Interleukin-6-induced plasminogen gene expression in murine hepatocytes is mediated by transcription factor CCAAT/enhancer binding protein β (C/EBPβ)

Journal of Thrombosis and Haemostasis

Volumn 2, Issue 12, 2004, Pages 2205-2212

  Bannach, F G ^a,b   Gutierrez Fernandez, A ^a   Parmer, R J ^b,c   Miles, L A ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

Author keywords

C EBP ; Interleukin 6; Plasminogen

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CCAAT ENHANCER BINDING PROTEIN BETA; INTERLEUKIN 6; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE; NUCLEAR PROTEIN; PLASMINOGEN; STAT PROTEIN;

ANIMAL CELL; ARTICLE; BINDING SITE; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME INHIBITION; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; GENE SEQUENCE; GENETIC TRANSFECTION; LIVER CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; REPORTER GENE; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION;

ACUTE-PHASE REACTION; ANIMALS; BASE SEQUENCE; BINDING SITES; CCAAT-ENHANCER-BINDING PROTEINS; CELL LINE, TUMOR; CELL NUCLEUS; ENZYME INHIBITORS; FLAVONOIDS; GENE EXPRESSION REGULATION; GENES, REPORTER; HEPATOCYTES; INTERLEUKIN-6; LUCIFERASES; MAP KINASE SIGNALING SYSTEM; MICE; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; OLIGONUCLEOTIDES; PLASMIDS; PLASMINOGEN; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; SEQUENCE HOMOLOGY, NUCLEIC ACID; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; TRANSFECTION; UP-REGULATION;

EID: 13244265658     PISSN: 15387933     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2004.01022.x     Document Type: Article

References (42)

1. Carmeliet P, Schoonjans L, Kieckens L, Ream B, Degen J, Bronson R, De Vos R, van den Oord JJ, Collen D, Mulligan RC. Physiological consequences of loss of plasminogen activator gene function in mice. Nature 1994; 368: 419-24.
2. Collen D, Lijnen HR. Basic and clinical aspects of fibrinolysis and thrombolysis. Blood 1991; 78: 3114-24.
3. Irigoyen JP, Munoz-Canoves P, Montero L, Koziczak M, Nagamine Y. The plasminogen activator system: biology and regulation. Cell Mol Life Sci 1999; 56: 104-32.
4. Blasi F. Proteolysis, cell adhesion, chemotaxis, and invasiveness are regulated by the u-PA-u-PAR-PAI-1 system. Thromb Haemost 1999; 82: 298-304.
5. Ploplis VA, French EL, Carmeliet P, Collen D, Plow EF. Plasminogen deficiency differentially affects recruitment of inflammatory cell populations in mice. Blood 1998; 91: 2005-9.
6. Plow EF, Ploplis VA, Busuttil S, Carmeliet P, Collen D. A role of plasminogen in atherosclerosis and restenosis models in mice. Thromb Haemost 1999; 82 (Suppl. 1): 4-7.
7. Swaisgood CM, Schmitt D, Eaton D, Plow EF. In vivo regulation of plasminogen function by plasma carboxypeptidase B. J Clin Invest 2002; 110: 1275-82.
8. Bohmfalk JF, Fuller GM. Plasminogen is synthesized by primary cultures of rat hepatocytes. Science 1980; 209: 408-10.
9. Raum D, Marcus D, Alper CA, Levey R, Taylor PD, Starzl TE. Synthesis of human plasminogen by the liver. Science 1980; 208 1036-7.
10. Saito H, Hamilton SM, Tavill AS, Louis L, Ratnoff OD. Production and release of plasminogen by isolated perfused rat liver. Proc Natl Acad Sci USA 1980; 77: 6837-40.
11. Zhang L, Seiffert D, Fowler BJ, Jenkins GR, Thinnes TC, Loskutoff DJ, Parmer RJ, Miles LA. Plasminogen has a broad extrahepatic distribution. Thromb Haemost 2002; 87: 493-501.
12. Lackner H, Javid JP. The clinical significance of the plasminogen level. Am J Clin Pathol 1973; 60: 175-81.
13. Liesen H, Dufaux B, Hollman W. Modifications of serum glycoproteins the days following a prolonged physical exercise and the influence of physical training. Eur J App Physiol Occup Physiol 1997; 37: 243-54.
14. Topper MJ, Prasse KW. Analysis of coagulation proteins as acute-phase reactants in horses with colic. Am J Vet Res 1998; 59: 542-5.
15. Gabay C, Kushner I. Acute-phase proteins and other systemic responses to inflammation. N Engl J Med 1999; 11: 448-54.
16. Folsom AR, Aleksic N, Park E, Salomaa V, Juneja H, Wu KK. Prospective study of fibrinolytic factors and incident coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) Study. Arterioscler Thromb Vasc Biol 2001; 21: 611-7.
17. Ceciliani F, Giordano A, Spagnolo V. The systemic reaction during inflammation: the acute-phase proteins. Protein Pept Lett 2002; 9: 211-23.
18. Jenkins GR, Seiffert D, Partner RJ, Miles LA. Regulation of plasminogen gene expression by interleukin-6. Blood 1997; 89: 2394-403.
19. Bannach FG, Gutierrez A, Fowler BJ, Bugge TH, Degen JL, Parmer RJ, Miles LA. Localization of regulatory elements mediating constitutive and cytokine-stimulated plasminogen gene expression. J Biol Chem 2002; 277: 38579-88.
20. Petersen TE, Martzen MR, Ichinose AG, Davie EW. Characterization of the gene for human plasminogen, a key proenzyme in the fibrinolytic system. J Biol Chem 1990; 265: 6104-11.
21. Malgaretti N, Bruno L, Pontoglio M, Candiani G, Meroni G, Ottolenghi S, Taramelli R. Definition of the transcription initiation site of human plasminogen gene in liver and non hepatic cell lines. Biochem Biophys Res Commun 1990; 173: 1013-8.
22. Wade DP, Cloche JG, Lindahl GE, Liu AC, Zysow BR, Meer K, Schwartz K, Lawn RM. 5′-control regions of the apolipoprotein(a) gene and members of the related plasminogen gene family. Proc Natl Acad Sci USA 1993; 90: 1369-73.
23. Wingender E, Chen X, Hehl R, Karas H, Liebich I, Matys V, Meinhardt T, Pruss M, Reuter I, Schacherer F. TRANSFAC: an integrated system for gene expression regulation. Nucl Acids Res 2000; 28 316-9.
24. Johnson PF. Identification of C/EBP basic region residues involved in DNA sequence recognition and half-site spacing preference. Mol Cell Biol 1993; 13: 6919-30.
25. Agrawal A, Cha-Molstad H, Samols D, Kushner I. Transactivation of C-reactive protein by IL-6 requires synergistic interaction of CCAAT/enhancer binding protein beta (C/EBP beta) and Rel p50. J Immunol 2001; 166: 2378-84.
26. Baumann H, Morella KK, Campos SP, Cao Z, Jahreis GP. Role of CAAT-enhancer binding protein isoforms in the cytokine regulation of acute-phase plasma protein genes. J Biol Chem 1992; 267: 19744-51.
27. Ramji DP, Vitelli A, Tronche F, Cortese R, Ciliberto G. The two C/EBP isoforms, IL-6DBP/NF-IL6 and C/EBP delta/NF-IL6 beta, are induced by IL-6 to promote acute phase gene transcription via different mechanisms. Nucl Acids Res 1993; 21: 289-94.
28. Wegenka UM, Buschmann J, Lutticken C, Heinrich PC, Horn F. Acute-phase response factor, a nuclear factor binding to acute-phase response elements, is rapidly activated by interleukin-6 at the post-translational level. Mol Cell Biol 1993; 13: 276-88.
29. Zhong Z, Wen Z, Darnell JE Jr. Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science 1994; 264: 95-8.
30. Heim MH. The Jak-STAT pathway: cytokine signalling from the receptor to the nucleus. J Recept Signal Transduct Res 1999; 19 75-120.
31. Davis RJ. Transcriptional regulation by MAP kinases. Mol Reprod Dev 1995; 42: 459-67.
32. Moshage H. Cytokines and the acute phase response. J Pathol 1997; 181: 257-66.
33. Gutierrez-Fernandez A, Gingles NA, Zhang L, Bannach FG, Jenkins GR, Loskutoff DJ, Parmer RJ, Miles LA. Regulation of plasminogen gene expression. In: Waisman DM, ed. Plasminogen: Structure, Activation and Regulation. New York, NY: Kluwer Academic/Plenum Publishers, 2003: 103-19.
34. Hsu W, Kerppola TK, Chen PL, Curran T, Chen-Kiang S. Fos and Jun repress transcription activation by NF-IL6 through association at the basic zipper region. Mol Cell Biol 1994; 14: 268-76.
35. Kim JW, Ahn A. C/EBP binding activity to site F of the rat GLUT2 glucose transporter gene promoter is attenuated by c-Jun in vitro. Exp Mol Med 2002; 34: 379-84.
36. Milosavljevic T, Lazic T, Uskokovic A, Petrovic M, Grigorov I. Expression of the rat liver haptoglobin gene is mediated by isoforms of C/EBPalpha-beta, and -delta proteins. Gen Physiol Biophys 2003; 22: 181-90.
37. Milosavljevic T, Petrovic MV, Cvetkovic ID, Grigorov II. DNA binding activity of C/EBPbeta and C/EBPdelta for the rat alpha2-macroglobulin gene promoter is regulated in an acute-phase dependent manner. Biochemistry (Mosc) 2002; 67: 918-26.
38. Alessi DR, Cuenda A, Cohen P, Dudley DT, Saltiel AR. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J Biol Chem 1995; 270: 27489-94.
39. Hungness ES, Luo GJ, Pritts TA, Sun X, Robb BW, Hershko D, Hasselgren PO. Transcription factors C/EBP-beta and -delta regulate IL-6 production in IL-1beta-stimulated human enterocytes. J Cell Physiol 2002; 192: 64-70.
40. Hanlon M, Sturgill TW, Sealy L. ERK2- and p90 (Rsk2)-dependent pathways regulate the CCAAT/enhancer-binding protein-beta interaction with serum response factor. J Biol Chem 2001; 276: 38449-56.
41. Piwien-Pilipuk G, MacDougald O, Schwartz J. Subnuclear localization of C/EBP beta is regulated by growth hormone and dependent on MAPK. J Biol Chem 2002; 277: 44557-65.
42. Cabal-Manzano R, Bhargava P, Torres-Duarte A, Marshall J, Bhargava P, Wainer IW. Proteolysis-inducing factor is expressed in tumours of patients with gastrointestinal cancers and correlates with weight loss. Br J Cancer 2001; 84: 1599-601.