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Volumn 7, Issue 5, 2009, Pages 507-515

Conformational mAb as a tool for integrin ligand discovery

Author keywords

[No Author keywords available]

Indexed keywords

BETA1 INTEGRIN; LIGAND; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY HUTS 21; N (2,6 DICHLOROBENZOYL) LEVO 4 (2',6' BIS METHOXYPHENYL)PHENYLALANINE; PHENYLALANINE DERIVATIVE; TR 14035; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; VERY LATE ACTIVATION ANTIGEN 4;

EID: 70450286210     PISSN: 1540658X     EISSN: None     Source Type: Journal    
DOI: 10.1089/adt.2009.0203     Document Type: Article
Times cited : (17)

References (30)
  • 1
    • 33746797624 scopus 로고    scopus 로고
    • Vascular integrins in tumor angiogenesis: Mediators and therapeutic targets
    • Alghisi GC, Ruegg C: Vascular integrins in tumor angiogenesis: mediators and therapeutic targets. Endothelium 2006;13:113-135.
    • (2006) Endothelium , vol.13 , pp. 113-135
    • Alghisi, G.C.1    Ruegg, C.2
  • 2
    • 33645551144 scopus 로고    scopus 로고
    • Integrins: Molecular targets in cancer therapy
    • Tucker GC: Integrins: molecular targets in cancer therapy. Curr Oncol Rep 2006;8:96-103.
    • (2006) Curr Oncol Rep , vol.8 , pp. 96-103
    • Tucker, G.C.1
  • 3
    • 33750256352 scopus 로고    scopus 로고
    • Integrin antagonists as therapeutics for infl ammatory diseases
    • Vanderslice P, Woodside DG: Integrin antagonists as therapeutics for infl ammatory diseases. Expert Opin Investig Drugs 2006;15:1235-1255.
    • (2006) Expert Opin Investig Drugs , vol.15 , pp. 1235-1255
    • Vanderslice, P.1    Woodside, D.G.2
  • 4
    • 40949084807 scopus 로고    scopus 로고
    • Cell adhesion antagonists: Therapeutic potential in asthma and chronic obstructive pulmonary disease
    • Woodside DG, Vanderslice P: Cell adhesion antagonists: therapeutic potential in asthma and chronic obstructive pulmonary disease. BioDrugs 2008;22:85-100.
    • (2008) BioDrugs , vol.22 , pp. 85-100
    • Woodside, D.G.1    Vanderslice, P.2
  • 5
  • 6
    • 34249815827 scopus 로고    scopus 로고
    • Regulation of cell adhesion by affi nity and conformational unbending of alpha4beta1 integrin
    • Chigaev A, Waller A, Zwartz GJ, Buranda T, Sklar LA: Regulation of cell adhesion by affi nity and conformational unbending of alpha4beta1 integrin. J Immunol 2007;178:6828-6839.
    • (2007) J Immunol , vol.178 , pp. 6828-6839
    • Chigaev, A.1    Waller, A.2    Zwartz, G.J.3    Buranda, T.4    Sklar, L.A.5
  • 7
    • 20144366948 scopus 로고    scopus 로고
    • Dissociation of i domain and global conformational changes in LFA-1: Refi nement of small molecule- i domain structure-activity relationships
    • Larson RS, Davis T, Bologa C, Semenuk G, Vijayan S, Li Y, et al.: Dissociation of I domain and global conformational changes in LFA-1: refi nement of small molecule- I domain structure-activity relationships. Biochemistry 2005;44: 4322-4331.
    • (2005) Biochemistry , vol.44 , pp. 4322-4331
    • Larson, R.S.1    Davis, T.2    Bologa, C.3    Semenuk, G.4    Vijayan, S.5    Li, Y.6
  • 8
    • 0025241904 scopus 로고
    • Selective inhibition of integrin function by antibodies specifi c for ligand-occupied receptor conformers
    • Frelinger AL, III, Cohen I, Plow EF, Smith MA, Roberts J, Lam SC, et al.: Selective inhibition of integrin function by antibodies specifi c for ligand-occupied receptor conformers. J Biol Chem 1990;265:6346-6352.
    • (1990) J Biol Chem , vol.265 , pp. 6346-6352
    • Frelinger, A.L.1    Iii Cohen, I.2    Plow, E.F.3    Smith, M.A.4    Roberts, J.5    Lam, S.C.6
  • 9
    • 0013307787 scopus 로고    scopus 로고
    • Conformational changes in the integrin beta A domain provide a mechanism for signal transduction via hybrid domain movement
    • Mould AP, Barton SJ, Askari JA, McEwan PA, Buckley PA, Craig SE, et al.: Conformational changes in the integrin beta A domain provide a mechanism for signal transduction via hybrid domain movement. J Biol Chem 2003;278:17028- 17035.
    • (2003) J Biol Chem , vol.278 , pp. 17028-17035
    • Mould, A.P.1    Barton, S.J.2    Askari, J.A.3    McEwan, P.A.4    Buckley, P.A.5    Craig, S.E.6
  • 10
    • 20044361821 scopus 로고    scopus 로고
    • Evidence that monoclonal antibodies directed against the integrin beta subunit plexin/ semaphorin/integrin domain stimulate function by inducing receptor extension
    • Mould AP, Travis MA, Barton SJ, Hamilton JA, Askari JA, Craig SE, et al.: Evidence that monoclonal antibodies directed against the integrin beta subunit plexin/ semaphorin/integrin domain stimulate function by inducing receptor extension. J Biol Chem 2005;280:4238-4246.
    • (2005) J Biol Chem , vol.280 , pp. 4238-4246
    • Mould, A.P.1    Travis, M.A.2    Barton, S.J.3    Hamilton, J.A.4    Askari, J.A.5    Craig, S.E.6
  • 11
    • 0036259277 scopus 로고    scopus 로고
    • Alpha 4 integrin antagonists
    • Jackson DY: Alpha 4 integrin antagonists. Curr Pharm Des 2002;8:1229-1253.
    • (2002) Curr Pharm des , vol.8 , pp. 1229-1253
    • Jackson, D.Y.1
  • 12
    • 35248879157 scopus 로고    scopus 로고
    • Flow cytometry for drug discovery, receptor pharmacology and high-throughput screening
    • Sklar LA, Carter MB, Edwards BS: Flow cytometry for drug discovery, receptor pharmacology and high-throughput screening. Curr Opin Pharmacol 2007;7:527-534.
    • (2007) Curr Opin Pharmacol , vol.7 , pp. 527-534
    • Sklar, L.A.1    Carter, M.B.2    Edwards, B.S.3
  • 13
    • 0035966054 scopus 로고    scopus 로고
    • Real time analysis of the affi nity regulation of alpha 4-integrin. the physiologically activated receptor is intermediate in affi nity between resting and Mn(2+) or antibody activation
    • Chigaev A, Blenc AM, Braaten JV, Kumaraswamy N, Kepley CL, Andrews RP, et al.: Real time analysis of the affi nity regulation of alpha 4-integrin. The physiologically activated receptor is intermediate in affi nity between resting and Mn(2+) or antibody activation. J Biol Chem 2001;276:48670-48678.
    • (2001) J Biol Chem , Issue.276 , pp. 48670-48678
    • Chigaev, A.1    Blenc, A.M.2    Braaten, J.V.3    Kumaraswamy, N.4    Kepley, C.L.5    Andrews, R.P.6
  • 15
  • 16
    • 0036088732 scopus 로고    scopus 로고
    • Alpha(4) beta(7)/alpha(4)beta(1) dual integrin antagonists block alpha(4)beta(7)-dependent adhesion under shear flow
    • Egger LA, Kidambi U, Cao J, Van Riper G, McCauley E, Mumford RA, et al.: Alpha(4) beta(7)/alpha(4)beta(1) dual integrin antagonists block alpha(4)beta(7)-dependent adhesion under shear flow. J Pharmacol Exp Ther 2002;302:153-162.
    • (2002) J Pharmacol Exp Ther , vol.302 , pp. 153-162
    • Egger, L.A.1    Kidambi, U.2    Cao, J.3    Van Riper, G.4    McCauley, E.5    Mumford, R.A.6
  • 17
    • 32144432437 scopus 로고    scopus 로고
    • The SWISS-MODEL workspace: A webbased environment for protein structure homology modelling
    • Arnold K, Bordoli L, Kopp J, Schwede T: The SWISS-MODEL workspace: a webbased environment for protein structure homology modelling. Bioinformatics 2006;22:195-201.
    • (2006) Bioinformatics , vol.22 , pp. 195-201
    • Arnold, K.1    Bordoli, L.2    Kopp, J.3    Schwede, T.4
  • 18
    • 0031473847 scopus 로고    scopus 로고
    • SWISS-MODEL and the Swiss-PdbViewer: An environment for comparative protein modeling
    • Guex N, Peitsch MC: SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling. Electrophoresis 1997;18:2714-2723.
    • (1997) Electrophoresis , vol.18 , pp. 2714-2723
    • Guex, N.1    Peitsch, M.C.2
  • 19
    • 0042622380 scopus 로고    scopus 로고
    • SWISS-MODEL: An automated protein homology-modeling server
    • Schwede T, Kopp J, Guex N, Peitsch MC: SWISS-MODEL: An automated protein homology-modeling server. Nucleic Acids Res 2003;31:3381-3385.
    • (2003) Nucleic Acids Res , vol.31 , pp. 3381-3385
    • Schwede, T.1    Kopp, J.2    Guex, N.3    Peitsch, M.C.4
  • 20
    • 0034623005 scopus 로고    scopus 로고
    • T-Coffee: A novel method for fast and accurate multiple sequence alignment
    • Notredame C, Higgins DG, Heringa J: T-Coffee: a novel method for fast and accurate multiple sequence alignment. J Mol Biol 2000;302:205-217.
    • (2000) J Mol Biol , vol.302 , pp. 205-217
    • Notredame, C.1    Higgins, D.G.2    Heringa, J.3
  • 21
    • 0043123123 scopus 로고    scopus 로고
    • Tcoffee@igs: A web server for computing, evaluating and combining multiple sequence alignments
    • Poirot O, O'Toole E, Notredame C: Tcoffee@igs: A web server for computing, evaluating and combining multiple sequence alignments. Nucleic Acids Res 2003;31:3503-3506.
    • (2003) Nucleic Acids Res , vol.31 , pp. 3503-3506
    • Poirot, O.1    O'Toole, E.2    Notredame, C.3
  • 22
    • 47349134204 scopus 로고    scopus 로고
    • GalphaS-coupled receptor signaling actively down-regulates alpha4beta1-integrin affi nity: A possible mechanism for cell deadhesion
    • Chigaev A, Waller A, Amit O, Sklar LA: GalphaS-coupled receptor signaling actively down-regulates alpha4beta1-integrin affi nity: a possible mechanism for cell de-adhesion. BMC Immunol 2008;9:26.
    • (2008) BMC Immunol , vol.9 , pp. 26
    • Chigaev, A.1    Waller, A.2    Amit, O.3    Sklar, L.A.4
  • 23
    • 33846027057 scopus 로고    scopus 로고
    • Phospholipase C, calcium, and calmodulin are critical for alpha4beta1 integrin affi nity up-regulation and monocyte arrest triggered by chemoattractants
    • Hyduk SJ, Chan JR, Duffy ST, Chen M, Peterson MD, Waddell TK, et al.: Phospholipase C, calcium, and calmodulin are critical for alpha4beta1 integrin affi nity up-regulation and monocyte arrest triggered by chemoattractants. Blood 2007;109:176-184.
    • (2007) Blood , vol.109 , pp. 176-184
    • Hyduk, S.J.1    Chan, J.R.2    Duffy, S.T.3    Chen, M.4    Peterson, M.D.5    Waddell, T.K.6
  • 24
    • 33744798761 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of novel pyridazinone-based alpha4 integrin receptor antagonists
    • Gong Y, Barbay JK, Dyatkin AB, Miskowski TA, Kimball ES, Prouty SM, et al.: Synthesis and biological evaluation of novel pyridazinone-based alpha4 integrin receptor antagonists. J Med Chem 2006;49:3402-3411.
    • (2006) J Med Chem , vol.49 , pp. 3402-3411
    • Gong, Y.1    Barbay, J.K.2    Dyatkin, A.B.3    Miskowski, T.A.4    Kimball, E.S.5    Prouty, S.M.6
  • 25
    • 0033545639 scopus 로고    scopus 로고
    • Selective, tight-binding inhibitors of integrin alpha4beta1 that inhibit allergic airway responses
    • Lin K, Ateeq HS, Hsiung SH, Chong LT, Zimmerman CN, Castro A, et al.: Selective, tight-binding inhibitors of integrin alpha4beta1 that inhibit allergic airway responses. J Med Chem 1999;42:920-934.
    • (1999) J Med Chem , vol.42 , pp. 920-934
    • Lin, K.1    Ateeq, H.S.2    Hsiung, S.H.3    Chong, L.T.4    Zimmerman, C.N.5    Castro, A.6
  • 26
    • 67649819843 scopus 로고    scopus 로고
    • Realtime analysis of conformation-sensitive antibody binding provides new insights into integrin conformational regulation
    • Chigaev A, Waller A, Amit O, Halip L, Bologa CG, Sklar LA: Realtime analysis of conformation-sensitive antibody binding provides new insights into integrin conformational regulation. J Biol Chem 2009;284:14337-14346.
    • (2009) J Biol Chem , vol.284 , pp. 14337-14346
    • Chigaev, A.1    Waller, A.2    Amit, O.3    Halip, L.4    Bologa, C.G.5    Sklar, L.A.6
  • 27
    • 0036754547 scopus 로고    scopus 로고
    • Current understanding of stem cell mobilization: The roles of chemokines, proteolytic enzymes, adhesion molecules, cytokines, and stromal cells
    • Lapidot T, Petit I: Current understanding of stem cell mobilization: the roles of chemokines, proteolytic enzymes, adhesion molecules, cytokines, and stromal cells. Exp Hematol 2002;30:973-981.
    • (2002) Exp Hematol , vol.30 , pp. 973-981
    • Lapidot, T.1    Petit, I.2
  • 28
    • 23244435467 scopus 로고    scopus 로고
    • How do stem cells fi nd their way home?
    • Lapidot T, Dar A, Kollet O: How do stem cells fi nd their way home?. Blood 2005;106:1901-1910.
    • (2005) Blood , vol.106 , pp. 1901-1910
    • Lapidot, T.1    Dar, A.2    Kollet, O.3


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