Transcriptional repression by Myc

Trends in Cell Biology

Volumn 13, Issue 3, 2003, Pages 146-150

  Wanzel, Michael ^a   Herold, Steffi ^a   Eilers, Martin ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; DNA; MYC PROTEIN; ONCOPROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR MIZ 1; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

CANCER INHIBITION; CELL CYCLE; COMPLEX FORMATION; DNA DAMAGE; GENE ACTIVATION; GENE REPRESSION; NONHUMAN; ONCOGENE MYC; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY MECHANISM; REVIEW; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

EID: 0037334340     PISSN: 09628924     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0962-8924(03)00003-5     Document Type: Review

References (58)

1. Schwab M., et al. Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour. Nature. 305:1983;245-248.
2. Brodeur G.M., et al. Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage. Science. 224:1984;1121-1124.
3. He T.C., et al. Identification of c-MYC as a target of the APC pathway. Science. 281:1998;1509-1512.
4. van de Wetering M., et al. The β-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell. 111:2002;241-250.
5. Li L., et al. c-Myc represses transcription in vivo by a novel mechanism dependent on the initiator element and Myc box II. EMBO J. 13:1994;4070-4079.
6. Marhin W.W., et al. Myc represses the growth arrest gene gadd45. Oncogene. 14:1997;2825-2834.
7. Wu K.J., et al. Coordinated regulation of iron-controlling genes, H-ferritin and IRP2, by c-MYC. Science. 283:1999;676-679.
8. Eisenman R.N. Deconstructing myc. Genes Dev. 15:2001;2023-2030.
9. McMahon S.B., et al. The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-Myc. Mol. Cell. Biol. 20:2000;556-562.
10. Park J., et al. The ATM-related domain of TRRAP is required for histone acetyltransferase recruitment and Myc-dependent oncogenesis. Genes Dev. 15:2001;1619-1624.
11. Frank S.R., et al. Binding of c-Myc to chromatin mediates mitogen-induced acetylation of histone H4 and gene activation. Genes Dev. 15:2001;2069-2082.
12. Bouchard C., et al. Regulation of cyclin D2 gene expression by the Myc/Max/Mad network: Myc-dependent TRRAP recruitment and histone acetylation at the cyclin D2 promoter. Genes Dev. 15:2001;2042-2047.
13. Nikiforov M.A., et al. TRRAP-dependent and TRRAP-independent transcriptional activation by Myc family oncoproteins. Mol. Cell. Biol. 22:2002;5054-5063.
14. Eberhardy S.R., Farnham P.J. Myc recruits P-TEFb to mediate the final step in the transcriptional activation of the cad promoter. J. Biol. Chem. 277:2002;40156-40162.
15. Levens D. Disentangling the MYC web. Proc. Natl. Acad. Sci. U. S. A. 99:2002;5757-5759.
16. Ayer D.E., et al. Mad-Myc transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3. Cell. 80:1995;767-776.
17. Staller P., et al. Repression of p15INK4b expression by Myc through association with Miz-1. Nat. Cell Biol. 3:2001;392-399.
18. James L., Eisenman R.N. Myc and Mad bHLHZ domains possess identical DNA-binding specificities but only partially overlapping functions in vivo. Proc. Natl. Acad. Sci. U. S. A. 99:2002;10429-10434.
19. O'Hagan R.C., et al. Gene-target recognition among members of the myc superfamily and implications for oncogenesis. Nat. Genet. 24:2000;113-119.
20. James L., Eisenman R. Myc and Mad bHLHZ domains possess identical DNA-binding specificities but only partially overlapping functions in vivo. Proc. Natl. Acad. Sci. U. S. A. 99:2002;10429-10434.
21. Freytag S.O., Geddes T.J. Reciprocal regulation of adipogenesis by Myc and C/EBPα Science. 256:1992;379-382.
22. Inghirami G., et al. Down-regulation of LFA-1 adhesion receptors by c-myc oncogene in human B lymphoblastoid cells. Science. 250:1990;682-686.
23. Lee L.A., et al. A link between c-Myc-mediated transcriptional repression and neoplastic transformation. J. Clin. Invest. 97:1996;1687-1695.
24. Conzen S.D., et al. Induction of cell cycle progression and acceleration of apoptosis are two separable functions of c-Myc: transrepression correlates with acceleration of apoptosis. Mol. Cell. Biol. 20:2000;6008-6018.
25. Philipp A., et al. Repression of Cyclin D1: a novel function of MYC. Mol. Cell. Biol. 14:1994;4032-4043.
26. Gartel A.L., et al. Myc represses the p21(WAF1/CIP1) promoter and interacts with Sp1/Sp3. Proc. Natl. Acad. Sci. U. S. A. 98:2001;4510-4515.
27. Yang W., et al. Repression of transcription of the p27(Kip1) cyclin-dependent kinase inhibitor gene by c-Myc. Oncogene. 20:2001;1688-1702.
28. Seoane J., et al. TGFβ influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b. Nat. Cell Biol. 3:2001;400-408.
29. Wu, S. et al. Myc represses differentiation-induced p21Cip1 expression via Miz-1-dependent interaction with the p21 core promoter. Oncogene (in press).
30. Roy A.L., et al. Cooperative interaction of an initiator-binding transcription initiation factor and the helix-loop-helix activator USF. Nature. 354:1991;245-248.
31. Shrivastava A., et al. Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc. Science. 262:1993;1889-1891.
32. Peukert K., et al. An alternative pathway for gene regulation by Myc. EMBO J. 16:1997;5672-5686.
33. Feng X.H., et al. Smad2, smad3 and smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-β EMBO J. 19:2000;5178-5193.
34. Izumi H., et al. Mechanism for the transcriptional repression by c-Myc on PDGF beta-receptor. J. Cell Sci. 114:2001;1533-1544.
35. Wetering M.v.d. et al. (2002). The β-catenin/TCF4 complex controls the proliferation/differentiation switch in colon epithelium through c-MYC-mediated repression of p21CIP1/WAF1. Cell (in press).
36. Herold S., et al. Negative regulation of the mammalian UV response by Myc through association with Miz-1. Mol. Cell. 10:2002;509-521.
37. Seoane, J. et al. Myc suppression of p21Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage. Nature (in press).
38. Kime, L. and Wright, S.C. (2002) Mad4 is regulated by a transcriptional repressor complex that contains Miz-1 and c-Myc. Biochem. J. (in press).
39. McMahon S.B., et al. The novel ATM-related protein TRRAP is an essential cofactor for the c- Myc and E2F oncoproteins. Cell. 94:1998;363-374.
40. Lee T.C., et al. Myc represses transcription of the growth arrest gene gas1. Proc. Natl. Acad. Sci. U. S. A. 94:1997;12886-12891.
41. Rogatsky I., et al. Factor recruitment and TIF2/GRIP1 corepressor activity at a collagenase-3 response element that mediates regulation by phorbol esters and hormones. EMBO J. 20:2001;6071-6083.
42. Porse B.T., et al. E2F repression by C/EBPα is required for adipogenesis and granulopoiesis in vivo. Cell. 107:2001;247-258.
43. Schmidt M., et al. Cell cycle inhibition by FoxO forkhead transcription factors involves downregulation of cyclin D. Mol. Cell. Biol. 22:2002;7842-7852.
44. Derynck R., et al. TGF-beta signaling in tumor suppression and cancer progression. Nat. Genet. 29:2001;117-129.
45. INK4b is a potential effector of cell cycle arrest mediated by TGF-β Nature. 371:1994;257-261.
46. Chen C., et al. E2F4/5 and p107 as Smad cofactors linking the TGFβ receptor to c-myc repression. Cell. 110:2002;19-32.
47. Warner B.J., et al. Myc downregulation by transforming growth factor required for activation of the p15ink4b g1 arrest pathway. Mol. Cell. Biol. 19:1999;5913-5922.
48. Feng X.H., et al. Direct interaction of c-Myc with Smad2 and Smad3 to inhibit TGF-beta- mediated induction of the CDK inhibitor p15(Ink4B). Mol. Cell. 9:2002;133-143.
49. van de Wetering M., et al. The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell. 111:2002;241-250.
50. van Es J.H., et al. The many faces of the tumor suppressor gene APC. Exp. Cell Res. 264:2001;126-134.
51. Wu, S. et al. Myc represses differentiation-induced p21Cip1 expression via Miz-1-dependent interaction with the p21 core promoter. (in press).
52. Ayer D.E., Eisenman R.N. A switch from Myc: Max to Mad: Max heterocomplexes accompanies monocyte/macrophage differentiation. Genes Dev. 7:1993;2110-2119.
53. Sheen J.H., Dickson R.B. Overexpression of c-Myc alters G(1)/S arrest following ionizing radiation. Mol. Cell. Biol. 22:2002;1819-1833.
54. Vafa O., et al. c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function. A mechanism for oncogene-induced genetic instability. Mol. Cell. 9:2002;1031-1044.
55. Li Q., Dang C.V. c-Myc overexpression uncouples DNA replication from mitosis. Mol. Cell. Biol. 19:1999;5339-5351.
56. Felsher D.W., Bishop J.M. Transient excess of MYC activity can elicit genomic instability and tumorigenesis. Proc. Natl. Acad. Sci. U. S. A. 96:1999;3940-3944.
57. Soucek L., Evan G. Myc-Is this the oncogene from hell? Cancer Cell. 1:2002;406-408.
58. Pelengaris S., et al. Suppression of myc-induced apoptosis in Beta cells exposes multiple oncogenic properties of myc and triggers carcinogenic progression. Cell. 109:2002;321-334.