Clinical utilities of peripheral blood gene expression profiling in the management of cardiac transplant patients

Journal of Immunotoxicology

Volumn 4, Issue 3, 2007, Pages 209-217

  Fang, Kenneth C ^a,b  

^a XDx Inc   (United States)

^b XDx Inc   (United States)

Author keywords

Acute cellular rejection; Cardiac allografts; Gene expression profiling

Indexed keywords

STEROID;

CARDIAC GRAFT REJECTION; CELL DAMAGE; CELL INFILTRATION; CONFERENCE PAPER; DRUG DOSE REDUCTION; DRUG WITHDRAWAL; ELECTROCARDIOGRAM; GENE EXPRESSION; HEART GRAFT; HEART MUSCLE BIOPSY; HUMAN; HUMORAL IMMUNITY; INFLAMMATORY CELL; MUSCLE CELL; PERIPHERAL BLOOD MONONUCLEAR CELL; PHYSICAL EXAMINATION; PRIORITY JOURNAL; UNSPECIFIED SIDE EFFECT;

EID: 34548393200     PISSN: 1547691X     EISSN: 1547691X     Source Type: Journal    
DOI: 10.1080/15476910701385570     Document Type: Conference Paper

References (39)

1. Baraldi-Junkins, C., Levin, H. R., Kasper, E. K., Rayburn, B. K., Herskowitz, A., and Baughman, K. L. 1993. Complications of endomyocardial biopsy in heart transplant patients. J. Heart Lung Transplant. 12:63-67.
2. Bernstein, D., Berry, G., Billingham, M., Marboe, C. C., Deng, M. C., Mital, S., Eisen, H., Williams, G. E., Baron, H. Klingler, T. M., Wohlgemuth, J. G., and Kobashigawa, J. 2007. Gene expression profiling distinguishes moderate to severe from mild acute cellular rejection in cardiac allograft recipients. J. Heart Lung Transplant 26:S115.
3. Bernstein, D., Mital, S., Addonizio, L., Hunt, S., Deng, M. C., Baron, H., Murali, S., Tayama, D. Y., Klingler, T. M., Wohlgemuth, J. G., and Webber, S. 2005. Gene expression profiling of cardiac allograft recipients with mild acute cellular rejection. J. Heart Lung Transplant 24:S65.
4. Bhat, G., Burwig, S., and Walsh, R. 1993. Morbidity of endomyocardial biopsy in cardiac transplant recipients. Am. Heart J. 125:1180-1181.
5. Billingham, M. E., Cary, N. R., Hammond, M. E., Kemnitz, J., Marboe, C., McCallister, H. A., Snovar, D. C., Winters, G. L., and Zerbe, A. 1990. A working formulation for the standardization of nomenclature in the diagnosis of heart and lung rejection: Heart Rejection Study Group. The International Society for Heart Transplantation. J. Heart Transplant 9:587-593.
6. Caves, P. K., Stinson, E. B., Billingham, M. E., and Shumway, N. E. 1974. Serial transvenous biopsy of the transplanted human heart. Improved management of acute rejection episodes. Lancet (7862):821-826.
7. Caves, P. K., Stinson, E. B., Billingham, M. E., and Shumway, N. E. 1973. Percutaneous transvenous endomyocardial biopsy in human heart recipients. Experience with a new technique. Ann. Thorac. Surg. 16:325-336.
8. Deng, M. C., Eisen, H. J., and Mehra, M. R. 2006a. Methodological challenges of genomic research - the CARGO study. Am. J. Transplant 6:1086-1087.
9. Deng, M. C., Eisen, H. J., Mehra, M. R., Billingham, M., Marboe, C. C., Berry, G., Kobashigawa, J., Johnson, F. L., Starling, R. C., Murali, S., Pauly, D. F., Baron, H., Wohlgemuth, J. G., Woodward, R. N., Klingler, T. M., Walther, D., Lal, P. G., Rosenberg, S., and Hunt, S. 2006b. Non-invasive discrimination of rejection in cardiac allograft recipients using gene expression profiling. Am. J. Transplant 6:150-160.
10. Deng, M. C., Mehra, M., Hunt, S., Valantine, H., Miner, R., Phillips, J., Wohlgemuth, J. G., Chernoff, D., Woodward, E., and Eisen, H. J. 2004. Leukocyte gene expression signature of CMV viremia in cardiac allograft recipients is distinct from that seen during allograft rejection. Am. J. Transplant 2004;4e:455.
11. Eisen, H. J., Tuzcu, E. M., Dorent, R., Kobashigawa, J., Mancini, D., Valantinevon Kaeppler, H. A., Starling, R. C., Sorensen, K., Hummel, M., Lind, J. M., Abeywickrama, K. H., and Bernhardt, P. 2003. Everolimus for the prevention of allograft rejection and vasculopathy in cardiac-transplant recipients. N. Engl. J. Med. 349:847-858.
12. Fishman, J. A., and Rubin, R. H. 1998. Infection in organ-transplant recipients. N. Engl. J. Med. 338:1741-1751.
13. Gradek, W. Q., D'Amico, C., Smith, A. L., Vega, D., and Book, W. M. 2001. Routine surveillance endomyocardial biopsy continues to detect significant rejection late after heart transplantation. J. Heart Lung Transplant 20:497-502.
14. Halloran, P. F., Reeve, J., and Kaplan, B. 2006. Lies, damn lies, and statistics: The perils of the P value. Am. J. Transplant. 6:10-11.
15. Hauck, A. J., and Edwards, W. D. 1992. Histopathologic examination of tissues obtained by endomyocardial biopsy. In: Cardiac Biopsy (Faules, R. G. ed.). Mount Kisco, NY: Futura Publishing, pp. 95-153.
16. Horwitz, P. A., Tsai, E. J., Putt, M. E., Gilmore, J. M., Lepore, J. J., Parmacek, M. S., Kao, A. C., Desai, S. S., Goldberg, L. R., Brozena, S. C., Jessup, M. L., Epstein, J. A., and Cappola, T. P. 2004. Detection of cardiac allograft rejection and response to immunosuppressive therapy with peripheral blood gene expression. Circulation 110:3815-3821.
17. Jenner, R. G., and Young, R. A. 2005. Insights into host responses against pathogens from transcriptional profiling. Nat. Rev. Microbiol. 3:281-294.
18. Joshi, A., Masek, M. A., Brown, B. W., Jr., Weiss, L. M., and Billingham, M. E. 1995. "Quilty" revisited: A 10-year perspective. Human Pathol. 26:547-557.
19. Klingenberg, R., Koch, A., Schnabel, P. A., Zimmermann, R., Sack, F. U., Haass, M., and Dengler, T. J. 2003. Allograft rejection of ISHLT grade ≥3A occurring late after heart transplantation - a distinct entity? J. Heart Lung Transplant 22:1005-1013.
20. Kobashigawa, J. A., Miller, L. W., Russell, S. D., Ewald, G. A., Zucker, M. J., Goldberg, L. R., Eisen, H. J., Salm, K., Tolzman, D., Gao, J., Fitzsimmons, W., and First, R. 2006. Tacrolimus with mycophenolate mofetil (MMF) or sirolimus vs. cyclosporine with MMF in cardiac transplant patients: 1-year report. Am. J. Transplant. 6:1377-1386.
21. Marboe, C. C., Billingham, M., Eisen, H., Deng, M. C., Baron, H., Mehra, M., Hunt, S., Wohlgemuth, J., Mahmood, I., Prentice, J., and Berry, G. 2005. Nodular endocardial infiltrates (Quilty lesions) cause significant variability in diagnosis of ISHLT Grade 2 and 3A rejection in cardiac allograft recipients. J. Heart Lung Transplant 24:S219-226.
22. Mehra, M. R., Deng, M. C., Starling, R. C., Murali, S., Lal, P., Cadeiras, M., Baron, H., Rosenberg, S., and Eisen, H. 2007. Does induction therapy influence the utility of gene expression testing for cardiac allograft rejection? J. Heart Lung Transplant 26:S115-116.
23. Mehra, M. R., Kobashigawa, J. A., Deng, M. C., Johnson, F. L., Baron, H. M., Uber, P. A., Lal, P., Klingler, T., Rosenberg, S., and Eisen, H. J. 2006. The clinical role of gene expression testing in anticipating the future development of acute cardiac allograft rejection. J. Heart Lung Transplant 25:S110.
24. Mehra, M. R., Uber, P. A., Uber, W. E., Park, M. H., and Scott, R. L. 2002. Anything but a biopsy: Non-invasive monitoring for cardiac allograft rejection. Curr. Opin. Cardiol. 17:131-136.
25. Nielsen, H., Sorensen, F. B., Nielsen, B., Bagger, J. P., Thayssen, P., and Baandrup, U. 1993. Reproducibility of the acute rejection diagnosis in human cardiac allografts. The Stanford Classification and the International Grading System. J. Heart Lung Transplant 12:239-243.
26. Pardo-Mindan, F. J., and Lozano, M. D. 1991. "Quilty effect" in heart transplantation: Is it related to acute rejection? J. Heart Lung Transplant 10:937-941.
27. Patel, J. K., and Kobashigawa, J. A. 2006. Should we be doing routine biopsy after heart transplantation in a new era of anti-rejection? Curr. Opin. Cardiol. 21:127-131.
28. Riegelman R. K. (Ed.) 2005a. Results. In: Studying a Study & Testing a Test. Philadelphia: Lippincott Williams and Wilkins, pp. 157-163.
29. Riegelman, R. K. (Ed.) 2005b. Interpretation. In: Studying A Study & Testing a Test. Philadelphia: Lippincott Williams and Wilkins, pp. 164-171.
30. Rosenbaum, D. H., Adams, B. C., Mitchell, J. D., Jessen, M. E., Paul, M. C., Kaiser, P. A., Pappas, P. A., Meyer, D. M., Wait, M. A., Drazner, M. H., Yancy, C. W., Jr. Ring, W. S., and DiMaio, J. M. 2006. Effects of early steroid withdrawal after heart transplantation. Ann. Thor. Surg. 82:637-644.
31. Schoels, M., Dengler, T. J., Richter, R., Meuer, S. C., and Giese, T. 2004. Detection of cardiac allograft rejection by real-time PCR analysis of circulating mononuclear cells. Clin. Transplant 18:513-517.
32. Starling, R. C., Pham, M., Valantine, H., Miller, L., Eisen, H., Rodriguez, E. R., Taylor, D. O., Yamani, M. H., Kobashigawa, J., McCurry, K., Marboe, C., Mehra, M. R., Zuckerman, A., and Deng, M. C. 2006. Molecular testing in the management of cardiac transplant recipients: Initial clinical experience. J. Heart Lung Transplant 25:1389-1395.
33. Stewart, S., Winters, G. L., Fishbein, M. C., Tazelaar, H. D., Kobashigawa, J., Abrams, J., Andersen, C. B., Angelini, A., Berry, G. J., Burke, M. M., Demetris, A. J., Hammond, E., Itescu, S., Marboe, C. C., Bruce McManus, B., Reed, E. F., Reinsmoen, N. L., Rodriguez, E. R., Rose, A. G., Rose, M., Suciu-Focia, N., Zeevi, A. and Billingham, M. E. 2005. Revision of the 1990 working formulation for the standardization of nomenclature in the diagnosis of heart rejection. J. Heart Lung Transplant 24:1710-1720.
34. Subherwal, S., Kobashigawa, J. A., Cogert, G., Patel, J., Espejo, M., and Oeser, B. 2004. Incidence of acute cellular rejection and noncellular rejection in cardiac transplantation. Transplant Proc. 36:3171-3172.
35. Williams, M. J., Lee, M. Y., DiSalvo, T. G., Dec, G. W., Picard, M. H., Palacios, I. F., and Semigran, M. J. 1996. Biopsy-induced flail tricuspid leaflet and tricuspid regurgitation following orthotopic cardiac transplantation. Am. J. Cardiol. 77:1339-1344.
36. Winters, G. L., and McManus, B. M. 1996. Consistencies and controversies in the application of the International Society for Heart and Lung Transplantation working formulation for heart transplant biopsy specimens. Rapamycin Cardiac Rejection Treatment Trial Pathologists. J. Heart Lung Transplant 15:728-735.
37. Yamani, M. H., Rodriguez, R., Cook, D. J., Wohlgemuth, J. G., McNeill, A., Zhou, L., Taylor, D. O., Hobbs, R., Young, J. B., Smedira, N., and Starling, R. C. 2005. Transplant vasculopathy is associated with increased AlloMap gene expression score. Circulation 112:457.
38. Zamora, M. R., Davis, R. D., and Leonard, C. 2005. Management of cytomegalovirus infection in lung transplant recipients: Evidence-based recommendations. Transplantation 80:157-163.
39. Zeevi, A., Dedrick, R. L., Rosenberg, S., Starling, R. C., Cadeiras, M., and Deng, M. C. 2006. Gene expression profiles of peripheral blood cells in acute cellular cardiac rejection reflect multiple molecular pathways. J. Heart Lung Transplant 25:S140-141.