Hepatotoxin-induced hypercreatinaemia and hypercreatinuria: Their relationship to one another, to liver damage and to weakened nutritional status

Archives of Toxicology

Volumn 78, Issue 2, 2004, Pages 86-96

  Clayton, T Andrew ^a   Lindon, John C ^a   Everett, Jeremy R ^b   Charuel, Claude ^c   Hanton, Gilles ^c   Le Net, Jean Loic ^c   Provost, Jean Pierre ^c   Nicholson, Jeremy K ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^c PFIZER INC   (United States)

Author keywords

Creatine; Hepatotoxin; Hypercreatinaemia; Hypercreatinuria; NMR

Indexed keywords

1 NAPHTHYL ISOTHIOCYANATE; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CHLORPROMAZINE; CREATININE; ETHIONINE; FORMIC ACID DERIVATIVE; THIOACETAMIDE;

AMINOACIDEMIA; AMINOACIDURIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORRELATION COEFFICIENT; CREATININE BLOOD LEVEL; CREATININE URINE LEVEL; ENZYME ACTIVITY; HYPERCREATINEMIA; HYPERCREATINURIA; KETOACIDOSIS; LIVER INJURY; LIVER NECROSIS; LIVER TOXICITY; MALE; NONHUMAN; NUTRITIONAL STATUS; PLASMA; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; RAT STRAIN; STEATOSIS; URINALYSIS;

ADMINISTRATION, ORAL; ANIMALS; CREATININE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HEPATITIS, TOXIC; INJECTIONS, INTRAPERITONEAL; MAGNETIC RESONANCE SPECTROSCOPY; MALE; NUTRITION DISORDERS; RATS; TOXINS, BIOLOGICAL;

ANIMALIA;

EID: 1542313741     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-003-0515-2     Document Type: Article

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