Human CYP1A1GFP expression in transgenic mice serves as a biomarker for environmental toxicant exposure

Toxicological Sciences

Volumn 95, Issue 1, 2007, Pages 98-107

  Operaña, Theresa N ^a   Nguyen, Nghia ^a   Chen, Shujuan ^a   Beaton, Deirdre ^a   Tukey, Robert H ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Ah receptor; CYPIAI; Flourescent; Gene expression; TCDD; UGT

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON RECEPTOR; BENZO[A]PYRENE; BIOLOGICAL MARKER; CYTOCHROME P450 1A1; FLUORESCENT DYE; GREEN FLUORESCENT PROTEIN; XENOBIOTIC AGENT; 3 METHYLCHOLANTHRENE; BETA NAPHTHOFLAVONE; BILIRUBIN URIDINE DIPHOSPHOGLUCURONOSYL TRANSFERASE 1A1; BILIRUBIN URIDINE-DIPHOSPHOGLUCURONOSYL TRANSFERASE 1A1; GLUCURONOSYLTRANSFERASE; HYBRID PROTEIN;

ARTICLE; CELL CULTURE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; ENZYME INDUCTION; ENZYME REGULATION; FIRST PASS EFFECT; FLUORESCENCE ANALYSIS; GASTROINTESTINAL TRACT; GENE CONTROL; GENE LOCUS; HUMAN; HUMAN CELL; IN VIVO STUDY; LIVER CELL; LIVER CIRCULATION; LIVER PARENCHYMA; LUNG PARENCHYMA; MOUSE; NONHUMAN; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; REPORTER GENE; SENSITIVITY ANALYSIS; TOXICITY TESTING; TRANSGENIC MOUSE; WESTERN BLOTTING; XENOBIOTIC METABOLISM; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; DRUG EFFECT; ENVIRONMENTAL MONITORING; ENZYMOLOGY; FLUORESCENCE MICROSCOPY; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; GENETICS; LIVER; LUNG; METABOLISM; METHODOLOGY; POLLUTANT; TUMOR CELL LINE;

MUS MUSCULUS;

ANIMALS; BENZO(A)PYRENE; BETA-NAPHTHOFLAVONE; BIOLOGICAL MARKERS; BLOTTING, WESTERN; CELL LINE, TUMOR; CELLS, CULTURED; CYTOCHROME P-450 CYP1A1; ENVIRONMENTAL MONITORING; ENVIRONMENTAL POLLUTANTS; ENZYME INDUCTION; GLUCURONOSYLTRANSFERASE; GREEN FLUORESCENT PROTEINS; HEPATOCYTES; HUMANS; LIVER; LUNG; METHYLCHOLANTHRENE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROSCOPY, FLUORESCENCE; RECEPTORS, ARYL HYDROCARBON; RECOMBINANT FUSION PROTEINS; TETRACHLORODIBENZODIOXIN; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 33845637779     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfl144     Document Type: Article

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