Miz1 is a signal- and pathway-specific modulator or regulator (SMOR) that suppresses TNF-α-induced JNK1 activation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 43, 2009, Pages 18279-18284

  Liu, Jing ^a,c   Zhao, Yingming ^a   Eilers, Martin ^b   Lin, Anning ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

^c NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

I KAPPA B BETA; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; MITOGEN ACTIVATED PROTEIN KINASE P38; MYC INTERACTING ZINC FINGER PROTEIN 1; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

ANIMAL CELL; ARTICLE; CELL DEATH; EMBRYO; ENZYME ACTIVATION; FIBROBLAST; MOUSE; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEOMICS; SCREENING; SIGNAL TRANSDUCTION; UBIQUITINATION; YEAST;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; I-KAPPA B KINASE; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MICE; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASE 8; NUCLEAR PROTEINS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; PROTEIN INHIBITORS OF ACTIVATED STAT; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA; UBIQUITINATION;

EID: 70849088411     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0906328106     Document Type: Article

References (43)

1. Hibi M, Lin A, Smeal T, Minden A, Karin M (1993) Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. Genes Dev 7:2135-2148. (Pubitemid 23336140)
2. Kyriakis JM, et al. (1994) The stress-activated protein kinase subfamily of c-Jun kinases. Nature 369:156-160.
3. Chang L, Karin M (2001) Mammalian MAP kinase signaling cascades. Nature 410:37-40. (Pubitemid 32225829)
4. Davis RJ (2000) Signal transduction by the JNK group of MAP kinases. Cell 103:239-252.
5. Lin A (2003) Activation of the JNK signaling pathway: Breaking the brake on apoptosis. BioEssays 25:1-8.
6. Karin M (1995) The regulation of AP-1 activity by mitogen-activated protein kinases. J Biol Chem 270:16483-16486.
7. Liu J, Lin A (2007) Wiring the cell signaling circuitry by the NF-κB and JNK1 cross-talk and its applications in human diseases. Oncogene 26:3267-3278. (Pubitemid 46763020)
8. Chang L, et al. (2006) The E3 ubiquitin ligase itch couples JNK activation to TNFα-induced cell death by inducing c-FLIPL turnover. Cell 124:601-613. (Pubitemid 43199444)
9. Deng H, et al. (2008) Phosphorylation of Bad at Thr-201 by JNK1 promotes glycolysis through activation of phosphofructokinase-1. J Biol Chem 283:20754-20760.
10. Greten FR, et al. (2004) IKKβ links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell 118:285-296.
11. Maeda S, et al. (2005) IKKβcouples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell 121:977-990. (Pubitemid 40884391)
12. Liu J, Minemoto Y, Lin A (2004) c-Jun N-terminal protein kinase 1 (JNK1), but not JNK2, is essential for tumor necrosis factor α-induced c-Jun kinase activation and apoptosis. Mol Cell Biol 24:10844-10856. (Pubitemid 39603140)
13. Liu J, et al. (2006) NF-κBis required for UV-induced JNK activation via induction of PKCδ. Mol Cell 21:467-480. (Pubitemid 43228003)
14. Sakurai T, Maeda S, Chang L, Karin M (2006) Loss of hepatic NF-κB activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation. Proc Natl Acad Sci USA 103:10544-10551. (Pubitemid 44078014)
15. Sabpathy K, et al. (2004) Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation. Mol Cell 15:713-725.
16. Yu C, et al. (2004) JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD. Mol Cell 13:329-340. (Pubitemid 38229806)
17. De Smaele E, et al. (2001) Induction of gadd45β by NF-κB down-regulates proapoptotic JNK signaling. Nature 414:308-313.
18. Kamata H, et al. (2005) Reactive oxygen species promote TNFα-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell 120:649-661. (Pubitemid 40343077)
19. Karin M, Lin A (2002) NF-κB at the crossroads of life and death. Nat Immunol 3:221-227.
20. Maeda S, et al. (2003) IKKβ is required for prevention of apoptosis mediated by cell-bound but not by circulating TNFα. Immunity 19:725-737. (Pubitemid 37490797)
21. Tang G, et al. (2001) Inhibition of JNK activation through NF-κB target genes. Nature 414:313-317. (Pubitemid 33097808)
22. Tang F, et al. (2002) Absence of NF-κB-mediated inhibition of c-Jun N-terminal kinase activation contributes to tumor necrosis factor α-induced apoptosis. Mol Cell Biol 22:8571-8579. (Pubitemid 35397172)
23. 2-terminal kinase is essential for the regulation of AP-1 by tumor necrosis factor. Mol Cell Biol 23:2871-2882.
24. Karin M, Gallagher E (2005) From JNK to pay dirt: Jun kinases, their biochemistry, physiology and clinical importance. IUBMB Life 57:283-295. (Pubitemid 40904256)
25. Bardwell VJ, Treisman R (1994) The POZ domain: A conserved protein-protein interaction motif. Genes Dev 8:1664-1677.
26. Schulz TC, Hopwood B, Rathjen PD, Wells JR (1995) An unusual arrangement of 13 zinc fingers in the vertebrate gene Z13. Biochem J 311:219-224.
27. Peukert K, et al. (1997) An alternative pathway for gene regulation by Myc. EMBO J 16:5672-5686. (Pubitemid 27399859)
28. Herold S, et al. (2002) Negative regulation of the mammalian UV response by Myc through association with Miz-1. Mol Cell 10:509-521. (Pubitemid 35284171)
29. Ziegelbauer J, et al. (2001) Transcription factor MIZ-1 is regulated via microtubule association. Mol Cell 8:339-349. (Pubitemid 32831551)
30. Wanzel M, Herold S, Eilers M (2003) Transcriptional repression by Myc. Trends Cell Biol 13:146-150.
31. Adhikary S, et al. (2003) Miz1 is required for early embryonic development during gastrulation. Mol Cell Biol 23:7648-7657. (Pubitemid 37271463)
32. Kallunki T, et al. (1994) JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation. Genes Dev 8:2996-3007.
33. Lin A, et al. (1995) Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2. Science 268:286-290.
34. 2-terminal protein kinase (JNK)-activating kinase 2 as an activator of JNK but not p38. J Biol Chem 272:24751-24754.
35. Liu ZG, Hsu H, Goeddel DV, Karin M (1996) Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-κB activation prevents cell death. Cell 87:565-576. (Pubitemid 26374329)
36. Tada K, et al. (2001) Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-κB activation and protection from cell death. J Biol Chem 276:36530-36534. (Pubitemid 37384264)
37. Yeh W-C, et al. (1997) Early lethality, functional NF-κB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice. Immunity 7:715-725.
38. Shi C-S, Kehrl JH (2003) Tumor necrosis factor (TNF)-induced germinal center kinase-related (GCKR) and stress-activated protein kinase (SAPK) activation depends upon the E2/E3 complex Ubc13-Uev1A/TNF receptor-associated factor 2 (TRAF2). J Biol Chem 278:15429-15434.
39. Habelhah H, et al. (2004) Ubiquitination and translocation of TRAF2 is required for activation of JNK but not of p38 or NF-κB. EMBO J 23:322-332. (Pubitemid 38294497)
40. Tournier C, et al. (2000) Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway. Science 288:870-874. (Pubitemid 30257738)
41. Lin Y, et al. (2000) The death domain kinase RIP is essential for TRAIL (Apo2L)-induced activation of IκB kinase and c-Jun N-terminal kinase. Mol Cell Biol 20:6638-6645. (Pubitemid 30700782)
42. Raman M, Earnest S, Zhang K, Zhao Y, Cobb MH (2007) TAO kinases mediate activation of p38 in response to DNA damage. EMBO J 26:2005-2014. (Pubitemid 46625802)
43. Chen Y, Kwon SW, Kim SC, Zhao Y (2005) Integrated approach for manual evaluation of peptides identified by searching protein sequence databases with tandem mass spectra. J Proteome Res 4:998-1005. (Pubitemid 40863290)