The economic implications of noninvasive molecular testing for cardiac allograft rejection

American Journal of Transplantation

Volumn 5, Issue 6, 2005, Pages 1553-1558

  Evans, Roger W ^a   Williams, Gavin E ^b   Baron, Helen M ^c   Deng, Mario C ^c   Eisen, Howard J ^d   Hunt, Sharon A ^e   Khan, Mahmud M ^f   Kobashigawa, Jon A ^g   Marton, Eric N ^h   Mehra, Mandeep R ⁱ   Mital, Seema R ^c  

^a XDx Inc ^*

^b XDx Inc   (United States)

^c Och Spine at New York Presbyterian Hospitals   (United States)

^d DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^e STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f TULANE UNIVERSITY   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

^h Cardiovascular Medical Group   (United States)

ⁱ UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Cost; Economics; Endomyocardial biopsy; Gene expression profiling; Heart transplantation; Reimbursement

Indexed keywords

ARTICLE; CARDIAC GRAFT REJECTION; COST CONTROL; ECONOMIC EVALUATION; FOLLOW UP; GENE EXPRESSION PROFILING; HEART MUSCLE BIOPSY; HEART TRANSPLANTATION; HUMAN; LEUKOCYTE; MEDICARE; MULTICENTER STUDY; OUTPATIENT CARE; PRIORITY JOURNAL; REIMBURSEMENT; UNITED STATES;

EID: 20544443149     PISSN: 16006135     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2005.00869.x     Document Type: Article

References (20)

1. Taylor DO, Edwards LB, Boucek MM et al. The Registry of the International Society for Heart and Lung Transplantation: twenty-first official adult heart transplant report- 2004. J Heart Lung Transplant 2004; 23: 796-803.
2. Kirklin JK, Young JB, McGiffin DC. Heart Transplantation. Philadelphia; PA, USA: W.B. Saunders; 2002.
3. Caves PK, Schultz WP, Dong E, Stinson EB, Shumway NE. New instrument for transvenous cardiac biopsy. Am J Cardiol 1974; 33: 264-267.
4. Deckers JW, Hare JM, Baughman KL. Complications of transvenous right ventricular biopsy in adult patient with cardiomyopathy: a seven-year survey of 546 consecutive diagnostic procedures in a tertiary referral center. J Am Coll Cardiol 1992; 19: 43-47.
5. Baraldi-Junkins C, Levin HR, Kasper EK, Rayburn BK, Herskowitz A, Baughman KL. Complications of endomyocardial biopsy in heart transplant patients. J Heart Lung Transplant 1993; 12: 63-67.
6. Bhat G, Burwig S, Walsh R. Morbidity of endomyocardial biopsy in cardiac transplant recipients. Am Heart J 1993; 125: 1180-1181.
7. Winters GL, Marboe CC, Billingham ME. The International Society for Heart and Lung Transplantation grading system for heart transplant biopsy specimens: clarification and commentary. J Heart Lung Transplant 1998; 17: 754-760.
8. Pophal SG, Sigfusson G, Booth KL et al. Complications of endomyocardial biopsy in children. J Am Coll Cardiol 1999; 34: 2105-2110.
9. Mehra MR, Uber PA, Uber WE, Park MH, Scott RL. Anything but a biopsy: noninvasive monitoring for cardiac allograft rejection. Curr Opin Cardiol 2002; 17: 131-136.
10. Kasper EK. Monitoring of cardiac rejection. In: Baumgartner WA, Reitz B, Kasper E, Theodore J, eds. Heart and Lung Transplantation. Philadelphia, PA USA: W.B. Saunders Company; 2002: 246.
11. Eisen HJ, Deng M, Mehra M et al. Non-invasive molecular screening for acute cardiac rejection: a multicenter prospective clinical study. J Heart Lung Transplant 2003; 22: S74.
12. Mehra MR, Kobashigawa J, Hunt S et al. Molecular testing and prediction of clinical outcome in heart transplantation: a prospective multicenter trial. J Heart Lung Transplant 2004; 23: S106.
13. Webber S, Bernstein D, Mital S et al. Discovery and validation of molecular pathways and diagnostic testing for cardiac rejection in children: a multi-center study. J Heart Lung Transplant 2004; 23: S167.
14. Marboe CC, Billingham M, Eisen HJ et al. Refining pathological classification of acute rejection in cardiac allograft recipients: a multicenter study using peripheral blood gene expression profiling. J Heart Lung Transplant 2004; 23: S42.
15. Berman HJ, Kukla SF, Weeks LE. The Financial Management of Hospitals. 8th Edn. Ann Arbor, MI, USA: Health Administration Press; 1994.
16. Finkler SA. Essential Cost Accounting for Health Care Organizations. Gaithersburg, MD USA: Aspen Publishers, Inc.; 1994.
17. Evans RW. Socioeconomic aspects of heart transplantation. Curr Opin Cardiol 1995; 10: 169-179.
18. Evans RW. Economic, actuarial, and contracting perspectives on liver transplantation. In: Maddrey WC, Schiff ER, Sorrell MF, eds. Transplantation of the Liver. Philadelphia, PA, USA: Lippincott Williams & Wilkins; 2000: 479-489.
19. Drummond MF, O'Brien B, Stoddart GL, Torrance GW. Methods for the Economic Evaluation of Health Care Programmes. 2nd Edn. New York, NY, USA: Oxford University Press; 1997.
20. Robinson R. Economic evaluation and health care: costs and cost minimization analysis. BMJ 1993; 307: 726-728.