메뉴 건너뛰기




Volumn 3, Issue 5, 2009, Pages 605-615

Genomic and metabolomic advances in the identification of disease and adverse event biomarkers

Author keywords

Biomarker; Genomic; Medicine; Metabolomic; Metabonomic; Personalized; Pharmacogenomic

Indexed keywords

BIOLOGICAL MARKER; EPIDERMAL GROWTH FACTOR RECEPTOR 2; GALACTOSAMINE; GLYCOCHENODEOXYCHOLIC ACID; HOMOVANILLIC ACID; KIDNEY INJURY MOLECULE 1; MICRORNA; PARACETAMOL; TRASTUZUMAB;

EID: 70450263593     PISSN: 17520363     EISSN: None     Source Type: Journal    
DOI: 10.2217/bmm.09.43     Document Type: Review
Times cited : (31)

References (105)
  • 1
    • 0034844646 scopus 로고    scopus 로고
    • Clinical application of pharmacogenetics
    • Ground-breaking article exploring the efficacy rate of marketed compounds
    • Spear BB, Heath-Chiozzi M, Huff J: Clinical application of pharmacogenetics. Trends Mol. Med. 7, 201-204 (2001). ■■ Ground-breaking article exploring the efficacy rate of marketed compounds.
    • (2001) Trends Mol. Med. , vol.7 , pp. 201-204
    • Spear, B.B.1    Heath-Chiozzi, M.2    Huff, J.3
  • 2
    • 33846646004 scopus 로고    scopus 로고
    • The prospects for "personalized medicine" in drug development and drug therapy
    • Woodcock J: The prospects for "personalized medicine" in drug development and drug therapy. Clin. Pharmacol. Ther. 81, 164-169 (2007).
    • (2007) Clin. Pharmacol. Ther. , vol.81 , pp. 164-169
    • Woodcock, J.1
  • 3
    • 66549086084 scopus 로고    scopus 로고
    • US Department of Health and Human Services US Department of Health and Human Services, DC, USA
    • US Department of Health and Human Services. Personalized Health Care: Pioneers, Partnerships, Progress. US Department of Health and Human Services, DC, USA (2008)
    • (2008) Personalized Health Care: Pioneers, Partnerships, Progress
  • 5
    • 39749134121 scopus 로고    scopus 로고
    • Strategic paths for biomarker qualification
    • Goodsaid FM, Frueh FW, Mattes W: Strategic paths for biomarker qualification. Toxicology 245, 219-223 (2008).
    • (2008) Toxicology , vol.245 , pp. 219-223
    • Goodsaid, F.M.1    Frueh, F.W.2    Mattes, W.3
  • 6
    • 60349116928 scopus 로고    scopus 로고
    • Translational toxicology and the work of the predictive safety testing consortium
    • Mattes WB , Walker EG: Translational toxicology and the work of the predictive safety testing consortium. Clin. Pharmacol. Ther. 85, 327-330 (2009).
    • (2009) Clin. Pharmacol. Ther. , vol.85 , pp. 327-330
    • Mattes, W.B.1    Walker, E.G.2
  • 7
    • 84934435468 scopus 로고    scopus 로고
    • Public consortium efforts in toxicogenomics
    • Mendrick DL, Mattes WB (Eds). Humana, NJ, USA
    • Mattes WB: Public consortium efforts in toxicogenomics. In: Essential Concepts in Toxicogenomics. Mendrick DL, Mattes WB (Eds). Humana, NJ, USA, 221-238 (2008).
    • (2008) Essential Concepts in Toxicogenomics , pp. 221-238
    • Mattes, W.B.1
  • 8
    • 0035100888 scopus 로고    scopus 로고
    • Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework
    • Biomarkers Working Group
    • Biomarkers Working Group: Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin.Pharmacol. Ther. 69, 89-95 (2001).
    • (2001) Clin.Pharmacol. Ther. , vol.69 , pp. 89-95
  • 9
    • 34248562343 scopus 로고    scopus 로고
    • Evaluation of felbamate and other antiepileptic drug toxicity potential based on hepatic protein covalent binding and gene expression
    • Leone AM, Kao LM, McMillian MK et al.: Evaluation of felbamate and other antiepileptic drug toxicity potential based on hepatic protein covalent binding and gene expression. Chem. Res. Toxicol. 20, 600-608 (2007).
    • (2007) Chem. Res. Toxicol. , vol.20 , pp. 600-608
    • Leone, A.M.1    Kao, L.M.2    McMillian, M.K.3
  • 10
    • 33751572319 scopus 로고    scopus 로고
    • Predictive models of hepatotoxicity using gene expression data from primary rat hepatocytes
    • Hultin-Rosenberg L, Jagannathan S, Nilsson KC et al.: Predictive models of hepatotoxicity using gene expression data from primary rat hepatocytes. Xenobiotica 36, 1122-1139 (2006).
    • (2006) Xenobiotica , vol.36 , pp. 1122-1139
    • Hultin-Rosenberg, L.1    Jagannathan, S.2    Nilsson, K.C.3
  • 11
    • 84934444321 scopus 로고    scopus 로고
    • Use of traditional end points and gene dysregulation to understand mechanisms of toxicity: Toxicogenomics in mechanistic toxicology
    • Mendrick DL, Mattes WB (Eds). Humana, NJ, USA
    • Buck WR, Waring JF, Blomme EA:. Use of traditional end points and gene dysregulation to understand mechanisms of toxicity: toxicogenomics in mechanistic toxicology. In: Essential Concepts in Toxicogenomics. Mendrick DL, Mattes WB (Eds). Humana, NJ, USA, 23-44 (2008).
    • (2008) Essential Concepts in Toxicogenomics , pp. 23-44
    • Buck, W.R.1    Waring, J.F.2    Blomme, E.A.3
  • 12
    • 33750479344 scopus 로고    scopus 로고
    • Toxicogenomics strategies for predicting drug toxicity
    • Martin R, Rose D, Yu K, Barros S: Toxicogenomics strategies for predicting drug toxicity. Pharmacogenomics 7, 1003-1016 (2006).
    • (2006) Pharmacogenomics , vol.7 , pp. 1003-1016
    • Martin, R.1    Rose, D.2    Yu, K.3    Barros, S.4
  • 13
    • 38949191601 scopus 로고    scopus 로고
    • Molecular pathology in anatomic pathology practice: A review of basic principles
    • Hunt JL: Molecular pathology in anatomic pathology practice: a review of basic principles. Arch. Pathol. Lab. Med. 132, 248-260 (2008).
    • (2008) Arch. Pathol. Lab. Med. , vol.132 , pp. 248-260
    • Hunt, J.L.1
  • 14
    • 38349077745 scopus 로고    scopus 로고
    • From the bench to the clinic and back again: Translational biomarker discovery using in silico mining of pharmacogenomic data
    • Mendrick DL , Daniels KK: From the bench to the clinic and back again: translational biomarker discovery using in silico mining of pharmacogenomic data. Biomarkers Med. 1, 319-333 (2007).
    • (2007) Biomarkers Med. , vol.1 , pp. 319-333
    • Mendrick, D.L.1    Daniels, K.K.2
  • 15
    • 33344454373 scopus 로고    scopus 로고
    • The peripheral blood transcriptome dynamically reflects system wide biology: A potential diagnostic tool
    • Liew CC, Ma J, Tang HC, Zheng R, Dempsey AA: The peripheral blood transcriptome dynamically reflects system wide biology: a potential diagnostic tool. J. Lab. Clin. Med. 147, 126-132 (2006).
    • (2006) J. Lab. Clin. Med. , vol.147 , pp. 126-132
    • Liew, C.C.1    Ma, J.2    Tang, H.C.3    Zheng, R.4    Dempsey, A.A.5
  • 16
    • 33645959506 scopus 로고    scopus 로고
    • Transcriptional profiling of peripheral blood cells in clinical pharmacogenomic studies
    • Excellent article on the use of transcriptomics to identify biomarkers in circulating blood cells
    • Burczynski ME , Dorner AJ: Transcriptional profiling of peripheral blood cells in clinical pharmacogenomic studies. Pharmacogenomics 7, 187-202 (2006). ■■ Excellent article on the use of transcriptomics to identify biomarkers in circulating blood cells.
    • (2006) Pharmacogenomics , vol.7 , pp. 187-202
    • Burczynski, M.E.1    Dorner, A.J.2
  • 17
    • 33846582464 scopus 로고    scopus 로고
    • Genomic profiles of stroke in blood
    • Sharp FR, Xu H, Lit L et al.: Genomic profiles of stroke in blood. Stroke 38, 691-693 (2007).
    • (2007) Stroke , vol.38 , pp. 691-693
    • Sharp, F.R.1    Xu, H.2    Lit, L.3
  • 18
    • 33751020244 scopus 로고    scopus 로고
    • The future of genomic profiling of neurological diseases using blood
    • Sharp FR, Xu H, Lit L et al.: The future of genomic profiling of neurological diseases using blood. Arch. Neurol. 63, 1529-1536 (2006).
    • (2006) Arch. Neurol. , vol.63 , pp. 1529-1536
    • Sharp, F.R.1    Xu, H.2    Lit, L.3
  • 19
    • 18444386162 scopus 로고    scopus 로고
    • Peripheral blood mononuclear cell gene expression profiles identify emergent post-traumatic stress disorder among trauma survivors
    • Segman RH, Shefi N, Goltser-Dubner T, Friedman N, Kaminski N, Shalev AY: Peripheral blood mononuclear cell gene expression profiles identify emergent post-traumatic stress disorder among trauma survivors. Mol. Psychiatry 10, 500-513 (2005).
    • (2005) Mol. Psychiatry , vol.10 , pp. 500-513
    • Segman, R.H.1    Shefi, N.2    Goltser-Dubner, T.3    Friedman, N.4    Kaminski, N.5    Shalev, A.Y.6
  • 20
    • 32944470084 scopus 로고    scopus 로고
    • Molecular classification of Crohn's disease and ulcerative colitis patients using transcriptional profiles in peripheral blood mononuclear cells
    • Burczynski ME, Peterson RL, Twine NC et al.: Molecular classification of Crohn's disease and ulcerative colitis patients using transcriptional profiles in peripheral blood mononuclear cells. J. Mol. Diagn. 8, 51-61 (2006).
    • (2006) J. Mol. Diagn. , vol.8 , pp. 51-61
    • Burczynski, M.E.1    Peterson, R.L.2    Twine, N.C.3
  • 21
    • 36749009126 scopus 로고    scopus 로고
    • Blood gene expression signatures predict exposure levels
    • Interesting article demonstrating the potential of translational, genomic biomarkers
    • Bushel PR, Heinloth AN, Li J et al.: Blood gene expression signatures predict exposure levels. Proc. Natl Acad. Sci. USA 104, 18211-18216 (2007). ■ Interesting article demonstrating the potential of translational, genomic biomarkers.
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 18211-18216
    • Bushel, P.R.1    Heinloth, A.N.2    Li, J.3
  • 22
    • 33644610514 scopus 로고    scopus 로고
    • Noninvasive discrimination of rejection in cardiac allograft recipients using gene expression profiling
    • Deng MC, Eisen HJ, Mehra MR et al.: Noninvasive discrimination of rejection in cardiac allograft recipients using gene expression profiling. Am. J. Transplant. 6, 150-160 (2006).
    • (2006) Am. J. Transplant. , vol.6 , pp. 150-160
    • Deng, M.C.1    Eisen, H.J.2    Mehra, M.R.3
  • 23
    • 34548393200 scopus 로고    scopus 로고
    • Clinical utilities of peripheral blood gene expression profiling in the management of cardiac transplant patients
    • Fang KC: Clinical utilities of peripheral blood gene expression profiling in the management of cardiac transplant patients. J. Immunotoxicol. 4, 209-217 (2007).
    • (2007) J. Immunotoxicol. , vol.4 , pp. 209-217
    • Fang, K.C.1
  • 24
    • 33745904218 scopus 로고    scopus 로고
    • Gene expression in blood changes rapidly in neutrophils and monocytes after ischemic stroke in humans: A microarray study
    • Tang Y, Xu H, Du X et al.: Gene expression in blood changes rapidly in neutrophils and monocytes after ischemic stroke in humans: a microarray study. J. Cereb. Blood Flow Metab. 26, 1089-1102 (2006).
    • (2006) J. Cereb. Blood Flow Metab. , vol.26 , pp. 1089-1102
    • Tang, Y.1    Xu, H.2    Du, X.3
  • 25
    • 19944430313 scopus 로고    scopus 로고
    • Using peripheral blood mononuclear cells to determine a gene expression profile of acute ischemic stroke: A pilot investigation
    • Moore DF, Li H, Jeffries N et al.: Using peripheral blood mononuclear cells to determine a gene expression profile of acute ischemic stroke: a pilot investigation. Circulation 111, 212-221 (2005).
    • (2005) Circulation , vol.111 , pp. 212-221
    • Moore, D.F.1    Li, H.2    Jeffries, N.3
  • 26
    • 46049098369 scopus 로고    scopus 로고
    • Gene expression in peripheral blood differs after cardioembolic compared with large-vessel atherosclerotic stroke: Biomarkers for the etiology of ischemic stroke
    • Xu H, Tang Y, Liu DZ et al.: Gene expression in peripheral blood differs after cardioembolic compared with large-vessel atherosclerotic stroke: biomarkers for the etiology of ischemic stroke. J. Cereb. Blood Flow Metab. 28, 1320-1328 (2008).
    • (2008) J. Cereb. Blood Flow Metab. , vol.28 , pp. 1320-1328
    • Xu, H.1    Tang, Y.2    Liu, D.Z.3
  • 27
    • 63149121152 scopus 로고    scopus 로고
    • Circulating microRNAs, potential biomarkers for drug-induced liver injury
    • Wang K, Zhang S, Marzolf B et al.: Circulating microRNAs, potential biomarkers for drug-induced liver injury. Proc. Natl Acad. Sci. USA 106, 4402-4407 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 4402-4407
    • Wang, K.1    Zhang, S.2    Marzolf, B.3
  • 28
    • 56649120704 scopus 로고    scopus 로고
    • Detection of cell-free, liver-specific mRNAs in peripheral blood from rats with hepatotoxicity: A potential toxicological biomarker for safety evaluation
    • Miyamoto M, Yanai M, Ookubo S, Awasaki N, Takami K, Imai R: Detection of cell-free, liver-specific mRNAs in peripheral blood from rats with hepatotoxicity: a potential toxicological biomarker for safety evaluation. Toxicol. Sci. 106, 538-545 (2008).
    • (2008) Toxicol. Sci. , vol.106 , pp. 538-545
    • Miyamoto, M.1    Yanai, M.2    Ookubo, S.3    Awasaki, N.4    Takami, K.5    Imai, R.6
  • 29
    • 34247366346 scopus 로고    scopus 로고
    • The use of transcriptomic biomarkers for personalized medicine
    • Heidecker B, Hare JM: The use of transcriptomic biomarkers for personalized medicine. Heart Fail. Rev. 12, 1-11 (2007).
    • (2007) Heart Fail. Rev. , vol.12 , pp. 1-11
    • Heidecker, B.1    Hare, J.M.2
  • 30
    • 44649190467 scopus 로고    scopus 로고
    • Multigene ana lysis can discriminate between ulcerative colitis, Crohn's disease, and irritable bowel syndrome
    • von Stein P, Lofberg R, Kuznetsov NV et al.: Multigene ana lysis can discriminate between ulcerative colitis, Crohn's disease, and irritable bowel syndrome. Gastroenterology 134, 1869-1881 (2008).
    • (2008) Gastroenterology , vol.134 , pp. 1869-1881
    • Von Stein, P.1    Lofberg, R.2    Kuznetsov, N.V.3
  • 31
    • 42149107985 scopus 로고    scopus 로고
    • Interlaboratory evaluation of genomic signatures for predicting carcinogenicity in the rat
    • Fielden MR, Nie A, McMillian M et al.: Interlaboratory evaluation of genomic signatures for predicting carcinogenicity in the rat. Toxicol. Sci. 103, 28-34 (2008).
    • (2008) Toxicol. Sci. , vol.103 , pp. 28-34
    • Fielden, M.R.1    Nie, A.2    McMillian, M.3
  • 32
    • 0032512724 scopus 로고    scopus 로고
    • Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury
    • Ichimura T, Bonventre JV, Bailly V et al.: Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury. J. Biol. Chem. 273, 4135-4142 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 4135-4142
    • Ichimura, T.1    Bonventre, J.V.2    Bailly, V.3
  • 33
    • 33748491517 scopus 로고    scopus 로고
    • The MicroArray Quality Control (MAQC) project shows inter- And intraplatform reproducibility of gene expression measurements
    • Shi L, Reid LH, Jones WD et al.: The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements. Nat. Biotechnol. 24, 1151-1161 (2006).
    • (2006) Nat. Biotechnol. , vol.24 , pp. 1151-1161
    • Shi, L.1    Reid, L.H.2    Jones, W.D.3
  • 34
    • 33748495591 scopus 로고    scopus 로고
    • Rat toxicogenomic study reveals analytical consistency across microarray platforms
    • Guo L, Lobenhofer EK, Wang C et al.: Rat toxicogenomic study reveals analytical consistency across microarray platforms. Nat. Biotechnol. 24, 1162-1169 (2006).
    • (2006) Nat. Biotechnol. , vol.24 , pp. 1162-1169
    • Guo, L.1    Lobenhofer, E.K.2    Wang, C.3
  • 35
    • 33748491718 scopus 로고    scopus 로고
    • Performance comparison of one-color and two-color platforms within the MicroArray Quality Control (MAQC) project
    • Patterson TA, Lobenhofer EK, Fulmer-Smentek SB et al.: Performance comparison of one-color and two-color platforms within the MicroArray Quality Control (MAQC) project. Nat. Biotechnol. 24, 1140-1150 (2006).
    • (2006) Nat. Biotechnol. , vol.24 , pp. 1140-1150
    • Patterson, T.A.1    Lobenhofer, E.K.2    Fulmer-Smentek, S.B.3
  • 36
    • 33748503420 scopus 로고    scopus 로고
    • Evaluation of DNA microarray results with quantitative gene expression platforms
    • Canales RD, Luo Y, Willey JC et al.: Evaluation of DNA microarray results with quantitative gene expression platforms. Nat. Biotechnol. 24, 1115-1122 (2006).
    • (2006) Nat. Biotechnol. , vol.24 , pp. 1115-1122
    • Canales, R.D.1    Luo, Y.2    Willey, J.C.3
  • 37
    • 0036007687 scopus 로고    scopus 로고
    • Metabolomics: The link between genotypes and phenotypes
    • Fiehn O: Metabolomics: the link between genotypes and phenotypes. Plant Mol. Biol. 48, 155-171 (2002).
    • (2002) Plant Mol. Biol. , vol.48 , pp. 155-171
    • Fiehn, O.1
  • 38
    • 0032694577 scopus 로고    scopus 로고
    • 'Metabonomics': Understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical ana lysis of biological NMR spectroscopic data
    • Nicholson JK, Lindon JC, Holmes E: 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical ana lysis of biological NMR spectroscopic data. Xenobiotica 29, 1181-1189 (1999).
    • (1999) Xenobiotica , vol.29 , pp. 1181-1189
    • Nicholson, J.K.1    Lindon, J.C.2    Holmes, E.3
  • 40
    • 60849139445 scopus 로고    scopus 로고
    • Metabolic profiling of human colorectal cancer using high-resolution magic angle spinning nuclear magnetic resonance (HR-MAS NMR) spectroscopy and gas chromatography mass spectrometry (GC/MS)
    • Chan EC, Koh PK, Mal M et al.: Metabolic profiling of human colorectal cancer using high-resolution magic angle spinning nuclear magnetic resonance (HR-MAS NMR) spectroscopy and gas chromatography mass spectrometry (GC/MS). J. Proteome Res. 8, 352-361 (2009).
    • (2009) J. Proteome Res. , vol.8 , pp. 352-361
    • Chan, E.C.1    Koh, P.K.2    Mal, M.3
  • 41
    • 60149091657 scopus 로고    scopus 로고
    • Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression
    • Sreekumar A, Poisson LM, Rajendiran TM et al.: Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature 457, 910-914 (2009).
    • (2009) Nature , vol.457 , pp. 910-914
    • Sreekumar, A.1    Poisson, L.M.2    Rajendiran, T.M.3
  • 42
    • 33745823913 scopus 로고    scopus 로고
    • Systems toxicology: Integrated genomic, proteomic and metabonomic ana lysis of methapyrilene induced hepatotoxicity in the rat
    • Craig A, Sidaway J, Holmes E et al.: Systems toxicology: integrated genomic, proteomic and metabonomic ana lysis of methapyrilene induced hepatotoxicity in the rat. J. Proteome Res. 5, 1586-1601 (2006).
    • (2006) J. Proteome Res. , vol.5 , pp. 1586-1601
    • Craig, A.1    Sidaway, J.2    Holmes, E.3
  • 43
    • 34547223504 scopus 로고    scopus 로고
    • The mechanism of galactosamine toxicity revisited; a metabonomic study
    • Coen M, Hong YS, Clayton TA et al.: The mechanism of galactosamine toxicity revisited; a metabonomic study. J. Proteome Res. 6, 2711-2719 (2007).
    • (2007) J. Proteome Res. , vol.6 , pp. 2711-2719
    • Coen, M.1    Hong, Y.S.2    Clayton, T.A.3
  • 44
    • 38149081481 scopus 로고    scopus 로고
    • Metabonomic evaluation of metabolic dysregulation in rats induced by PF 376304, a novel inhibitor of phosphoinositide 3-kinase
    • Robertson DG, Datta K, Wells D et al.: Metabonomic evaluation of metabolic dysregulation in rats induced by PF 376304, a novel inhibitor of phosphoinositide 3-kinase. Chem. Res. Toxicol. 20, 1871-1877 (2007).
    • (2007) Chem. Res. Toxicol. , vol.20 , pp. 1871-1877
    • Robertson, D.G.1    Datta, K.2    Wells, D.3
  • 45
    • 48749108374 scopus 로고    scopus 로고
    • Metabonomics evaluation of urine from rats given acute and chronic doses of acetaminophen using NMR and UPLC/MS
    • Sun J, Schnackenberg LK, Holland RD et al.: Metabonomics evaluation of urine from rats given acute and chronic doses of acetaminophen using NMR and UPLC/MS. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 871, 328-340 (2008).
    • (2008) J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. , vol.871 , pp. 328-340
    • Sun, J.1    Schnackenberg, L.K.2    Holland, R.D.3
  • 46
    • 39149086688 scopus 로고    scopus 로고
    • Aristolochic acid induced changes in the metabolic profile of rat urine
    • Chan W , Cai Z: Aristolochic acid induced changes in the metabolic profile of rat urine. J. Pharm. Biomed. Anal. 46, 757-762 (2008).
    • (2008) J. Pharm. Biomed. Anal. , vol.46 , pp. 757-762
    • Chan, W.1    Cai, Z.2
  • 47
    • 47549093353 scopus 로고    scopus 로고
    • Age-related differences in susceptibility to toxic effects of valproic acid in rats
    • Espandiari P, Zhang J, Schnackenberg LK et al.: Age-related differences in susceptibility to toxic effects of valproic acid in rats. J. Appl. Toxicol. 28, 628-637 (2008).
    • (2008) J. Appl. Toxicol. , vol.28 , pp. 628-637
    • Espandiari, P.1    Zhang, J.2    Schnackenberg, L.K.3
  • 48
    • 39849110282 scopus 로고    scopus 로고
    • Toxicological effects of cinnabar in rats by NMR-based metabolic profiling of urine and serum
    • Wei L, Liao P, Wu H et al.: Toxicological effects of cinnabar in rats by NMR-based metabolic profiling of urine and serum. Toxicol. Appl. Pharmacol. 227, 417-429 (2008).
    • (2008) Toxicol. Appl. Pharmacol. , vol.227 , pp. 417-429
    • Wei, L.1    Liao, P.2    Wu, H.3
  • 50
    • 59149103599 scopus 로고    scopus 로고
    • Evaluations of the trans-sulfuration pathway in multiple liver toxicity studies
    • Schnackenberg LK, Chen M, Sun J et al.: Evaluations of the trans-sulfuration pathway in multiple liver toxicity studies. Toxicol. Appl. Pharmacol. 235, 25-32 (2009).
    • (2009) Toxicol. Appl. Pharmacol. , vol.235 , pp. 25-32
    • Schnackenberg, L.K.1    Chen, M.2    Sun, J.3
  • 52
    • 67049173139 scopus 로고    scopus 로고
    • Discovery of metabolomics biomarkers for early detection of nephrotoxicity
    • Boudonck KJ, Mitchell MW, Nemet L et al.: Discovery of metabolomics biomarkers for early detection of nephrotoxicity. Toxicol. Pathol. 37, 280-292 (2009).
    • (2009) Toxicol. Pathol. , vol.37 , pp. 280-292
    • Boudonck, K.J.1    Mitchell, M.W.2    Nemet, L.3
  • 53
    • 33745111884 scopus 로고    scopus 로고
    • Metabolomic study of cisplatin-induced nephrotoxicity
    • Portilla D, Li S, Nagothu KK et al.: Metabolomic study of cisplatin-induced nephrotoxicity. Kidney Int. 69, 2194-2204 (2006).
    • (2006) Kidney Int. , vol.69 , pp. 2194-2204
    • Portilla, D.1    Li, S.2    Nagothu, K.K.3
  • 54
    • 0037444362 scopus 로고    scopus 로고
    • Contemporary issues in toxicology the role of metabonomics in toxicology and its evaluation by the COMET project
    • Lindon JC, Nicholson JK, Holmes E et al.: Contemporary issues in toxicology the role of metabonomics in toxicology and its evaluation by the COMET project. Toxicol. Appl. Pharmacol. 187, 137-146 (2003).
    • (2003) Toxicol. Appl. Pharmacol. , vol.187 , pp. 137-146
    • Lindon, J.C.1    Nicholson, J.K.2    Holmes, E.3
  • 56
    • 36348960223 scopus 로고    scopus 로고
    • Prediction and classification of drug toxicity using probabilistic modeling of temporal metabolic data: The consortium on metabonomic toxicology screening approach
    • Ebbels TM, Keun HC, Beckonert OP et al.: Prediction and classification of drug toxicity using probabilistic modeling of temporal metabolic data: the consortium on metabonomic toxicology screening approach. J. Proteome Res. 6, 4407-4422 (2007).
    • (2007) J. Proteome Res. , vol.6 , pp. 4407-4422
    • Ebbels, T.M.1    Keun, H.C.2    Beckonert, O.P.3
  • 57
    • 54049147731 scopus 로고    scopus 로고
    • Alzheimer's disease beyond the genomic era: Nuclear magnetic resonance (NMR) spectroscopybased metabolomics
    • Barba I, Fernandez-Montesinos R, Garcia-Dorado D, Pozo D: Alzheimer's disease beyond the genomic era: nuclear magnetic resonance (NMR) spectroscopybased metabolomics. J. Cell Mol. Med. 12, 1477-1485 (2008).
    • (2008) J. Cell Mol. Med. , vol.12 , pp. 1477-1485
    • Barba, I.1    Fernandez-Montesinos, R.2    Garcia-Dorado, D.3    Pozo, D.4
  • 59
    • 46349084465 scopus 로고    scopus 로고
    • Bioinformatics ana lysis of targeted metabolomics - Uncovering old and new tales of diabetic mice under medication
    • Altmaier E, Ramsay SL, Graber A, Mewes HW, Weinberger KM, Suhre K: Bioinformatics ana lysis of targeted metabolomics - uncovering old and new tales of diabetic mice under medication. Endocrinology 149, 3478-3489 (2008).
    • (2008) Endocrinology , vol.149 , pp. 3478-3489
    • Altmaier, E.1    Ramsay, S.L.2    Graber, A.3    Mewes, H.W.4    Weinberger, K.M.5    Suhre, K.6
  • 60
    • 34848857902 scopus 로고    scopus 로고
    • Metabolomics (liver and blood profiling) in a mouse model in response to fasting: A study of hepatic steatosis
    • van Ginneken V, Verhey E, Poelmann R et al.: Metabolomics (liver and blood profiling) in a mouse model in response to fasting: a study of hepatic steatosis. Biochim. Biophys. Acta 1771, 1263-1270 (2007).
    • (2007) Biochim. Biophys. Acta , vol.1771 , pp. 1263-1270
    • Van Ginneken, V.1    Verhey, E.2    Poelmann, R.3
  • 61
    • 33745673138 scopus 로고    scopus 로고
    • The application of NMR-based metabonomics in neurological disorders
    • Holmes E, Tsang TM, Tabrizi SJ: The application of NMR-based metabonomics in neurological disorders. NeuroRx 3, 358-372 (2006).
    • (2006) NeuroRx , vol.3 , pp. 358-372
    • Holmes, E.1    Tsang, T.M.2    Tabrizi, S.J.3
  • 63
    • 0037225665 scopus 로고    scopus 로고
    • Proton nuclear magnetic resonance spectroscopy of body fluids in the field of inborn errors of metabolism
    • Moolenaar SH, Engelke UF, Wevers RA: Proton nuclear magnetic resonance spectroscopy of body fluids in the field of inborn errors of metabolism. Ann. Clin. Biochem. 40, 16-24 (2003).
    • (2003) Ann. Clin. Biochem. , vol.40 , pp. 16-24
    • Moolenaar, S.H.1    Engelke, U.F.2    Wevers, R.A.3
  • 64
    • 63049134550 scopus 로고    scopus 로고
    • Urine metabolomics ana lysis for kidney cancer detection and biomarker discovery
    • Kim K, Aronov P, Zakharkin SO et al.: Urine metabolomics ana lysis for kidney cancer detection and biomarker discovery. Mol. Cell. Proteomics 8, 558-570 (2009).
    • (2009) Mol. Cell. Proteomics , vol.8 , pp. 558-570
    • Kim, K.1    Aronov, P.2    Zakharkin, S.O.3
  • 65
    • 59449097019 scopus 로고    scopus 로고
    • Clinical applications of metabolomics in oncology: A review
    • Spratlin JL, Serkova NJ, Eckhardt SG: Clinical applications of metabolomics in oncology: a review. Clin. Cancer Res. 15, 431-440 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , pp. 431-440
    • Spratlin, J.L.1    Serkova, N.J.2    Eckhardt, S.G.3
  • 66
    • 48949096538 scopus 로고    scopus 로고
    • Metabolomics: A complementary tool in renal transplantation
    • Wishart DS: Metabolomics: a complementary tool in renal transplantation. Contrib. Nephrol. 160, 76-87 (2008).
    • (2008) Contrib. Nephrol. , vol.160 , pp. 76-87
    • Wishart, D.S.1
  • 67
    • 46849088403 scopus 로고    scopus 로고
    • Nuclear magnetic resonance-based metabolomics predicts exercise-induced ischemia in patients with suspected coronary artery disease
    • Barba I, de LG, Martin E et al.: Nuclear magnetic resonance-based metabolomics predicts exercise-induced ischemia in patients with suspected coronary artery disease. Magn. Reson. Med. 60, 27-32 (2008).
    • (2008) Magn. Reson. Med. , vol.60 , pp. 27-32
    • Barba, I.1    De Martin E, L.G.2
  • 68
    • 28044450369 scopus 로고    scopus 로고
    • Proton nuclear magnetic resonance-based metabonomics for rapid diagnosis of meningitis and ventriculitis
    • Coen M, O'Sullivan M, Bubb WA, Kuchel PW, Sorrell T: Proton nuclear magnetic resonance-based metabonomics for rapid diagnosis of meningitis and ventriculitis. Clin. Infect. Dis. 41, 1582-1590 (2005).
    • (2005) Clin. Infect. Dis. , vol.41 , pp. 1582-1590
    • Coen, M.1    O'Sullivan, M.2    Bubb, W.A.3    Kuchel, P.W.4    Sorrell, T.5
  • 71
    • 34249079641 scopus 로고    scopus 로고
    • SiDMAP: A metabolomics approach to assess the effects of drug candidates on the dynamic properties of biochemical pathways
    • Maguire G, Lee P, Manheim D, Boros L: SiDMAP: a metabolomics approach to assess the effects of drug candidates on the dynamic properties of biochemical pathways. Expert Opin. Drug Discov. 1, 351-359 (2006).
    • (2006) Expert Opin. Drug Discov. , vol.1 , pp. 351-359
    • Maguire, G.1    Lee, P.2    Manheim, D.3    Boros, L.4
  • 72
    • 67349273062 scopus 로고    scopus 로고
    • From differentiating metabolites to biomarkers
    • Discusses the need to validate metabolic biomarkers and its associated challenges
    • Koulman A, Lane GA, Harrison SJ, Volmer DA: From differentiating metabolites to biomarkers. Anal. Bioanal. Chem. 394, 663-670 (2009). ■ Discusses the need to validate metabolic biomarkers and its associated challenges.
    • (2009) Anal. Bioanal. Chem. , vol.394 , pp. 663-670
    • Koulman, A.1    Lane, G.A.2    Harrison, S.J.3    Volmer, D.A.4
  • 73
    • 33644835571 scopus 로고    scopus 로고
    • High performance liquid chromatography-mass spectrometry for metabonomics: Potential biomarkers for acute deterioration of liver function in chronic hepatitis B
    • Yang J, Zhao X, Liu X et al.: High performance liquid chromatography-mass spectrometry for metabonomics: potential biomarkers for acute deterioration of liver function in chronic hepatitis B. J. Proteome Res. 5, 554-561 (2006).
    • (2006) J. Proteome Res. , vol.5 , pp. 554-561
    • Yang, J.1    Zhao, X.2    Liu, X.3
  • 74
    • 0027227827 scopus 로고
    • Glycochenodeoxycholate-induced lethal hepatocellular injury in rat hepatocytes. Role of ATP depletion and cytosolic free calcium
    • Spivey JR, Bronk SF, Gores GJ: Glycochenodeoxycholate-induced lethal hepatocellular injury in rat hepatocytes. Role of ATP depletion and cytosolic free calcium. J. Clin. Invest. 92, 17-24 (1993).
    • (1993) J. Clin. Invest. , vol.92 , pp. 17-24
    • Spivey, J.R.1    Bronk, S.F.2    Gores, G.J.3
  • 75
    • 33748316468 scopus 로고    scopus 로고
    • Metabonomics study of intestinal fistulas based on ultraperformance liquid chromatography coupled with Q-TOF mass spectrometry (UPLC/Q-TOF MS)
    • Yin P, Zhao X, Li Q, Wang J, Li J, Xu G: Metabonomics study of intestinal fistulas based on ultraperformance liquid chromatography coupled with Q-TOF mass spectrometry (UPLC/Q-TOF MS). J. Proteome Res. 5, 2135-2143 (2006).
    • (2006) J. Proteome Res. , vol.5 , pp. 2135-2143
    • Yin, P.1    Zhao, X.2    Li, Q.3    Wang, J.4    Li, J.5    Xu, G.6
  • 76
    • 33745209659 scopus 로고    scopus 로고
    • Differential metabolomics reveals ophthalmic acid as an oxidative stress biomarker indicating hepatic glutathione consumption
    • Soga T, Baran R, Suematsu M et al.: Differential metabolomics reveals ophthalmic acid as an oxidative stress biomarker indicating hepatic glutathione consumption. J. Biol. Chem. 281, 16768-16776 (2006).
    • (2006) J. Biol. Chem. , vol.281 , pp. 16768-16776
    • Soga, T.1    Baran, R.2    Suematsu, M.3
  • 77
    • 42649114091 scopus 로고    scopus 로고
    • Metabonomics of acute kidney injury in children after cardiac surgery
    • Beger RD, Holland RD, Sun J et al.: Metabonomics of acute kidney injury in children after cardiac surgery. Pediatr. Nephrol. 23(6), 977-984 (2008).
    • (2008) Pediatr. Nephrol. , vol.23 , Issue.6 , pp. 977-984
    • Beger, R.D.1    Holland, R.D.2    Sun, J.3
  • 78
    • 33750216997 scopus 로고    scopus 로고
    • Metabolomics in monitoring kidney transplants
    • Interesting article that demonstrates how metabolomics analyses can be applied to monitor patients following kidney transplantation
    • Wishart DS: Metabolomics in monitoring kidney transplants. Curr. Opin. Nephrol. Hypertens. 15, 637-642 (2006). ■ Interesting article that demonstrates how metabolomics analyses can be applied to monitor patients following kidney transplantation.
    • (2006) Curr. Opin. Nephrol. Hypertens. , vol.15 , pp. 637-642
    • Wishart, D.S.1
  • 79
    • 0038243866 scopus 로고    scopus 로고
    • An hypothesis for a mechanism underlying hepatotoxin-induced hypercreatinuria
    • Clayton TA, Lindon JC, Everett JR et al.: An hypothesis for a mechanism underlying hepatotoxin-induced hypercreatinuria. Arch. Toxicol. 77, 208-217 (2003).
    • (2003) Arch. Toxicol. , vol.77 , pp. 208-217
    • Clayton, T.A.1    Lindon, J.C.2    Everett, J.R.3
  • 80
    • 1542313741 scopus 로고    scopus 로고
    • Hepatotoxin-induced hypercreatinaemia and hypercreatinuria: Their relationship to one another, to liver damage and to weakened nutritional status
    • Clayton TA, Lindon JC, Everett JR et al.: Hepatotoxin-induced hypercreatinaemia and hypercreatinuria: their relationship to one another, to liver damage and to weakened nutritional status. Arch. Toxicol. 78, 86-96 (2004).
    • (2004) Arch. Toxicol. , vol.78 , pp. 86-96
    • Clayton, T.A.1    Lindon, J.C.2    Everett, J.R.3
  • 81
    • 34249027854 scopus 로고    scopus 로고
    • Evaluation of NMR spectral data of urine in conjunction with measured clinical chemistry and histopathology parameters to assess the effects of liver and kidney toxicants
    • Schnackenberg LK, Dragan YP, Reily MD, Robertson DG, Beger RD: Evaluation of NMR spectral data of urine in conjunction with measured clinical chemistry and histopathology parameters to assess the effects of liver and kidney toxicants. Metabolomics 3, 87-100 (2007).
    • (2007) Metabolomics , vol.3 , pp. 87-100
    • Schnackenberg, L.K.1    Dragan, Y.P.2    Reily, M.D.3    Robertson, D.G.4    Beger, R.D.5
  • 82
    • 57949103373 scopus 로고    scopus 로고
    • Mass spectrometry based metabolomic approaches in urinary biomarker study of women's cancers
    • Woo HM, Kim KM, Choi MH et al.: Mass spectrometry based metabolomic approaches in urinary biomarker study of women's cancers. Clin. Chim. Acta 400, 63-69 (2009).
    • (2009) Clin. Chim. Acta , vol.400 , pp. 63-69
    • Woo, H.M.1    Kim, K.M.2    Choi, M.H.3
  • 83
    • 33749165575 scopus 로고    scopus 로고
    • Metabonomic models of human pancreatic cancer using 1D proton NMR spectra of lipids in plasma
    • Beger R, Schnackenberg L, Holland R, Li D, Dragan Y: Metabonomic models of human pancreatic cancer using 1D proton NMR spectra of lipids in plasma. Metabolomics 2, 125-134 (2006).
    • (2006) Metabolomics , vol.2 , pp. 125-134
    • Beger, R.1    Schnackenberg, L.2    Holland, R.3    Li, D.4    Dragan, Y.5
  • 84
    • 58349109682 scopus 로고    scopus 로고
    • Metabolomic biomarkers in a model of asthma exacerbation: Urine nuclear magnetic resonance
    • Saude EJ, Obiefuna IP, Somorjai RL et al.: Metabolomic biomarkers in a model of asthma exacerbation: urine nuclear magnetic resonance. Am. J. Respir. Crit. Care Med. 179, 25-34 (2009).
    • (2009) Am. J. Respir. Crit. Care Med. , vol.179 , pp. 25-34
    • Saude, E.J.1    Obiefuna, I.P.2    Somorjai, R.L.3
  • 85
    • 58249138618 scopus 로고    scopus 로고
    • Comprehensive two-dimensional gas chromatography/ time-of-flight mass spectrometry for metabonomics: Biomarker discovery for diabetes mellitus
    • Li X, Xu Z, Lu X et al.: Comprehensive two-dimensional gas chromatography/ time-of-flight mass spectrometry for metabonomics: biomarker discovery for diabetes mellitus. Anal. Chim. Acta 633, 257-262 (2009).
    • (2009) Anal. Chim. Acta , vol.633 , pp. 257-262
    • Li, X.1    Xu, Z.2    Lu, X.3
  • 87
    • 34047177929 scopus 로고    scopus 로고
    • Biomarker qualification pilot process at the US Food and Drug Administration
    • Goodsaid FM , Frueh FW: Biomarker qualification pilot process at the US Food and Drug Administration. AAPS J. 9, E105-E108 (2007).
    • (2007) AAPS J. , vol.9
    • Goodsaid, F.M.1    Frueh, F.W.2
  • 88
    • 41149162296 scopus 로고    scopus 로고
    • Metabolomics: A global biochemical approach to drug response and disease
    • Comprehensive article that provides a good overview of metabolomics, including analytical platforms, informatics tools and potential applications of the technology
    • Kaddurah-Daouk R, Kristal BS, Weinshilboum RM: Metabolomics: a global biochemical approach to drug response and disease. Annu. Rev. Pharmacol. Toxicol. 48, 653-683 (2008). ■ Comprehensive article that provides a good overview of metabolomics, including analytical platforms, informatics tools and potential applications of the technology.
    • (2008) Annu. Rev. Pharmacol. Toxicol. , vol.48 , pp. 653-683
    • Kaddurah-Daouk, R.1    Kristal, B.S.2    Weinshilboum, R.M.3
  • 89
    • 50149086997 scopus 로고    scopus 로고
    • Applications of metabolomics in drug discovery and development
    • Wishart DS: Applications of metabolomics in drug discovery and development. Drugs R. D. 9, 307-322 (2008).
    • (2008) Drugs R. D. , vol.9 , pp. 307-322
    • Wishart, D.S.1
  • 91
    • 41049096359 scopus 로고    scopus 로고
    • Quantitative metabolomics using NMR
    • Wishart DS: Quantitative metabolomics using NMR. Trends Analyt. Chem 27, 228-237 (2008).
    • (2008) Trends Analyt. Chem , vol.27 , pp. 228-237
    • Wishart, D.S.1
  • 92
    • 41949108590 scopus 로고    scopus 로고
    • Metabolic profiling as a tool for understanding mechanisms of toxicity
    • Clarke CJ , Haselden JN: Metabolic profiling as a tool for understanding mechanisms of toxicity. Toxicol. Pathol. 36, 140-147 (2008).
    • (2008) Toxicol. Pathol. , vol.36 , pp. 140-147
    • Clarke, C.J.1    Haselden, J.N.2
  • 93
    • 18344396568 scopus 로고    scopus 로고
    • Minimum information about a microarray experiment (MIAME) - Toward standards for microarray data
    • Brazma A, Hingamp P, Quackenbush J et al.: Minimum information about a microarray experiment (MIAME) - toward standards for microarray data. Nat. Genet. 29, 365-371 (2001).
    • (2001) Nat. Genet. , vol.29 , pp. 365-371
    • Brazma, A.1    Hingamp, P.2    Quackenbush, J.3
  • 94
    • 34748838949 scopus 로고    scopus 로고
    • The metabolomics standards initiative (MSI)
    • Fiehn O, Robertson D, Griffin J et al.: The metabolomics standards initiative (MSI). Metabolomics 3, 175-178 (2007).
    • (2007) Metabolomics , vol.3 , pp. 175-178
    • Fiehn, O.1    Robertson, D.2    Griffin, J.3
  • 95
    • 34547778398 scopus 로고    scopus 로고
    • The metabolomics standards initiative
    • Sansone SA, Fan T, Goodacre R et al.: The metabolomics standards initiative. Nat. Biotechnol. 25, 846-848 (2007).
    • (2007) Nat. Biotechnol. , vol.25 , pp. 846-848
    • Sansone, S.A.1    Fan, T.2    Goodacre, R.3
  • 96
    • 20544443149 scopus 로고    scopus 로고
    • The economic implications of noninvasive molecular testing for cardiac allograft rejection
    • Evans RW, Williams GE, Baron HM et al.: The economic implications of noninvasive molecular testing for cardiac allograft rejection. Am. J. Transplant. 5, 1553-1558 (2005).
    • (2005) Am. J. Transplant. , vol.5 , pp. 1553-1558
    • Evans, R.W.1    Williams, G.E.2    Baron, H.M.3
  • 97
    • 64549116875 scopus 로고    scopus 로고
    • Pharmacogenomics, evidence, and the role of payers
    • Deverka PA: Pharmacogenomics, evidence, and the role of payers. Public Health Genomics 12, 149-157 (2009).
    • (2009) Public Health Genomics , vol.12 , pp. 149-157
    • Deverka, P.A.1
  • 98
    • 57749195712 scopus 로고    scopus 로고
    • RNA-Seq: A revolutionary tool for transcriptomics
    • Wang Z, Gerstein M, Snyder M: RNA-Seq: a revolutionary tool for transcriptomics. Nat. Rev. Genet. 10, 57-63 (2009).
    • (2009) Nat. Rev. Genet. , vol.10 , pp. 57-63
    • Wang, Z.1    Gerstein, M.2    Snyder, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.