Enhanced delivery and expression of a nanoencapsulated DNA vaccine vector for respiratory syncytial virus

Nanomedicine: Nanotechnology, Biology, and Medicine

Volumn 5, Issue 4, 2009, Pages 463-472

  Boyoglu, Seyhan ^a   Vig, Komal ^a   Pillai, Shreekumar ^a   Rangari, Vijay ^b   Dennis, Vida A ^c   Khazi, Fayaz ^d   Singh, Shree R ^a  

^a ALABAMA STATE UNIVERSITY   (United States)

^b TUSKEGEE UNIVERSITY   (United States)

^c TULANE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^d INTREXON CORPORATION   (United States)

Author keywords

Chitosan; DNA vaccine; Nanoencapsulation; Respiratory syncytial virus

Indexed keywords

CHITOSAN NANOPARTICLES; COMPLEX COACERVATION; DNA DEGRADATION; DNA RELEASE; DNA VACCINE; ENCAPSULATION EFFICIENCY; EXPRESSION VECTORS; HUMAN CYTOMEGALOVIRUS; MOUSE TISSUES; NAKED DNA; NANO-ENCAPSULATION; PROTEIN EXPRESSIONS; REAL-TIME POLYMERASE CHAIN REACTION; RESPIRATORY SYNCYTIAL VIRUS; SPHERICAL SHAPE; UNIFORM SIZE;

CHITIN; CHITOSAN; CLONING; DIFFERENTIAL SCANNING CALORIMETRY; DNA; ENCAPSULATION; HISTOLOGY; LEAKAGE (FLUID); NUCLEIC ACIDS; PROTEINS; SEMICONDUCTOR QUANTUM DOTS; VACCINES; VECTORS;

GENES;

CHITOSAN; DNA VACCINE; NAKED DNA; NUCLEASE;

ANIMAL CELL; ARTICLE; COACERVATION; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DNA DEGRADATION; GENE EXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; NANOENCAPSULATION; NONHUMAN; PARTICLE SIZE; PH; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RESPIRATORY SYNCYTIAL PNEUMOVIRUS;

ANIMALS; CALORIMETRY, DIFFERENTIAL SCANNING; CELL DEATH; CERCOPITHECUS AETHIOPS; CHITOSAN; COS CELLS; DNA, VIRAL; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMANS; IMMUNOHISTOCHEMISTRY; INJECTIONS, INTRAVENOUS; MICE; MICROSCOPY, ATOMIC FORCE; MICROSCOPY, ELECTRON, TRANSMISSION; NANOPARTICLES; RESPIRATORY SYNCYTIAL VIRUS VACCINES; RESPIRATORY SYNCYTIAL VIRUSES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SURFACE PROPERTIES; TRANSFECTION; VACCINES, DNA; VIRAL PROTEINS;

HUMAN HERPESVIRUS 5; RESPIRATORY SYNCYTIAL VIRUS; RICE STRIPE VIRUS;

EID: 70749118334     PISSN: 15499634     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nano.2009.02.004     Document Type: Article

References (29)

1. Karron R.A., Buonagurio D.A., Georgiu A.F., Whitehead S.S., Adamus J.E., Clements-Mann J.L., et al. Respiratory syncytial virus (RSV) SH and G proteins are not essential for viral replication in vitro: clinical evaluation and molecular characterization of a cold-passaged attenuated RSV subgroup B mutant. Proc Natl Acad Sci USA 94 (1997) 13961-13966
2. Li X., Sambhara S., Xin Li C., Ewasyshyn M., Parrington M., Caterini J., et al. Protection against respiratory syncytial virus infection by DNA immunization. J Exp Med 188 (1998) 681-688
3. Collins P.L., Hill M.G., and Johnson P.R. The two open reading frames of the 22K mRNA of human respiratory syncytial virus: sequence comparison of antigenic subgroups A and B and expression in vitro. J Gen Virol 71 (1990) 3015-3020
4. Cane P.A. Molecular epidemiology of respiratory syncytial virus. Rev Med Virol 11 (2001) 103-116
5. Reschel T., Konák C., Oupický D., Seymour L.W., and Ulbrich K. Physical properties and in vitro transfection efficiency of gene delivery vectors based on complexes of DNA with synthetic polycations. J Control Release 81 (2002) 201-217
6. Borchard G. Chitosans for gene delivery. Adv Drug Deliv Rev 52 (2001) 145-150
7. Bozkir A., and Saka O.M. Chitosan-DNA nanoparticles: effect on DNA integrity, bacterial transformation and transfection efficiency. J Drug Target 12 (2004) 281-288
8. Ishii T., Okahata Y., and Sato T. Mechanism of cell transfection with plasmid/chitosan complexes. Biochim Biophys Acta 1514 (2001) 51-64
9. Mao H.Q., Roy K., Troung-Le V.L., Janes K.A., Lin K.Y., Wang Y., et al. Chitosan-DNA nanoparticles as gene carriers: synthesis, characterization and transfection efficiency. J Control Release 70 (2001) 399-421
10. Roy K., Mao H.Q., Huang S.K., and Leong K.W. Oral gene delivery with chitosan-DNA nanoparticles generates immunologic protection in a murine model of peanut allergy. Nat Med 5 (1999) 387-391
11. Illum L., Jabbal-Gill I., Hinchcliffe M., Fisher A.N., and Davis S.S. Chitosan as a novel nasal delivery system for vaccines. Adv Drug Deliv Rev 51 (2001) 81-96
12. Gan Q., Wang T., Cochrane C., and McCarron P. Modulation of surface charge, particle size and morphological properties of chitosan-TPP nanoparticles intended for gene delivery. Colloids Surf B 44 (2005) 65-73
13. Iqbal M., Lin W., Jabbal-Gill I., Davis S.S., Steward M.W., and Illum L. Nasal delivery of chitosan-DNA plasmid expressing epitopes of respiratory syncytial virus (RSV) induces protective CTL responses in BALB/c mice. Vaccine 21 (2003) 1478-1485
14. Yu-Hong L., Min-Wen F., Zhi C., Qi Z., and Hai-Rui Y. Chitosan-DNA microparticles as mucosal delivery system: synthesis, characterization and release in vitro. Chin Med J 118 (2005) 936-941
15. Loretz B., and Bernkop-Schnürch A. In vitro evaluation of chitosan-EDTA conjugate polyplexes as a nanoparticulate gene delivery system. AAPS J 8 (2006) 756-764
16. Leong K.W., Mao H.Q., Truong-Le V.L., Roy K., Walsh S.M., and August J.T. DNA-polycation nanospheres as non-viral gene delivery vehicles. J Control Release 53 (1998) 183-193
17. Hejazi R., and Amiji M. Chitosan-based gastrointestinal delivery systems. J Control Release 89 (2003) 151-165
18. Hu Y., Jiang X., Ding Y., Ge H., Yuan Y., and Yang C. Synthesis and characterization of chitosan-poly(acrylic acid) nanoparticles. Biomaterials 23 (2002) 3193-3201
19. Köping-Höggård M., Tubulekas I., Guan H., Edwards K., Nilsson M., Vårum K.M., et al. Chitosan as a nonviral gene delivery system. Structure-property relationships and characteristics compared with polyethylenimine in vitro and after lung administration in vivo. Gene Ther 8 (2001) 1108-1121
20. de Moura M.R., Aouada F.A., and Mattosa L.H. Preparation of chitosan nanoparticles using methacrylic acid. J Colloid Interface Sci 321 (2008) 477-483
21. Pimpha N., Rattanonchai U., Surassmo S., Opanasopit P., Rattanarungchai C., and Sunintaboon P. Preparation of PMMA/acid-modified chitosan core-shell nanoparticles and their potential as gene carriers. Colloid Polym Sci 286 (2008) 907-916
22. Corsi F.C., Yahia L.H., and Julio C.F. Mesenchymal stem cells, MG63 and HEK293 transfection using chitosan-DNA nanoparticles. Biomaterials. 24 (2003) 1255-1264
23. Lavertu M., Méthot S., Tran-Khanh N., and Buschmann M.D. High efficiency gene transfer using chitosan/DNA nanoparticles with specific combinations of molecular weight and degree of deacetylation. Biomaterials. 27 (2006) 4815-4824
24. Seymour M.A. Atomic force microscopic analysis of the influence of the molecular weight of poly (l) lysine on the size of polyelectrolyte complexes formed with DNA. Gene Ther (1996) 269-273
25. Mumper R.J., Claspell J.M., and Rolland A.P. Novel polymeric condensing carriers for gene delivery. Proc Natl Acad Sci USA 22 (1995) 178-179
26. Vinogradov S.V., and Kabanov A.V. Nanosized cationic hyrogels for drug delivery: preparation, properties and interactions with cells. Adv Drug Deliv Rev 54 (2002) 135-147
27. Erbacher P., Zou S., Bettinger T., Steffan A.M., and Remy J.S. Chitosan-based vector/DNA complexes for gene delivery: biophysical characteristics and transfection ability. Pharm Res 15 (1998) 1332-1339
28. MacLaughlin F.C., Mumper R.J., Wang J., Tagliaferri J.M., Gill I., Hinchliffe M., et al. Chitosan and depolymerised chitosan oligomers as condensing carriers for in vivo plasmid delivery. J Control Release 56 (1998) 259-272
29. Lueßen H.L., Langemeyer M.W.E., de Boer A.G., Verhoef J.C., and Junginger H.E. Mucoadhesive polymers in peroral peptide drug delivery. VI. Carbomer and chitosan improve the intestinal absorption of the peptide drug buserelin in vivo. Pharm Res 13 (1996) 1668-1672