrophied left ventricle of spontaneously hypertensive rats
    • doi:10.1016/S0008-6363(98)00010-8
    • Fujino, T., Hasebe, N., Fujita, M., Takeuchi, K., Kawabe, J., Tobise, K., et al. 1998. Enhanced expression of heparin-binding EGF-like growth factor and its receptor in hypertrophied left ventricle of spontaneously hypertensive rats. Cardiovasc. Res. 38: 365-374. doi:10.1016/S0008-6363(98)00010-8.
    • (1998) Cardiovasc. Res , vol.38 , pp. 365-374
    • Fujino, T.1    Hasebe, N.2    Fujita, M.3    Takeuchi, K.4    Kawabe, J.5    Tobise, K.6
  • 20
    • 0032560638 scopus 로고    scopus 로고
    • N-acetyl-cysteine decreases the matrix-degrading capacity of macrophage-derived foam cells: New target for antioxidant therapy?
    • Galis, Z.S., Asanuma, K., Godin, D., and Meng, X. 1998. N-acetyl-cysteine decreases the matrix-degrading capacity of macrophage-derived foam cells: new target for antioxidant therapy? Circulation, 97: 2445-2453.
    • (1998) Circulation , vol.97 , pp. 2445-2453
    • Galis, Z.S.1    Asanuma, K.2    Godin, D.3    Meng, X.4
  • 21
    • 0034677947 scopus 로고    scopus 로고
    • NAD(P)H oxidase: Role in cardiovascular biology and disease
    • Griendling, K.K., Sorescu, D., and Ushio-Fukai, M. 2000. NAD(P)H oxidase: role in cardiovascular biology and disease. Circ. Res. 86: 494-501.
    • (2000) Circ. Res , vol.86 , pp. 494-501
    • Griendling, K.K.1    Sorescu, D.2    Ushio-Fukai, M.3
  • 22
    • 0347951238 scopus 로고    scopus 로고
    • Agonist-induced activation of matrix metalloproteinase-7 promotes vasoconstriction through the epidermal growth factor-receptor pathway
    • doi:10.1161/01.RES.0000109413.57726.91
    • Hao, L., Du, M., Lopez-Campistrous, A., and Fernandez-Patron, C. 2004. Agonist-induced activation of matrix metalloproteinase-7 promotes vasoconstriction through the epidermal growth factor-receptor pathway. Circ. Res. 94: 68-76. doi:10.1161/01.RES.0000109413.57726.91.
    • (2004) Circ. Res , vol.94 , pp. 68-76
    • Hao, L.1    Du, M.2    Lopez-Campistrous, A.3    Fernandez-Patron, C.4
  • 23
    • 33646686338 scopus 로고    scopus 로고
    • Vascular responses to alpha 1-adrenergic receptors in small rat mesenteric arteries depend on mitochondrial reactive oxygen species
    • Hao, L., Nishimura, T., Wo, H., and Fernandez-Patron, C. 2006. Vascular responses to alpha 1-adrenergic receptors in small rat mesenteric arteries depend on mitochondrial reactive oxygen species. Arterioscler. Thromb. Vasc. Biol. 26: 819-825.
    • (2006) Arterioscler. Thromb. Vasc. Biol , vol.26 , pp. 819-825
    • Hao, L.1    Nishimura, T.2    Wo, H.3    Fernandez-Patron, C.4
  • 24
    • 0033966350 scopus 로고    scopus 로고
    • Matrix metalloproteinase-7-dependent release of tumor necrosis factor-alpha in a model of herniated disc resorption
    • Haro, H., Crawford, H.C., Fingleton, B., Shinomiya, K., Spengler, D.M., and Matrisian, L.M. 2000. Matrix metalloproteinase-7-dependent release of tumor necrosis factor-alpha in a model of herniated disc resorption. J. Clin. Invest. 105: 143-150.
    • (2000) J. Clin. Invest , vol.105 , pp. 143-150
    • Haro, H.1    Crawford, H.C.2    Fingleton, B.3    Shinomiya, K.4    Spengler, D.M.5    Matrisian, L.M.6
  • 25
    • 0023641028 scopus 로고
    • Pharmacokinetic and pharmacodynamic properties of beta-blocking drugs influencing choice in treatment of systemic hypertension
    • doi:10.1016/0002-9149(87)90536-4
    • Harrison, D.C. 1987. Pharmacokinetic and pharmacodynamic properties of beta-blocking drugs influencing choice in treatment of systemic hypertension. Am. J. Cardiol. 60: 13E-16E. doi:10.1016/0002-9149(87)90536-4.
    • (1987) Am. J. Cardiol , vol.60
    • Harrison, D.C.1
  • 26
    • 0037143616 scopus 로고    scopus 로고
    • Angiotensin II-induced cardiac hypertrophy and hypertension are attenuated by epidermal growth factor receptor antisense
    • doi:10.1161/01.CIR.0000030181.63741.56
    • Kagiyama, S., Eguichi, S., Frank, G.D., Inagami, T., Zhang, Y.C., and Phillips, M.I. 2002. Angiotensin II-induced cardiac hypertrophy and hypertension are attenuated by epidermal growth factor receptor antisense. Circulation, 106: 909-912. doi:10.1161/01.CIR.0000030181.63741.56.
    • (2002) Circulation , vol.106 , pp. 909-912
    • Kagiyama, S.1    Eguichi, S.2    Frank, G.D.3    Inagami, T.4    Zhang, Y.C.5    Phillips, M.I.6
  • 27
    • 0037340170 scopus 로고    scopus 로고
    • Antisense to epidermal growth factor receptor prevents the development of left ventricular hypertrophy
    • doi:10.1161/01.HYP.0000047104. 42047.9B
    • Kagiyama, S., Qian, K., Kagiyama, T., and Phillips, M.I. 2003. Antisense to epidermal growth factor receptor prevents the development of left ventricular hypertrophy. Hypertension, 41: 824-829. doi:10.1161/01.HYP.0000047104. 42047.9B.
    • (2003) Hypertension , vol.41 , pp. 824-829
    • Kagiyama, S.1    Qian, K.2    Kagiyama, T.3    Phillips, M.I.4
  • 28
    • 0035680293 scopus 로고    scopus 로고
    • EGFR transactivation in the regulation of SMC function
    • Kalmes, A., Daum, G., and Clowes, A.W. 2001. EGFR transactivation in the regulation of SMC function. Ann. N.Y. Acad. Sci. 947: 42-54.
    • (2001) Ann. N.Y. Acad. Sci , vol.947 , pp. 42-54
    • Kalmes, A.1    Daum, G.2    Clowes, A.W.3
  • 29
    • 14644418500 scopus 로고    scopus 로고
    • Mitochondria-derived reactive oxygen species and vascular MAP kinases: Comparison of angiotensin II and diazoxide
    • doi:10.1161/01.HYP.0000157169.27818.ae
    • Kimura, S., Zhang, G.X., Nishiyama, A., Shokoji, T., Yao, L., Fan, Y.Y., Rahman, M., and Abe, Y. 2005. Mitochondria-derived reactive oxygen species and vascular MAP kinases: comparison of angiotensin II and diazoxide. Hypertension, 45: 438-444. doi:10.1161/01.HYP.0000157169.27818.ae.
    • (2005) Hypertension , vol.45 , pp. 438-444
    • Kimura, S.1    Zhang, G.X.2    Nishiyama, A.3    Shokoji, T.4    Yao, L.5    Fan, Y.Y.6    Rahman, M.7    Abe, Y.8
  • 30
    • 0042878465 scopus 로고    scopus 로고
    • Pleiotropic effects of angiotensin II receptor blocker in hypertensive patients
    • doi:10.1016/S0735-1097(03) 00846-5
    • Koh, K.K., Ahn, J.Y., Han, S.H., Kim, D.S., Jin, D.K., Kim, H.S., et al. 2003. Pleiotropic effects of angiotensin II receptor blocker in hypertensive patients. J. Am. Coll. Cardiol. 42: 905-910. doi:10.1016/S0735-1097(03) 00846-5.
    • (2003) J. Am. Coll. Cardiol , vol.42 , pp. 905-910
    • Koh, K.K.1    Ahn, J.Y.2    Han, S.H.3    Kim, D.S.4    Jin, D.K.5    Kim, H.S.6
  • 31
    • 23844557144 scopus 로고    scopus 로고
    • Angiotensin II and EGF receptor cross-talk in chronic kidney diseases: A new therapeutic approach
    • doi:10.1038/nm1275
    • Lautrette, A., Li, S., Alili, R., Sunnarborg, S.W., Burtin, M., Lee, D.C., Friedlander, G., and Terzi, F. 2005. Angiotensin II and EGF receptor cross-talk in chronic kidney diseases: a new therapeutic approach. Nat. Med. 11: 867-874. doi:10.1038/nm1275.
    • (2005) Nat. Med , vol.11 , pp. 867-874
    • Lautrette, A.1    Li, S.2    Alili, R.3    Sunnarborg, S.W.4    Burtin, M.5    Lee, D.C.6    Friedlander, G.7    Terzi, F.8
  • 32
    • 0034807142 scopus 로고    scopus 로고
    • Regulation of MAP kinase activity by peptide receptor signaling pathway: Paradigms of multiplicity
    • doi:10.1016/S0898-6568(01)00192-9
    • Liebmann, C. 2001. Regulation of MAP kinase activity by peptide receptor signaling pathway: paradigms of multiplicity. Cell. Signal. 13: 777-785. doi:10.1016/S0898-6568(01)00192-9.
    • (2001) Cell. Signal , vol.13 , pp. 777-785
    • Liebmann, C.1
  • 33
    • 0035936780 scopus 로고    scopus 로고
    • Molecular mechanisms of human hypertension
    • doi:10.1016/S0092-8674(01) 00241-0
    • Lifton, R.P., Gharavi, A.G., and Geller, D.S. 2001. Molecular mechanisms of human hypertension. Cell, 104: 545-556. doi:10.1016/S0092-8674(01) 00241-0.
    • (2001) Cell , vol.104 , pp. 545-556
    • Lifton, R.P.1    Gharavi, A.G.2    Geller, D.S.3
  • 34
    • 0026325282 scopus 로고
    • The epidermal growth factor receptor phosphorylates GTPase-activating protein (GAP) at Tyr-460, adjacent to the GAP SH2 domains
    • Liu, X.Q., and Pawson, T. 1991. The epidermal growth factor receptor phosphorylates GTPase-activating protein (GAP) at Tyr-460, adjacent to the GAP SH2 domains. Mol. Cell. Biol. 11: 2511-2516.
    • (1991) Mol. Cell. Biol , vol.11 , pp. 2511-2516
    • Liu, X.Q.1    Pawson, T.2
  • 35
    • 0023632982 scopus 로고
    • Calcium and vascular smooth muscle tone
    • doi:10.1016/0002-9343(87)90205-1
    • Morgan, K.G. 1987. Calcium and vascular smooth muscle tone. Am. J. Med. 82: 9-15. doi:10.1016/0002-9343(87)90205-1.
    • (1987) Am. J. Med , vol.82 , pp. 9-15
    • Morgan, K.G.1
  • 36
    • 0023526943 scopus 로고
    • Vascular structure and smooth muscle contractility in experimental hypertension
    • Mulvany, M.J. 1987. Vascular structure and smooth muscle contractility in experimental hypertension. J. Cardiovasc. Pharmacol. 10: Suppl. 6, S79-S85.
    • (1987) J. Cardiovasc. Pharmacol , vol.10 , Issue.SUPPL. 6
    • Mulvany, M.J.1
  • 37
    • 21644489724 scopus 로고    scopus 로고
    • Dilating the degradome: Matrix metalloproteinase 2 (MMP-2) cuts to the heart of the matter
    • Overall, C.M. 2004. Dilating the degradome: matrix metalloproteinase 2 (MMP-2) cuts to the heart of the matter. Biochem. J. 383: e5-e7.
    • (2004) Biochem. J , vol.383
    • Overall, C.M.1
  • 38
    • 0036006453 scopus 로고    scopus 로고
    • Prostaglandin E2 transactivates EGF receptor: A novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy
    • doi:10.1038/nm0302-289
    • Pai, R., Soreghan, B., Szabo, I.L., Pavelka, M., Baatar, D., and Tarnawski, A.S. 2002. Prostaglandin E2 transactivates EGF receptor: a novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy. Nat. Med. 8: 289-293. doi:10.1038/nm0302-289.
    • (2002) Nat. Med , vol.8 , pp. 289-293
    • Pai, R.1    Soreghan, B.2    Szabo, I.L.3    Pavelka, M.4    Baatar, D.5    Tarnawski, A.S.6
  • 39
    • 0033599039 scopus 로고    scopus 로고
    • EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF
    • Prenzel, N., Zwick, E., Daub, H., Leserer, M., Abraham, R., Wallasch, C., and Ullrich, A. 1999. EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF. Nature (London), 402: 884-888.
    • (1999) Nature (London) , vol.402 , pp. 884-888
    • Prenzel, N.1    Zwick, E.2    Daub, H.3    Leserer, M.4    Abraham, R.5    Wallasch, C.6    Ullrich, A.7
  • 40
    • 14344252076 scopus 로고    scopus 로고
    • Epidermal growth factor receptor-dependent and -independent pathways in hydrogen peroxide-induced mitogen-activated protein kinase activation in cardiomyocytes and heart fibroblasts
    • Purdom, S., and Chen, Q.M. 2005. Epidermal growth factor receptor-dependent and -independent pathways in hydrogen peroxide-induced mitogen-activated protein kinase activation in cardiomyocytes and heart fibroblasts. J. Pharmacol. Exp. Ther. 312: 1179-1186.
    • (2005) J. Pharmacol. Exp. Ther , vol.312 , pp. 1179-1186
    • Purdom, S.1    Chen, Q.M.2
  • 41
    • 0027294981 scopus 로고
    • The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSosl
    • doi:10.1038/363083a0
    • Rozakis-Adcock, M., Fernley, R., Wade, J., Pawson, T., and Bowtell, D. 1993. The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSosl. Nature (London), 363: 83-85. doi:10.1038/363083a0.
    • (1993) Nature (London) , vol.363 , pp. 83-85
    • Rozakis-Adcock, M.1    Fernley, R.2    Wade, J.3    Pawson, T.4    Bowtell, D.5
  • 42
    • 3843147335 scopus 로고    scopus 로고
    • Matrix metalloproteinase-dependent EGF receptor activation in hypertension and left ventricular hypertrophy
    • Shah, B.H., and Catt, K.J. 2004. Matrix metalloproteinase-dependent EGF receptor activation in hypertension and left ventricular hypertrophy. Trends Endocrinol. Metab. 15: 241-243.
    • (2004) Trends Endocrinol. Metab , vol.15 , pp. 241-243
    • Shah, B.H.1    Catt, K.J.2
  • 43
    • 2342525336 scopus 로고    scopus 로고
    • Angiotensin II type-1 receptor blocker valsartan enhances insulin sensitivity in skeletal muscles of diabetic mice
    • doi:10.1161/01.HYP.0000125142.41703.64
    • Shiuchi, T., Iwai, M., Li, H.S., Wu, L., Min, L.J., Li, J.M., et al. 2004. Angiotensin II type-1 receptor blocker valsartan enhances insulin sensitivity in skeletal muscles of diabetic mice. Hypertension, 43: 1003-1010. doi:10.1161/01.HYP.0000125142.41703.64.
    • (2004) Hypertension , vol.43 , pp. 1003-1010
    • Shiuchi, T.1    Iwai, M.2    Li, H.S.3    Wu, L.4    Min, L.J.5    Li, J.M.6
  • 44
    • 0037177164 scopus 로고    scopus 로고
    • Superoxide production and expression of nox family proteins in human atherosclerosis
    • doi:10.1161/01.CIR.0000012917.74432.66
    • Sorescu, D., Weiss, D., Lassegue, B., Clempus, R.E., Szocks, K., Sorescu, G.P., et al. 2002. Superoxide production and expression of nox family proteins in human atherosclerosis. Circulation, 105: 1429-1435. doi:10.1161/01.CIR.0000012917.74432.66.
    • (2002) Circulation , vol.105 , pp. 1429-1435
    • Sorescu, D.1    Weiss, D.2    Lassegue, B.3    Clempus, R.E.4    Szocks, K.5    Sorescu, G.P.6
  • 45
    • 0029806062 scopus 로고    scopus 로고
    • Elevated epidermal growth factor receptor levels in hypertensive Lyon rat kidney and aorta
    • Swaminathan, N., Vincent, M., Sassard, J., and Sambhi, M.P. 1996. Elevated epidermal growth factor receptor levels in hypertensive Lyon rat kidney and aorta. Clin. Exp. Pharmacol. Physiol. 23: 793-796.
    • (1996) Clin. Exp. Pharmacol. Physiol , vol.23 , pp. 793-796
    • Swaminathan, N.1    Vincent, M.2    Sassard, J.3    Sambhi, M.P.4
  • 46
    • 4744355650 scopus 로고    scopus 로고
    • ADAM binding protein Eve-1 is required for ectodomain shedding of epidermal growth factor receptor ligands
    • doi:10.1074/jbc.M400086200
    • Tanaka, M., Nanba, D., Mori, S., Shiba, F., Ishiguro, H., Yoshino, K., Matsuura, N., and Higashiyama, S. 2004. ADAM binding protein Eve-1 is required for ectodomain shedding of epidermal growth factor receptor ligands. J. Biol. Chem. 279: 41950-41959. doi:10.1074/jbc.M400086200.
    • (2004) J. Biol. Chem , vol.279 , pp. 41950-41959
    • Tanaka, M.1    Nanba, D.2    Mori, S.3    Shiba, F.4    Ishiguro, H.5    Yoshino, K.6    Matsuura, N.7    Higashiyama, S.8
  • 47
    • 0037335290 scopus 로고    scopus 로고
    • Recent advances in intracellular signalling in hypertension
    • doi:10.1097/00041552-200303000-00007
    • Touyz, R.M. 2003. Recent advances in intracellular signalling in hypertension. Curr. Opin. Nephrol. Hypertens. 12: 165-174. doi:10.1097/00041552-200303000-00007.
    • (2003) Curr. Opin. Nephrol. Hypertens , vol.12 , pp. 165-174
    • Touyz, R.M.1
  • 48
    • 22144435873 scopus 로고    scopus 로고
    • Intracellular mechanisms involved in vascular remodelling of resistance arteries in hypertension: Role of angiotensin II
    • doi:10.1113/expphysiol.2005.030080
    • Touyz, R.M. 2005a. Intracellular mechanisms involved in vascular remodelling of resistance arteries in hypertension: role of angiotensin II. Exp. Physiol. 90: 449-455. doi:10.1113/expphysiol.2005.030080.
    • (2005) Exp. Physiol , vol.90 , pp. 449-455
    • Touyz, R.M.1
  • 49
    • 15444373092 scopus 로고    scopus 로고
    • Molecular and cellular mechanisms in vascular injury in hypertension: Role of angiotensin II
    • Touyz, R.M. 2005b. Molecular and cellular mechanisms in vascular injury in hypertension: role of angiotensin II. Curr. Opin. Nephrol. Hypertens. 14: 125-131.
    • (2005) Curr. Opin. Nephrol. Hypertens , vol.14 , pp. 125-131
    • Touyz, R.M.1
  • 50
    • 33646676497 scopus 로고    scopus 로고
    • Mitochondrial redox control of matrix metalloproteinase signaling in resistance arteries
    • Touyz, R.M. 2006. Mitochondrial redox control of matrix metalloproteinase signaling in resistance arteries. Arterioscler. Thromb. Vasc. Biol. 26: 685-688.
    • (2006) Arterioscler. Thromb. Vasc. Biol , vol.26 , pp. 685-688
    • Touyz, R.M.1
  • 51
    • 0346458560 scopus 로고    scopus 로고
    • Selective cleavage of nucleolar autoantigen B23 by granzyme B in differentiated vascular smooth muscle cells: Insights into the association of specific autoantibodies with distinct disease phenotypes
    • doi:10.1002/art.11485
    • Ulanet, D.B., Flavahan, N.A., Casciola-Rosen, L., and Rosen, A. 2004. Selective cleavage of nucleolar autoantigen B23 by granzyme B in differentiated vascular smooth muscle cells: insights into the association of specific autoantibodies with distinct disease phenotypes. Arthritis Rheum. 50: 233-241. doi:10.1002/art.11485.
    • (2004) Arthritis Rheum , vol.50 , pp. 233-241
    • Ulanet, D.B.1    Flavahan, N.A.2    Casciola-Rosen, L.3    Rosen, A.4
  • 52
    • 5444257487 scopus 로고    scopus 로고
    • Oxidative stress in uremia: Nature, mechanisms, and potential consequences
    • Vaziri, N.D. 2004. Oxidative stress in uremia: nature, mechanisms, and potential consequences. Semin. Nephrol. 24: 469-473.
    • (2004) Semin. Nephrol , vol.24 , pp. 469-473
    • Vaziri, N.D.1
  • 53
    • 0032991031 scopus 로고    scopus 로고
    • Nifedipine improves endothelial function in hypercholesterolemia, independently of an effect on blood pressure or plasma lipids
    • doi:10.1016/S0008- 6363(98) 00341-1
    • Verhaar, M.C., Honing, M.L., van Dam, T., Zwart, M., Koomans, H.A., Kastelein, J.J., and Rabelink, T.J. 1999. Nifedipine improves endothelial function in hypercholesterolemia, independently of an effect on blood pressure or plasma lipids. Cardiovasc. Res. 42: 752-760. doi:10.1016/S0008- 6363(98) 00341-1.
    • (1999) Cardiovasc. Res , vol.42 , pp. 752-760
    • Verhaar, M.C.1    Honing, M.L.2    van Dam, T.3    Zwart, M.4    Koomans, H.A.5    Kastelein, J.J.6    Rabelink, T.J.7
  • 54
    • 11144251210 scopus 로고    scopus 로고
    • Hypoxic pulmonary vasoconstriction: Redox events in oxygen sensing
    • Waypa, G.B., and Schumacker, P.T. 2005. Hypoxic pulmonary vasoconstriction: redox events in oxygen sensing. J. Appl. Physiol. 98: 404-414.
    • (2005) J. Appl. Physiol , vol.98 , pp. 404-414
    • Waypa, G.B.1    Schumacker, P.T.2
  • 55
    • 0035683053 scopus 로고    scopus 로고
    • Myocardial remodelling and matrix metalloproteinases in heart failure: Turmoil within the interstitium
    • Wilson, E.M., and Spinale, F.G. 2001. Myocardial remodelling and matrix metalloproteinases in heart failure: turmoil within the interstitium. Ann. Med. 33: 623-634.
    • (2001) Ann. Med , vol.33 , pp. 623-634
    • Wilson, E.M.1    Spinale, F.G.2
  • 56
    • 0037157854 scopus 로고    scopus 로고
    • The metalloprotease Kuzbanian (ADAM10) mediates the transactivation of EGF receptor by G protein-coupled receptors
    • doi:10.1083/jcb.200112026
    • Yan, Y., Shirakabe, K., and Werb, Z. 2002. The metalloprotease Kuzbanian (ADAM10) mediates the transactivation of EGF receptor by G protein-coupled receptors. J. Cell Biol. 158: 221-226. doi:10.1083/jcb.200112026.
    • (2002) J. Cell Biol , vol.158 , pp. 221-226
    • Yan, Y.1    Shirakabe, K.2    Werb, Z.3
  • 57
    • 8844228835 scopus 로고    scopus 로고
    • Transactivation of epidermal growth factor receptor mediates catecholamine-induced growth of vascular smooth muscle
    • doi:10.1161/01.RES.0000147962.01036.bb
    • Zhang, H., Chalothorn, D., Jackson, L.F., Lee, D.C., and Faber, J.E. 2004. Transactivation of epidermal growth factor receptor mediates catecholamine-induced growth of vascular smooth muscle. Circ. Res. 95: 989-997. doi:10.1161/01.RES.0000147962.01036.bb.
    • (2004) Circ. Res , vol.95 , pp. 989-997
    • Zhang, H.1    Chalothorn, D.2    Jackson, L.F.3    Lee, D.C.4    Faber, J.E.5
  • 58
    • 3542998086 scopus 로고    scopus 로고
    • Atorvastatin prevents end-organ injury in salt-sensitive hypertension: Role of eNOS and oxidant stress
    • doi:10.1161/01.HYP.0000136395.06810. cf
    • Zhou, M.S., Jaimes, E.A., and Raij, L. 2004. Atorvastatin prevents end-organ injury in salt-sensitive hypertension: role of eNOS and oxidant stress. Hypertension, 44: 186-190. doi:10.1161/01.HYP.0000136395.06810. cf.
    • (2004) Hypertension , vol.44 , pp. 186-190
    • Zhou, M.S.1    Jaimes, E.A.2    Raij, L.3
  • 59
    • 0033214444 scopus 로고    scopus 로고
    • The EGF receptor as central transducer of heterologous signalling systems
    • doi:10.1016/S0165-6147(99)01373-5
    • Zwick, E., Hackel, P.O., Prenzel, N., and Ullrich, A. 1999. The EGF receptor as central transducer of heterologous signalling systems. Trends Pharmacol. Sci. 20: 408-412. doi:10.1016/S0165-6147(99)01373-5.
    • (1999) Trends Pharmacol. Sci , vol.20 , pp. 408-412
    • Zwick, E.1    Hackel, P.O.2    Prenzel, N.3    Ullrich, A.4


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