Induction of Cyp1a1 and Cyp1b1 and formation of DNA adducts in C57BL/6, Balb/c, and F1 mice following in utero exposure to 3-methylcholanthrene

Toxicology and Applied Pharmacology

Volumn 209, Issue 1, 2005, Pages 28-38

  Xu, Mian ^a,d   Nelson, Garret B ^b   Moore, Joseph E ^a   McCoy, Thomas P ^a   Dai, Jian ^c   Manderville, Richard A ^c   Ross, Jeffrey A ^b   Miller, Mark Steven ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^c WAKE FOREST UNIVERSITY   (United States)

^d H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

3 methylcholanthrene; Cyp1a1; Cyp1b1; DNA adducts; Fetus; Lung tumors; Transplacental carcinogenesis

Indexed keywords

3 METHYLCHOLANTHRENE; CYTOCHROME P450 1A1; CYTOCHROME P450 1B1; DNA; PHOSPHORUS 32; RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; DEVELOPMENTAL STAGE; DNA ADDUCT; DNA REPAIR; FEMALE; FETUS LIVER; FETUS LUNG; FLUORESCENCE ANALYSIS; GENETIC SUSCEPTIBILITY; GESTATION PERIOD; HEREDITY; KINETICS; MALE; METABOLISM; MOUSE STRAIN; MUTATIONAL ANALYSIS; NONHUMAN; PLACENTAL TRANSFER; PROTEIN INDUCTION; QUANTITATIVE ANALYSIS; REACTION TIME; REAL TIME POLYMERASE CHAIN REACTION; STATISTICAL SIGNIFICANCE; STRAIN DIFFERENCE; TIME SERIES ANALYSIS; TRANSPLACENTAL CARCINOGENESIS;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CYTOCHROME P-450 CYP1A1; DNA ADDUCTS; DNA MUTATIONAL ANALYSIS; DNA, COMPLEMENTARY; ENZYME INDUCTION; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENES, RAS; LIVER; LUNG; METHYLCHOLANTHRENE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, INBRED STRAINS; PREGNANCY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA;

ANIMALIA;

EID: 27544464194     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2005.03.012     Document Type: Article

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