메뉴 건너뛰기




Volumn 79, Issue 3, 2010, Pages 463-470

Werner's syndrome helicase participates in transcription of phenobarbital-inducible CYP2B genes in rat and mouse liver

Author keywords

Chromatin immunoprecipitation; Gene regulation; Liver; Phenobarbital inducible genes; Transcription; Werner's syndrome

Indexed keywords

CYTOCHROME P450 2B; CYTOCHROME P450 2B10; CYTOCHROME P450 3A11; HELICASE; MESSENGER RNA; PHENOBARBITAL; UNCLASSIFIED DRUG; WERNER SYNDROME HELICASE;

EID: 70449646216     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2009.09.002     Document Type: Article
Times cited : (8)

References (61)
  • 1
    • 13944280713 scopus 로고    scopus 로고
    • Genetic modulation of senescent phenotypes in Homo sapiens
    • Martin G.M. Genetic modulation of senescent phenotypes in Homo sapiens. Cell 120 (2005) 523-532
    • (2005) Cell , vol.120 , pp. 523-532
    • Martin, G.M.1
  • 2
    • 0030476278 scopus 로고    scopus 로고
    • Werner syndrome: entering the helicase era
    • Epstein C.J., and Motulsky A.G. Werner syndrome: entering the helicase era. Bioessays 18 (1996) 1025-1027
    • (1996) Bioessays , vol.18 , pp. 1025-1027
    • Epstein, C.J.1    Motulsky, A.G.2
  • 3
    • 0030691121 scopus 로고    scopus 로고
    • Hierarchical deterioration of body systems in Werner's syndrome: implications for normal ageing
    • Goto M. Hierarchical deterioration of body systems in Werner's syndrome: implications for normal ageing. Mech Ageing Dev 98 (1997) 239-254
    • (1997) Mech Ageing Dev , vol.98 , pp. 239-254
    • Goto, M.1
  • 6
    • 0031569837 scopus 로고    scopus 로고
    • Cloning of a mouse homologue of the human Werner syndrome gene and assignment to 8A4 by fluorescence in situ hybridization
    • Imamura O., Ichikawa K., Yamabe Y., Goto M., Sugawara M., and Furuichi Y. Cloning of a mouse homologue of the human Werner syndrome gene and assignment to 8A4 by fluorescence in situ hybridization. Genomics 41 (1997) 298-300
    • (1997) Genomics , vol.41 , pp. 298-300
    • Imamura, O.1    Ichikawa, K.2    Yamabe, Y.3    Goto, M.4    Sugawara, M.5    Furuichi, Y.6
  • 7
    • 0032545423 scopus 로고    scopus 로고
    • Werner syndrome protein. II. Characterization of the integral 3′ → 5′ DNA exonuclease
    • Kamath-Loeb A.S., Shen J.C., Loeb L.A., and Fry M. Werner syndrome protein. II. Characterization of the integral 3′ → 5′ DNA exonuclease. J Biol Chem 273 (1998) 34145-34150
    • (1998) J Biol Chem , vol.273 , pp. 34145-34150
    • Kamath-Loeb, A.S.1    Shen, J.C.2    Loeb, L.A.3    Fry, M.4
  • 8
    • 0032545515 scopus 로고    scopus 로고
    • Werner syndrome protein. I. DNA helicase and DNA exonuclease reside on the same polypeptide
    • Shen J.C., Gray M.D., Oshima J., Kamath-Loeb A.S., Fry M., and Loeb L.A. Werner syndrome protein. I. DNA helicase and DNA exonuclease reside on the same polypeptide. J Biol Chem 273 (1998) 34139-34144
    • (1998) J Biol Chem , vol.273 , pp. 34139-34144
    • Shen, J.C.1    Gray, M.D.2    Oshima, J.3    Kamath-Loeb, A.S.4    Fry, M.5    Loeb, L.A.6
  • 9
    • 34247390746 scopus 로고    scopus 로고
    • Werner and Hutchinson-Gilford progeria syndromes: mechanistic basis of human progeroid diseases
    • Kudlow B.A., Kennedy B.K., and Monnat Jr. R.J. Werner and Hutchinson-Gilford progeria syndromes: mechanistic basis of human progeroid diseases. Nat Rev Mol Cell Biol 8 (2007) 394-404
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 394-404
    • Kudlow, B.A.1    Kennedy, B.K.2    Monnat Jr., R.J.3
  • 10
  • 11
    • 33748993124 scopus 로고    scopus 로고
    • Molecular bases of progeroid syndromes
    • Navarro C.L., Cau P., and Levy N. Molecular bases of progeroid syndromes. Hum Mol Genet 15 (2006) R151-R161
    • (2006) Hum Mol Genet , vol.15
    • Navarro, C.L.1    Cau, P.2    Levy, N.3
  • 12
    • 56449090762 scopus 로고    scopus 로고
    • Rising from the RecQ-age: the role of human RecQ helicases in genome maintenance
    • Bohr V.A. Rising from the RecQ-age: the role of human RecQ helicases in genome maintenance. Trends Biochem Sci 33 (2008) 609-620
    • (2008) Trends Biochem Sci , vol.33 , pp. 609-620
    • Bohr, V.A.1
  • 13
    • 0032803070 scopus 로고    scopus 로고
    • The Werner syndrome protein is involved in RNA polymerase II transcription
    • Balajee A.S., Machwe A., May A., Gray M.D., Oshima J., Martin G.M., et al. The Werner syndrome protein is involved in RNA polymerase II transcription. Mol Biol Cell 10 (1999) 2655-2668
    • (1999) Mol Biol Cell , vol.10 , pp. 2655-2668
    • Balajee, A.S.1    Machwe, A.2    May, A.3    Gray, M.D.4    Oshima, J.5    Martin, G.M.6
  • 14
    • 0142123097 scopus 로고    scopus 로고
    • Gene expression profiling in Werner syndrome closely resembles that of normal aging
    • Kyng K.J., May A., Kolvraa S., and Bohr V.A. Gene expression profiling in Werner syndrome closely resembles that of normal aging. Proc Natl Acad Sci USA 100 (2003) 12259-12264
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 12259-12264
    • Kyng, K.J.1    May, A.2    Kolvraa, S.3    Bohr, V.A.4
  • 15
    • 67650523677 scopus 로고    scopus 로고
    • The Werner syndrome protein affects the expression of genes involved in adipogenesis and inflammation in addition to cell cycle and DNA damage responses
    • Turaga R.V., Paquet E.R., Sild M., Vignard J., Garand C., Johnson F.B., et al. The Werner syndrome protein affects the expression of genes involved in adipogenesis and inflammation in addition to cell cycle and DNA damage responses. Cell Cycle 8 (2009) 2080-2092
    • (2009) Cell Cycle , vol.8 , pp. 2080-2092
    • Turaga, R.V.1    Paquet, E.R.2    Sild, M.3    Vignard, J.4    Garand, C.5    Johnson, F.B.6
  • 16
    • 68449098361 scopus 로고    scopus 로고
    • Werner syndrome resembles normal aging
    • Kyng K., Croteau D.L., and Bohr V.A. Werner syndrome resembles normal aging. Cell Cycle 8 (2009) 2323
    • (2009) Cell Cycle , vol.8 , pp. 2323
    • Kyng, K.1    Croteau, D.L.2    Bohr, V.A.3
  • 17
    • 4544312379 scopus 로고    scopus 로고
    • Phenobarbital for the treatment of epilepsy in the 21st century: a critical review
    • Kwan P., and Brodie M.J. Phenobarbital for the treatment of epilepsy in the 21st century: a critical review. Epilepsia 45 (2004) 1141-1149
    • (2004) Epilepsia , vol.45 , pp. 1141-1149
    • Kwan, P.1    Brodie, M.J.2
  • 18
    • 0025055648 scopus 로고
    • Enzyme induction in the cytochrome P-450 system
    • Okey A.B. Enzyme induction in the cytochrome P-450 system. Pharmacol Ther 45 (1990) 241-298
    • (1990) Pharmacol Ther , vol.45 , pp. 241-298
    • Okey, A.B.1
  • 19
    • 0026512675 scopus 로고
    • Phenobarbital induction of cytochrome P-450 gene expression
    • Waxman D.J., and Azaroff L. Phenobarbital induction of cytochrome P-450 gene expression. Biochem J 281 (1992) 577-592
    • (1992) Biochem J , vol.281 , pp. 577-592
    • Waxman, D.J.1    Azaroff, L.2
  • 20
    • 0023448111 scopus 로고
    • Expression and function of three cytochrome P-450 isozymes in rat extrahepatic tissues
    • Christou M., Wilson N.M., and Jefcoate C.R. Expression and function of three cytochrome P-450 isozymes in rat extrahepatic tissues. Arch Biochem Biophys 258 (1987) 519-534
    • (1987) Arch Biochem Biophys , vol.258 , pp. 519-534
    • Christou, M.1    Wilson, N.M.2    Jefcoate, C.R.3
  • 21
    • 0023237632 scopus 로고
    • Differential expression and function of three closely related phenobarbital-inducible cytochrome P-450 isozymes in untreated rat liver
    • Wilson N.M., Christou M., and Jefcoate C.R. Differential expression and function of three closely related phenobarbital-inducible cytochrome P-450 isozymes in untreated rat liver. Arch Biochem Biophys 256 (1987) 407-420
    • (1987) Arch Biochem Biophys , vol.256 , pp. 407-420
    • Wilson, N.M.1    Christou, M.2    Jefcoate, C.R.3
  • 22
    • 42449124513 scopus 로고    scopus 로고
    • The induction of CYP2B proteins in rodents by phenobarbital-like inducers: what has been discovered and what remains to be learned
    • Anderson A. The induction of CYP2B proteins in rodents by phenobarbital-like inducers: what has been discovered and what remains to be learned. Acta Chim Slov 55 (2008) 45-52
    • (2008) Acta Chim Slov , vol.55 , pp. 45-52
    • Anderson, A.1
  • 23
    • 0026762428 scopus 로고
    • Distinct induction profiles of 3 phenobarbital-responsive mouse liver cytochrome-P450 isozymes
    • Honkakoski P., Auriola S., and Lang M.A. Distinct induction profiles of 3 phenobarbital-responsive mouse liver cytochrome-P450 isozymes. Biochem Pharmacol 43 (1992) 2121-2128
    • (1992) Biochem Pharmacol , vol.43 , pp. 2121-2128
    • Honkakoski, P.1    Auriola, S.2    Lang, M.A.3
  • 24
    • 0020538616 scopus 로고
    • Transcriptional regulation of rat liver epoxide hydratase, NADPH-cytochrome P-450 oxidoreductase, and cytochrome P-450b genes by phenobarbital
    • Hardwick J.P., Gonzalez F.J., and Kasper C.B. Transcriptional regulation of rat liver epoxide hydratase, NADPH-cytochrome P-450 oxidoreductase, and cytochrome P-450b genes by phenobarbital. J Biol Chem 258 (1983) 8081-8085
    • (1983) J Biol Chem , vol.258 , pp. 8081-8085
    • Hardwick, J.P.1    Gonzalez, F.J.2    Kasper, C.B.3
  • 25
    • 33751088552 scopus 로고    scopus 로고
    • Stimulation of AMP-activated protein kinase is essential for the induction of drug metabolizing enzymes by phenobarbital in human and mouse liver
    • Rencurel F., Foretz M., Kaufmann M.R., Stroka D., Looser R., Leclerc I., et al. Stimulation of AMP-activated protein kinase is essential for the induction of drug metabolizing enzymes by phenobarbital in human and mouse liver. Mol Pharmacol 70 (2006) 1925-1934
    • (2006) Mol Pharmacol , vol.70 , pp. 1925-1934
    • Rencurel, F.1    Foretz, M.2    Kaufmann, M.R.3    Stroka, D.4    Looser, R.5    Leclerc, I.6
  • 26
    • 0035038008 scopus 로고    scopus 로고
    • Phenobarbital response elements of cytochrome P450 genes and nuclear receptors
    • Sueyoshi T., and Negishi M. Phenobarbital response elements of cytochrome P450 genes and nuclear receptors. Annu Rev Pharmacol Toxicol 41 (2001) 123-143
    • (2001) Annu Rev Pharmacol Toxicol , vol.41 , pp. 123-143
    • Sueyoshi, T.1    Negishi, M.2
  • 27
    • 0029035159 scopus 로고
    • Localization of a phenobarbital responsive element (PBRE) in the 5′-flanking region of the rat CYP2B2 gene
    • Trottier E., Belzil A., Stoltz C., and Anderson A. Localization of a phenobarbital responsive element (PBRE) in the 5′-flanking region of the rat CYP2B2 gene. Gene 158 (1995) 263-268
    • (1995) Gene , vol.158 , pp. 263-268
    • Trottier, E.1    Belzil, A.2    Stoltz, C.3    Anderson, A.4
  • 28
    • 0032478735 scopus 로고    scopus 로고
    • The CYP2B2 phenobarbital response unit contains an accessory factor element and a putative glucocorticoid response element essential for conferring maximal phenobarbital responsiveness
    • Stoltz C., Vachon M.-H., Trottier E., Dubois S., Paquet Y., and Anderson A. The CYP2B2 phenobarbital response unit contains an accessory factor element and a putative glucocorticoid response element essential for conferring maximal phenobarbital responsiveness. J Biol Chem 273 (1998) 8528-8536
    • (1998) J Biol Chem , vol.273 , pp. 8528-8536
    • Stoltz, C.1    Vachon, M.-H.2    Trottier, E.3    Dubois, S.4    Paquet, Y.5    Anderson, A.6
  • 29
    • 0034990905 scopus 로고    scopus 로고
    • Repression of phenobarbital-dependent CYP2B1 mRNA induction by reactive oxygen species in primary rat hepatocyte cultures
    • Hirsch-Ernst K.I., Schlaefer K., Bauer D., Heder A.F., and Kahl G.F. Repression of phenobarbital-dependent CYP2B1 mRNA induction by reactive oxygen species in primary rat hepatocyte cultures. Mol Pharmacol 59 (2001) 1402-1409
    • (2001) Mol Pharmacol , vol.59 , pp. 1402-1409
    • Hirsch-Ernst, K.I.1    Schlaefer, K.2    Bauer, D.3    Heder, A.F.4    Kahl, G.F.5
  • 30
    • 0030908295 scopus 로고    scopus 로고
    • Characterization of a phenobarbital-responsive enhancer module in mouse P450 Cyp2b10 gene
    • Honkakoski P., and Negishi M. Characterization of a phenobarbital-responsive enhancer module in mouse P450 Cyp2b10 gene. J Biol Chem 272 (1997) 14943-14949
    • (1997) J Biol Chem , vol.272 , pp. 14943-14949
    • Honkakoski, P.1    Negishi, M.2
  • 31
    • 0034623998 scopus 로고    scopus 로고
    • Mutational analysis of the CYP2B2 phenobarbital response unit and inhibitory effect of the constitutive androstane receptor on phenobarbital responsiveness
    • Paquet Y., Trottier E., Beaudet M.-J., and Anderson A. Mutational analysis of the CYP2B2 phenobarbital response unit and inhibitory effect of the constitutive androstane receptor on phenobarbital responsiveness. J Biol Chem 275 (2000) 38427-38436
    • (2000) J Biol Chem , vol.275 , pp. 38427-38436
    • Paquet, Y.1    Trottier, E.2    Beaudet, M.-J.3    Anderson, A.4
  • 32
    • 0031968936 scopus 로고    scopus 로고
    • Activation by diverse xenochemicals of the 51-base pair phenobarbital-responsive enhancer module in the CYP2B10 gene
    • Honkakoski P., Moore R., Washburn K.A., and Negishi M. Activation by diverse xenochemicals of the 51-base pair phenobarbital-responsive enhancer module in the CYP2B10 gene. Mol Pharmacol 53 (1998) 597-601
    • (1998) Mol Pharmacol , vol.53 , pp. 597-601
    • Honkakoski, P.1    Moore, R.2    Washburn, K.A.3    Negishi, M.4
  • 33
    • 20544442736 scopus 로고    scopus 로고
    • The CYP2B2 phenobarbital response unit contains binding sites for hepatocyte nuclear protein 4, PBX-PREP1, the thyroid receptor, and the liver X receptor
    • Beaudet M.-J., Desrochers M., Lachaud A.A., and Anderson A. The CYP2B2 phenobarbital response unit contains binding sites for hepatocyte nuclear protein 4, PBX-PREP1, the thyroid receptor, and the liver X receptor. Biochem J 388 (2005) 407-418
    • (2005) Biochem J , vol.388 , pp. 407-418
    • Beaudet, M.-J.1    Desrochers, M.2    Lachaud, A.A.3    Anderson, A.4
  • 34
    • 0031682988 scopus 로고    scopus 로고
    • The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene
    • Honkakoski P., Zelko I., Sueyoshi T., and Negishi M. The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene. Mol Cell Biol 18 (1998) 5652-5658
    • (1998) Mol Cell Biol , vol.18 , pp. 5652-5658
    • Honkakoski, P.1    Zelko, I.2    Sueyoshi, T.3    Negishi, M.4
  • 35
    • 0033999734 scopus 로고    scopus 로고
    • The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR
    • Tzameli I., Pissios P., Schuetz E.G., and Moore D.D. The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR. Mol Cell Biol 20 (2000) 2951-2958
    • (2000) Mol Cell Biol , vol.20 , pp. 2951-2958
    • Tzameli, I.1    Pissios, P.2    Schuetz, E.G.3    Moore, D.D.4
  • 36
    • 33745727736 scopus 로고    scopus 로고
    • Analysis of multiple nuclear receptor binding sites for CAR/RXR in the phenobarbital responsive unit of CYP2B2
    • Zhang Q., Bae Y., Kemper J.K., and Kemper B. Analysis of multiple nuclear receptor binding sites for CAR/RXR in the phenobarbital responsive unit of CYP2B2. Arch Biochem Biophys 451 (2006) 119-127
    • (2006) Arch Biochem Biophys , vol.451 , pp. 119-127
    • Zhang, Q.1    Bae, Y.2    Kemper, J.K.3    Kemper, B.4
  • 37
    • 0032766430 scopus 로고    scopus 로고
    • Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene
    • Kawamoto T., Sueyoshi T., Zelko I., Moore R., Washburn K., and Negishi M. Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene. Mol Cell Biol 19 (1999) 6318-6322
    • (1999) Mol Cell Biol , vol.19 , pp. 6318-6322
    • Kawamoto, T.1    Sueyoshi, T.2    Zelko, I.3    Moore, R.4    Washburn, K.5    Negishi, M.6
  • 38
    • 0034687397 scopus 로고    scopus 로고
    • The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism
    • Wei P., Zhang J., Egan-Hafley M., Liang S., and Moore D.D. The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism. Nature 407 (2000) 920-923
    • (2000) Nature , vol.407 , pp. 920-923
    • Wei, P.1    Zhang, J.2    Egan-Hafley, M.3    Liang, S.4    Moore, D.D.5
  • 39
    • 0032573157 scopus 로고    scopus 로고
    • A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity
    • Lebel M., and Leder P. A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity. Proc Natl Acad Sci USA 95 (1998) 13097-13102
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 13097-13102
    • Lebel, M.1    Leder, P.2
  • 40
    • 0023697056 scopus 로고
    • Simple sequence DNA associated with near sequence identity of the 3′-flanking regions of rat cytochrome P450b and P450e genes
    • Jean A., Rivkin E., and Anderson A. Simple sequence DNA associated with near sequence identity of the 3′-flanking regions of rat cytochrome P450b and P450e genes. DNA 7 (1988) 361-369
    • (1988) DNA , vol.7 , pp. 361-369
    • Jean, A.1    Rivkin, E.2    Anderson, A.3
  • 41
    • 0022006744 scopus 로고
    • Demonstration in multiple species of inducible hepatic cytochromes P-450 and their mRNAs related to the glucocorticoid-inducible cytochrome P-450 of the rat
    • Wrighton S.A., Schuetz E.G., Watkins P.B., Maurel P., Barwick J., Bailey B.S., et al. Demonstration in multiple species of inducible hepatic cytochromes P-450 and their mRNAs related to the glucocorticoid-inducible cytochrome P-450 of the rat. Mol Pharmacol 28 (1985) 312-321
    • (1985) Mol Pharmacol , vol.28 , pp. 312-321
    • Wrighton, S.A.1    Schuetz, E.G.2    Watkins, P.B.3    Maurel, P.4    Barwick, J.5    Bailey, B.S.6
  • 42
    • 0142181031 scopus 로고    scopus 로고
    • Induction of multidrug resistance protein 3 (MRP3) in vivo is independent of constitutive androstane receptor
    • Cherrington N.J., Slitt A.L., Maher J.M., Zhang X.X., Zhang J., Huang W., et al. Induction of multidrug resistance protein 3 (MRP3) in vivo is independent of constitutive androstane receptor. Drug Metab Dispos 31 (2004) 1315-1319
    • (2004) Drug Metab Dispos , vol.31 , pp. 1315-1319
    • Cherrington, N.J.1    Slitt, A.L.2    Maher, J.M.3    Zhang, X.X.4    Zhang, J.5    Huang, W.6
  • 43
    • 0030601796 scopus 로고    scopus 로고
    • New proteins in the rat CYP2B subfamily: presence in liver microsomes of the constitutive CYP2B3 protein and the phenobarbital-inducible protein product of alternatively spliced CYP2B2 mRNA
    • Desrochers M., Christou M., Jefcoate C., Belzil A., and Anderson A. New proteins in the rat CYP2B subfamily: presence in liver microsomes of the constitutive CYP2B3 protein and the phenobarbital-inducible protein product of alternatively spliced CYP2B2 mRNA. Biochem Pharmacol 52 (1996) 1311-1319
    • (1996) Biochem Pharmacol , vol.52 , pp. 1311-1319
    • Desrochers, M.1    Christou, M.2    Jefcoate, C.3    Belzil, A.4    Anderson, A.5
  • 44
    • 0021688840 scopus 로고
    • Rat hepatic cytochrome P-450 isoenzyme 2c. Identification as a male-specific, developmentally induced steroid 16-hydroxylase and comparison to a female-specific cytochrome P-450 isoenzyme
    • Waxman D.J. Rat hepatic cytochrome P-450 isoenzyme 2c. Identification as a male-specific, developmentally induced steroid 16-hydroxylase and comparison to a female-specific cytochrome P-450 isoenzyme. J Biol Chem 259 (1984) 15481-15490
    • (1984) J Biol Chem , vol.259 , pp. 15481-15490
    • Waxman, D.J.1
  • 45
    • 3142765079 scopus 로고    scopus 로고
    • Sexually dimorphic P450 gene expression in liver-specific hepatocyte nuclear factor 4-deficient mice
    • Wiwi C.A., Gupte M., and Waxman D.J. Sexually dimorphic P450 gene expression in liver-specific hepatocyte nuclear factor 4-deficient mice. Mol Endocrinol 18 (2004) 1975-1987
    • (2004) Mol Endocrinol , vol.18 , pp. 1975-1987
    • Wiwi, C.A.1    Gupte, M.2    Waxman, D.J.3
  • 46
    • 0028303297 scopus 로고
    • Molecular cloning and amino acid sequence of the porcine 17-estradiol dehydrogenase
    • Leenders F., Adamski J., Husen B., Thole H.H., and Jungblut P.W. Molecular cloning and amino acid sequence of the porcine 17-estradiol dehydrogenase. Eur J Biochem 222 (1994) 221-227
    • (1994) Eur J Biochem , vol.222 , pp. 221-227
    • Leenders, F.1    Adamski, J.2    Husen, B.3    Thole, H.H.4    Jungblut, P.W.5
  • 48
    • 0021367471 scopus 로고
    • Purification and characterization of epimeric estradiol dehydrogenases (17 and 17) from equine placenta
    • Henderson L.L., and Warren J.C. Purification and characterization of epimeric estradiol dehydrogenases (17 and 17) from equine placenta. Biochemistry 23 (1984) 486-491
    • (1984) Biochemistry , vol.23 , pp. 486-491
    • Henderson, L.L.1    Warren, J.C.2
  • 49
    • 1042265482 scopus 로고    scopus 로고
    • Sequential chromatin immunoprecipitation from animal tissues
    • Chaya D., and Zaret K.S. Sequential chromatin immunoprecipitation from animal tissues. Methods Enzymol 376 (2004) 361-372
    • (2004) Methods Enzymol , vol.376 , pp. 361-372
    • Chaya, D.1    Zaret, K.S.2
  • 50
    • 0015752890 scopus 로고
    • Preparation of rat liver cells. 3. Enzymatic requirements for tissue dispersion
    • Seglen P.O. Preparation of rat liver cells. 3. Enzymatic requirements for tissue dispersion. Exp Cell Res 82 (1973) 391-398
    • (1973) Exp Cell Res , vol.82 , pp. 391-398
    • Seglen, P.O.1
  • 51
    • 31544474304 scopus 로고    scopus 로고
    • Increased insulin, triglycerides, reactive oxygen species, and cardiac fibrosis in mice with a mutation in the helicase domain of the Werner syndrome gene homologue
    • Massip L., Garand C., Turaga R.V., Deschenes F., Thorin E., and Lebel M. Increased insulin, triglycerides, reactive oxygen species, and cardiac fibrosis in mice with a mutation in the helicase domain of the Werner syndrome gene homologue. Exp Gerontol 41 (2006) 157-168
    • (2006) Exp Gerontol , vol.41 , pp. 157-168
    • Massip, L.1    Garand, C.2    Turaga, R.V.3    Deschenes, F.4    Thorin, E.5    Lebel, M.6
  • 53
    • 0034090336 scopus 로고    scopus 로고
    • Detection of chemical-induced differential expression of rat hepatic cytochrome P450 mRNA transcripts using branched DNA signal amplification technology
    • Hartley D.P., and Klaassen C.D. Detection of chemical-induced differential expression of rat hepatic cytochrome P450 mRNA transcripts using branched DNA signal amplification technology. Drug Metab Dispos 28 (2005) 608-616
    • (2005) Drug Metab Dispos , vol.28 , pp. 608-616
    • Hartley, D.P.1    Klaassen, C.D.2
  • 54
    • 0041690966 scopus 로고    scopus 로고
    • Werner syndrome protein phosphorylation by Abl tyrosine kinase regulates its activity and distribution
    • Cheng W.H., von Kobbe C., Opresko P.L., Fields K.M., Ren J., Kufe D., et al. Werner syndrome protein phosphorylation by Abl tyrosine kinase regulates its activity and distribution. Mol Cell Biol 23 (2003) 6385-6395
    • (2003) Mol Cell Biol , vol.23 , pp. 6385-6395
    • Cheng, W.H.1    von Kobbe, C.2    Opresko, P.L.3    Fields, K.M.4    Ren, J.5    Kufe, D.6
  • 55
    • 0037530653 scopus 로고    scopus 로고
    • Werner syndrome and the function of the Werner protein; what they can teach us about the molecular aging process
    • Opresko P.L., Cheng W.H., von Kobbe C., Harrigan J.A., and Bohr V.A. Werner syndrome and the function of the Werner protein; what they can teach us about the molecular aging process. Carcinogenesis 24 (2003) 791-802
    • (2003) Carcinogenesis , vol.24 , pp. 791-802
    • Opresko, P.L.1    Cheng, W.H.2    von Kobbe, C.3    Harrigan, J.A.4    Bohr, V.A.5
  • 56
    • 0032832195 scopus 로고    scopus 로고
    • Physical and functional interaction between p53 and the Werner's syndrome protein
    • Blander G., Kipnis J., Leal J.F., Yu C.E., Schellenberg G.D., and Oren M. Physical and functional interaction between p53 and the Werner's syndrome protein. J Biol Chem 274 (1999) 29463-29469
    • (1999) J Biol Chem , vol.274 , pp. 29463-29469
    • Blander, G.1    Kipnis, J.2    Leal, J.F.3    Yu, C.E.4    Schellenberg, G.D.5    Oren, M.6
  • 57
    • 0029774715 scopus 로고    scopus 로고
    • The CYP2B1 proximal promoter contains a functional C/EBP regulatory element
    • Park Y., and Kemper B. The CYP2B1 proximal promoter contains a functional C/EBP regulatory element. DNA Cell Biol 15 (1996) 693-701
    • (1996) DNA Cell Biol , vol.15 , pp. 693-701
    • Park, Y.1    Kemper, B.2
  • 58
    • 0030019412 scopus 로고    scopus 로고
    • Transcriptional regulation of the CYP2B1 and CYP2B2 genes by C/EBP-related proteins
    • Luc P-VT, Adesnik M., Ganguly S., and Shaw P.M. Transcriptional regulation of the CYP2B1 and CYP2B2 genes by C/EBP-related proteins. Biochem Pharmacol 51 (1996) 345-356
    • (1996) Biochem Pharmacol , vol.51 , pp. 345-356
    • Luc P-VT1    Adesnik, M.2    Ganguly, S.3    Shaw, P.M.4
  • 59
    • 33846095506 scopus 로고    scopus 로고
    • The role of WRN in DNA repair is affected by post-translational modifications
    • Kusumoto R., Muftuoglu M., and Bohr V.A. The role of WRN in DNA repair is affected by post-translational modifications. Mech Ageing Dev 128 (2007) 50-57
    • (2007) Mech Ageing Dev , vol.128 , pp. 50-57
    • Kusumoto, R.1    Muftuoglu, M.2    Bohr, V.A.3
  • 60
    • 0347362703 scopus 로고    scopus 로고
    • Werner syndrome protein contains three structure-specific DNA binding domains
    • von Kobbe C., Thoma N.H., Czyzewski B.K., Pavletich N.P., and Bohr V.A. Werner syndrome protein contains three structure-specific DNA binding domains. J Biol Chem 278 (2003) 52997-53006
    • (2003) J Biol Chem , vol.278 , pp. 52997-53006
    • von Kobbe, C.1    Thoma, N.H.2    Czyzewski, B.K.3    Pavletich, N.P.4    Bohr, V.A.5
  • 61
    • 0034283889 scopus 로고    scopus 로고
    • Werner syndrome exonuclease catalyzes structure-dependent degradation of DNA
    • Shen J.C., and Loeb L.A. Werner syndrome exonuclease catalyzes structure-dependent degradation of DNA. Nucleic Acids Res 28 (2000) 3260-3268
    • (2000) Nucleic Acids Res , vol.28 , pp. 3260-3268
    • Shen, J.C.1    Loeb, L.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.