In vitro binding and in vivo biodistribution studies of the neuroprotective peptide humanin using [125I]humanin derivatives

Peptides

Volumn 30, Issue 12, 2009, Pages 2409-2417

  Evangelou, Alexandra ^a   Zikos, Christos ^a,b   Benaki, Dimitra ^a   Pelecanou, Maria ^a   Bouziotis, Penelope ^a   Papadopoulos, Minas ^a   Borovickova, Lenka ^c   Vesela, Iva ^c   Elbert, Tomas ^c   Kunešová, Gabriela ^d   Pirmettis, Ioannis ^a   Paravatou Petsotas, Maria ^a   Slaninová, Jirina ^c   Livaniou, Evangelia ^a  

^a INSTITUTE OF NANOSCIENCE AND NANOTECHNOLOGY   (Greece)

^b Biomedica Life Sciences   (Greece)

^c INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

^d UNIVERSITY OF DEFENCE   (Czech Republic)

Author keywords

125I Radiolabeling; Humanin derivatives; In vitro cell binding; In vivo biodistribution; Metabolic stability; Neuroprotective peptides

Indexed keywords

HUMANIN; IODINE 125; QUINUCLIDINYL BENZILATE; TYROSINE; TYROSYLPROLYLALANYLGLYCYLALANYLSERYLARGINYLLEUCYLLEUCYLLEUCYLLEUCYLTHREONYLGLYCYLGLUTAMYLISOLEUCYLASPARTYLLEUCYLPROLINE; TYROSYLPROLYLALANYLGLYCYLALANYLSERYLARGINYLLEUCYLLEUCYLLEUCYLTHREONYLGLYCYLGLUTAMYLISOLEUCYLASPARTYLLEUCYLPROLINE; TYROSYLSERYLALANYLLEUCYLLEUCYLARGINYLSERYLISOLEUCYLPROLYLALANYLPROLYLALANYLGLYCYLALANYLSERYLARGINYLLEUCYLLEUCYLLEUCYLLEUCYLTHREONYLGLYCYLGLUTAMYLISOLEUCYLASPARTYLLEUCYLPROLINE; TYROSYLSERYLALANYLLEUCYLLEUCYLARGINYLSERYLISOLEUCYLPROLYLALANYLPROLYLALANYLGLYCYLALANYLSERYLARGINYLLEUCYLLEUCYLLEUCYLTHREONYLGLYCYLGLUTAMYLISOLEUCYLASPARTYLLEUCYLPROLINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING KINETICS; BINDING SITE; BRAIN MEMBRANE; BRAIN TISSUE; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG METABOLISM; DRUG POTENCY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; ISOTOPE LABELING; MALE; MAZE TEST; MEMORY CONSOLIDATION; MEMORY DISORDER; MOUSE; NERVE CELL CULTURE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; RAT; SOLID PHASE SYNTHESIS; SPATIAL ORIENTATION; STOMACH MUCOSA;

ANIMALS; CELL LINE; CHROMATOGRAPHY, THIN LAYER; FEMALE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; IODINE RADIOISOTOPES; MALE; MAZE LEARNING; MEMORY; MICE; NEUROPROTECTIVE AGENTS; PROTEIN BINDING; RATS; RATS, WISTAR;

MUS; RATTUS;

EID: 70450223711     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2009.07.028     Document Type: Article

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