Sgk1 activates MDM2-dependent p53 degradation and affects cell proliferation, survival, and differentiation

Journal of Molecular Medicine

Volumn 87, Issue 12, 2009, Pages 1221-1239

  Amato, Rosario ^a   D'Antona, Lucia ^a   Porciatti, Giovanni ^a   Agosti, Valter ^a   Menniti, Miranda ^a   Rinaldo, Cinzia ^c   Costa, Nicola ^a   Bellacchio, Emanuele ^b,c   Mattarocci, Stefano ^c   Fuiano, Giorgio ^a   Soddu, Silvia ^c   Paggi, Marco G ^c   Lang, Florian ^d   Perrotti, Nicola ^a  

^a UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^b CASA SOLLIEVO DELLA SOFFERENZA HOSPITAL   (Italy)

^c REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

^d UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Cell death; Cell signaling; MDM2; P53; Sgk1

Indexed keywords

PROTEASOME; PROTEIN MDM2; PROTEIN P53; SERUM AND GLUCOCORTICOID REGULATED KINASE 1;

ANIMAL EXPERIMENT; ARTICLE; CELL CYCLE PROGRESSION; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CLONOGENESIS; CONTROLLED STUDY; EPITHELIUM CELL; HELA CELL; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN DEGRADATION; RNA INTERFERENCE; TRANSCRIPTION INITIATION; UBIQUITINATION; WILD TYPE;

ANIMALS; CELL DEATH; CELL DIFFERENTIATION; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; GENE EXPRESSION REGULATION, NEOPLASTIC; HELA CELLS; HUMANS; IMMEDIATE-EARLY PROTEINS; MALE; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-MDM2; SIGNAL TRANSDUCTION; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 70849085548     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00109-009-0525-5     Document Type: Article

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