Omeprazole transactivates human CYP1A1 and CYP1A2 expression through the common regulatory region containing multiple xenobiotic-responsive elements

Biochemical Pharmacology

Volumn 76, Issue 1, 2008, Pages 139-145

  Yoshinari, Kouichi ^a   Ueda, Rika ^a,b   Kusano, Kazutomi ^b   Yoshimura, Tsutomu ^b   Nagata, Kiyoshi ^a   Yamazoe, Yasushi ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b EISAI CO LTD   (Japan)

Author keywords

Aryl hydrocarbon receptor; CYP1A1; CYP1A2; Gene transcription; Omeprazole

Indexed keywords

3 METHYLCHOLANTHRENE; ALBENDAZOLE; AROMATIC HYDROCARBON RECEPTOR; BETA NAPHTHOFLAVONE; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; LANSOPRAZOLE; OMEPRAZOLE; PRIMAQUINE;

ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; ENZYME INDUCTION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSACTIVATION;

CARCINOMA, HEPATOCELLULAR; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP1A2; ENZYME INDUCTION; HUMANS; LIVER; LIVER NEOPLASMS; OMEPRAZOLE; REGULATORY SEQUENCES, NUCLEIC ACID; TRANS-ACTIVATION (GENETICS); XENOBIOTICS;

EID: 45049083306     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2008.04.005     Document Type: Article

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