Study of human RIG-I polymorphisms identifies two variants with an opposite impact on the antiviral immune response

PLoS ONE

Volumn 4, Issue 10, 2009, Pages

  Pothlichet, Julien ^a,b   Burtey, Anne ^a,b   Kubarenko, Andriy V ^c   Caignard, Gregory ^a   Solhonne, Brigitte ^a,b   Tangy, Frédéric ^a   Ben Ali, Meriem ^a,d   Quintana Murci, Lluis ^a,d   Heinzmann, Andrea ^e   Chiche, Jean Daniel ^f   Vidalain, Pierre Olivier ^a   Weber, Alexander N R ^c   Chignard, Michel ^a,b   Si Tahar, Mustapha ^a,b,f  

^a INSTITUT PASTEUR   (France)

^b INSERM   (France)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^d CNRS   (France)

^e UNIVERSITY OF FREIBURG   (Germany)

^f URA 3012 ^*  (France)

Author keywords

[No Author keywords available]

Indexed keywords

ISOLEUCINE; RETINOIC ACID INDUCIBLE PROTEIN I; SERINE; ANTIVIRUS AGENT; DDX58 PROTEIN, HUMAN; DEAD BOX PROTEIN;

ARTICLE; BIOCHEMISTRY; CONTROLLED STUDY; DOWN REGULATION; FRAMESHIFT MUTATION; GENE EXPRESSION REGULATION; GENE MUTATION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INNATE IMMUNITY; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; STRUCTURE ANALYSIS; VIRUS INHIBITION; BIOLOGICAL MODEL; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; DIMERIZATION; GENETIC POLYMORPHISM; GENETICS; IMMUNE SYSTEM; MISSENSE MUTATION; PHENOTYPE;

DNA VIRUSES;

ANTIVIRAL AGENTS; CELL LINE; DEAD-BOX RNA HELICASES; DIMERIZATION; GENETIC VARIATION; HUMANS; IMMUNE SYSTEM; IMMUNITY, INNATE; MODELS, GENETIC; MODELS, MOLECULAR; MUTATION, MISSENSE; PHENOTYPE; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; SIGNAL TRANSDUCTION;

EID: 70449568252     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0007582     Document Type: Article

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