Lysosomal ceramide mediates gemcitabine-induced death of glioma cells

Journal of Molecular Medicine

Volumn 87, Issue 11, 2009, Pages 1123-1132

  Dumitru, Claudia A ^a   Sandalcioglu, Ibrahim E ^a   Wagner, Marek ^a   Weller, Michael ^b   Gulbins, Erich ^a  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

Acid sphingomyelinase; Apoptosis; Ceramide; Death; Glioma; Lipid research; Lysosomes; Tumor

Indexed keywords

CATHEPSIN D; CERAMIDE; GEMCITABINE; PROTEIN BAX; SPHINGOMYELIN PHOSPHODIESTERASE;

ANIMAL CELL; ARTICLE; BRAIN MITOCHONDRION; CANCER CELL DESTRUCTION; CANCER CHEMOTHERAPY; CELL DEATH; CHEMOSENSITIZATION; CONTROLLED STUDY; ENZYME ACTIVATION; GENE DELETION; GENE INSERTION; GENE OVEREXPRESSION; GLIOMA CELL; HUMAN; HUMAN CELL; LYSOSOME; MOUSE; NONHUMAN; PROTEIN AGGREGATION; PROTEIN FUNCTION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; BCL-2-ASSOCIATED X PROTEIN; CATHEPSIN D; CELL DEATH; CELL LINE, TUMOR; CERAMIDES; DEOXYCYTIDINE; GLIOMA; HUMANS; LYSOSOMES; MICE; SPHINGOMYELIN PHOSPHODIESTERASE;

EID: 70449518968     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00109-009-0514-8     Document Type: Article

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