α4β7/α 4β1 dual integrin antagonists block α4β7-dependent adhesion under shear flow

Journal of Pharmacology and Experimental Therapeutics

Volumn 302, Issue 1, 2002, Pages 153-162

  Egger, Linda A ^a   Kidambi, Usha ^a   Cao, Jin ^a   Van Riper, Gail ^a   McCauley, Ermengilda ^b   Mumford, Richard A ^b   Amo, Suzanne ^b   Lingham, Russell ^a   Lanza, Thomas ^c   Lin, Linus S ^c   De Laszlo, Stephen E ^c   Young, David N ^c   Kopka, Ihor E ^a   Tong, Sharon ^a   Pikounis, Bill ^b   Benson, Evelyn ^b   Warwood, Sarah ^c   Bargatze, Robert F ^b   Hagmann, William K ^a   Schmidt, John A ^c   Detmers, Patricia A ^c   more..

^a RY80N A26 ^*

^b RY80N A26   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA4 INTEGRIN; BETA1 INTEGRIN; BETA7 INTEGRIN; HYBRID PROTEIN; IMMUNOMODULATING AGENT; INTEGRIN; INTEGRIN ANTAGONIST; MANGANESE; MONOCLONAL ANTIBODY; MUCOSAL ADDRESSIN CELL ADHESION MOLECULE 1; N (2,6 DICHLOROBENZOYL) 4 (2',6' BIS METHOXYPHENYL)PHENYLALANINE; N [N [(3,5 DICHLOROBENZENE)SULFONYL] 2 METHYLPROPYL]PHENYLALANINE; TR 14035; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG POTENCY; FEMALE; FLOW RATE; HUMAN; HUMAN CELL; LEUKOCYTE ADHERENCE INHIBITION; LYMPHOCYTE; MALE; MESENTERY LYMPH NODE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PEYER PATCH; PRIORITY JOURNAL; RAT; SHEAR RATE;

ANIMALS; ANTIBODIES, BLOCKING; ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CELL ADHESION; CELL ADHESION MOLECULES; CYCLOPHOSPHAMIDE; DOXORUBICIN; ENDOTHELIUM, VASCULAR; ETOPOSIDE; FEMALE; FLOW CYTOMETRY; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULINS; INTEGRIN ALPHA4BETA1; INTEGRINS; LIGANDS; LYMPHOCYTES; METHOTREXATE; MICE; MICE, INBRED BALB C; MUCOPROTEINS; PEYER'S PATCHES; PHENYLALANINE; RECEPTORS, LYMPHOCYTE HOMING; RECOMBINANT FUSION PROTEINS; RHEOLOGY;

EID: 0036088732     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.302.1.153     Document Type: Article

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