Alzheimer's disease beyond the genomic era: Nuclear magnetic resonance (NMR) spectroscopy-based metabolomics

Journal of Cellular and Molecular Medicine

Volumn 12, Issue 5A, 2008, Pages 1477-1485

  Barba, Ignasi ^a   Fernandez Montesinos, Rafael ^b   Garcia Dorado, David ^a   Pozo, David ^b  

^a HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^b UNIVERSITY OF SEVILLE   (Spain)

Author keywords

1H NMR; Alzheimer's Disease; Biomarkers; Metabolomics; Metabonomics; Neurodegenerative disease; Pattern recognition; Systems biology

Indexed keywords

ALZHEIMER DISEASE; ANIMAL; DISEASE MODEL; GENETICS; GENOME; HUMAN; METABOLISM; METABOLOMICS; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; REVIEW;

ALZHEIMER DISEASE; ANIMALS; DISEASE MODELS, ANIMAL; GENOME; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; METABOLOMICS;

ANIMALIA;

EID: 54049147731     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2008.00385.x     Document Type: Review

References (67)

1. Popescu BO. Still debating a cause and diagnostic criteria for Alzheimer's disease. J Cell Mol Med. 2007 11 : 1225 6.
2. Bird TD. Genetic factors in Alzheimer's disease. N Engl J Med. 2005 352 : 862 4.
3. Bird TD. Genetic aspects of Alzheimer disease. Genet Med. 2008 10 : 231 9.
4. Blair CK, Folsom AR, Knopman DS, Bray MS, Mosley TH, Boerwinkle E. ApoE genotype and cognitive decline in a middle-aged cohort. Neurology 2005 64 : 268 76.
5. Kozauer NA, Mielke MM, Chan GK, Rebok GW, Lyketsos CG. Apolipoprotein E genotype and life-time cognitive decline. Int Psychogeriatr. 2008 20 : 109 23.
6. Cosentino S, Scarmeas N, Helzner E, Glymour MM, Brandt J, Albert M, Blacker D, Stern Y. ApoE epsilon 4 allele predicts faster cognitive decline in mild Alzheimer disease. Neurology. 2008 70 : 1842 9.
7. Brickell KL, Steinbart EJ, Rumbaugh M, Payami H, Schellenberg GD, Van Deerlin V, Yuan W, Bird TD. Early-onset Alzheimer disease in families with late-onset Alzheimer disease: a potential important subtype of familial Alzheimer disease. Arch Neurol. 2006 63 : 1307 11.
8. Bertram L, McQueen MB, Mullin K, Blacker D, Tanzi RE. Systematic meta-analyses of Alzheimer disease genetic association studies: the ALZgene database. Nat Genet. 2007 39 : 17 23.
9. Jellinger KA, Janetzky B, Attems J, Kienzl E. Biomarkers for early diagnosis of Alzheimer disease: "Alzheimer associated gene" - a new blood biomarker? J Cell Mol Med. 2008.
10. Shaw LM, Korecka M, Clark CM, Lee VM, Trojanowski JQ. Biomarkers of neurode-generation for diagnosis and monitoring therapeutics. Nat Rev Drug Discov. 2007 6 : 295 303.
11. Oliver SG, Winson MK, Kell DB, Baganz F. Systematic functional analysis of the yeast genome. Trends Biotechnol. 1998 16 : 373 8.
12. Nicholson JK, Holmes E, Wilson ID. Gut microorganisms, mammalian metabolism and personalized health care. Nat Rev Microbiol. 2005 3 : 431 8.
13. Griffin JL. Understanding mouse models of disease through metabolomics. Curr Opin Chem Biol. 2006 10 : 309 15.
14. Raamsdonk LM, Teusink B, Broadhurst D, Zhang N, Hayes A, Walsh MC, Berden JA, Brindle KM, Kell DB, Rowland JJ, Westerhoff HV, van Dam K, Oliver SG. A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations. Nat Biotechnol. 2001 19 : 45 50.
15. Allen J, Davey HM, Broadhurst D, Heald JK, Rowland JJ, Oliver SG, Kell DB. High-throughput classification of yeast mutants for functional genomics using metabolic footprinting. Nat Biotechnol. 2003 21 : 692 6.
16. Fiehn O, Kopka J, Dormann P, Altmann T, Trethewey RN, Willmitzer L. Metabolite profiling for plant functional genomics. Nat Biotechnol. 2000 18 : 1157 61.
17. Jones GL, Sang E, Goddard C, Mortishire-Smith RJ, Sweatman BC, Haselden JN, Davies K, Grace AA, Clarke K, Griffin JL. A functional analysis of mouse models of cardiac disease through metabolic profiling. J Biol Chem. 2005 280 : 7530 9.
18. Mendes P, Kell DB, Westerhoff HV. Why and when channelling can decrease pool size at constant net flux in a simple dynamic channel. Biochim Biophys Acta. 1996 1289 : 175 86.
19. Urbanczyk-Wochniak E, Luedemann A, Kopka J, Selbig J, Roessner-Tunali U, Willmitzer L, Fernie AR. Parallel analysis of transcript and metabolic profiles: a new approach in systems biology. EMBO Rep. 2003 4 : 989 93.
20. Coen M, Holmes E, Lindon JC, Nicholson JK. NMR-based metabolic profiling and metabolonomic approaches to problems in molecular toxicology. Chem Res Toxicol. 2008 21 : 9 27.
21. Sabatine MS, Liu E, Morrow DA, Heller E, McCarroll R, Wiegand R, Berriz GF, Roth FP, Gerszten RE. Metabolomic identification of novel biomarkers of myocar-dial ischemia. Circulation. 2005 112 : 3868 75.
22. Preul MC, Caramanos Z, Collins DL, Villemure JG, Leblanc R, Olivier A, Pokrupa Rarnold DL. Accurate, noninva-sive diagnosis of human brain tumors by using proton magnetic resonance spec-troscopy. Nat Med. 1996 2 : 323 5.
23. Majos C, Julia-Sape M, Alonso J, Serrallonga M, Aguilera C, Acebes JJ, Arus C, Gili J. Brain tumor classification by proton MR spectroscopy: comparison of diagnostic accuracy at short and long TE. AJNR Am J Neuroradiol. 2004 25 : 1696 704.
24. Mueller SG, Schuff N, Weiner MW. Evaluation of treatment effects in Alzheimer's and other neurodegenerative diseases by MRI and MRS. NMR Biomed. 2006 19 : 655 68.
25. Beckonert O, Keun HC, Ebbels TM, Bundy J, Holmes E, Lindon JC, Nicholson JK. Metabolic profiling, metabolomic and metabonomic procedures for NMR spec-troscopy of urine, plasma, serum and tissue extracts. Nat Protoc. 2007 2 : 2692 703.
26. Shonk TK, Moats RA, Gifford P, Michaelis T, Mandigo JC, Izumi J, Ross BD. Probable Alzheimer disease: diagnosis with proton MR spectroscopy. Radiology. 1995 195 : 65 72.
27. Dedeoglu A, Choi JK, Cormier K, Kowall NW, Jenkins BG. Magnetic resonance spectroscopic analysis of Alzheimer's disease mouse brain that express mutant human APP shows altered neurochemical profile. Brain Res. 2004 1012 : 60 5.
28. Moffett JR, Namboodiri MA, Cangro CB, Neale JH. Immunohistochemical localization of n-acetylaspartate in rat brain. Neuroreport. 1991 2 : 131 4.
29. Simmons ML, Frondoza CG, Coyle JT. Immunocytochemical localization of n-acetyl-aspartate with monoclonal antibodies. Neuroscience. 1991 45 : 37 45.
30. Baslow M. N-acetylaspartate in the vertebrate brain: metabolism and function. Neurochem Res. 2003 28 : 941 53.
31. Choi JK, Dedeoglu A, Jenkins BG. Application of MRS to mouse models of neurodegenerative illness. NMR Biomed. 2007 20 : 216 37.
32. Brand A, Richter-Landsberg C, Leibfritz D. Multinuclear NMR studies on the energy metabolism of glial and neuronal cells. Dev Neurosci. 1993 15 : 289 98.
33. Firbank MJ, Harrison RM, O'Brien JT. A comprehensive review of proton magnetic resonance spectroscopy studies in dementia and Parkinson's disease. Dement Geriatr Cogn Disord. 2002 14 : 64 76.
34. Karrenbauer VD, Leoni V, Lim ET, Giovannoni G, Ingle GT, Sastre-Garriga J, Thompson AJ, Rashid W, Davies G, Miller DH, Bjorkhem I, Masterman T. Plasma cerebrosterol and magnetic resonance imaging measures in multiple sclerosis. Clin Neurol Neurosurg. 2006 108 : 456 60.
35. Griffin JL, Salek RM. Metabolomic applications to neuroscience: more challenges than chances? Expert Rev Proteomics. 2007 4 : 435 7.
36. Marjanska M, Curran GL, Wengenack TM, Henry PG, Bliss RL, Poduslo JF, Jack CR Jr., Ugurbil K, Garwood M. Monitoring disease progression in transgenic mouse models of Alzheimer's disease with proton magnetic resonance spectroscopy. Proc Natl Acad Sci USA. 2005 102 : 11906 10.
37. 1H-MRS changes in mild cognitive impairment and Alzheimer's disease. Neurobiol Aging. 2007 28 : 1330 39.
38. von Kienlin M, Kunnecke B, Metzger F, Steiner G, Richards JG, Ozmen L, Jacobsen H, Loetscher H. Altered metabolic profile in the frontal cortex of PS2APP trans-genic mice, monitored throughout their life span. Neurobiol Dis. 2005 18 : 32 9.
39. Cheng LL, Ma MJ, Becerra L, Ptak T, Tracey I, Lackner A, Gonzalez RG. Quantitative neuropathology by high resolution magic angle spinning proton magnetic resonance spectroscopy. Proc Natl Acad Sci USA. 1997 94 : 6408 13.
40. Cheng LL, Newell K, Mallory AE, Hyman BT, Gonzalez RG. Quantification of neurons in Alzheimer and control brains with ex vivo high resolution magic angle spinning proton magnetic resonance spec-troscopy and stereology. Magn Reson Imaging. 2002 20 : 527 33.
41. Griffin JL, Cemal CK, Pook MA. Defining a metabolic phenotype in the brain of a transgenic mouse model of spinocerebel-lar ataxia 3. Physiol Genomics. 2004 16 : 334 40.
42. 1H NMR-based metabolomics indicates a neurotransmitter cycling deficit in cerebral tissue from a mouse model of batten disease. J Biol Chem. 2005 280 : 42508 14.
43. Salek RM, Colebrooke RE, Macintosh R, Lynch PJ, Sweatman BC, Emson PC, Griffin JL. A metabolomic study of brain tissues from aged mice with low expression of the vesicular monoamine transporter 2 (VMAT2) gene. Neurochem Res. 2008 33 : 292 300.
44. Crowther DC, Page R, Chandraratna D, Lomas DA. A Drosophila model of Alzheimer's disease. Methods Enzymol. 2006 412 : 234 55.
45. Adalsteinsson E, Sullivan EV, Kleinhans N, Spielman DM, Pfefferbaum A. Longitudinal decline of the neuronal marker n-acetyl aspartate in Alzheimer's disease. Lancet. 2000 355 : 1696 7.
46. Block W, Jessen F, Traber F, Flacke S, Manka C, Lamerichs R, Keller E, Heun R, Schild H. Regional n-acetylaspartate reduction in the hippocampus detected with fast proton magnetic resonance spectroscopic imaging in patients with Alzheimer disease. Arch Neurol. 2002 59 : 828 34.
47. Rami L, Gomez-Anson B, Bosch B, Sanchez-Valle R, Monte GC, Villar A, Molinuevo JL. Cortical brain metabolism as measured by proton spectroscopy is related to memory performance in patients with amnestic mild cognitive impairment and Alzheimer's disease. Dement Geriatr Cogn Disord. 2007 24 : 274 9.
48. Miller BL, Moats RA, Shonk T, Ernst T, Woolley S, Ross BD. Alzheimer disease: depiction of increased cerebral myo-inosi-tol with proton MR spectroscopy. Radiology. 1993 187 : 433 7.
49. 31P MRS of PCA extracts of postmortem Alzheimer's disease brain. Neurobiol Aging. 1996 17 : 349 57.
50. Pettegrew J, Klunk W, Panchalingam K, McClure R, Stanley J. Magnetic resonance spectroscopic changes in Alzheimer's disease. Ann NY Acad Sci. 1997 826 : 282 306.
51. 1H magnetic resonance spectroscopy. Eur J Neurol. 2004 11 : 187 93.
52. Modrego PJ, Fayed N, Pina MA. Conversion from mild cognitive impairment to probable Alzheimer's disease predicted by brain magnetic resonance spec-troscopy. Am J Psychiatry. 2005 162 : 667 75.
53. Godbolt AK, Waldman AD, MacManus DG, Schott JM, Frost C, Cipolotti L, Fox NC, Rossor MN. MRS shows abnormalities before symptoms in familial Alzheimer disease. Neurology. 2006 66 : 718 22.
54. Schuff N, Capizzano AA, Du AT, Amend DL, O'Neill J, Norman D, Kramer J, Jagust W, Miller B, Wolkowitz OM, Yaffe K, Weiner MW. Selective reduction of n-acetylaspartate in medial temporal and parietal lobes in ad. Neurology. 2002 58 : 928 35.
55. 1H magnetic resonance spectro-scopic metabolite phenotypes. Neuroreport. 1996 7 : 1597 600.
56. Griffin JL, Kauppinen RA. A metabolomics perspective of human brain tumours. FEBS J. 2007 274 : 1132 9.
57. Kell DB. Metabolomics and systems biology: making sense of the soup. Curr Opin Microbiol. 2004 7 : 296 307.
58. Kell DB. Systems biology, metabolic modelling and metabolomics in drug discovery and development. Drug Discov Today. 2006 11 : 1085 92.
59. Oliver SG. From genomes to systems: the path with yeast. Philos Trans R Soc Lond B Biol Sci. 2006 361 : 477 82.
60. Barba I, Jaimez-Auguets E, Rodriguez-Sinovas A, Garcia-Dorado D. (1)H NMR-based metabolomic identification of at-risk areas after myocardial infarction in swine. Magma. 2007 20 : 265 71.
61. Jeong H, Tombor B, Albert R, Oltvai ZN, Barabasi AL. The large-scale organization of metabolic networks. Nature. 2000 407 : 651 4.
62. 1H-NMR-based metabonomics. Nat Med. 2002 8 : 1439 44.
63. 1H NMR spectroscopy of urine combined with pattern recognition. NMR Biomed. 1998 11 : 235 44.
64. Cheng LL, Lean CL, Bogdanova A, Wright SC Jr., Ackerman JL, Brady TJ, Garrido L. Enhanced resolution of proton NMR spectra of malignant lymph nodes using magic-angle spinning. Magn Reson Med. 1996 36 : 653 8.
65. Ebbels TM, Keun HC, Beckonert OP, Bollard ME, Lindon JC, Holmes E, Nicholson JK. Prediction and classification of drug toxicity using probabilistic modeling of temporal metabolic data: the consortium on metabonomic toxicology screening approach. J Proteome Res. 2007 6 : 4407 22.
66. Eriksson L, Antti H, Gottfries J, Holmes E, Johansson E, Lindgren F, Long I, Lundstedt T, Trygg J, Wold S. Using chemometrics for navigating in the large data sets of genomics, proteomics, and metabonomics (gpm). Anal Bioanal Chem. 2004 380 : 419 29.
67. Craig A, Cloarec O, Holmes E, Nicholson JK, Lindon JC. Scaling and normalization effects in NMR spectroscopic metabonomic data sets. Anal Chem. 2006 78 : 2262 7.