Stem cells-meet immunity

Journal of Molecular Medicine

Volumn 87, Issue 11, 2009, Pages 1061-1069

  Heng, Tracy S P ^a   Dudakov, Jarrod A ^a   Khong, Danika M P ^a   Chidgey, Ann P ^a   Boyd, Richard L ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

Haematopoietic stem cell transplantation; Immune tolerance; Stem cells; Thymus regeneration

Indexed keywords

ALLOANTIGEN; GAMMA INTERFERON; T LYMPHOCYTE RECEPTOR;

ANTIGEN RECOGNITION; CANCER RESEARCH; CELL DIFFERENTIATION; GRAFT REJECTION; HUMAN; IMMUNE SYSTEM; IMMUNITY; IMMUNOLOGICAL TOLERANCE; INCIDENCE; MAJOR HISTOCOMPATIBILITY COMPLEX; PLURIPOTENT STEM CELL; REVIEW; STEM CELL; STEM CELL TRANSPLANTATION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ANIMALS; HUMANS; IMMUNE SYSTEM; IMMUNE TOLERANCE; STEM CELL TRANSPLANTATION; STEM CELLS;

EID: 70449521312     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00109-009-0539-z     Document Type: Review

References (82)

1. W Krenger GA Hollander 2008 The immunopathology of thymic GVHD Semin Immunopathol 30 439 456 10.1007/s00281-008-0131-6 10.1007/s00281-008-0131-6 18974988
2. A Chidgey J Dudakov N Seach R Boyd 2007 Impact of niche aging on thymic regeneration and immune reconstitution Semin Immunol 19 331 340 S1044-5323(07)00080-2 [pii] 10.1016/j.smim.2007.10.006 10.1016/j.smim.2007.10. 006 1:CAS:528:DC%2BD2sXhtlyrurfM 18024073 (Pubitemid 350181532)
3. AL Fletcher TE Lowen S Sakkal JJ Reiseger MV Hammett N Seach HS Scott RL Boyd AP Chidgey 2009 Ablation and regeneration of tolerance-inducing medullary thymic epithelial cells after cyclosporine, cyclophosphamide, and dexamethasone treatment J Immunol jimmunol.0900225 [pii] 10.4049/jimmunol.0900225
4. AP Chidgey D Layton A Trounson RL Boyd 2008 Tolerance strategies for stem-cell-based therapies Nature 453 330 337 nature07041 [pii] 10.1038/nature07041 10.1038/nature07041 1:CAS:528:DC%2BD1cXlvV2qtbc%3D 18480814 (Pubitemid 351693139)
5. JE Till CE Mc 1961 A direct measurement of the radiation sensitivity of normal mouse bone marrow cells Radiat Res 14 213 222 10.2307/3570892 1:STN:280:DyaF3c%2FpslSgug%3D%3D 13776896
6. M Boyiadzis S Pavletic 2004 Haematopoietic stem cell transplantation: indications, clinical developments and future directions Expert Opin Pharmacother 5 97 108 10.1517/14656566.5.1.97 10.1517/14656566.5.1.97 1:CAS:528:DC%2BD3sXpvVeqtb0%3D 14680439 (Pubitemid 38072722)
7. F Doetsch I Caille DA Lim JM Garcia-Verdugo A Alvarez-Buylla 1999 Subventricular zone astrocytes are neural stem cells in the adult mammalian brain Cell 97 703 716 S0092-8674(00)80783-7 [pii] 10.1016/S0092-8674(00)80783-7 1:CAS:528:DyaK1MXjvFOju78%3D 10380923 (Pubitemid 29278045)
8. G Taylor MS Lehrer PJ Jensen TT Sun RM Lavker 2000 Involvement of follicular stem cells in forming not only the follicle but also the epidermis Cell 102 451 461 S0092-8674(00)00050-7 [pii] 10.1016/S0092-8674(00)00050-7 1:CAS:528:DC%2BD3cXmtFOrsLo%3D 10966107
9. N Barker JH van Es J Kuipers P Kujala M van den Born M Cozijnsen A Haegebarth J Korving H Begthel PJ Peters H Clevers 2007 Identification of stem cells in small intestine and colon by marker gene Lgr5 Nature 449 1003 1007 nature06196 [pii] 10.1038/nature06196 10.1038/nature06196 1:CAS:528: DC%2BD2sXht1Wgtr3E 17934449 (Pubitemid 350014593)
10. RI Sherwood JL Christensen IM Conboy MJ Conboy TA Rando IL Weissman AJ Wagers 2004 Isolation of adult mouse myogenic progenitors: functional heterogeneity of cells within and engrafting skeletal muscle Cell 119 543 554 S0092867404010360 [pii] 10.1016/j.cell.2004.10.021 10.1016/j.cell.2004.10.021 1:CAS:528:DC%2BD2cXhtVCjt7fE 15537543 (Pubitemid 39482353)
11. RJ Swijnenburg M Tanaka H Vogel J Baker T Kofidis F Gunawan DR Lebl AD Caffarelli JL de Bruin EV Fedoseyeva RC Robbins 2005 Embryonic stem cell immunogenicity increases upon differentiation after transplantation into ischemic myocardium Circulation 112 I166 I172 112/9-suppl/I-166 [pii] 10.1161/CIRCULATIONAHA.104.525824 16159810 (Pubitemid 41266669)
12. G Amabile A Meissner 2009 Induced pluripotent stem cells: current progress and potential for regenerative medicine Trends Mol Med 15 59 68 S1471-4914(09)00016-1 [pii] 10.1016/j.molmed.2008.12.003 10.1016/j.molmed.2008. 12.003 1:CAS:528:DC%2BD1MXhvF2mur4%3D 19162546
13. H Zhou S Wu JY Joo S Zhu DW Han T Lin S Trauger G Bien S Yao Y Zhu G Siuzdak HR Scholer L Duan S Ding 2009 Generation of induced pluripotent stem cells using recombinant proteins Cell Stem Cell 4 381 384 S1934-5909(09)00159-3 [pii] 10.1016/j.stem.2009.04.005 10.1016/j.stem.2009.04.005 1:CAS:528: DC%2BD1MXlvVGjtLw%3D 19398399
14. D Kim CH Kim JI Moon YG Chung MY Chang BS Han S Ko E Yang KY Cha R Lanza KS Kim 2009 Generation of human induced pluripotent stem cells by direct delivery of reprogramming proteins Cell Stem Cell 4 472 476 S1934-5909(09)00214- 8 [pii] 10.1016/j.stem.2009.05.005 10.1016/j.stem.2009.05.005 1:CAS:528:DC%2BD1MXnt1Ggt7o%3D 19481515
15. K Takahashi S Yamanaka 2006 Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors Cell 126 663 676 S0092-8674(06)00976-7 [pii] 10.1016/j.cell.2006.07.024 10.1016/j.cell.2006. 07.024 1:CAS:528:DC%2BD28Xpt1aktbs%3D 16904174 (Pubitemid 44233629)
16. M Wernig A Meissner R Foreman T Brambrink M Ku K Hochedlinger BE Bernstein R Jaenisch 2007 In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state Nature 448 318 324 nature05944 [pii] 10.1038/nature05944 10.1038/nature05944 1:CAS:528:DC%2BD2sXnvVeqsLg%3D 17554336 (Pubitemid 47080337)
17. IH Park R Zhao JA West A Yabuuchi H Huo TA Ince PH Lerou MW Lensch GQ Daley 2008 Reprogramming of human somatic cells to pluripotency with defined factors Nature 451 141 146 nature06534 [pii] 10.1038/nature06534 10.1038/nature06534 1:CAS:528:DC%2BD1cXksVGhtQ%3D%3D 18157115
18. S Nishikawa RA Goldstein CR Nierras 2008 The promise of human induced pluripotent stem cells for research and therapy Nat Rev Mol Cell Biol 9 725 729 nrm2466 [pii] 10.1038/nrm2466 10.1038/nrm2466 1:CAS:528:DC%2BD1cXhtVWgu7jE 18698329
19. DJ Rossi CH Jamieson IL Weissman 2008 Stems cells and the pathways to aging and cancer Cell 132 681 696 S0092-8674(08)00137-2 [pii] 10.1016/j.cell.2008.01.036 10.1016/j.cell.2008.01.036 1:CAS:528: DC%2BD1cXivVagt74%3D 18295583 (Pubitemid 351253688)
20. ME Carlson IM Conboy 2007 Loss of stem cell regenerative capacity within aged niches Aging Cell 6 371 382 ACE286 [pii] 10.1111/j.1474-9726.2007.00286.x 10.1111/j.1474-9726.2007.00286.x 1:CAS:528:DC%2BD2sXntVOjsr0%3D 17381551 (Pubitemid 46785142)
21. F Fandrich X Lin GX Chai M Schulze D Ganten M Bader J Holle DS Huang R Parwaresch N Zavazava B Binas 2002 Preimplantation-stage stem cells induce long-term allogeneic graft acceptance without supplementary host conditioning Nat Med 8 171 178 10.1038/nm0202-171 nm0202-171 [pii] 10.1038/nm0202-171 1:CAS:528:DC%2BD38Xht1equ7o%3D 11821902 (Pubitemid 34155129)
22. L Li ML Baroja A Majumdar K Chadwick A Rouleau L Gallacher I Ferber J Lebkowski T Martin J Madrenas M Bhatia 2004 Human embryonic stem cells possess immune-privileged properties Stem Cells 22 448 456 22/4/448 [pii] 10.1634/stemcells.22-4-448 10.1634/stemcells.22-4-448 1:CAS:528: DC%2BD2cXps1Kns74%3D 15277692
23. M Drukker G Katz A Urbach M Schuldiner G Markel J Itskovitz-Eldor B Reubinoff O Mandelboim N Benvenisty 2002 Characterization of the expression of MHC proteins in human embryonic stem cells Proc Natl Acad Sci USA 99 9864 9869 10.1073/pnas.142298299 142298299 [pii] 10.1073/pnas.142298299 1:CAS:528:DC%2BD38XlslKgsLg%3D 12114532 (Pubitemid 34831138)
24. M Drukker N Benvenisty 2004 The immunogenicity of human embryonic stem-derived cells Trends Biotechnol 22 136 141 10.1016/j.tibtech.2004.01.003 S0167779904000198 [pii] 10.1016/j.tibtech.2004.01.003 1:CAS:528: DC%2BD2cXhsV2nurg%3D 15036864 (Pubitemid 38230392)
25. RJ Swijnenburg S Schrepfer JA Govaert F Cao K Ransohoff AY Sheikh M Haddad AJ Connolly MM Davis RC Robbins JC Wu 2008 Immunosuppressive therapy mitigates immunological rejection of human embryonic stem cell xenografts Proc Natl Acad Sci U S A 105 12991 12996 0805802105 [pii] 10.1073/pnas.0805802105 10.1073/pnas.0805802105 1:CAS:528:DC%2BD1cXhtFSmtrnK 18728188
26. CJ Taylor EM Bolton S Pocock LD Sharples RA Pedersen JA Bradley 2005 Banking on human embryonic stem cells: estimating the number of donor cell lines needed for HLA matching Lancet 366 2019 2025 S0140-6736(05)67813-0 [pii] 10.1016/S0140-6736(05)67813-0 10.1016/S0140-6736(05)67813-0 16338451 (Pubitemid 41773377)
27. NJ Robertson FA Brook RL Gardner SP Cobbold H Waldmann PJ Fairchild 2007 Embryonic stem cell-derived tissues are immunogenic but their inherent immune privilege promotes the induction of tolerance Proc Natl Acad Sci U S A 104 20920 20925 0710265105 [pii] 10.1073/pnas.0710265105 10.1073/pnas.0710265105 1:CAS:528:DC%2BD1cXktlGisw%3D%3D 18093946
28. DW Mason HM Charlton AJ Jones CB Lavy M Puklavec SJ Simmonds 1986 The fate of allogeneic and xenogeneic neuronal tissue transplanted into the third ventricle of rodents Neuroscience 19 685 694 10.1016/0306-4522(86)90292-7 1:STN:280:DyaL2s%2FptVKisw%3D%3D 3796814 (Pubitemid 17181206)
29. NS Liao M Bix M Zijlstra R Jaenisch D Raulet 1991 MHC class I deficiency: susceptibility to natural killer (NK) cells and impaired NK activity Science 253 199 202 10.1126/science.1853205 1:CAS:528:DyaK3MXltFags7g%3D 1853205
30. MJ Grusby H Auchincloss Jr R Lee RS Johnson JP Spencer M Zijlstra R Jaenisch VE Papaioannou LH Glimcher 1993 Mice lacking major histocompatibility complex class I and class II molecules Proc Natl Acad Sci U S A 90 3913 3917 10.1073/pnas.90.9.3913 1:STN:280:DyaK3s3kvVajsg%3D%3D 8483910
31. A Dierich SH Chan C Benoist D Mathis 1993 Graft rejection by T cells not restricted by conventional major histocompatibility complex molecules Eur J Immunol 23 2725 2728 10.1002/eji.1830231055 1:CAS:528:DyaK2cXmslWq 8104801
32. DR Green TA Ferguson 2001 The role of Fas ligand in immune privilege Nat Rev Mol Cell Biol 2 917 924 10.1038/35103104 35103104 [pii] 10.1038/35103104 1:CAS:528:DC%2BD3MXptF2rtLc%3D 11733771 (Pubitemid 33674091)
33. D Golshayan M Pascual 2008 Tolerance-inducing immunosuppressive strategies in clinical transplantation: an overview Drugs 68 2113 2130 68154 [pii] 10.2165/00003495-200868150-00004 1:CAS:528:DC%2BD1cXhsFCrsrvE 18840003
34. H von Boehmer 2005 Mechanisms of suppression by suppressor T cells Nat Immunol 6 338 344 ni1180 [pii] 10.1038/ni1180 10.1038/ni1180 (Pubitemid 41716770)
35. K Kretschmer TS Heng H von Boehmer 2006 De novo production of antigen-specific suppressor cells in vivo Nat Protoc 1 653 661 10.1038/nprot.2006.105 1:CAS:528:DC%2BD28XhtFOitLnJ 17802642
36. P Verginis KA McLaughlin KW Wucherpfennig H von Boehmer I Apostolou 2008 Induction of antigen-specific regulatory T cells in wild-type mice: visualization and targets of suppression Proc Natl Acad Sci U S A 105 3479 3484 0800149105 [pii] 10.1073/pnas.0800149105 10.1073/pnas.0800149105 1:CAS:528:DC%2BD1cXjtlamsr4%3D 18299571 (Pubitemid 351723578)
37. A Keating 2006 Mesenchymal stromal cells Curr Opin Hematol 13 419 425 10.1097/01.moh.0000245697.54887.6f 00062752-200611000-00004 [pii] 10.1097/01.moh.0000245697.54887.6f 17053453 (Pubitemid 44607442)
38. M Owen AJ Friedenstein 1988 Stromal stem cells: marrow-derived osteogenic precursors Ciba Found Symp 136 42 60 1:STN:280:DyaL1M7lt1Gmsw%3D%3D 3068016
39. K Bieback S Kern H Kluter H Eichler 2004 Critical parameters for the isolation of mesenchymal stem cells from umbilical cord blood Stem Cells 22 625 634 22/4/625 [pii] 10.1634/stemcells.22-4-625 15277708
40. PS In 't Anker SA Scherjon C Kleijburg-van der Keur GM de Groot-Swings FH Claas WE Fibbe HH Kanhai 2004 Isolation of mesenchymal stem cells of fetal or maternal origin from human placenta Stem Cells 22 1338 1345 22/7/1338 [pii] 10.1634/stemcells.2004-0058 15579651 (Pubitemid 39636409)
41. PA Zuk M Zhu P Ashjian DA De Ugarte JI Huang H Mizuno ZC Alfonso JK Fraser P Benhaim MH Hedrick 2002 Human adipose tissue is a source of multipotent stem cells Mol Biol Cell 13 4279 4295 10.1091/mbc.E02-02-0105 10.1091/mbc.E02-02-0105 1:CAS:528:DC%2BD38XpsFOqsrw%3D 12475952 (Pubitemid 35471185)
42. DG Phinney DJ Prockop 2007 Concise review: mesenchymal stem/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair-current views Stem Cells 25 2896 2902 2007-0637 [pii] 10.1634/stemcells.2007-0637 10.1634/stemcells.2007-0637 17901396 (Pubitemid 350127874)
43. A Uccelli L Moretta V Pistoia 2008 Mesenchymal stem cells in health and disease Nat Rev Immunol 8 726 736 10.1038/nri2395 1:CAS:528:DC%2BD1cXhtVamu7vF 19172693
44. G Ren L Zhang X Zhao G Xu Y Zhang AI Roberts RC Zhao Y Shi 2008 Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide Cell Stem Cell 2 141 150 S1934-5909(07)00314-1 [pii] 10.1016/j.stem.2007.11.014 10.1016/j.stem.2007.11.014 1:CAS:528: DC%2BD1cXitlygtb8%3D 18371435 (Pubitemid 351181031)
45. S Ilancheran A Michalska G Peh EM Wallace M Pera U Manuelpillai 2007 Stem cells derived from human fetal membranes display multilineage differentiation potential Biol Reprod 77 577 588 biolreprod.106.055244 [pii] 10.1095/biolreprod.106.055244 10.1095/biolreprod.106.055244 1:CAS:528: DC%2BD2sXpvFCru74%3D 17494917 (Pubitemid 47328622)
46. S Wolbank A Peterbauer M Fahrner S Hennerbichler M van Griensven G Stadler H Redl C Gabriel 2007 Dose-dependent immunomodulatory effect of human stem cells from amniotic membrane: a comparison with human mesenchymal stem cells from adipose tissue Tissue Eng 13 1173 1183 10.1089/ten.2006.0313 10.1089/ten.2006.0313 1:CAS:528:DC%2BD2sXms1WhsLo%3D 17518752 (Pubitemid 46986718)
47. R Jaenisch R Young 2008 Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming Cell 132 567 582 S0092-8674(08)00115-3 [pii] 10.1016/j.cell.2008.01.015 10.1016/j.cell.2008.01.015 1:CAS:528: DC%2BD1cXivVagtr0%3D 18295576 (Pubitemid 351253686)
48. A Raya I Rodriguez-Piza G Guenechea R Vassena S Navarro MJ Barrero A Consiglio M Castella P Rio E Sleep F Gonzalez G Tiscornia E Garreta T Aasen A Veiga IM Verma J Surralles J Bueren JC Belmonte 2009 Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells Nature nature08129 [pii] 10.1038/nature08129
49. JT Dimos KT Rodolfa KK Niakan LM Weisenthal H Mitsumoto W Chung GF Croft G Saphier R Leibel R Goland H Wichterle CE Henderson K Eggan 2008 Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons Science 321 1218 1221 1158799 [pii] 10.1126/science.1158799 10.1126/science.1158799 1:CAS:528:DC%2BD1cXhtVGgt7zL 18669821
50. MH Chin MJ Mason W Xie S Volinia M Singer C Peterson G Ambartsumyan O Aimiuwu L Richter J Zhang I Khvorostov V Ott M Grunstein N Lavon N Benvenisty CM Croce AT Clark T Baxter AD Pyle MA Teitell M Pelegrini K Plath WE Lowry 2009 Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures Cell Stem Cell 5 111 123 S1934-5909(09)00292-6 [pii] 10.1016/j.stem.2009.06.008 10.1016/j.stem.2009.06.008 1:CAS:528: DC%2BD1MXoslCns7s%3D 19570518
51. IL Weissman JA Shizuru 2008 The origins of the identification and isolation of hematopoietic stem cells, and their capability to induce donor-specific transplantation tolerance and treat autoimmune diseases Blood 112 3543 3553 112/9/3543 [pii] 10.1182/blood-2008-08-078220 10.1182/blood-2008-08- 078220 1:CAS:528:DC%2BD1cXhtlCntr3F 18948588
52. AM Gallegos MJ Bevan 2004 Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation J Exp Med 200 1039 1049 jem.20041457 [pii] 10.1084/jem.20041457 10.1084/jem.20041457 1:CAS:528:DC%2BD2cXovVensb4%3D 15492126 (Pubitemid 39431128)
53. M Sykes 2007 Mechanisms of tolerance induced via mixed chimerism Front Biosci 12 2922 2934 2282 [pii] 10.2741/2282 1:CAS:528:DC%2BD2sXms1KmsL8%3D 17485269
54. NJ Olsen WJ Kovacs 2001 Effects of androgens on T and B lymphocyte development Immunol Res 23 281 288 IR:23:2-3:281 [pii] 10.1385/IR:23:2-3:281 10.1385/IR:23:2-3:281 1:CAS:528:DC%2BD3MXltFWqtrg%3D 11444393 (Pubitemid 32575369)
55. PW Kincade KL Medina KJ Payne MI Rossi KS Tudor Y Yamashita T Kouro 2000 Early B-lymphocyte precursors and their regulation by sex steroids Immunol Rev 175 128 137 10.1111/j.1600-065X.2000.imr017502.x 1:CAS:528:DC%2BD3cXls12gs7k%3D 10933598
56. JS Sutherland GL Goldberg MV Hammett AP Uldrich SP Berzins TS Heng BR Blazar JL Millar MA Malin AP Chidgey RL Boyd 2005 Activation of thymic regeneration in mice and humans following androgen blockade J Immunol 175 2741 2753 175/4/2741 [pii] 1:CAS:528:DC%2BD2MXntVSqsbY%3D 16081852
57. AC Roden MT Moser SD Tri M Mercader SM Kuntz H Dong AA Hurwitz DJ McKean E Celis BC Leibovich JP Allison ED Kwon 2004 Augmentation of T cell levels and responses induced by androgen deprivation J Immunol 173 6098 6108 173/10/6098 [pii] 1:CAS:528:DC%2BD2cXpt1Ols70%3D 15528346
58. TS Heng GL Goldberg DH Gray JS Sutherland AP Chidgey RL Boyd 2005 Effects of castration on thymocyte development in two different models of thymic involution J Immunol 175 2982 2993 175/5/2982 [pii] 1:CAS:528: DC%2BD2MXos1GitL0%3D 16116185
59. JA Dudakov GL Goldberg JJ Reiseger AP Chidgey RL Boyd 2009 Withdrawal of sex steroids reverses age- and chemotherapy-related defects in bone marrow lymphopoiesis J Immunol 182 6247 6260 182/10/6247 [pii] 10.4049/jimmunol.0802446 10.4049/jimmunol.0802446 1:CAS:528:DC%2BD1MXltlynurw%3D 19414778
60. GL Goldberg JS Sutherland MV Hammet MK Milton TS Heng AP Chidgey RL Boyd 2005 Sex steroid ablation enhances lymphoid recovery following autologous hematopoietic stem cell transplantation Transplantation 80 1604 1613 00007890-200512150-00015 [pii] 10.1097/01.tp.0000183962.64777.da 16371932 (Pubitemid 43005872)
61. GL Goldberg O Alpdogan SJ Muriglan MV Hammett MK Milton JM Eng VM Hubbard A Kochman LM Willis AS Greenberg KH Tjoe JS Sutherland A Chidgey MR van den Brink RL Boyd 2007 Enhanced immune reconstitution by sex steroid ablation following allogeneic hemopoietic stem cell transplantation J Immunol 178 7473 7484 178/11/7473 [pii] 1:CAS:528:DC%2BD2sXlsVOksbs%3D 17513799
62. GL Goldberg CG King RA Nejat DY Suh OM Smith JC Bretz RM Samstein JA Dudakov AP Chidgey S Chen-Kiang RL Boyd MR van den Brink 2009 Luteinizing hormone-releasing hormone enhances T cell recovery following allogeneic bone marrow transplantation J Immunol 182 5846 5854 182/9/5846 [pii] 10.4049/jimmunol.0801458 10.4049/jimmunol.0801458 1:CAS:528:DC%2BD1MXkslKhtrk%3D 19380833
63. JS Sutherland L Spyroglou JL Muirhead TS Heng A Prieto-Hinojosa HM Prince AP Chidgey AP Schwarer RL Boyd 2008 Enhanced immune system regeneration in humans following allogeneic or autologous hemopoietic stem cell transplantation by temporary sex steroid blockade Clin Cancer Res 14 1138 1149 14/4/1138 [pii] 10.1158/1078-0432.CCR-07-1784 10.1158/1078-0432.CCR-07-1784 1:CAS:528: DC%2BD1cXhvF2nsL0%3D 18281548 (Pubitemid 351302562)
64. O Alpdogan VM Hubbard OM Smith N Patel S Lu GL Goldberg DH Gray J Feinman AA Kochman JM Eng D Suh SJ Muriglan RL Boyd MR van den Brink 2006 Keratinocyte growth factor (KGF) is required for postnatal thymic regeneration Blood 107 2453 2460 2005-07-2831 [pii] 10.1182/blood-2005-07-2831 10.1182/blood-2005-07-2831 1:CAS:528:DC%2BD28XisFOjuro%3D 16304055 (Pubitemid 43345567)
65. D Min A Panoskaltsis-Mortari OM Kuro GA Hollander BR Blazar KI Weinberg 2007 Sustained thymopoiesis and improvement in functional immunity induced by exogenous KGF administration in murine models of aging Blood 109 2529 2537 blood-2006-08-043794 [pii] 10.1182/blood-2006-08-043794 10.1182/blood-2006-08- 043794 1:CAS:528:DC%2BD2sXnslygsbo%3D 17138819 (Pubitemid 46425898)
66. SW Rossi LT Jeker T Ueno S Kuse MP Keller S Zuklys AV Gudkov Y Takahama W Krenger BR Blazar GA Hollander 2007 Keratinocyte growth factor (KGF) enhances postnatal T-cell development via enhancements in proliferation and function of thymic epithelial cells Blood 109 3803 3811 blood-2006-10-049767 [pii] 10.1182/blood-2006-10-049767 10.1182/blood-2006-10-049767 1:CAS:528: DC%2BD2sXkvFCitLo%3D 17213286 (Pubitemid 46641731)
67. S Rossi BR Blazar CL Farrell DM Danilenko DL Lacey KI Weinberg W Krenger GA Hollander 2002 Keratinocyte growth factor preserves normal thymopoiesis and thymic microenvironment during experimental graft-versus-host disease Blood 100 682 691 10.1182/blood.V100.2.682 1:CAS:528:DC%2BD38XlsVWgtbk%3D 12091365 (Pubitemid 34761136)
68. RM Kelly SL Highfill A Panoskaltsis-Mortari PA Taylor RL Boyd GA Hollander BR Blazar 2008 Keratinocyte growth factor and androgen blockade work in concert to protect against conditioning regimen-induced thymic epithelial damage and enhance T-cell reconstitution after murine bone marrow transplantation Blood 111 5734 5744 blood-2008-01-136531 [pii] 10.1182/blood-2008-01-136531 10.1182/blood-2008-01-136531 1:CAS:528: DC%2BD1cXnsVOkur8%3D 18334670
69. D Andrew R Aspinall 2001 Il-7 and not stem cell factor reverses both the increase in apoptosis and the decline in thymopoiesis seen in aged mice J Immunol 166 1524 1530 1:CAS:528:DC%2BD3MXhtVSjtLY%3D 11160192
70. O Alpdogan SJ Muriglan JM Eng LM Willis AS Greenberg BJ Kappel MR van den Brink 2003 IL-7 enhances peripheral T cell reconstitution after allogeneic hematopoietic stem cell transplantation J Clin Invest 112 1095 1107 10.1172/JCI17865 112/7/1095 [pii] 1:CAS:528:DC%2BD3sXnvFGrsbw%3D 14523046
71. TJ Fry M Moniuszko S Creekmore SJ Donohue DC Douek S Giardina TT Hecht BJ Hill K Komschlies J Tomaszewski G Franchini CL Mackall 2003 IL-7 therapy dramatically alters peripheral T-cell homeostasis in normal and SIV-infected nonhuman primates Blood 101 2294 2299 10.1182/blood-2002-07-2297 2002-07-2297 [pii] 10.1182/blood-2002-07-2297 1:CAS:528:DC%2BD3sXit1egsbc%3D 12411295 (Pubitemid 36302072)
72. YW Chu SA Memon SO Sharrow FT Hakim M Eckhaus PJ Lucas RE Gress 2004 Exogenous IL-7 increases recent thymic emigrants in peripheral lymphoid tissue without enhanced thymic function Blood 104 1110 1119 10.1182/blood-2003-10-3635 2003-10-3635 [pii] 10.1182/blood-2003-10-3635 1:CAS:528:DC%2BD2cXmslKgsLg%3D 15130942 (Pubitemid 39038032)
73. EJ Wils E Braakman GM Verjans EJ Rombouts AE Broers HG Niesters G Wagemaker FJ Staal B Lowenberg H Spits JJ Cornelissen 2007 Flt3 ligand expands lymphoid progenitors prior to recovery of thymopoiesis and accelerates T cell reconstitution after bone marrow transplantation J Immunol 178 3551 3557 178/6/3551 [pii] 1:CAS:528:DC%2BD2sXisVGjs7Y%3D 17339451
74. TJ Fry M Sinha M Milliron YW Chu V Kapoor RE Gress E Thomas CL Mackall 2004 Flt3 ligand enhances thymic-dependent and thymic-independent immune reconstitution Blood 104 2794 2800 10.1182/blood-2003-11-3789 2003-11-3789 [pii] 10.1182/blood-2003-11-3789 1:CAS:528:DC%2BD2cXpslKjt7Y%3D 15226184 (Pubitemid 39434964)
75. L Kenins JW Gill RL Boyd GA Hollander A Wodnar-Filipowicz 2008 Intrathymic expression of Flt3 ligand enhances thymic recovery after irradiation J Exp Med 205 523 531 jem.20072065 [pii] 10.1084/jem.20072065 10.1084/jem.20072065 1:CAS:528:DC%2BD1cXjs1ahtb8%3D 18299401
76. VD Dixit H Yang Y Sun AT Weeraratna YH Youm RG Smith DD Taub 2007 Ghrelin promotes thymopoiesis during aging J Clin Invest 117 2778 2790 10.1172/JCI30248 10.1172/JCI30248 1:CAS:528:DC%2BD2sXhtFCnt73O 17823656 (Pubitemid 47529609)
77. LA Napolitano D Schmidt MB Gotway N Ameli EL Filbert MM Ng JL Clor L Epling E Sinclair PD Baum K Li ML Killian P Bacchetti JM McCune 2008 Growth hormone enhances thymic function in HIV-1-infected adults J Clin Invest 118 1085 1098 10.1172/JCI32830 1:CAS:528:DC%2BD1cXivFemsLY%3D 18292808
78. C Carlo-Stella M Di Nicola R Milani P Longoni M Milanesi C Bifulco C Stucchi A Guidetti L Cleris F Formelli G Garotta AM Gianni 2004 Age- and irradiation-associated loss of bone marrow hematopoietic function in mice is reversed by recombinant human growth hormone Exp Hematol 32 171 178 10.1016/j.exphem.2003.11.007 S0301472X03003941 [pii] 10.1016/j.exphem.2003.11. 007 1:CAS:528:DC%2BD2cXhtV2rs74%3D 15102478 (Pubitemid 38180563)
79. RN La Motte-Mohs E Herer JC Zuniga-Pflucker 2005 Induction of T-cell development from human cord blood hematopoietic stem cells by Delta-like 1 in vitro Blood 105 1431 1439 2004-04-1293 [pii] 10.1182/blood-2004-04-1293 10.1182/blood-2004-04-1293 15494433 (Pubitemid 40223658)
80. TM Schmitt RF de Pooter MA Gronski SK Cho PS Ohashi JC Zuniga-Pflucker 2004 Induction of T cell development and establishment of T cell competence from embryonic stem cells differentiated in vitro Nat Immunol 5 410 417 10.1038/ni1055 ni1055 [pii] 10.1038/ni1055 1:CAS:528:DC%2BD2cXisF2ktbg%3D 15034575 (Pubitemid 38500090)
81. J Gill M Malin GA Hollander R Boyd 2002 Generation of a complete thymic microenvironment by MTS24(+) thymic epithelial cells Nat Immunol 3 635 642 10.1038/ni812 ni812 [pii] 10.1038/ni812 1:CAS:528:DC%2BD38Xksl2muro%3D 12068292 (Pubitemid 34752472)
82. N Seach D Layton J Lim A Chidgey R Boyd 2007 Thymic generation and regeneration: a new paradigm for establishing clinical tolerance of stem cell-based therapies Curr Opin Biotechnol 18 441 447 S0958-1669(07)00083-3 [pii] 10.1016/j.copbio.2007.07.001 10.1016/j.copbio.2007.07.001 1:CAS:528: DC%2BD2sXhtlGhu7zJ 17702564 (Pubitemid 350119857)